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Items: 1 to 50 of 377

1.

Selection of phage-displayed accessible recombinant targeted antibodies (SPARTA): methodology and applications.

D'Angelo S, Staquicini FI, Ferrara F, Staquicini DI, Sharma G, Tarleton CA, Nguyen H, Naranjo LA, Sidman RL, Arap W, Bradbury AR, Pasqualini R.

JCI Insight. 2018 May 3;3(9). pii: 98305. doi: 10.1172/jci.insight.98305. [Epub ahead of print]

2.

MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811. doi: 10.1073/pnas.1722106115. Epub 2018 Feb 28.

3.

Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.

Staquicini DI, D'Angelo S, Ferrara F, Karjalainen K, Sharma G, Smith TL, Tarleton CA, Jaalouk DE, Kuniyasu A, Baze WB, Chaffee BK, Hanley PW, Barnhart KF, Koivunen E, Marchiò S, Sidman RL, Cortes JE, Kantarjian HM, Arap W, Pasqualini R.

Pharmacogenomics J. 2018 May 22;18(3):436-443. doi: 10.1038/tpj.2017.46. Epub 2017 Dec 5.

PMID:
29205207
4.

A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies.

Amorim MG, Valieris R, Drummond RD, Pizzi MP, Freitas VM, Sinigaglia-Coimbra R, Calin GA, Pasqualini R, Arap W, Silva IT, Dias-Neto E, Nunes DN.

Sci Rep. 2017 Oct 31;7(1):14395. doi: 10.1038/s41598-017-14264-5.

5.

Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.

Al-Hashimi AA, Lebeau P, Majeed F, Polena E, Lhotak Š, Collins CAF, Pinthus JH, Gonzalez-Gronow M, Hoogenes J, Pizzo SV, Crowther M, Kapoor A, Rak J, Gyulay G, D'Angelo S, Marchiò S, Pasqualini R, Arap W, Shayegan B, Austin RC.

J Biol Chem. 2017 Dec 22;292(51):21180-21192. doi: 10.1074/jbc.M117.799908. Epub 2017 Oct 24.

PMID:
29066620
6.

Monoclonal IgG in MGUS and multiple myeloma targets infectious pathogens.

Bosseboeuf A, Feron D, Tallet A, Rossi C, Charlier C, Garderet L, Caillot D, Moreau P, Cardó-Vila M, Pasqualini R, Arap W, Nelson AD, Wilson BS, Perreault H, Piver E, Weigel P, Girodon F, Harb J, Bigot-Corbel E, Hermouet S.

JCI Insight. 2017 Oct 5;2(19). pii: 95367. doi: 10.1172/jci.insight.95367. [Epub ahead of print]

7.

Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses.

Teixeira AA, Marchiò S, Dias-Neto E, Nunes DN, da Silva IT, Chackerian B, Barry M, Lauer RC, Giordano RJ, Sidman RL, Wheeler CM, Cavenee WK, Pasqualini R, Arap W.

EMBO Mol Med. 2017 Oct;9(10):1327-1330. doi: 10.15252/emmm.201708072. No abstract available.

8.

BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation.

Lewis VO, Devarajan E, Cardó-Vila M, Thomas DG, Kleinerman ES, Marchiò S, Sidman RL, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8065-8070. doi: 10.1073/pnas.1704173114. Epub 2017 Jul 11.

9.

Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting.

Staquicini DI, Rangel R, Guzman-Rojas L, Staquicini FI, Dobroff AS, Tarleton CA, Ozbun MA, Kolonin MG, Gelovani JG, Marchiò S, Sidman RL, Hajjar KA, Arap W, Pasqualini R.

Sci Rep. 2017 Jun 26;7(1):4243. doi: 10.1038/s41598-017-03470-w.

10.

An AAVP-based solid-phase transducing matrix for transgene delivery: potential for translational applications.

Smith TL, Souza GR, Sidman RL, Arap W, Pasqualini R.

Cancer Gene Ther. 2017 Aug;24(8):358-360. doi: 10.1038/cgt.2017.19. Epub 2017 May 26.

11.

Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.

