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Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.

Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M.

Lancet Oncol. 2019 Jul;20(7):1011-1022. doi: 10.1016/S1470-2045(19)30277-3. Epub 2019 May 28.


Measurement of Projections Between Dentate Nucleus and Contralateral Frontal Cortex in Human Brain Via Diffusion Tensor Tractography.

Ji Q, Edwards A, Glass JO, Brinkman TM, Patay Z, Reddick WE.

Cerebellum. 2019 Aug;18(4):761-769. doi: 10.1007/s12311-019-01035-3.


Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression.

Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH, Fan Y, Shaw TI, Silveira AB, Qu C, Xu R, Zhu X, Zhang J, Russell HR, Peters JL, Finkelstein D, Xu B, Lin T, Tinkle CL, Patay Z, Onar-Thomas A, Pounds SB, McKinnon PJ, Ellison DW, Zhang J, Baker SJ.

Cancer Cell. 2019 Jan 14;35(1):140-155.e7. doi: 10.1016/j.ccell.2018.11.015. Epub 2018 Dec 27.


Childhood Medulloblastoma Revisited.

Cassia GSE, Alves CAPF, Taranath A, López NS, Oztekin O, Gonçalves FG, Patay Z.

Top Magn Reson Imaging. 2018 Dec;27(6):479-502. doi: 10.1097/RMR.0000000000000184. Review.


Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion.

Chiang J, Dalton J, Upadhyaya SA, Patay Z, Qaddoumi I, Li X, Segura AD, Sharma S, Ismail A, Shurtleff SA, Raimondi SC.

Acta Neuropathol. 2019 Jan;137(1):179-181. doi: 10.1007/s00401-018-1940-x. Epub 2018 Nov 21. No abstract available.


Cerebellar mutism syndrome.

Catsman-Berrevoets C, Patay Z.

Handb Clin Neurol. 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. Review.


Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial.

Robinson GW, Rudneva VA, Buchhalter I, Billups CA, Waszak SM, Smith KS, Bowers DC, Bendel A, Fisher PG, Partap S, Crawford JR, Hassall T, Indelicato DJ, Boop F, Klimo P, Sabin ND, Patay Z, Merchant TE, Stewart CF, Orr BA, Korbel JO, Jones DTW, Sharma T, Lichter P, Kool M, Korshunov A, Pfister SM, Gilbertson RJ, Sanders RP, Onar-Thomas A, Ellison DW, Gajjar A, Northcott PA.

Lancet Oncol. 2018 Jun;19(6):768-784. doi: 10.1016/S1470-2045(18)30204-3. Epub 2018 May 16.


Treatment-Related Noncontiguous Radiologic Changes in Children With Diffuse Intrinsic Pontine Glioma Treated With Expanded Irradiation Fields and Antiangiogenic Therapy.

Patay Z, Merchant TE, Nguyen R, Pierson CR, Onar-Thomas A, Broniscer A.

Int J Radiat Oncol Biol Phys. 2017 Dec 1;99(5):1295-1305. doi: 10.1016/j.ijrobp.2017.08.021. Epub 2017 Aug 24.


Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation.

Svolos P, Reddick WE, Edwards A, Sykes A, Li Y, Glass JO, Patay Z.

AJNR Am J Neuroradiol. 2017 Jun;38(6):1235-1241. doi: 10.3174/ajnr.A5159. Epub 2017 Apr 20.


Posttreatment DSC-MRI is Predictive of Early Treatment Failure in Children with Supratentorial High-Grade Glioma Treated with Erlotinib.

Lucas JT Jr, Knapp BJ, Uh J, Hua CH, Merchant TE, Hwang SN, Patay Z, Broniscer A.

Clin Neuroradiol. 2018 Sep;28(3):393-400. doi: 10.1007/s00062-017-0580-1. Epub 2017 Apr 5.


Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma.

Tinkle CL, Orr BA, Lucas JT Jr, Klimo P, Patay Z, Baker SJ, Broniscer A, Qaddoumi I.

Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26416. Epub 2017 Jan 13.


Unusual magnetic resonance imaging presentation of post-BMT cerebral toxoplasmosis masquerading as meningoencephalitis and ventriculitis.

Helton KJ, Maron G, Mamcarz E, Leventaki V, Patay Z, Sadighi Z.

Bone Marrow Transplant. 2016 Nov;51(11):1533-1536. doi: 10.1038/bmt.2016.168. Epub 2016 Jun 27. No abstract available.


Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.

