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Items: 29

1.

Targeting the thioredoxin system as a novel strategy against B cell acute lymphoblastic leukemia.

Fidyt K, Pastorczak A, Goral A, Szczygiel K, Fendler W, Muchowicz A, Bartlomiejczyk MA, Madzio J, Cyran J, Graczyk-Jarzynka A, Jansen E, Patkowska E, Lech-Maranda E, Pal D, Blair H, Burdzinska A, Pedzisz P, Glodkowska-Mrowka E, Demkow U, Gawle-Krawczyk K, Matysiak M, Winiarska M, Juszczynski P, Mlynarski W, Heidenreich O, Golab J, Firczuk M.

Mol Oncol. 2019 Mar 12. doi: 10.1002/1878-0261.12476. [Epub ahead of print]

2.

GATA3 germline variant is associated with CRLF2 expression and predicts outcome in pediatric B-cell precursor acute lymphoblastic leukemia.

Madzio J, Pastorczak A, Sedek L, Braun M, Taha J, Wypyszczak K, Trelinska J, Lejman M, Muszynska-Roslan K, Tomasik B, Derwich K, Koltan A, Kazanowska B, Irga-Jaworska N, Badowska W, Matysiak M, Kowalczyk J, Styczynski J, Fendler W, Szczepanski T, Mlynarski W.

Genes Chromosomes Cancer. 2019 Mar 11. doi: 10.1002/gcc.22748. [Epub ahead of print]

PMID:
30859636
3.

Validation of the United Kingdom copy-number alteration classifier in 3239 children with B-cell precursor ALL.

Hamadeh L, Enshaei A, Schwab C, Alonso CN, Attarbaschi A, Barbany G, den Boer ML, Boer JM, Braun M, Dalla Pozza L, Elitzur S, Emerenciano M, Fechina L, Felice MS, Fronkova E, Haltrich I, Heyman MM, Horibe K, Imamura T, Jeison M, Kovács G, Kuiper RP, Mlynarski W, Nebral K, Ivanov Öfverholm I, Pastorczak A, Pieters R, Piko H, Pombo-de-Oliveira MS, Rubio P, Strehl S, Stary J, Sutton R, Trka J, Tsaur G, Venn N, Vora A, Yano M, Harrison CJ, Moorman AV; International BFM Study Group.

Blood Adv. 2019 Jan 22;3(2):148-157. doi: 10.1182/bloodadvances.2018025718.

4.

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.

Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A.

Nat Commun. 2018 Nov 12;9(1):4760. doi: 10.1038/s41467-018-06925-4.

5.

Surface expression of Cytokine Receptor-Like Factor 2 increases risk of relapse in pediatric acute lymphoblastic leukemia patients harboring IKZF1 deletions.

Pastorczak A, Sedek L, Braun M, Madzio J, Sonsala A, Twardoch M, Fendler W, Nebral K, Taha J, Bielska M, Gorniak P, Romiszewska M, Matysiak M, Derwich K, Lejman M, Kowalczyk J, Badowska W, Niedzwiecki M, Kazanowska B, Muszynska-Roslan K, Sobol-Milejska G, Karolczyk G, Koltan A, Ociepa T, Szczepanski T, Młynarski W.

Oncotarget. 2018 May 25;9(40):25971-25982. doi: 10.18632/oncotarget.25411. eCollection 2018 May 25.

6.

Heterozygous carriers of germline c.657_661del5 founder mutation in NBN gene are at risk of central nervous system relapse of B-cell precursor acute lymphoblastic leukemia.

Tomasik B, Pastorczak A, Fendler W, Bartłomiejczyk M, Braun M, Mycko M, Madzio J, Polakowska E, Ulińska E, Matysiak M, Derwich K, Lejman M, Kowalczyk J, Badowska W, Kazanowska B, Szczepański T, Styczyński J, Irga-Jaworska N, Młynarski W; Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG).

Haematologica. 2018 May;103(5):e200-e203. doi: 10.3324/haematol.2017.181198. Epub 2018 Feb 1. No abstract available.

7.

High Yield of Pathogenic Germline Mutations Causative or Likely Causative of the Cancer Phenotype in Selected Children with Cancer.