Kolonin MG, Sergeeva A, Staquicini DI, Smith TL, Tarleton CA, Molldrem JJ, Sidman RL, Marchiò S, Pasqualini R, Arap W.

Cancer Res. 2017 Jun 15;77(12):3144-3150. doi: 10.1158/0008-5472.CAN-16-0708. Epub 2017 Apr 20.

12.

An antivascular vaccine to boost self-immunity and strike the tumor.

Marchiò S, Bansal P, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3164-E3165. doi: 10.1073/pnas.1701452114. Epub 2017 Apr 11. No abstract available.

13.

Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer.

Ferrara F, Staquicini DI, Driessen WH, D'Angelo S, Dobroff AS, Barry M, Lomo LC, Staquicini FI, Cardó-Vila M, Soghomonyan S, Alauddin MM, Flores LG 2nd, Arap MA, Lauer RC, Mathew P, Efstathiou E, Aparicio AM, Troncoso P, Navone NM, Logothetis CJ, Marchiò S, Gelovani JG, Sidman RL, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2016 Oct 24. pii: 201615400. [Epub ahead of print]

14.

Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.

Dobroff AS, D'Angelo S, Eckhardt BL, Ferrara F, Staquicini DI, Cardó-Vila M, Staquicini FI, Nunes DN, Kim K, Driessen WH, Hajitou A, Lomo LC, Barry M, Krishnamurthy S, Sahin A, Woodward WA, Prossnitz ER, Anderson RL, Dias-Neto E, Brown-Glaberman UA, Royce ME, Ueno NT, Cristofanilli M, Hortobagyi GN, Marchiò S, Gelovani JG, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Oct 24. pii: 201615288. [Epub ahead of print]

15.

CTHRSSVVC Peptide as a Possible Early Molecular Imaging Target for Atherosclerosis.

Silva RA, Giordano RJ, Gutierrez PS, Rocha VZ, Rudnicki M, Kee P, Abdalla DS, Puech-Leão P, Caramelli B, Arap W, Pasqualini R, Meneghetti JC, Marques FL, Khoobchandani M, Katti KV, Lugão AB, Kalil J.

Int J Mol Sci. 2016 Aug 24;17(9). pii: E1383. doi: 10.3390/ijms17091383.

16.

Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue.

Salameh A, Daquinag AC, Staquicini DI, An Z, Hajjar KA, Pasqualini R, Arap W, Kolonin MG.

JCI Insight. 2016 Jul 7;1(10). pii: e86351.

17.

Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity.

Cardó-Vila M, Marchiò S, Sato M, Staquicini FI, Smith TL, Bronk JK, Yin G, Zurita AJ, Sun M, Behrens C, Sidman RL, Lee JJ, Hong WK, Wistuba II, Arap W, Pasqualini R.

Am J Pathol. 2016 Aug;186(8):2162-2170. doi: 10.1016/j.ajpath.2016.04.013. Epub 2016 Jun 16.

18.

Brain endothelial cell-targeted gene therapy of neurovascular disorders.

Marchiò S, Sidman RL, Arap W, Pasqualini R.

EMBO Mol Med. 2016 Jun 1;8(6):592-4. doi: 10.15252/emmm.201606407. Print 2016 Jun. No abstract available.

19.

BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer.

Bartolini A, Cardaci S, Lamba S, Oddo D, Marchiò C, Cassoni P, Amoreo CA, Corti G, Testori A, Bussolino F, Pasqualini R, Arap W, Corà D, Di Nicolantonio F, Marchiò S.

Clin Cancer Res. 2016 Oct 1;22(19):4923-4933. Epub 2016 May 3.

20.

Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries.

Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M.

Mol Ther. 2016 Jun;24(6):1050-1061. doi: 10.1038/mt.2016.62. Epub 2016 Mar 28.

21.

AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas.

Smith TL, Yuan Z, Cardó-Vila M, Sanchez Claros C, Adem A, Cui MH, Branch CA, Gelovani JG, Libutti SK, Sidman RL, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2466-71. doi: 10.1073/pnas.1525709113. Epub 2016 Feb 16.

22.

Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors.

