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Items: 46


Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches.

Parra ER, Villalobos P, Behrens C, Jiang M, Pataer A, Swisher SG, William WN Jr, Zhang J, Lee J, Cascone T, Heymach JV, Forget MA, Haymaker C, Bernatchez C, Kalhor N, Weissferdt A, Moran C, Zhang J, Vaporciyan A, Gibbons DL, Sepesi B, Wistuba II.

J Immunother Cancer. 2018 Jun 6;6(1):48. doi: 10.1186/s40425-018-0368-0.


Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy.

Pataer A, Shao R, Correa AM, Behrens C, Roth JA, Vaporciyan AA, Wistuba II, Swisher SG.

Cancer Med. 2018 Jun;7(6):2405-2414. doi: 10.1002/cam4.1505. Epub 2018 Apr 19.


Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer.

Cascone T, Gold KA, Swisher SG, Liu DD, Fossella FV, Sepesi B, Pataer A, Weissferdt A, Kalhor N, Vaporciyan AA, Hofstetter WL, Wistuba II, Heymach JV, Kim ES, William WN Jr.

Ann Thorac Surg. 2018 Feb;105(2):418-424. doi: 10.1016/j.athoracsur.2017.08.052. Epub 2017 Dec 6.


Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics.

Gentile E, Oba T, Lin J, Shao R, Meng F, Cao X, Lin HY, Mourad M, Pataer A, Baladandayuthapani V, Cai D, Roth JA, Ji L.

Oncotarget. 2017 Jul 18;8(29):48222-48239. doi: 10.18632/oncotarget.18421.


Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG, Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED.

Cell Rep. 2017 May 23;19(8):1669-1684. doi: 10.1016/j.celrep.2017.04.077.


Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance.

Hao C, Shao R, Raju U, Fang B, Swisher SG, Pataer A.

Oncotarget. 2016 Jun 21;7(25):38235-38242. doi: 10.18632/oncotarget.9428.


Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties.

Bozorov K, Zhao JY, Elmuradov B, Pataer A, Aisa HA.

Eur J Med Chem. 2015 Sep 18;102:552-73. doi: 10.1016/j.ejmech.2015.08.018. Epub 2015 Aug 13. Review.


RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer.

Guo C, Hao C, Shao R, Fang B, Correa AM, Hofstetter WL, Roth JA, Behrens C, Kalhor N, Wistuba II, Swisher SG, Pataer A.

Oncotarget. 2015 May 10;6(13):11114-24.


Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer.

Hao C, Wang L, Peng S, Cao M, Li H, Hu J, Huang X, Liu W, Zhang H, Wu S, Pataer A, Heymach JV, Eterovic AK, Zhang Q, Shaw KR, Chen K, Futreal A, Wang M, Hofstetter W, Mehran R, Rice D, Roth JA, Sepesi B, Swisher SG, Vaporciyan A, Walsh GL, Johnson FM, Fang B.

Cancer Lett. 2015 Feb 1;357(1):179-185. doi: 10.1016/j.canlet.2014.11.024. Epub 2014 Nov 18.


Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint.

Hellmann MD, Chaft JE, William WN Jr, Rusch V, Pisters KM, Kalhor N, Pataer A, Travis WD, Swisher SG, Kris MG; University of Texas MD Anderson Lung Cancer Collaborative Group.

Lancet Oncol. 2014 Jan;15(1):e42-50. doi: 10.1016/S1470-2045(13)70334-6. Review.


Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival.

Guo C, Lu H, Gao W, Wang L, Lu K, Wu S, Pataer A, Huang M, El-Zein R, Lin T, Roth JA, Mehran R, Hofstetter W, Swisher SG, Wu X, Fang B.

PLoS One. 2013 Sep 17;8(9):e74973. doi: 10.1371/journal.pone.0074973. eCollection 2013.


Prognostic significance of combinations of RNA-dependent protein kinase and EphA2 biomarkers for NSCLC.

Guo C, Shao R, Correa AM, Behrens C, Johnson FM, Raso MG, Prudkin L, Solis LM, Nunez MI, Fang B, Roth JA, Wistuba II, Swisher SG, Lin T, Pataer A.

