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Items: 1 to 50 of 72

1.

Cellular Senescence: Defining a Path Forward.

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M.

Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005. Review.

PMID:
31675495
2.

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.

Victorelli S, Lagnado A, Halim J, Moore W, Talbot D, Barrett K, Chapman J, Birch J, Ogrodnik M, Meves A, Pawlikowski JS, Jurk D, Adams PD, van Heemst D, Beekman M, Slagboom PE, Gunn DA, Passos JF.

EMBO J. 2019 Dec 2;38(23):e101982. doi: 10.15252/embj.2019101982. Epub 2019 Oct 21.

PMID:
31633821
3.

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL.

EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18.

4.

Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence.

Ogrodnik M, Salmonowicz H, Jurk D, Passos JF.

Trends Biochem Sci. 2019 Dec;44(12):996-1008. doi: 10.1016/j.tibs.2019.06.011. Epub 2019 Jul 22. Review.

PMID:
31345557
5.

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship.

Chapman J, Fielder E, Passos JF.

FEBS Lett. 2019 Jul;593(13):1566-1579. doi: 10.1002/1873-3468.13498. Epub 2019 Jun 27. Review.

PMID:
31211858
6.

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.

Hari P, Millar FR, Tarrats N, Birch J, Quintanilla A, Rink CJ, Fernández-Duran I, Muir M, Finch AJ, Brunton VG, Passos JF, Morton JP, Boulter L, Acosta JC.

Sci Adv. 2019 Jun 5;5(6):eaaw0254. doi: 10.1126/sciadv.aaw0254. eCollection 2019 Jun.

7.

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.

Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J, Akbar AN.

Nat Commun. 2019 Jun 3;10(1):2387. doi: 10.1038/s41467-019-10335-5.

8.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 May 7;29(5):1233. doi: 10.1016/j.cmet.2019.01.013. No abstract available.

9.

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.

Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot S, Victorelli S, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD.

Aging Cell. 2019 Jun;18(3):e12945. doi: 10.1111/acel.12945. Epub 2019 Mar 28.

10.

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8.

11.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 May 7;29(5):1061-1077.e8. doi: 10.1016/j.cmet.2018.12.008. Epub 2019 Jan 3. Erratum in: Cell Metab. 2019 May 7;29(5):1233.

12.

Genetic structure and diversity in Brazilian populations of Anastrepha obliqua (Diptera: Tephritidae).

Passos JF, Nascimento DB, Menezes RST, Adaime R, Araujo EL, Lima KM, Zucchi RA, Teles BR, Nascimento RR, Arce RR, Barr NB, McPheron BA, Silva JG.

PLoS One. 2018 Dec 20;13(12):e0208997. doi: 10.1371/journal.pone.0208997. eCollection 2018.

13.

Reactive Oxygen Species Detection in Senescent Cells.

Victorelli S, Passos JF.

Methods Mol Biol. 2019;1896:21-29. doi: 10.1007/978-1-4939-8931-7_3.

PMID:
30474836
14.

Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.

Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF.

Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23.

15.

Mitochondria and cellular senescence: Implications for musculoskeletal ageing.

Habiballa L, Salmonowicz H, Passos JF.

Free Radic Biol Med. 2019 Feb 20;132:3-10. doi: 10.1016/j.freeradbiomed.2018.10.417. Epub 2018 Oct 15. Review.

PMID:
30336251
16.

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.

Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW.

EMBO J. 2018 Sep 3;37(17). pii: e99238. doi: 10.15252/embj.201899238. Epub 2018 Jul 26.

17.

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.

Manzella N, Santin Y, Maggiorani D, Martini H, Douin-Echinard V, Passos JF, Lezoualc'h F, Binda C, Parini A, Mialet-Perez J.

Aging Cell. 2018 Oct;17(5):e12811. doi: 10.1111/acel.12811. Epub 2018 Jul 12.

18.

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.

Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN.

Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.

19.

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.

Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI.

Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z.

20.

Mechanisms driving the ageing heart.

Anderson R, Richardson GD, Passos JF.

Exp Gerontol. 2018 Aug;109:5-15. doi: 10.1016/j.exger.2017.10.015. Epub 2017 Oct 18. Review.

PMID:
29054534
21.

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease.

Birch J, Barnes PJ, Passos JF.

Pharmacol Ther. 2018 Mar;183:34-49. doi: 10.1016/j.pharmthera.2017.10.005. Epub 2017 Oct 4. Review.

22.

Stress, cell senescence and organismal ageing.

de Magalhães JP, Passos JF.

Mech Ageing Dev. 2018 Mar;170:2-9. doi: 10.1016/j.mad.2017.07.001. Epub 2017 Jul 5. Review.

23.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

24.

Telomeres and Cell Senescence - Size Matters Not.

Victorelli S, Passos JF.

EBioMedicine. 2017 Jul;21:14-20. doi: 10.1016/j.ebiom.2017.03.027. Epub 2017 Mar 21. Review.

25.

Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.

26.

Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

Birch J, Passos JF.

Bioessays. 2017 May;39(5). doi: 10.1002/bies.201600235. Epub 2017 Feb 20. Review.

PMID:
28217839
27.

