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Items: 1 to 50 of 63

1.

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Feb 8. pii: e100492. doi: 10.15252/embj.2018100492. [Epub ahead of print]

2.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 Jan 3. pii: S1550-4131(18)30745-9. doi: 10.1016/j.cmet.2018.12.008. [Epub ahead of print]

3.

Genetic structure and diversity in Brazilian populations of Anastrepha obliqua (Diptera: Tephritidae).

Passos JF, Nascimento DB, Menezes RST, Adaime R, Araujo EL, Lima KM, Zucchi RA, Teles BR, Nascimento RR, Arce RR, Barr NB, McPheron BA, Silva JG.

PLoS One. 2018 Dec 20;13(12):e0208997. doi: 10.1371/journal.pone.0208997. eCollection 2018.

4.

Reactive Oxygen Species Detection in Senescent Cells.

Victorelli S, Passos JF.

Methods Mol Biol. 2019;1896:21-29. doi: 10.1007/978-1-4939-8931-7_3.

PMID:
30474836
5.

Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.

Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF.

Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23.

6.

Mitochondria and cellular senescence: Implications for musculoskeletal ageing.

Habiballa L, Salmonowicz H, Passos JF.

Free Radic Biol Med. 2019 Feb 20;132:3-10. doi: 10.1016/j.freeradbiomed.2018.10.417. Epub 2018 Oct 15. Review.

PMID:
30336251
7.

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.

Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW.

EMBO J. 2018 Sep 3;37(17). pii: e99238. doi: 10.15252/embj.201899238. Epub 2018 Jul 26.

8.

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.

Manzella N, Santin Y, Maggiorani D, Martini H, Douin-Echinard V, Passos JF, Lezoualc'h F, Binda C, Parini A, Mialet-Perez J.

Aging Cell. 2018 Oct;17(5):e12811. doi: 10.1111/acel.12811. Epub 2018 Jul 12.

9.

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.

Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN.

Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.

PMID:
29719225
10.

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.

Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI.

Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z.

11.

Mechanisms driving the ageing heart.

Anderson R, Richardson GD, Passos JF.

Exp Gerontol. 2018 Aug;109:5-15. doi: 10.1016/j.exger.2017.10.015. Epub 2017 Oct 18. Review.

PMID:
29054534
12.

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease.

Birch J, Barnes PJ, Passos JF.

Pharmacol Ther. 2018 Mar;183:34-49. doi: 10.1016/j.pharmthera.2017.10.005. Epub 2017 Oct 4. Review.

13.

Stress, cell senescence and organismal ageing.

de Magalhães JP, Passos JF.

Mech Ageing Dev. 2018 Mar;170:2-9. doi: 10.1016/j.mad.2017.07.001. Epub 2017 Jul 5. Review.

14.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

15.

Telomeres and Cell Senescence - Size Matters Not.

Victorelli S, Passos JF.

EBioMedicine. 2017 Jul;21:14-20. doi: 10.1016/j.ebiom.2017.03.027. Epub 2017 Mar 21. Review.

16.

Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.

17.

Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

Birch J, Passos JF.

Bioessays. 2017 May;39(5). doi: 10.1002/bies.201600235. Epub 2017 Feb 20. Review.

PMID:
28217839
18.

Detecting senescence: a new method for an old pigment.

Salmonowicz H, Passos JF.

Aging Cell. 2017 Jun;16(3):432-434. doi: 10.1111/acel.12580. Epub 2017 Feb 9. Erratum in: Aging Cell. 2017 Dec;16(6):1439.

19.

Depletion of mitochondria in mammalian cells through enforced mitophagy.

Correia-Melo C, Ichim G, Tait SW, Passos JF.

Nat Protoc. 2017 Jan;12(1):183-194. doi: 10.1038/nprot.2016.159. Epub 2016 Dec 22.

PMID:
28005069
20.

Powering senescence: The ugly side of mitochondria.

Correia-Melo C, Birch J, Passos JF.

Cell Cycle. 2016 Oct;15(19):2541-2542. Epub 2016 Jul 11. No abstract available.

21.

Demystifying the role of mitochondria in senescence.

Correia-Melo C, Passos JF.

Mol Cell Oncol. 2016 Mar 28;3(4):e1162896. doi: 10.1080/23723556.2016.1162896. eCollection 2016 Jul.

22.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

23.

Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis.

Birch J, Victorelli S, Rahmatika D, Anderson RK, Jiwa K, Moisey E, Ward C, Fisher AJ, De Soyza A, Passos JF.

Am J Respir Crit Care Med. 2016 Apr 15;193(8):929-32. doi: 10.1164/rccm.201510-2035LE. No abstract available.

24.

Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.

25.

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI.

Elife. 2016 Jan 7;5. pii: e11058. doi: 10.7554/eLife.11058.

26.

Corrigendum: NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.

Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Bagchi Chakraborty J, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA.

Nat Commun. 2015 Sep 21;6:8411. doi: 10.1038/ncomms9411. No abstract available.

27.

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1124-37. doi: 10.1152/ajplung.00293.2015. Epub 2015 Sep 18.

28.

Mitochondria: Are they causal players in cellular senescence?

Correia-Melo C, Passos JF.

Biochim Biophys Acta. 2015 Nov;1847(11):1373-9. doi: 10.1016/j.bbabio.2015.05.017. Epub 2015 May 28. Review.