Löbel U, Hwang S, Edwards A, Li Y, Li X, Broniscer A, Patay Z.

Neuroradiology. 2016 Oct;58(10):1027-1034. Epub 2016 Jul 20.


Fast frequency-sweep spectroscopic imaging with an ultra-low flip angle.

Guo J, Patay Z, Reddick WE.

Sci Rep. 2016 Jul 21;6:30066. doi: 10.1038/srep30066.


MRI Evaluation of Non-Necrotic T2-Hyperintense Foci in Pediatric Diffuse Intrinsic Pontine Glioma.

Clerk-Lamalice O, Reddick WE, Li X, Li Y, Edwards A, Glass JO, Patay Z.

AJNR Am J Neuroradiol. 2016 Oct;37(10):1930-1937. doi: 10.3174/ajnr.A4814. Epub 2016 May 19.


Neurometabolic diseases of childhood.

Patay Z, Blaser SI, Poretti A, Huisman TA.

Pediatr Radiol. 2015 Sep;45 Suppl 3:S473-84. doi: 10.1007/s00247-015-3279-y. Epub 2015 Sep 7. Review.


MR Imaging Characteristics of Wingless-Type-Subgroup Pediatric Medulloblastoma.

Patay Z, DeSain LA, Hwang SN, Coan A, Li Y, Ellison DW.

AJNR Am J Neuroradiol. 2015 Dec;36(12):2386-93. doi: 10.3174/ajnr.A4495. Epub 2015 Sep 3.


Atypical teratoid/rhabdoid tumor (ATRT) arising from the 3rd cranial nerve in infants: a clinical-radiological entity?

Oh CC, Orr BA, Bernardi B, Garré ML, Rossi A, Figà-Talamanca L, Robinson GW, Patay Z.

J Neurooncol. 2015 Sep;124(2):175-83. doi: 10.1007/s11060-015-1787-0. Epub 2015 Jul 7.


Postoperative posterior fossa syndrome: unraveling the etiology and underlying pathophysiology by using magnetic resonance imaging.

Patay Z.

Childs Nerv Syst. 2015 Oct;31(10):1853-8. doi: 10.1007/s00381-015-2796-1. Epub 2015 Jul 5. Review.


Brain magnetic resonance imaging and proton MR spectroscopic findings after metabolic crisis in 3-methylcrotonylglycinuria.

Alshumrani GA, Patay Z.

Ann Saudi Med. 2015 Jan-Feb;35(1):64-8. doi: 10.5144/0256-4947.2015.64.


Postoperative intraspinal subdural collections after pediatric posterior fossa tumor resection: incidence, imaging, and clinical features.

Harreld JH, Mohammed N, Goldsberry G, Li X, Li Y, Boop F, Patay Z.

AJNR Am J Neuroradiol. 2015 May;36(5):993-9. doi: 10.3174/ajnr.A4221. Epub 2015 Jan 22.


Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections.

Wright KD, Panetta JC, Onar-Thomas A, Reddick WE, Patay Z, Qaddoumi I, Broniscer A, Robinson G, Boop FA, Klimo P Jr, Ward D, Gajjar A, Stewart CF.

Cancer Chemother Pharmacol. 2015 Jan;75(1):27-35. doi: 10.1007/s00280-014-2614-6. Epub 2014 Oct 24.


Successive distinct high-grade gliomas in L-2-hydroxyglutaric aciduria.

Patay Z, Orr BA, Shulkin BL, Hwang SN, Ying Y, Broniscer A, Boop FA, Ellison DW.

J Inherit Metab Dis. 2015 Mar;38(2):273-7. doi: 10.1007/s10545-014-9782-8. Epub 2014 Oct 23.


Quantitative longitudinal evaluation of diaschisis-related cerebellar perfusion and diffusion parameters in patients with supratentorial hemispheric high-grade gliomas after surgery.

Patay Z, Parra C, Hawk H, George A, Li Y, Scoggins M, Broniscer A, Ogg RJ.

Cerebellum. 2014 Oct;13(5):580-7. doi: 10.1007/s12311-014-0575-2.


Elevated cerebral blood volume contributes to increased FLAIR signal in the cerebral sulci of propofol-sedated children.

Harreld JH, Sabin ND, Rossi MG, Awwad R, Reddick WE, Yuan Y, Glass JO, Ji Q, Gajjar A, Patay Z.

AJNR Am J Neuroradiol. 2014 Aug;35(8):1574-9. doi: 10.3174/ajnr.A3911. Epub 2014 Apr 3.