Diets IJ, Waanders E, Ligtenberg MJ, van Bladel DAG, Kamping EJ, Hoogerbrugge PM, Hopman S, Olderode-Berends MJ, Gerkes EH, Koolen DA, Marcelis C, Santen GW, van Belzen MJ, Mordaunt D, McGregor L, Thompson E, Kattamis A, Pastorczak A, Mlynarski W, Ilencikova D, van Silfhout AV, Gardeitchik T, de Bont ES, Loeffen J, Wagner A, Mensenkamp AR, Kuiper RP, Hoogerbrugge N, Jongmans MC.

Clin Cancer Res. 2018 Apr 1;24(7):1594-1603. doi: 10.1158/1078-0432.CCR-17-1725. Epub 2018 Jan 19.

PMID:
29351919
8.

Perforin gene variation influences survival in childhood acute lymphoblastic leukemia.

Jaworowska A, Pastorczak A, Trelinska J, Wypyszczak K, Borowiec M, Fendler W, Sedek L, Szczepanski T, Ploski R, Młynarski W.

Leuk Res. 2018 Feb;65:29-33. doi: 10.1016/j.leukres.2017.12.011. Epub 2018 Jan 2.

PMID:
29304394
9.

Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

Schwab C, Nebral K, Chilton L, Leschi C, Waanders E, Boer JM, Žaliová M, Sutton R, Öfverholm II, Ohki K, Yamashita Y, Groeneveld-Krentz S, Froňková E, Bakkus M, Tchinda J, Barbosa TDC, Fazio G, Mlynarski W, Pastorczak A, Cazzaniga G, Pombo-de-Oliveira MS, Trka J, Kirschner-Schwabe R, Imamura T, Barbany G, Stanulla M, Attarbaschi A, Panzer-Grümayer R, Kuiper RP, den Boer ML, Cavé H, Moorman AV, Harrison CJ, Strehl S.

Blood Adv. 2017 Aug 14;1(19):1473-1477. doi: 10.1182/bloodadvances.2017006734. eCollection 2017 Aug 22.

10.

Selected miRNA levels are associated with IKZF1 microdeletions in pediatric acute lymphoblastic leukemia.

Krzanowski J, Madzio J, Pastorczak A, Tracz A, Braun M, Tabarkiewicz J, Pluta A, Młynarski W, Zawlik I.

Oncol Lett. 2017 Sep;14(3):3853-3861. doi: 10.3892/ol.2017.6599. Epub 2017 Jul 18.

11.

Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma.

Bielska M, Borowiec M, Jesionek-Kupnicka D, Braun M, Bojo M, Pastorczak A, Kalinka-Warzocha E, Prochorec-Sobieszek M, Robak T, Warzocha K, Młynarski W, Lech-Marańda E.

Int J Hematol. 2017 Dec;106(6):794-800. doi: 10.1007/s12185-017-2315-0. Epub 2017 Sep 6.

PMID:
28879630
12.

Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis.

Ratnaparkhe M, Hlevnjak M, Kolb T, Jauch A, Maass KK, Devens F, Rode A, Hovestadt V, Korshunov A, Pastorczak A, Mlynarski W, Sungalee S, Korbel J, Hoell J, Fischer U, Milde T, Kramm C, Nathrath M, Chrzanowska K, Tausch E, Takagi M, Taga T, Constantini S, Loeffen J, Meijerink J, Zielen S, Gohring G, Schlegelberger B, Maass E, Siebert R, Kunz J, Kulozik AE, Worst B, Jones DT, Pfister SM, Zapatka M, Lichter P, Ernst A.

Leukemia. 2017 Oct;31(10):2048-2056. doi: 10.1038/leu.2017.55. Epub 2017 Feb 15.

PMID:
28196983
13.

The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia.

Janczar S, Janczar K, Pastorczak A, Harb H, Paige AJ, Zalewska-Szewczyk B, Danilewicz M, Mlynarski W.

Cancers (Basel). 2017 Jan 3;9(1). pii: E2. doi: 10.3390/cancers9010002. Review.

14.

