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Items: 1 to 50 of 91

1.

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.

Murthy SE, Loud MC, Daou I, Marshall KL, Schwaller F, Kühnemund J, Francisco AG, Keenan WT, Dubin AE, Lewin GR, Patapoutian A.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat9897. doi: 10.1126/scitranslmed.aat9897.

PMID:
30305457
2.

Structure of the human volume regulated anion channel.

Kefauver JM, Saotome K, Dubin AE, Pallesen J, Cottrell CA, Cahalan SM, Qiu Z, Hong G, Crowley CS, Whitwam T, Lee WH, Ward AB, Patapoutian A.

Elife. 2018 Aug 10;7. pii: e38461. doi: 10.7554/eLife.38461.

3.

GPR68 Senses Flow and Is Essential for Vascular Physiology.

Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, Walker JR, Ma S, Lukacs V, Bordone L, Bandell M, Laffitte B, Xu Y, Chien S, Henrion D, Patapoutian A.

Cell. 2018 Apr 19;173(3):762-775.e16. doi: 10.1016/j.cell.2018.03.076.

PMID:
29677517
4.

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A.

Cell. 2018 Apr 5;173(2):443-455.e12. doi: 10.1016/j.cell.2018.02.047. Epub 2018 Mar 22.

PMID:
29576450
5.

Structure of the mechanically activated ion channel Piezo1.

Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB.

Nature. 2018 Feb 22;554(7693):481-486. doi: 10.1038/nature25453. Epub 2017 Dec 20.

6.

Piezos thrive under pressure: mechanically activated ion channels in health and disease.

Murthy SE, Dubin AE, Patapoutian A.

Nat Rev Mol Cell Biol. 2017 Dec;18(12):771-783. doi: 10.1038/nrm.2017.92. Epub 2017 Oct 4. Review.

PMID:
28974772
7.

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):266-270.e3. doi: 10.1016/j.neuron.2017.03.039.

8.

Editorial Note to: Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):265. doi: 10.1016/j.neuron.2017.03.041. No abstract available.

9.

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.

Nonomura K, Woo SH, Chang RB, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A.

Nature. 2017 Jan 12;541(7636):176-181. doi: 10.1038/nature20793. Epub 2016 Dec 21.

10.

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.

Wu Z, Grillet N, Zhao B, Cunningham C, Harkins-Perry S, Coste B, Ranade S, Zebarjadi N, Beurg M, Fettiplace R, Patapoutian A, Mueller U.

Nat Neurosci. 2017 Jan;20(1):24-33. doi: 10.1038/nn.4449. Epub 2016 Nov 28.

11.

Piezo1 Channels Are Inherently Mechanosensitive.

Syeda R, Florendo MN, Cox CD, Kefauver JM, Santos JS, Martinac B, Patapoutian A.

Cell Rep. 2016 Nov 8;17(7):1739-1746. doi: 10.1016/j.celrep.2016.10.033.

12.

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

Syeda R, Qiu Z, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC, Montal M, Patapoutian A.

Cell. 2016 Jan 28;164(3):499-511. doi: 10.1016/j.cell.2015.12.031.

13.

Piezo2 is the principal mechanotransduction channel for proprioception.

Woo SH, Lukacs V, de Nooij JC, Zaytseva D, Criddle CR, Francisco A, Jessell TM, Wilkinson KA, Patapoutian A.

Nat Neurosci. 2015 Dec;18(12):1756-62. doi: 10.1038/nn.4162. Epub 2015 Nov 9.

14.

Mechanically Activated Ion Channels.

Ranade SS, Syeda R, Patapoutian A.

Neuron. 2015 Sep 23;87(6):1162-1179. doi: 10.1016/j.neuron.2015.08.032. Review. Erratum in: Neuron. 2015 Oct 21;88(2):433.

15.

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia.

Lukacs V, Mathur J, Mao R, Bayrak-Toydemir P, Procter M, Cahalan SM, Kim HJ, Bandell M, Longo N, Day RW, Stevenson DA, Patapoutian A, Krock BL.

Nat Commun. 2015 Sep 21;6:8329. doi: 10.1038/ncomms9329.

16.

Piezo1 ion channel pore properties are dictated by C-terminal region.