"Occult" post-contrast signal enhancement in pediatric diffuse intrinsic pontine glioma is the MRI marker of angiogenesis?

Conway AE, Reddick WE, Li Y, Yuan Y, Glass JO, Baker JN, Kun LE, Broniscer A, Patay Z.

Neuroradiology. 2014 May;56(5):405-12. doi: 10.1007/s00234-014-1348-9. Epub 2014 Mar 14.


Incidental detection of late subsequent intracranial neoplasms with magnetic resonance imaging among adult survivors of childhood cancer.

Sabin ND, Santucci AK, Klimo P Jr, Hudson MM, Srivastava D, Zhang N, Kun LE, Krasin MJ, Pui CH, Patay Z, Reddick WE, Ogg RJ, Hillenbrand CM, Robison LL, Krull KR, Armstrong GT.

J Cancer Surviv. 2014 Sep;8(3):329-35. doi: 10.1007/s11764-014-0344-8. Epub 2014 Feb 2.


MR imaging evaluation of inferior olivary nuclei: comparison of postoperative subjects with and without posterior fossa syndrome.

Patay Z, Enterkin J, Harreld JH, Yuan Y, Löbel U, Rumboldt Z, Khan R, Boop F.

AJNR Am J Neuroradiol. 2014 Apr;35(4):797-802. doi: 10.3174/ajnr.A3762. Epub 2013 Nov 1.


Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma.

Jackson S, Patay Z, Howarth R, Pai Panandiker AS, Onar-Thomas A, Gajjar A, Broniscer A.

J Neurooncol. 2013 Sep;114(3):339-44. doi: 10.1007/s11060-013-1189-0. Epub 2013 Jun 29.


The effects of propofol on cerebral perfusion MRI in children.

Harreld JH, Helton KJ, Kaddoum RN, Reddick WE, Li Y, Glass JO, Sansgiri R, Ji Q, Feng T, Parish ME, Gajjar A, Patay Z.

Neuroradiology. 2013 Aug;55(8):1049-1056. doi: 10.1007/s00234-013-1187-0. Epub 2013 May 15.


Authors' response to correspondence on "mesial temporal sclerosis in a cohort of children with SCN1A gene mutation".

Van Poppel K, Patay Z, Roberts D, Clarke D, McGregor A, Perkins FF, Wheless J.

J Child Neurol. 2013 Apr;28(4):542. doi: 10.1177/0883073812473509. No abstract available.


Fludarabine-induced severe necrotizing leukoencephalopathy in pediatric hematopoietic cell transplantation.

Helton KJ, Patay Z, Triplett BM.

Bone Marrow Transplant. 2013 May;48(5):729-31. doi: 10.1038/bmt.2012.196. Epub 2012 Oct 22. No abstract available.


Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy.

Sabin ND, Merchant TE, Harreld JH, Patay Z, Klimo P Jr, Qaddoumi I, Armstrong GT, Wright K, Gray J, Indelicato DJ, Gajjar A.

AJNR Am J Neuroradiol. 2013 Feb;34(2):446-50. doi: 10.3174/ajnr.A3219. Epub 2012 Jul 19.


Mesial temporal sclerosis in a cohort of children with SCN1A gene mutation.

Van Poppel K, Patay Z, Roberts D, Clarke DF, McGregor A, Perkins FF, Wheless JW.

J Child Neurol. 2012 Jul;27(7):893-7. doi: 10.1177/0883073811435325. Epub 2012 Apr 24.


Cerebral neoplasms in L-2 hydroxyglutaric aciduria: 3 new cases and meta-analysis of literature data.

Patay Z, Mills JC, Löbel U, Lambert A, Sablauer A, Ellison DW.

AJNR Am J Neuroradiol. 2012 May;33(5):940-3. doi: 10.3174/ajnr.A2869. Epub 2012 Jan 12. Review.


Isochromosome 17q, MYC amplification and large cell/anaplastic phenotype in a case of medullomyoblastoma with extracranial metastases.

Wright KD, von der Embse K, Coleman J, Patay Z, Ellison DW, Gajjar A.

Pediatr Blood Cancer. 2012 Sep;59(3):561-4. doi: 10.1002/pbc.24002. Epub 2011 Dec 6.


MR imaging workup of inborn errors of metabolism of early postnatal onset.

Patay Z.

