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Items: 1 to 50 of 78

1.

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Yamashita M, Passegué E.

Cell Stem Cell. 2019 Sep 5;25(3):357-372.e7. doi: 10.1016/j.stem.2019.05.019. Epub 2019 Jun 20.

PMID:
31230859
2.

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation.

Verovskaya EV, Dellorusso PV, Passegué E.

Trends Mol Med. 2019 Jun;25(6):494-515. doi: 10.1016/j.molmed.2019.04.006. Epub 2019 May 17. Review.

PMID:
31109796
3.

Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia.

Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC.

Blood Adv. 2018 Oct 9;2(19):2462-2466. doi: 10.1182/bloodadvances.2018018929.

4.

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A.

Science. 2018 Mar 16;359(6381):1277-1283. doi: 10.1126/science.aag3048. Epub 2018 Mar 15.

5.

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E.

Nature. 2017 Apr 6;544(7648):53-58. doi: 10.1038/nature21693. Epub 2017 Mar 29.

6.

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.

Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR.

Nature. 2017 Apr 6;544(7648):105-109. doi: 10.1038/nature21706. Epub 2017 Mar 22.

7.

Autophagy maintains the metabolism and function of young and old stem cells.

Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV, Figueroa ME, Passegué E.

Nature. 2017 Mar 9;543(7644):205-210. doi: 10.1038/nature21388. Epub 2017 Mar 1.

8.

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.

Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F.

Nat Immunol. 2017 Feb;18(2):184-195. doi: 10.1038/ni.3644. Epub 2016 Dec 19.

9.

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

Chandel NS, Jasper H, Ho TT, Passegué E.

Nat Cell Biol. 2016 Aug;18(8):823-32. doi: 10.1038/ncb3385. Epub 2016 Jul 18. Review.

PMID:
27428307
10.

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.

Pietras EM, Mirantes-Barbeito C, Fong S, Loeffler D, Kovtonyuk LV, Zhang S, Lakshminarasimhan R, Chin CP, Techner JM, Will B, Nerlov C, Steidl U, Manz MG, Schroeder T, Passegué E.

Nat Cell Biol. 2016 Jun;18(6):607-18. doi: 10.1038/ncb3346. Epub 2016 Apr 25.

11.

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells.

Ugarte F, Sousae R, Cinquin B, Martin EW, Krietsch J, Sanchez G, Inman M, Tsang H, Warr M, Passegué E, Larabell CA, Forsberg EC.

Stem Cell Reports. 2015 Nov 10;5(5):728-740. doi: 10.1016/j.stemcr.2015.09.009. Epub 2015 Oct 17.

12.

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J.

Nat Commun. 2015 Oct 12;6:8548. doi: 10.1038/ncomms9548.

13.

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.

Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K.

Elife. 2015 Jul 20;4. doi: 10.7554/eLife.07839.

14.

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.

Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt AD, Stuart JM, Göttgens B, Passegué E.

Cell Stem Cell. 2015 Jul 2;17(1):35-46. doi: 10.1016/j.stem.2015.05.003. Epub 2015 Jun 18.

15.

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.

Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC.

Haematologica. 2015 Aug;100(8):1064-75. doi: 10.3324/haematol.2014.123018. Epub 2015 Jun 18.

16.

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.

Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M.

Nat Commun. 2015 Mar 10;6:6471. doi: 10.1038/ncomms7471.

17.

Normal and leukemic stem cell niches: insights and therapeutic opportunities.

Schepers K, Campbell TB, Passegué E.

Cell Stem Cell. 2015 Mar 5;16(3):254-67. doi: 10.1016/j.stem.2015.02.014. Review.

18.

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.

Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75. doi: 10.1073/pnas.1424927112. Epub 2015 Jan 26.

19.

Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.

Mirantes C, Passegué E, Pietras EM.

Exp Cell Res. 2014 Dec 10;329(2):248-54. doi: 10.1016/j.yexcr.2014.08.017. Epub 2014 Aug 19. Review.

20.

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.

Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Méndez J, Morrison CG, Passegué E.

Nature. 2014 Aug 14;512(7513):198-202. doi: 10.1038/nature13619. Epub 2014 Jul 30.

21.

Surviving change: the metabolic journey of hematopoietic stem cells.

Kohli L, Passegué E.

Trends Cell Biol. 2014 Aug;24(8):479-87. doi: 10.1016/j.tcb.2014.04.001. Epub 2014 Apr 24. Review.

22.

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.

Pietras EM, Lakshminarasimhan R, Techner JM, Fong S, Flach J, Binnewies M, Passegué E.

J Exp Med. 2014 Feb 10;211(2):245-62. doi: 10.1084/jem.20131043. Epub 2014 Feb 3.

23.

Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells.

Bakker ST, Passegué E.

Exp Hematol. 2013 Nov;41(11):915-23. doi: 10.1016/j.exphem.2013.09.007. Epub 2013 Sep 22. Review.

24.

Linking HSCs to their youth.

Pietras EM, Passegué E.

Nat Cell Biol. 2013 Aug;15(8):885-7. doi: 10.1038/ncb2817. Erratum in: Nat Cell Biol. 2013 Sep;15(9):1131.

PMID:
23907190
25.

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E.

Cell Stem Cell. 2013 Sep 5;13(3):285-99. doi: 10.1016/j.stem.2013.06.009. Epub 2013 Jul 11.

26.

Born to survive: autophagy in hematopoietic stem cell maintenance.

Warr MR, Kohli L, Passegué E.

Cell Cycle. 2013 Jul 1;12(13):1979-80. doi: 10.4161/cc.25303. Epub 2013 Jun 10. No abstract available.