Biallelic loss of CDKN2A is associated with poor response to treatment in pediatric acute lymphoblastic leukemia.

Braun M, Pastorczak A, Fendler W, Madzio J, Tomasik B, Taha J, Bielska M, Sedek L, Szczepanski T, Matysiak M, Derwich K, Lejman M, Kowalczyk J, Kazanowska B, Badowska W, Styczynski J, Irga-Jaworska N, Trelinska J, Zalewska-Szewczyk B, Pierlejewski F, Wlodarska I, Młynarski W; Polish Pediatric Leukemia/Lymphoma Study Group.

Leuk Lymphoma. 2017 May;58(5):1162-1171. doi: 10.1080/10428194.2016.1228925. Epub 2016 Oct 18.

PMID:
27756164
15.

Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences.

Waanders E, Scheijen B, Jongmans MC, Venselaar H, van Reijmersdal SV, van Dijk AH, Pastorczak A, Weren RD, van der Schoot CE, van de Vorst M, Sonneveld E, Hoogerbrugge N, van der Velden VH, Gruhn B, Hoogerbrugge PM, van Dongen JJ, Geurts van Kessel A, van Leeuwen FN, Kuiper RP.

Leukemia. 2017 Apr;31(4):821-828. doi: 10.1038/leu.2016.277. Epub 2016 Oct 13.

PMID:
27733777
16.

Impact of mTOR expression on clinical outcome in paediatric patients with B-cell acute lymphoblastic leukaemia - preliminary report.

Ulińska E, Mycko K, Sałacińska-Łoś E, Pastorczak A, Siwicka A, Młynarski W, Matysiak M.

Contemp Oncol (Pozn). 2016;20(4):291-6. doi: 10.5114/wo.2016.61848. Epub 2016 Sep 5.

17.

Clinical course and therapeutic implications for lymphoid malignancies in Nijmegen breakage syndrome.

Pastorczak A, Szczepanski T, Mlynarski W; International Berlin-Frankfurt-Munster (I-BFM) ALL host genetic variation working group.

Eur J Med Genet. 2016 Mar;59(3):126-32. doi: 10.1016/j.ejmg.2016.01.007. Epub 2016 Jan 27. Review.

PMID:
26826318
18.

Haemophilia A and cardiovascular morbidity in a female SHAM syndrome carrier due to skewed X chromosome inactivation.

Janczar S, Kosinska J, Ploski R, Pastorczak A, Wegner O, Zalewska-Szewczyk B, Paige AJ, Borowiec M, Mlynarski W.

Eur J Med Genet. 2016 Jan;59(1):43-7. doi: 10.1016/j.ejmg.2015.12.004. Epub 2015 Dec 10.

PMID:
26691666
19.

Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia.

Janczar K, Janczar S, Pastorczak A, Mycko K, Paige AJ, Zalewska-Szewczyk B, Wagrowska-Danilewicz M, Danilewicz M, Mlynarski W.

Leuk Res. 2015 Dec;39(12):1455-61. doi: 10.1016/j.leukres.2015.10.006. Epub 2015 Oct 20.

PMID:
26520622
20.

Novel severe hemophilia A and moyamoya (SHAM) syndrome caused by Xq28 deletions encompassing F8 and BRCC3 genes.

Janczar S, Fogtman A, Koblowska M, Baranska D, Pastorczak A, Wegner O, Kostrzewska M, Laguna P, Borowiec M, Mlynarski W.

Blood. 2014 Jun 19;123(25):4002-4. doi: 10.1182/blood-2014-02-553685. No abstract available.

21.

DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia.

van der Sligte NE, Krumbholz M, Pastorczak A, Scheijen B, Tauer JT, Nowasz C, Sonneveld E, de Bock GH, Meeuwsen-de Boer TG, van Reijmersdal S, Kuiper RP, Bradtke J, Metzler M, Suttorp M, de Bont ES, van Leeuwen FN.

Br J Haematol. 2014 Jul;166(2):250-3. doi: 10.1111/bjh.12850. Epub 2014 Mar 27. Erratum in: Br J Haematol. 2014 Nov;167(4):584.

PMID:
24673583
22.