Magn Reson Imaging Clin N Am. 2011 Nov;19(4):733-59; vii. doi: 10.1016/j.mric.2011.09.001. Epub 2011 Oct 22.


Magnetic resonance imaging features of meningiomas in children and young adults: a retrospective analysis.

Pinto PS, Huisman TA, Ahn E, Jordan LC, Burger P, Cohen KJ, Patay Z, Tekes A.

J Neuroradiol. 2012 Oct;39(4):218-26. doi: 10.1016/j.neurad.2011.06.003. Epub 2011 Aug 12.


Accelerated myelination with motor system involvement in a neonate with immediate postnatal onset of seizures and hemimegalencephaly.

Goldsberry G, Mitra D, MacDonald D, Patay Z.

Epilepsy Behav. 2011 Oct;22(2):391-4. doi: 10.1016/j.yebeh.2011.06.025. Epub 2011 Jul 29.


Surgical management of tumors producing the thalamopeduncular syndrome of childhood.

Broadway SJ, Ogg RJ, Scoggins MA, Sanford R, Patay Z, Boop FA.

J Neurosurg Pediatr. 2011 Jun;7(6):589-95. doi: 10.3171/2011.4.PEDS119.


MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC).

Poussaint TY, Kocak M, Vajapeyam S, Packer RI, Robertson RL, Geyer R, Haas-Kogan D, Pollack IF, Vezina G, Zimmerman R, Cha S, Patay Z, Boyett JM, Kun LE.

Neuro Oncol. 2011 Apr;13(4):417-27. doi: 10.1093/neuonc/noq200. Epub 2011 Feb 4.


Infiltrative cerebellar ganglioglioma: conventional and advanced MRI, proton MR spectroscopic, and FDG PET findings in an 18-month-old child.

Löbel U, Ellison DW, Shulkin BL, Patay Z.

Clin Radiol. 2011 Feb;66(2):194-201. doi: 10.1016/j.crad.2010.10.005. Epub 2010 Nov 19. Review. No abstract available.


Subtypes of medulloblastoma have distinct developmental origins.

Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ.

Nature. 2010 Dec 23;468(7327):1095-9. doi: 10.1038/nature09587. Epub 2010 Dec 8.


Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma.

Löbel U, Sedlacik J, Reddick WE, Kocak M, Ji Q, Broniscer A, Hillenbrand CM, Patay Z.

AJNR Am J Neuroradiol. 2011 Feb;32(2):315-22. doi: 10.3174/ajnr.A2277. Epub 2010 Nov 18.


Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma.

Löbel U, Sedlacik J, Sabin ND, Kocak M, Broniscer A, Hillenbrand CM, Patay Z.

Neuroradiology. 2010 Dec;52(12):1167-77. doi: 10.1007/s00234-010-0771-9. Epub 2010 Sep 28.


Successful treatment of early detected trilateral retinoblastoma using standard infant brain tumor therapy.

Wright KD, Qaddoumi I, Patay Z, Gajjar A, Wilson MW, Rodriguez-Galindo C.

Pediatr Blood Cancer. 2010 Sep;55(3):570-2. doi: 10.1002/pbc.22545.


Regional white matter anisotropy and reading ability in patients treated for pediatric embryonal tumors.

Palmer SL, Reddick WE, Glass JO, Ogg R, Patay Z, Wallace D, Gajjar A.

Brain Imaging Behav. 2010 Jun;4(2):132-40. doi: 10.1007/s11682-010-9092-1.


Alexander Disease: An Important Mimicker of Focal Brainstem Glioma-Response.

Van Poppel K, Ellison D, Broniscer A, Patay Z, Morris EB.

Pediatr Blood Cancer. 2010 Mar;54(3):487. No abstract available.


Attenuation of cerebral venous contrast in susceptibility-weighted imaging of spontaneously breathing pediatric patients sedated with propofol.

Sedlacik J, Löbel U, Kocak M, Loeffler RB, Reichenbach JR, Broniscer A, Patay Z, Hillenbrand CM.

AJNR Am J Neuroradiol. 2010 May;31(5):901-6. doi: 10.3174/ajnr.A1960. Epub 2010 Jan 6.


Sphingolipid activator protein B deficiency: report of 9 Saudi patients and review of the literature.

Al-Hassnan ZN, Al Dhalaan H, Patay Z, Faqeih E, Al-Owain M, Al-Duraihem A, Faiyaz-Ul-Haque M.

J Child Neurol. 2009 Dec;24(12):1513-9. doi: 10.1177/0883073809341269. Review.


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