Detecting senescence: a new method for an old pigment.

Salmonowicz H, Passos JF.

Aging Cell. 2017 Jun;16(3):432-434. doi: 10.1111/acel.12580. Epub 2017 Feb 9. Erratum in: Aging Cell. 2017 Dec;16(6):1439.

28.

Depletion of mitochondria in mammalian cells through enforced mitophagy.

Correia-Melo C, Ichim G, Tait SW, Passos JF.

Nat Protoc. 2017 Jan;12(1):183-194. doi: 10.1038/nprot.2016.159. Epub 2016 Dec 22.

PMID:
28005069
29.

Powering senescence: The ugly side of mitochondria.

Correia-Melo C, Birch J, Passos JF.

Cell Cycle. 2016 Oct;15(19):2541-2542. Epub 2016 Jul 11. No abstract available.

30.

Demystifying the role of mitochondria in senescence.

Correia-Melo C, Passos JF.

Mol Cell Oncol. 2016 Mar 28;3(4):e1162896. doi: 10.1080/23723556.2016.1162896. eCollection 2016 Jul.

31.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

32.

Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis.

Birch J, Victorelli S, Rahmatika D, Anderson RK, Jiwa K, Moisey E, Ward C, Fisher AJ, De Soyza A, Passos JF.

Am J Respir Crit Care Med. 2016 Apr 15;193(8):929-32. doi: 10.1164/rccm.201510-2035LE. No abstract available.

33.

Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.

34.

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI.

Elife. 2016 Jan 7;5. pii: e11058. doi: 10.7554/eLife.11058.

35.

Corrigendum: NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.

Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Bagchi Chakraborty J, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA.

Nat Commun. 2015 Sep 21;6:8411. doi: 10.1038/ncomms9411. No abstract available.

36.

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1124-37. doi: 10.1152/ajplung.00293.2015. Epub 2015 Sep 18.

37.

Mitochondria: Are they causal players in cellular senescence?

Correia-Melo C, Passos JF.

Biochim Biophys Acta. 2015 Nov;1847(11):1373-9. doi: 10.1016/j.bbabio.2015.05.017. Epub 2015 May 28. Review.

38.

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.

Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Chakraborty JB, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA.

Nat Commun. 2015 Apr 16;6:6818. doi: 10.1038/ncomms7818. Erratum in: Nat Commun. 2015;6:8411.

39.

A model to explain plant growth promotion traits: a multivariate analysis of 2,211 bacterial isolates.

da Costa PB, Granada CE, Ambrosini A, Moreira F, de Souza R, dos Passos JF, Arruda L, Passaglia LM.

PLoS One. 2014 Dec 26;9(12):e116020. doi: 10.1371/journal.pone.0116020. eCollection 2014.

40.

CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells.

Neganova I, Tilgner K, Buskin A, Paraskevopoulou I, Atkinson SP, Peberdy D, Passos JF, Lako M.

Cell Death Dis. 2014 Nov 6;5:e1508. doi: 10.1038/cddis.2014.464.

41.

Cultivable bacteria isolated from apple trees cultivated under different crop systems: Diversity and antagonistic activity against Colletotrichum gloeosporioides.

Dos Passos JF, da Costa PB, Costa MD, Zaffari GR, Nava G, Boneti JI, de Oliveira AM, Passaglia LM.

Genet Mol Biol. 2014 Sep;37(3):560-72.

42.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T.

Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.

43.

Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?

Correia-Melo C, Hewitt G, Passos JF.

Longev Healthspan. 2014 Jan 16;3(1):1. doi: 10.1186/2046-2395-3-1.

44.

Cell sorting of young and senescent cells.

Hewitt G, von Zglinicki T, Passos JF.

Methods Mol Biol. 2013;1048:31-47. doi: 10.1007/978-1-62703-556-9_4.

PMID:
23929096
45.

Lysosome-mediated processing of chromatin in senescence.

Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD.

J Cell Biol. 2013 Jul 8;202(1):129-43. doi: 10.1083/jcb.201212110. Epub 2013 Jul 1.

46.

Robust multiparametric assessment of cellular senescence.

Correia-Melo C, Jurk D, Passos JF.

Methods Mol Biol. 2013;965:409-19. doi: 10.1007/978-1-62703-239-1_27.

PMID:
23296674
47.

Measuring reactive oxygen species in senescent cells.

Passos JF, Miwa S, von Zglinicki T.

Methods Mol Biol. 2013;965:253-63. doi: 10.1007/978-1-62703-239-1_17.

PMID:
23296664
48.

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

Hewitt G, Jurk D, Marques FD, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF.

Nat Commun. 2012 Feb 28;3:708. doi: 10.1038/ncomms1708.

49.

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.

Lawless C, Jurk D, Gillespie CS, Shanley D, Saretzki G, von Zglinicki T, Passos JF.

PLoS One. 2012;7(2):e32117. doi: 10.1371/journal.pone.0032117. Epub 2012 Feb 16.

50.

Mitochondrial dysfunction and cell senescence--skin deep into mammalian aging.

Passos JF, Zglinicki Tv.

Aging (Albany NY). 2012 Feb;4(2):74-5.

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