Secondary acute monocytic leukemia positive for 11q23 rearrangement in Nijmegen breakage syndrome.

Pastorczak A, Szczepanski T, Trelinska J, Finalet Ferreiro J, Wlodarska I, Mycko K, Polucha A, Sedek L, Meyer C, Marschalek R, Młynarski W.

Pediatr Blood Cancer. 2014 Aug;61(8):1469-71. doi: 10.1002/pbc.24994. Epub 2014 Mar 11.

PMID:
24619942
23.

Polymorphism in IKZF1 gene affects age at onset of childhood acute lymphoblastic leukemia.

Górniak P, Pastorczak A, Zalewska-Szewczyk B, Lejman M, Trelińska J, Chmielewska M, Sokół-Jeżewska A, Kowalczyk J, Szczepanski T, Matysiak M, Kazanowska B, Mlynarski W; Polish Pediatric Leukemia/Lymphoma Study Group.

Leuk Lymphoma. 2014 Sep;55(9):2174-8. doi: 10.3109/10428194.2013.866661. Epub 2014 Apr 2.

PMID:
24597983
24.

Asparagine synthetase (ASNS) gene polymorphism is associated with the outcome of childhood acute lymphoblastic leukemia by affecting early response to treatment.

Pastorczak A, Fendler W, Zalewska-Szewczyk B, Górniak P, Lejman M, Trelińska J, Walenciak J, Kowalczyk J, Szczepanski T, Mlynarski W; Polish Pediatric Leukemia/Lymphoma Study Group.

Leuk Res. 2014 Feb;38(2):180-3. doi: 10.1016/j.leukres.2013.10.027. Epub 2013 Nov 5.

PMID:
24268318
25.

Polymorphisms of TNF and IL-10 genes and clinical outcome of patients with chronic lymphocytic leukemia.

Lech-Maranda E, Mlynarski W, Grzybowska-Izydorczyk O, Borowiec M, Pastorczak A, Cebula-Obrzut B, Klimkiewicz-Wojciechowska G, Wcislo M, Majewski M, Kotkowska A, Robak T, Warzocha K.

Genes Chromosomes Cancer. 2013 Mar;52(3):287-96. doi: 10.1002/gcc.22028. Epub 2012 Dec 8.

PMID:
23225254
26.

Role of base-excision repair in the treatment of childhood acute lymphoblastic leukaemia with 6-mercaptopurine and high doses of methotrexate.

Stanczyk M, Sliwinski T, Trelinska J, Cuchra M, Markiewicz L, Dziki L, Bieniek A, Bielecka-Kowalska A, Kowalski M, Pastorczak A, Szemraj J, Mlynarski W, Majsterek I.

Mutat Res. 2012 Jan 24;741(1-2):13-21. doi: 10.1016/j.mrgentox.2011.10.009. Epub 2011 Oct 30.

PMID:
22064329
27.

Role of 657del5 NBN mutation and 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) variation and risk of childhood ALL in the Polish population.

Pastorczak A, Górniak P, Sherborne A, Hosking F, Trelińska J, Lejman M, Szczepański T, Borowiec M, Fendler W, Kowalczyk J, Houlston RS, Młynarski W.

Leuk Res. 2011 Nov;35(11):1534-6. doi: 10.1016/j.leukres.2011.07.034. Epub 2011 Sep 1.

PMID:
21889209
28.

Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk.

Kusinska R, Górniak P, Pastorczak A, Fendler W, Potemski P, Mlynarski W, Kordek R.

Mol Biol Rep. 2012 Mar;39(3):2915-9. doi: 10.1007/s11033-011-1053-2. Epub 2011 Jun 19.

29.

Nijmegen breakage syndrome (NBS) as a risk factor for CNS involvement in childhood acute lymphoblastic leukemia.

Pastorczak A, Stolarska M, Trelińska J, Zawitkowska J, Kowalczyk J, Mlynarski W; Polish Pediatric Leukemia/Lymphoma Study Group.

Pediatr Blood Cancer. 2011 Jul 15;57(1):160-2. doi: 10.1002/pbc.23073. Epub 2011 Mar 8.

PMID:
21557461

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