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Items: 1 to 50 of 69

1.

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.

Chandramohan V, Bao X, Yu X, Parker S, McDowall C, Yu YR, Healy P, Desjardins A, Gunn MD, Gromeier M, Nair SK, Pastan IH, Bigner DD.

J Immunother Cancer. 2019 May 29;7(1):142. doi: 10.1186/s40425-019-0614-0.

2.

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.

Yu X, Dobrikov M, Keir ST, Gromeier M, Pastan IH, Reisfeld R, Bigner DD, Chandramohan V.

PLoS One. 2019 Jan 9;14(1):e0210608. doi: 10.1371/journal.pone.0210608. eCollection 2019.

3.

Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial.

Chandramohan V, Pegram CN, Piao H, Szafranski SE, Kuan CT, Pastan IH, Bigner DD.

Appl Microbiol Biotechnol. 2017 Apr;101(7):2747-2766. doi: 10.1007/s00253-016-8063-x. Epub 2016 Dec 24.

4.

Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.

Bao X, Chandramohan V, Reynolds RP, Norton JN, Wetsel WC, Rodriguiz RM, Aryal DK, McLendon RE, Levin ED, Petry NA, Zalutsky MR, Burnett BK, Kuan CT, Pastan IH, Bigner DD.

Invest New Drugs. 2016 Apr;34(2):149-58. doi: 10.1007/s10637-015-0318-3. Epub 2016 Jan 4.

5.

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene.

Gottesman MM, Pastan IH.

J Natl Cancer Inst. 2015 Aug 18;107(9). pii: djv222. doi: 10.1093/jnci/djv222. Print 2015 Sep. No abstract available.

6.

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.

Onda M, Ghoreschi K, Steward-Tharp S, Thomas C, O'Shea JJ, Pastan IH, FitzGerald DJ.

J Immunol. 2014 Jul 1;193(1):48-55. doi: 10.4049/jimmunol.1400063. Epub 2014 Jun 2.

7.

Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas.

Piao H, Kuan CT, Chandramohan V, Keir ST, Pegram CN, Bao X, MÃ¥nsson JE, Pastan IH, Bigner DD.

MAbs. 2013 Sep-Oct;5(5):748-62. doi: 10.4161/mabs.25860. Epub 2013 Jul 25.

8.

Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy.

Chandramohan V, Bao X, Keir ST, Pegram CN, Szafranski SE, Piao H, Wikstrand CJ, McLendon RE, Kuan CT, Pastan IH, Bigner DD.

Clin Cancer Res. 2013 Sep 1;19(17):4717-27. doi: 10.1158/1078-0432.CCR-12-3891. Epub 2013 Jul 15.

9.

Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.

Haso W, Lee DW, Shah NN, Stetler-Stevenson M, Yuan CM, Pastan IH, Dimitrov DS, Morgan RA, FitzGerald DJ, Barrett DM, Wayne AS, Mackall CL, Orentas RJ.

Blood. 2013 Feb 14;121(7):1165-74. doi: 10.1182/blood-2012-06-438002. Epub 2012 Dec 14.

10.

Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors.

Chandramohan V, Bao X, Kato Kaneko M, Kato Y, Keir ST, Szafranski SE, Kuan CT, Pastan IH, Bigner DD.

Int J Cancer. 2013 May 15;132(10):2339-48. doi: 10.1002/ijc.27919. Epub 2012 Nov 23.

11.

Anoctamin and transmembrane channel-like proteins are evolutionarily related.

Hahn Y, Kim DS, Pastan IH, Lee B.

Int J Mol Med. 2009 Jul;24(1):51-5.

12.

EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells.

Ochiai H, Archer GE, Herndon JE 2nd, Kuan CT, Mitchell DA, Bigner DD, Pastan IH, Sampson JH.

Cancer Immunol Immunother. 2008 Jan;57(1):115-21. Epub 2007 Jul 19.

13.

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

Hahn Y, Bera TK, Pastan IH, Lee B.

Gene. 2006 Feb 1;366(2):238-45. Epub 2005 Dec 20.

PMID:
16364570
14.

Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy.

Nagata S, Ise T, Onda M, Nakamura K, Ho M, Raubitschek A, Pastan IH.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):7946-51. Epub 2005 May 19. Erratum in: Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):3007.

15.

Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.

Hahn Y, Bera TK, Gehlhaus K, Kirsch IR, Pastan IH, Lee B.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13257-61. Epub 2004 Aug 23.

16.

TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates.

Bera TK, Hahn Y, Lee B, Pastan IH.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):1209-15.

PMID:
14652002
17.

Cloning, molecular characterization, and expression analysis of Copine 8.

Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B.

Biochem Biophys Res Commun. 2003 Apr 11;303(3):842-7.

PMID:
12670487
18.
19.

Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.

Archer GE, Sampson JH, Lorimer IA, McLendon RE, Kuan CT, Friedman AH, Friedman HS, Pastan IH, Bigner DD.

Clin Cancer Res. 1999 Sep;5(9):2646-52.

20.

Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis.

Bigner DD, Archer GE, McLendon RE, Friedman HS, Fuchs HE, Pai LH, Herndon JE 2nd, Pastan IH.

Clin Cancer Res. 1995 Dec;1(12):1545-55.

21.

Recombinant toxins: new therapeutic agents for cancer.