Coste B, Murthy SE, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A.

Nat Commun. 2015 May 26;6:7223. doi: 10.1038/ncomms8223.

17.

Chemical activation of the mechanotransduction channel Piezo1.

Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A.

Elife. 2015 May 22;4. doi: 10.7554/eLife.07369.

18.

Piezo1 links mechanical forces to red blood cell volume.

Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A.

Elife. 2015 May 22;4. doi: 10.7554/eLife.07370.

19.

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.

Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS.

Sci Transl Med. 2015 May 13;7(287):287ra72. doi: 10.1126/scitranslmed.3009986.

20.

Merkel cells and neurons keep in touch.

Woo SH, Lumpkin EA, Patapoutian A.

Trends Cell Biol. 2015 Feb;25(2):74-81. doi: 10.1016/j.tcb.2014.10.003. Epub 2014 Dec 2. Review.

21.

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.

Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A.

Nature. 2014 Dec 4;516(7529):121-5. doi: 10.1038/nature13980.

22.

Piezo1, a mechanically activated ion channel, is required for vascular development in mice.

Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347-52. doi: 10.1073/pnas.1409233111. Epub 2014 Jun 23.

23.

Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.

Rooney L, Vidal A, D'Souza AM, Devereux N, Masick B, Boissel V, West R, Head V, Stringer R, Lao J, Petrus MJ, Patapoutian A, Nash M, Stoakley N, Panesar M, Verkuyl JM, Schumacher AM, Petrassi HM, Tully DC.

J Med Chem. 2014 Jun 26;57(12):5129-40. doi: 10.1021/jm401986p. Epub 2014 Jun 13.

PMID:
24884675
24.

Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six.

Jabba S, Goyal R, Sosa-Pagán JO, Moldenhauer H, Wu J, Kalmeta B, Bandell M, Latorre R, Patapoutian A, Grandl J.

Neuron. 2014 Jun 4;82(5):1017-31. doi: 10.1016/j.neuron.2014.04.016. Epub 2014 May 8.

25.

SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A.

Cell. 2014 Apr 10;157(2):447-458. doi: 10.1016/j.cell.2014.03.024.

26.

Piezo2 is required for Merkel-cell mechanotransduction.

Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A.

Nature. 2014 May 29;509(7502):622-6. doi: 10.1038/nature13251. Epub 2014 Apr 6.

27.

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors.

Maksimovic S, Nakatani M, Baba Y, Nelson AM, Marshall KL, Wellnitz SA, Firozi P, Woo SH, Ranade S, Patapoutian A, Lumpkin EA.

Nature. 2014 May 29;509(7502):617-21. doi: 10.1038/nature13250. Epub 2014 Apr 6.

28.

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels.

Albuisson J, Murthy SE, Bandell M, Coste B, Louis-Dit-Picard H, Mathur J, Fénéant-Thibault M, Tertian G, de Jaureguiberry JP, Syfuss PY, Cahalan S, Garçon L, Toutain F, Simon Rohrlich P, Delaunay J, Picard V, Jeunemaitre X, Patapoutian A.

Nat Commun. 2013;4:1884. doi: 10.1038/ncomms2899. Erratum in: Nat Commun. 2013;4:2440.

29.

Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations.

Kim SE, Patapoutian A, Grandl J.

PLoS One. 2013;8(3):e59593. doi: 10.1371/journal.pone.0059593. Epub 2013 Mar 26.

30.

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.

Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, Philippakis A, Hoischen A, Riemer G, Steen U, Steen VM, Mathur J, Cox J, Lebo M, Rehm H, Weiss ST, Wood JN, Maas RL, Sunyaev SR, Patapoutian A.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4667-72. doi: 10.1073/pnas.1221400110. Epub 2013 Mar 4.

31.

Neuroscience: Salty sensations.

Coste B, Patapoutian A.

Nature. 2013 Feb 7;494(7435):44-5. doi: 10.1038/nature11946. Epub 2013 Jan 30. No abstract available.

PMID:
23364688
32.

Inflammatory signals enhance piezo2-mediated mechanosensitive currents.

Dubin AE, Schmidt M, Mathur J, Petrus MJ, Xiao B, Coste B, Patapoutian A.