29.

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.

Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Chakraborty JB, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA.

Nat Commun. 2015 Apr 16;6:6818. doi: 10.1038/ncomms7818. Erratum in: Nat Commun. 2015;6:8411.

30.

A model to explain plant growth promotion traits: a multivariate analysis of 2,211 bacterial isolates.

da Costa PB, Granada CE, Ambrosini A, Moreira F, de Souza R, dos Passos JF, Arruda L, Passaglia LM.

PLoS One. 2014 Dec 26;9(12):e116020. doi: 10.1371/journal.pone.0116020. eCollection 2014.

31.

CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells.

Neganova I, Tilgner K, Buskin A, Paraskevopoulou I, Atkinson SP, Peberdy D, Passos JF, Lako M.

Cell Death Dis. 2014 Nov 6;5:e1508. doi: 10.1038/cddis.2014.464.

32.

Cultivable bacteria isolated from apple trees cultivated under different crop systems: Diversity and antagonistic activity against Colletotrichum gloeosporioides.

Dos Passos JF, da Costa PB, Costa MD, Zaffari GR, Nava G, Boneti JI, de Oliveira AM, Passaglia LM.

Genet Mol Biol. 2014 Sep;37(3):560-72.

33.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T.

Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.

34.

Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?

Correia-Melo C, Hewitt G, Passos JF.

Longev Healthspan. 2014 Jan 16;3(1):1. doi: 10.1186/2046-2395-3-1.

35.

Cell sorting of young and senescent cells.

Hewitt G, von Zglinicki T, Passos JF.

Methods Mol Biol. 2013;1048:31-47. doi: 10.1007/978-1-62703-556-9_4.

PMID:
23929096
36.

Lysosome-mediated processing of chromatin in senescence.

Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD.

J Cell Biol. 2013 Jul 8;202(1):129-43. doi: 10.1083/jcb.201212110. Epub 2013 Jul 1.

37.

Robust multiparametric assessment of cellular senescence.

Correia-Melo C, Jurk D, Passos JF.

Methods Mol Biol. 2013;965:409-19. doi: 10.1007/978-1-62703-239-1_27.

PMID:
23296674
38.

Measuring reactive oxygen species in senescent cells.

Passos JF, Miwa S, von Zglinicki T.

Methods Mol Biol. 2013;965:253-63. doi: 10.1007/978-1-62703-239-1_17.

PMID:
23296664
39.

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

Hewitt G, Jurk D, Marques FD, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF.

Nat Commun. 2012 Feb 28;3:708. doi: 10.1038/ncomms1708.

40.

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.

Lawless C, Jurk D, Gillespie CS, Shanley D, Saretzki G, von Zglinicki T, Passos JF.

PLoS One. 2012;7(2):e32117. doi: 10.1371/journal.pone.0032117. Epub 2012 Feb 16.

41.

Mitochondrial dysfunction and cell senescence--skin deep into mammalian aging.

Passos JF, Zglinicki Tv.

Aging (Albany NY). 2012 Feb;4(2):74-5.

42.

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

Neganova I, Vilella F, Atkinson SP, Lloret M, Passos JF, von Zglinicki T, O'Connor JE, Burks D, Jones R, Armstrong L, Lako M.

Stem Cells. 2011 Apr;29(4):651-9. doi: 10.1002/stem.620.

43.

Feedback between p21 and reactive oxygen production is necessary for cell senescence.

Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T.

Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16.

44.

Quantitative assessment of markers for cell senescence.

Lawless C, Wang C, Jurk D, Merz A, Zglinicki Tv, Passos JF.

Exp Gerontol. 2010 Oct;45(10):772-8. doi: 10.1016/j.exger.2010.01.018. Epub 2010 Feb 1.

PMID:
20117203
45.

Cellular senescence: unravelling complexity.

Passos JF, Simillion C, Hallinan J, Wipat A, von Zglinicki T.

Age (Dordr). 2009 Dec;31(4):353-63. doi: 10.1007/s11357-009-9108-1. Review.

46.

The relationship between the aging- and photo-dependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts.

Birket MJ, Passos JF, von Zglinicki T, Birch-Machin MA.

J Invest Dermatol. 2009 Jun;129(6):1361-6. doi: 10.1038/jid.2008.373. Epub 2008 Dec 4.

47.

ssDNA fragments induce cell senescence by telomere uncapping.

Tsolou A, Passos JF, Nelson G, Arai Y, Zglinicki Tv.

Exp Gerontol. 2008 Oct;43(10):892-9. doi: 10.1016/j.exger.2008.08.043. Epub 2008 Aug 22.

PMID:
18778766
48.

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.

Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G.

J Cell Sci. 2008 Apr 1;121(Pt 7):1046-53. doi: 10.1242/jcs.019372. Epub 2008 Mar 11.

49.

Portugal gets ready to embrace ageing research.

Passos JF.

Biogerontology. 2008 Jun;9(3):209-211. doi: 10.1007/s10522-008-9128-8. Epub 2008 Feb 12. No abstract available.

PMID:
18266070
50.

Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose.

Ksiazek K, Passos JF, Olijslagers S, von Zglinicki T.

Biochem Biophys Res Commun. 2008 Feb 15;366(3):793-9. Epub 2007 Dec 17.

PMID:
18082137

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