Dondossola E, Dobroff AS, Marchiò S, Cardó-Vila M, Hosoya H, Libutti SK, Corti A, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2223-8. doi: 10.1073/pnas.1525697113. Epub 2016 Feb 8.

23.

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

Hosoya H, Dobroff AS, Driessen WH, Cristini V, Brinker LM, Staquicini FI, Cardó-Vila M, D'Angelo S, Ferrara F, Proneth B, Lin YS, Dunphy DR, Dogra P, Melancon MP, Stafford RJ, Miyazono K, Gelovani JG, Kataoka K, Brinker CJ, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1877-82. doi: 10.1073/pnas.1525796113. Epub 2016 Feb 2.

24.

Ligand-targeted theranostic nanomedicines against cancer.

Yao VJ, D'Angelo S, Butler KS, Theron C, Smith TL, Marchiò S, Gelovani JG, Sidman RL, Dobroff AS, Brinker CJ, Bradbury ARM, Arap W, Pasqualini R.

J Control Release. 2016 Oct 28;240:267-286. doi: 10.1016/j.jconrel.2016.01.002. Epub 2016 Jan 6. Review.

25.

The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease.

Sidman RL, Li J, Lawrence M, Hu W, Musso GF, Giordano RJ, Cardó-Vila M, Pasqualini R, Arap W.

Sci Transl Med. 2015 Oct 14;7(309):309ra165. doi: 10.1126/scitranslmed.aac4882.

26.

The Neuronal Pentraxin-2 Pathway Is an Unrecognized Target in Human Neuroblastoma, Which Also Offers Prognostic Value in Patients.

Bartolini A, Di Paolo D, Noghero A, Murgia D, Sementa AR, Cilli M, Pasqualini R, Arap W, Bussolino F, Ponzoni M, Pastorino F, Marchiò S.

Cancer Res. 2015 Oct 15;75(20):4265-71. doi: 10.1158/0008-5472.CAN-15-0649. Epub 2015 Aug 20.

27.

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.

Salameh A, Lee AK, Cardó-Vila M, Nunes DN, Efstathiou E, Staquicini FI, Dobroff AS, Marchiò S, Navone NM, Hosoya H, Lauer RC, Wen S, Salmeron CC, Hoang A, Newsham I, Lima LA, Carraro DM, Oliviero S, Kolonin MG, Sidman RL, Do KA, Troncoso P, Logothetis CJ, Brentani RR, Calin GA, Cavenee WK, Dias-Neto E, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8403-8. doi: 10.1073/pnas.1507882112. Epub 2015 Jun 15.

28.

Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study.

Pasqualini R, Millikan RE, Christianson DR, Cardó-Vila M, Driessen WH, Giordano RJ, Hajitou A, Hoang AG, Wen S, Barnhart KF, Baze WB, Marcott VD, Hawke DH, Do KA, Navone NM, Efstathiou E, Troncoso P, Lobb RR, Logothetis CJ, Arap W.

Cancer. 2015 Jul 15;121(14):2411-21. doi: 10.1002/cncr.29344. Epub 2015 Apr 1.

29.

Linear mRNA amplification approach for RNAseq from limited amount of RNA.

Ferreira EN, de Campos Molina G, Puga RD, Nagai MA, Campos AH, Guimarães GC, Nunes DN, Pasqualini R, Arap W, Brentani H, Dias-Neto E, Brentani RR, Carraro DM.

Gene. 2015 Jun 15;564(2):220-7. doi: 10.1016/j.gene.2015.03.058. Epub 2015 Mar 28.

30.

Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens.

Karjalainen K, Jaalouk DE, Bueso-Ramos C, Bover L, Sun Y, Kuniyasu A, Driessen WH, Cardó-Vila M, Rietz C, Zurita AJ, O'Brien S, Kantarjian HM, Cortes JE, Calin GA, Koivunen E, Arap W, Pasqualini R.

Clin Cancer Res. 2015 Jul 1;21(13):3041-51. doi: 10.1158/1078-0432.CCR-13-3059. Epub 2015 Mar 16.

31.

Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch.

