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Items: 14


Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance.

Yuzefovych LV, Pastukh VM, Ruchko MV, Simmons JD, Richards WO, Rachek LI.

PLoS One. 2019 Oct 10;14(10):e0222278. doi: 10.1371/journal.pone.0222278. eCollection 2019.


Enhanced Mitochondrial DNA Repair Resuscitates Transplantable Lungs Donated After Circulatory Death.

Tan YB, Pastukh VM, Gorodnya OM, Mulekar MS, Simmons JD, Machuca TN, Beaver TM, Wilson GL, Gillespie MN.

J Surg Res. 2020 Jan;245:273-280. doi: 10.1016/j.jss.2019.07.057. Epub 2019 Aug 14.


Plasma Transfusion Products and Contamination with Cellular and Associated Pro-Inflammatory Debris.

Tan YB, Rieske RR, Audia JP, Pastukh VM, Capley GC, Gillespie MN, Smith AA, Tatum DM, Duchesne JC, Kutcher ME, Kerby JD, Simmons JD.

J Am Coll Surg. 2019 Sep;229(3):252-258. doi: 10.1016/j.jamcollsurg.2019.04.017. Epub 2019 Apr 25.


Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions.

Simmons JD, Lee YL, Pastukh VM, Capley G, Muscat CA, Muscat DC, Marshall ML, Brevard SB, Gillespie MN.

J Trauma Acute Care Surg. 2017 Jun;82(6):1023-1029. doi: 10.1097/TA.0000000000001421.


Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa.

Lee YL, Obiako B, Gorodnya OM, Ruchko MV, Kuck JL, Pastukh VM, Wilson GL, Simmons JD, Gillespie MN.

Shock. 2017 Jul;48(1):54-60. doi: 10.1097/SHK.0000000000000838.


Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I.

Simmons JD, Freno DR, Muscat CA, Obiako B, Lee YL, Pastukh VM, Brevard SB, Gillespie MN.

J Trauma Acute Care Surg. 2017 Jan;82(1):120-125. doi: 10.1097/TA.0000000000001269.


Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.

Pastukh VM, Gorodnya OM, Gillespie MN, Ruchko MV.

Free Radic Biol Med. 2016 Jul;96:78-88. doi: 10.1016/j.freeradbiomed.2016.04.011. Epub 2016 Apr 25.


Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs.

Kuck JL, Obiako BO, Gorodnya OM, Pastukh VM, Kua J, Simmons JD, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1078-85. doi: 10.1152/ajplung.00015.2015. Epub 2015 Mar 20.


Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription.

Al-Mehdi AB, Pastukh VM, Swiger BM, Reed DJ, Patel MR, Bardwell GC, Pastukh VV, Alexeyev MF, Gillespie MN.

Sci Signal. 2012 Jul 3;5(231):ra47. doi: 10.1126/scisignal.2002712.


Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs.

Chouteau JM, Obiako B, Gorodnya OM, Pastukh VM, Ruchko MV, Wright AJ, Wilson GL, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L892-8. doi: 10.1152/ajplung.00210.2011. Epub 2011 Sep 2.


Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences.

Pastukh VM, Zhang L, Ruchko MV, Gorodnya O, Bardwell GC, Tuder RM, Gillespie MN.

Int J Chron Obstruct Pulmon Dis. 2011;6:209-17. doi: 10.2147/COPD.S15922. Epub 2011 Mar 13.


The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells.

Ruchko MV, Gorodnya OM, Zuleta A, Pastukh VM, Gillespie MN.

Free Radic Biol Med. 2011 May 1;50(9):1107-13. doi: 10.1016/j.freeradbiomed.2010.10.692. Epub 2010 Oct 20.


Controlled DNA "damage" and repair in hypoxic signaling.

Gillespie MN, Pastukh VM, Ruchko MV.

Respir Physiol Neurobiol. 2010 Dec 31;174(3):244-51. doi: 10.1016/j.resp.2010.08.025. Epub 2010 Sep 8. Review.


Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes.

Ruchko MV, Gorodnya OM, Pastukh VM, Swiger BM, Middleton NS, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2009 Feb 1;46(3):352-9. doi: 10.1016/j.freeradbiomed.2008.09.038. Epub 2008 Oct 18.

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