Cell Rep. 2012 Sep 27;2(3):511-7. doi: 10.1016/j.celrep.2012.07.014. Epub 2012 Aug 23.

33.

A hot new channel.

Bandell M, Patapoutian A.

Nat Neurosci. 2012 Jun 26;15(7):931-3. doi: 10.1038/nn.3148. No abstract available.

PMID:
22735512
34.

Piezo proteins are pore-forming subunits of mechanically activated channels.

Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A.

Nature. 2012 Feb 19;483(7388):176-81. doi: 10.1038/nature10812.

35.

The role of Drosophila Piezo in mechanical nociception.

Kim SE, Coste B, Chadha A, Cook B, Patapoutian A.

Nature. 2012 Feb 19;483(7388):209-12. doi: 10.1038/nature10801.

36.

Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.

Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton KU, Patapoutian A, Beutler B.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19413-8. doi: 10.1073/pnas.1117020108. Epub 2011 Nov 15.

37.

Why does morphine make you itch?

Miyamoto T, Patapoutian A.

Cell. 2011 Oct 14;147(2):261-2. doi: 10.1016/j.cell.2011.09.026.

38.

TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin.

Miyamoto T, Petrus MJ, Dubin AE, Patapoutian A.

Nat Commun. 2011 Jun 28;2:369. doi: 10.1038/ncomms1371.

39.

Scratching the surface: a role of pain-sensing TRPA1 in itch.

Xiao B, Patapoutian A.

Nat Neurosci. 2011 May;14(5):540-2. doi: 10.1038/nn.2813. No abstract available.

PMID:
21522144
40.

Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression.

Xiao B, Coste B, Mathur J, Patapoutian A.

Nat Chem Biol. 2011 Jun;7(6):351-8. doi: 10.1038/nchembio.558. Epub 2011 Apr 17.

41.

TRPA1 contributes to cold hypersensitivity.

del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM.

J Neurosci. 2010 Nov 10;30(45):15165-74. doi: 10.1523/JNEUROSCI.2580-10.2010.

42.

Nociceptors: the sensors of the pain pathway.

Dubin AE, Patapoutian A.

J Clin Invest. 2010 Nov;120(11):3760-72. doi: 10.1172/JCI42843. Epub 2010 Nov 1. Review.

43.

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.

Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A.

Science. 2010 Oct 1;330(6000):55-60. doi: 10.1126/science.1193270. Epub 2010 Sep 2.

44.

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.

Grandl J, Kim SE, Uzzell V, Bursulaya B, Petrus M, Bandell M, Patapoutian A.

Nat Neurosci. 2010 Jun;13(6):708-14. doi: 10.1038/nn.2552. Epub 2010 Apr 22.

45.

Channels: flies feel your pain.

Macpherson LJ, Patapoutian A.

Nat Chem Biol. 2010 Apr;6(4):252-3. doi: 10.1038/nchembio.339. No abstract available.

PMID:
20300095
46.

Itching for insight.

Bandell M, Patapoutian A.

Cell. 2009 Dec 24;139(7):1224-6. doi: 10.1016/j.cell.2009.12.012.

47.

Nociceptive signals induce trafficking of TRPA1 to the plasma membrane.

Schmidt M, Dubin AE, Petrus MJ, Earley TJ, Patapoutian A.

Neuron. 2009 Nov 25;64(4):498-509. doi: 10.1016/j.neuron.2009.09.030.

48.

TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice.

Miyamoto T, Dubin AE, Petrus MJ, Patapoutian A.

PLoS One. 2009 Oct 29;4(10):e7596. doi: 10.1371/journal.pone.0007596.

49.

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP.

Mandadi S, Sokabe T, Shibasaki K, Katanosaka K, Mizuno A, Moqrich A, Patapoutian A, Fukumi-Tominaga T, Mizumura K, Tominaga M.

Pflugers Arch. 2009 Oct;458(6):1093-102. doi: 10.1007/s00424-009-0703-x. Epub 2009 Aug 8.

50.

Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.

Mandadi S, Nakanishi ST, Takashima Y, Dhaka A, Patapoutian A, McKemy DD, Whelan PJ.

Neuroscience. 2009 Sep 15;162(4):1377-97. doi: 10.1016/j.neuroscience.2009.05.063. Epub 2009 May 29.

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