J Thorac Oncol. 2013 Mar;8(3):301-8. doi: 10.1097/JTO.0b013e318282def7.


Computed tomography RECIST assessment of histopathologic response and prediction of survival in patients with resectable non-small-cell lung cancer after neoadjuvant chemotherapy.

William WN Jr, Pataer A, Kalhor N, Correa AM, Rice DC, Wistuba II, Heymach J, Lee JJ, Kim ES, Munden R, Gold KA, Papadimitrakopoulou V, Swisher SG, Erasmus JJ; University of Texas M.D. Anderson Lung Cancer Collaborative Research Group.

J Thorac Oncol. 2013 Feb;8(2):222-8. doi: 10.1097/JTO.0b013e3182774108.


Histopathologic response criteria predict survival of patients with resected lung cancer after neoadjuvant chemotherapy.

Pataer A, Kalhor N, Correa AM, Raso MG, Erasmus JJ, Kim ES, Behrens C, Lee JJ, Roth JA, Stewart DJ, Vaporciyan AA, Wistuba II, Swisher SG; University of Texas M. D. Anderson Lung Cancer Collaborative Research Group.

J Thorac Oncol. 2012 May;7(5):825-32. doi: 10.1097/JTO.0b013e318247504a.


Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters.

He Y, Zhou Z, Hofstetter WL, Zhou Y, Hu W, Guo C, Wang L, Guo W, Pataer A, Correa AM, Lu Y, Wang J, Diao L, Byers LA, Wistuba II, Roth JA, Swisher SG, Heymach JV, Fang B.

PLoS One. 2012;7(2):e31087. doi: 10.1371/journal.pone.0031087. Epub 2012 Feb 10.


The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer.

He Y, Correa AM, Raso MG, Hofstetter WL, Fang B, Behrens C, Roth JA, Zhou Y, Yu L, Wistuba II, Swisher SG, Pataer A.

PLoS One. 2011;6(11):e24855. doi: 10.1371/journal.pone.0024855. Epub 2011 Nov 10.


Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients.

Pataer A, Raso MG, Correa AM, Behrens C, Tsuta K, Solis L, Fang B, Roth JA, Wistuba II, Swisher SG.

Clin Cancer Res. 2010 Nov 15;16(22):5522-8. doi: 10.1158/1078-0432.CCR-10-0753. Epub 2010 Oct 7.


KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression.

Zhou Y, Hofstetter WL, He Y, Hu W, Pataer A, Wang L, Wang J, Zhou Y, Yu L, Fang B, Swisher SG.

Cancer Biol Ther. 2010 Apr 1;9(7):507-13. Epub 2010 Apr 1.


Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma.

Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG, Fang B.

Clin Cancer Res. 2009 Sep 15;15(18):5688-95. doi: 10.1158/1078-0432.CCR-09-0310. Epub 2009 Sep 8.


Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity.

Fuson KL, Zheng M, Craxton M, Pataer A, Ramesh R, Chada S, Sutton RB.

J Biol Chem. 2009 Oct 30;284(44):30526-33. doi: 10.1074/jbc.M109.036061. Epub 2009 Sep 4.


Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.

Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn PG.

Cancer Biol Ther. 2009 Feb;8(3):245-52. Epub 2009 Feb 8.


Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound.

Hu W, Hofstetter W, Wei X, Guo W, Zhou Y, Pataer A, Li H, Fang B, Swisher SG.

J Pharmacol Exp Ther. 2009 Mar;328(3):866-72. doi: 10.1124/jpet.108.141754. Epub 2008 Dec 9.


Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing.

Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG.

Mol Cancer Ther. 2008 Aug;7(8):2528-35. doi: 10.1158/1535-7163.MCT-08-0083.


JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase.

Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B.

Cancer Gene Ther. 2008 Sep;15(9):616-24. doi: 10.1038/cgt.2008.32. Epub 2008 Jun 6.


Development of Ad-mda7/IL-24-resistant lung cancer cell lines.

Pataer A, Chada S, Roth JA, Hunt KK, Swisher SG.

Cancer Biol Ther. 2008 Jan;7(1):103-8. Epub 2007 Oct 13.