27.

Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations.

Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC.

Leukemia. 2013 Jul;27(7):1570-3. doi: 10.1038/leu.2013.15. Epub 2013 Jan 16. No abstract available.

28.

FOXO3A directs a protective autophagy program in haematopoietic stem cells.

Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E.

Nature. 2013 Feb 21;494(7437):323-7. doi: 10.1038/nature11895. Epub 2013 Feb 6.

29.

Metabolic makeover for HSCs.

Warr MR, Passegué E.

Cell Stem Cell. 2013 Jan 3;12(1):1-3. doi: 10.1016/j.stem.2012.12.005.

30.

Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.

Schepers K, Hsiao EC, Garg T, Scott MJ, Passegué E.

Blood. 2012 Oct 25;120(17):3425-35. doi: 10.1182/blood-2011-11-395418. Epub 2012 Aug 2.

31.

Stem cells assessed.

Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S.

Nat Rev Mol Cell Biol. 2012 Jun 8;13(7):471-6. doi: 10.1038/nrm3371. Review.

PMID:
22678486
32.

Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations.

Smith-Berdan S, Schepers K, Ly A, Passegué E, Forsberg EC.

Cell Cycle. 2012 Feb 15;11(4):675-82. doi: 10.4161/cc.11.4.19146. Epub 2012 Feb 15.

PMID:
22313734
33.

Cell cycle regulation in hematopoietic stem cells.

Pietras EM, Warr MR, Passegué E.

J Cell Biol. 2011 Nov 28;195(5):709-20. doi: 10.1083/jcb.201102131. Review.

34.

IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development.

Reynaud D, Pietras E, Barry-Holson K, Mir A, Binnewies M, Jeanne M, Sala-Torra O, Radich JP, Passegué E.

Cancer Cell. 2011 Nov 15;20(5):661-73. doi: 10.1016/j.ccr.2011.10.012.

35.

Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

Garcia D, Warr MR, Martins CP, Brown Swigart L, Passegué E, Evan GI.

Genes Dev. 2011 Aug 15;25(16):1746-57. doi: 10.1101/gad.16722111.

36.

Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies.

Warr MR, Pietras EM, Passegué E.

Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec;3(6):681-701. doi: 10.1002/wsbm.145. Epub 2011 Mar 15. Review.

PMID:
21412991
37.

DNA-damage response in tissue-specific and cancer stem cells.

Blanpain C, Mohrin M, Sotiropoulou PA, Passegué E.

Cell Stem Cell. 2011 Jan 7;8(1):16-29. doi: 10.1016/j.stem.2010.12.012. Review.

38.

On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.

Elefanty AG, Blelloch R, Passegué E, Wernig M, Mummery CL.

Cell Stem Cell. 2010 Oct 8;7(4):443-50. doi: 10.1016/j.stem.2010.09.002.

39.

PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.

Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R.

Cancer Res. 2010 Nov 1;70(21):8792-801. doi: 10.1158/0008-5472.CAN-08-4481. Epub 2010 Sep 21. Erratum in: Cancer Res. 2011 Apr 1;71(7):2805.

40.

The transcription factor Srf regulates hematopoietic stem cell adhesion.

Ragu C, Elain G, Mylonas E, Ottolenghi C, Cagnard N, Daegelen D, Passegué E, Vainchenker W, Bernard OA, Penard-Lacronique V.

Blood. 2010 Nov 25;116(22):4464-73. doi: 10.1182/blood-2009-11-251587. Epub 2010 Aug 13.

PMID:
20709909
41.

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis.

Mohrin M, Bourke E, Alexander D, Warr MR, Barry-Holson K, Le Beau MM, Morrison CG, Passegué E.

Cell Stem Cell. 2010 Aug 6;7(2):174-85. doi: 10.1016/j.stem.2010.06.014. Epub 2010 Jul 8.

42.

Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.

Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL.

PLoS One. 2010 Jan 20;5(1):e8785. doi: 10.1371/journal.pone.0008785.

43.

IFN-alpha wakes up sleeping hematopoietic stem cells.

Passegué E, Ernst P.

Nat Med. 2009 Jun;15(6):612-3. doi: 10.1038/nm0609-612. No abstract available.

44.

JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.

Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E.

Cancer Cell. 2009 Apr 7;15(4):341-52. doi: 10.1016/j.ccr.2009.02.016.

45.

Oncogenic Kras initiates leukemia in hematopoietic stem cells.

Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS.

PLoS Biol. 2009 Mar 17;7(3):e59. doi: 10.1371/journal.pbio.1000059.

46.

Cancer stem cells are everywhere.

Passegué E, Rafii S, Herlyn M.

Nat Med. 2009 Jan;15(1):23. doi: 10.1038/nm0109-23. No abstract available.

PMID:
19129778
47.

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.

Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J.

Cell Stem Cell. 2008 Oct 9;3(4):416-28. doi: 10.1016/j.stem.2008.07.009.

48.

MicroRNA-126 regulates HOXA9 by binding to the homeobox.

Shen WF, Hu YL, Uttarwar L, Passegue E, Largman C.

Mol Cell Biol. 2008 Jul;28(14):4609-19. doi: 10.1128/MCB.01652-07. Epub 2008 May 12.

49.

The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.

Min IM, Pietramaggiori G, Kim FS, Passegué E, Stevenson KE, Wagers AJ.

Cell Stem Cell. 2008 Apr 10;2(4):380-91. doi: 10.1016/j.stem.2008.01.015.

50.

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.

Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G.

Cancer Cell. 2008 Mar;13(3):206-20. doi: 10.1016/j.ccr.2008.01.034.

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