Pastan IH, Pai LH, Brinkmann U, Fitzgerald DJ.

Ann N Y Acad Sci. 1995 Jun 30;758:345-54. Review. No abstract available.

PMID:
7625703
22.

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.

Pastan IH, Archer GE, McLendon RE, Friedman HS, Fuchs HE, Wang QC, Pai LH, Herndon J, Bigner DD.

Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2765-9.

23.

Recombinant immunotoxins: new therapeutic agents for cancer treatment.

Pastan IH.

Cancer Detect Prev. 1993;17(2):289-93.

PMID:
8402714
24.

The multichain interleukin-2 receptor: a target for immunotherapy.

Waldmann TA, Pastan IH, Gansow OA, Junghans RP.

Ann Intern Med. 1992 Jan 15;116(2):148-60. Review.

PMID:
1727619
25.

Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.

McLachlin JR, Eglitis MA, Ueda K, Kantoff PW, Pastan IH, Anderson WF, Gottesman MM.

J Natl Cancer Inst. 1990 Aug 1;82(15):1260-3.

PMID:
2374175
26.

Molecular biology of multidrug resistance in human cells.

Pastan IH, Gottesman MM.

Important Adv Oncol. 1988:3-16. Review. No abstract available.

PMID:
3042608
27.

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

Willingham MC, Richert ND, Cornwell MM, Tsuruo T, Hamada H, Gottesman MM, Pastan IH.

J Histochem Cytochem. 1987 Dec;35(12):1451-6.

PMID:
2890686
28.

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

Cornwell MM, Gottesman MM, Pastan IH.

J Biol Chem. 1986 Jun 15;261(17):7921-8.

29.
30.

Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs.

King CR, Kraus MH, Williams LT, Merlino GT, Pastan IH, Aaronson SA.

Nucleic Acids Res. 1985 Dec 9;13(23):8477-86.

31.
32.

src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.

Yu KT, Werth DK, Pastan IH, Czech MP.

J Biol Chem. 1985 May 10;260(9):5838-46.

33.

Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src.

Perrotti N, Taylor SI, Richert ND, Rapp UR, Pastan IH, Roth J.

Science. 1985 Feb 15;227(4688):761-3.

PMID:
3918346
35.

The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells. Studies on A431, KB, and 3T3 cells, using multiple methods of labelling.

Willingham MC, Haigler HT, Fitzgerald DJ, Gallo MG, Rutherford AV, Pastan IH.

Exp Cell Res. 1983 Jun;146(1):163-75.

PMID:
6190668
36.

Ultrastructural immunocytochemical localization of calmodulin in cultured cells.

Willingham MC, Wehland J, Klee CB, Richert ND, Rutherford AV, Pastan IH.

J Histochem Cytochem. 1983 Apr;31(4):445-61.

PMID:
6338107
37.
38.

alpha 2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites.

Hanover JA, Cheng S, Willingham MC, Pastan IH.

J Biol Chem. 1983 Jan 10;258(1):370-7.

39.

Image intensification techniques for detection of proteins in cultured cells.

Willingham MC, Pastan IH.

Methods Enzymol. 1983;98:266-83, 635.

PMID:
6669050
40.

Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.

Willingham MC, Pastan IH, Sahagian GG.

J Histochem Cytochem. 1983 Jan;31(1):1-11.

PMID:
6300218
41.
42.

Saturable binding sites for vesicular stomatitis virus on the surface of Vero cells.

Schlegel R, Willingham MC, Pastan IH.

J Virol. 1982 Sep;43(3):871-5.

43.

Transit of epidermal growth factor through coated pits of the Golgi system.

Willingham MC, Pastan IH.

J Cell Biol. 1982 Jul;94(1):207-12.

44.

Reversible and irreversible inhibitors of clustering of alpha 2M in clathrin-coated pits on the surface of fibroblasts.

Dickson RB, Schlegel R, Willingham MC, Pastan IH.

Exp Cell Res. 1982 Jul;140(1):215-25. No abstract available.

PMID:
6179782
45.

Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor.

Blithe DL, Richert ND, Pastan IH.

J Biol Chem. 1982 Jun 25;257(12):7135-42.

46.

Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin.

Schlegel R, Dickson RB, Willingham MC, Pastan IH.

Proc Natl Acad Sci U S A. 1982 Apr;79(7):2291-5.

47.

Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity.

Pastan IH, Willingham M, de Crombrugghe B, Gottesman MM.

Natl Cancer Inst Monogr. 1982;60:7-15. No abstract available.

PMID:
6289108
48.

Receptor-mediated endocytosis of alpha 2-macroglobulin: inhibition by ionophores and stimulation by Na+ and HCO3(-).

Dickson RB, Willingham MC, Pastan IH.

Ann N Y Acad Sci. 1982;401:38-49. Review. No abstract available.

PMID:
6188403
49.

Ultrastructural immunocytochemical localization of myosin in cultured fibroblastic cells.

Willingham MC, Yamada SS, Bechtel PJ, Rutherford AV, Pastan IH.

J Histochem Cytochem. 1981 Nov;29(11):1289-301.

PMID:
7033361
50.

Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

Willingham MC, Pastan IH, Sahagian GG, Jourdian GW, Neufeld EF.

Proc Natl Acad Sci U S A. 1981 Nov;78(11):6967-71.

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