The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation.

von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG.

Clin Cancer Res. 2007 Oct 15;13(20):6032-9.


Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue.

Pataer A, Bocangel D, Chada S, Roth JA, Hunt KK, Swisher SG.

Cancer Gene Ther. 2007 Jan;14(1):12-8. Epub 2006 Oct 6.


Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.

Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB.

Oncogene. 2007 Feb 22;26(8):1201-12. Epub 2006 Aug 21.


Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53.

Pataer A, Fanale MA, Roth JA, Swisher SG, Hunt KK.

Cancer Gene Ther. 2006 Aug;13(8):806-14. Epub 2006 Apr 21.


mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members.

Chada S, Mhashilkar AM, Liu Y, Nishikawa T, Bocangel D, Zheng M, Vorburger SA, Pataer A, Swisher SG, Ramesh R, Kawase K, Meyn RE, Hunt KK.

Cancer Gene Ther. 2006 May;13(5):490-502.


Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-alpha gene therapy in esophageal cancer.

von Holzen U, Bocangel D, Pataer A, Vorburger SA, Liu Y, Lu X, Hunt KK, Swisher SG.

Surgery. 2005 Aug;138(2):261-8.


Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.

Pataer A, Vorburger SA, Chada S, Balachandran S, Barber GN, Roth JA, Hunt KK, Swisher SG.

Mol Ther. 2005 May;11(5):717-23.


Genetically targeted cancer therapy: tumor destruction by PKR activation.

Vorburger SA, Pataer A, Swisher SG, Hunt KK.

Am J Pharmacogenomics. 2004;4(3):189-98. Review.


The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells.

Sieger KA, Mhashilkar AM, Stewart A, Sutton RB, Strube RW, Chen SY, Pataer A, Swisher SG, Grimm EA, Ramesh R, Chada S.

Mol Ther. 2004 Mar;9(3):355-67.


The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells.

Vorburger SA, Pataer A, Yoshida K, Liu Y, Lu X, Swisher SG, Hunt KK.

Ann Surg Oncol. 2003 Apr;10(3):314-22.


Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.

Vorburger SA, Pataer A, Yoshida K, Barber GN, Xia W, Chiao P, Ellis LM, Hung MC, Swisher SG, Hunt KK.

Oncogene. 2002 Sep 12;21(41):6278-88.


Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Yang H, Stewart AL, Balachandran S, Roth JA, Hunt KK, Swisher SG.

Cancer Res. 2002 Apr 15;62(8):2239-43.


Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis.

Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ.

J Biol Chem. 2002 Jun 7;277(23):20301-8. Epub 2002 Mar 21.


Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores.

Nutt LK, Pataer A, Pahler J, Fang B, Roth J, McConkey DJ, Swisher SG.

J Biol Chem. 2002 Mar 15;277(11):9219-25. Epub 2001 Dec 6.


Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines.

Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA, Swisher SG.

J Thorac Cardiovasc Surg. 2001 Jan;121(1):61-7.


Adenoviral Bak overexpression mediates caspase-dependent tumor killing.

Pataer A, Fang B, Yu R, Kagawa S, Hunt KK, McDonnell TJ, Roth JA, Swisher SG.

Cancer Res. 2000 Feb 15;60(4):788-92.


Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred mouse strains.

Pataer A, Nishimura M, Kamoto T, Ichioka K, Sato M, Hiai H.

Cancer Res. 1997 Jul 15;57(14):2904-8.


Expression of LECAM-1 and LFA-1 on pre-B lymphoma cells but not on preneoplastic pre-B cells in SL/KH mice.

Lu LM, Ogawa M, Kamoto T, Yamada Y, Pataer A, Hiai H.

Leuk Res. 1997 Apr;21(4):337-42.


Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms.

Pataer A, Kamoto T, Lu LM, Yamada Y, Hiai H.

Cancer Res. 1996 Aug 15;56(16):3716-20.


A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas.

Kamoto T, Shisa H, Pataer A, Lu L, Yoshida O, Yamada Y, Hiai H.

Jpn J Cancer Res. 1996 Apr;87(4):401-4.

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