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Items: 1 to 20 of 80

1.

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

Kang YA, Pietras EM, Passegué E.

J Exp Med. 2020 Mar 2;217(3). pii: e20190787. doi: 10.1084/jem.20190787.

PMID:
31886826
2.

Adult stem cells and regenerative medicine-a symposium report.

Cable J, Fuchs E, Weissman I, Jasper H, Glass D, Rando TA, Blau H, Debnath S, Oliva A, Park S, Passegué E, Kim C, Krasnow MA.

Ann N Y Acad Sci. 2019 Oct 26. doi: 10.1111/nyas.14243. [Epub ahead of print]

PMID:
31655007
3.

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Yamashita M, Passegué E.

Cell Stem Cell. 2019 Sep 5;25(3):357-372.e7. doi: 10.1016/j.stem.2019.05.019. Epub 2019 Jun 20.

PMID:
31230859
4.

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation.

Verovskaya EV, Dellorusso PV, Passegué E.

Trends Mol Med. 2019 Jun;25(6):494-515. doi: 10.1016/j.molmed.2019.04.006. Epub 2019 May 17. Review.

PMID:
31109796
5.

Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia.

Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC.

Blood Adv. 2018 Oct 9;2(19):2462-2466. doi: 10.1182/bloodadvances.2018018929.

6.

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A.

Science. 2018 Mar 16;359(6381):1277-1283. doi: 10.1126/science.aag3048. Epub 2018 Mar 15.

7.

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E.

Nature. 2017 Apr 6;544(7648):53-58. doi: 10.1038/nature21693. Epub 2017 Mar 29.

8.

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.

Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR.

Nature. 2017 Apr 6;544(7648):105-109. doi: 10.1038/nature21706. Epub 2017 Mar 22.

9.

Autophagy maintains the metabolism and function of young and old stem cells.

Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV, Figueroa ME, Passegué E.

Nature. 2017 Mar 9;543(7644):205-210. doi: 10.1038/nature21388. Epub 2017 Mar 1.

10.

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.

Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F.

Nat Immunol. 2017 Feb;18(2):184-195. doi: 10.1038/ni.3644. Epub 2016 Dec 19.

11.

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

Chandel NS, Jasper H, Ho TT, Passegué E.

Nat Cell Biol. 2016 Aug;18(8):823-32. doi: 10.1038/ncb3385. Epub 2016 Jul 18. Review.

PMID:
27428307
12.

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.

Pietras EM, Mirantes-Barbeito C, Fong S, Loeffler D, Kovtonyuk LV, Zhang S, Lakshminarasimhan R, Chin CP, Techner JM, Will B, Nerlov C, Steidl U, Manz MG, Schroeder T, Passegué E.

Nat Cell Biol. 2016 Jun;18(6):607-18. doi: 10.1038/ncb3346. Epub 2016 Apr 25.

13.

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells.

Ugarte F, Sousae R, Cinquin B, Martin EW, Krietsch J, Sanchez G, Inman M, Tsang H, Warr M, Passegué E, Larabell CA, Forsberg EC.

Stem Cell Reports. 2015 Nov 10;5(5):728-740. doi: 10.1016/j.stemcr.2015.09.009. Epub 2015 Oct 17.

14.

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J.

Nat Commun. 2015 Oct 12;6:8548. doi: 10.1038/ncomms9548.

15.

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.

Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K.

Elife. 2015 Jul 20;4. doi: 10.7554/eLife.07839.

16.

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.

Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt AD, Stuart JM, Göttgens B, Passegué E.

Cell Stem Cell. 2015 Jul 2;17(1):35-46. doi: 10.1016/j.stem.2015.05.003. Epub 2015 Jun 18.

17.

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.

Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC.

Haematologica. 2015 Aug;100(8):1064-75. doi: 10.3324/haematol.2014.123018. Epub 2015 Jun 18.

18.

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.

Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M.

Nat Commun. 2015 Mar 10;6:6471. doi: 10.1038/ncomms7471.

19.

Normal and leukemic stem cell niches: insights and therapeutic opportunities.

Schepers K, Campbell TB, Passegué E.

Cell Stem Cell. 2015 Mar 5;16(3):254-67. doi: 10.1016/j.stem.2015.02.014. Review.

20.

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.

Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75. doi: 10.1073/pnas.1424927112. Epub 2015 Jan 26.

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