Nunes DN, Dias-Neto E, Cardó-Vila M, Edwards JK, Dobroff AS, Giordano RJ, Mandelin J, Brentani HP, Hasselgren C, Yao VJ, Marchiò S, Pereira CA, Passetti F, Calin GA, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3770-5. doi: 10.1073/pnas.1500008112. Epub 2015 Mar 9.

32.

Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors.

Mandelin J, Cardó-Vila M, Driessen WH, Mathew P, Navone NM, Lin SH, Logothetis CJ, Rietz AC, Dobroff AS, Proneth B, Sidman RL, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3776-81. doi: 10.1073/pnas.1500128112. Epub 2015 Mar 11.

33.

An anti-ubiquitin antibody response in transitional cell carcinoma of the urinary bladder.

Ardelt PU, Ebbing J, Adams F, Reiss C, Arap W, Pasqualini R, Bachmann A, Wetterauer U, Riedmiller H, Kneitz B.

PLoS One. 2015 Mar 5;10(3):e0118646. doi: 10.1371/journal.pone.0118646. eCollection 2015.

34.

Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer.

Mintz PJ, Rietz AC, Cardó-Vila M, Ozawa MG, Dondossola E, Do KA, Kim J, Troncoso P, Logothetis CJ, Sidman RL, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2515-20. doi: 10.1073/pnas.1500097112. Epub 2015 Feb 9.

35.

Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis.

Christianson DR, Dobroff AS, Proneth B, Zurita AJ, Salameh A, Dondossola E, Makino J, Bologa CG, Smith TL, Yao VJ, Calderone TL, O'Connell DJ, Oprea TI, Kataoka K, Cahill DJ, Gershenwald JE, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2521-6. doi: 10.1073/pnas.1424994112. Epub 2015 Feb 6.

36.

Ligand-directed profiling of organelles with internalizing phage libraries.

Dobroff AS, Rangel R, Guzman-Roja L, Salmeron CC, Gelovani JG, Sidman RL, Bologa CG, Oprea TI, Brinker CJ, Pasqualini R, Arap W.

Curr Protoc Protein Sci. 2015 Feb 2;79:30.4.1-30. doi: 10.1002/0471140864.ps3004s79.

37.

Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer.

Staquicini FI, Qian MD, Salameh A, Dobroff AS, Edwards JK, Cimino DF, Moeller BJ, Kelly P, Nunez MI, Tang X, Liu DD, Lee JJ, Hong WK, Ferrara F, Bradbury AR, Lobb RR, Edelman MJ, Sidman RL, Wistuba II, Arap W, Pasqualini R.

J Biol Chem. 2015 Mar 20;290(12):7345-59. doi: 10.1074/jbc.M114.630525. Epub 2015 Jan 26.

38.

Drug design strategies for the treatment of prostate cancer.

Lauer RC, Friend SC, Rietz C, Pasqualini R, Arap W.

Expert Opin Drug Discov. 2015 Jan;10(1):81-90. doi: 10.1517/17460441.2015.978855. Epub 2014 Nov 4. Review.

PMID:
25366417
39.

Bone marrow-derived CD13+ cells sustain tumor progression: A potential non-malignant target for anticancer therapy.

Dondossola E, Corti A, Sidman RL, Arap W, Pasqualini R.

Oncoimmunology. 2014 Jan 16;3:e27716. eCollection 2014.

40.

Successful live birth from oocytes after more than 14 years of cryopreservation.

Urquiza MF, Carretero I, Cano Carabajal PR, Pasqualini RA, Felici MM, Pasqualini RS, Quintans CJ.

J Assist Reprod Genet. 2014 Nov;31(11):1553-5. doi: 10.1007/s10815-014-0318-9. Epub 2014 Sep 10.

41.

[Uterine subrogation: medical and legal aspects of the first legally supported case in Argentina].

Urquiza MF, Carretero I, Quaini FM, Inciarte F, Pasqualini RA, Pasqualini RS.

Medicina (B Aires). 2014;74(3):233-8. Spanish.

42.

A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium.

Bronk JK, Russell BH, Rivera JJ, Pasqualini R, Arap W, Höök M, Barbu EM.

Acta Biomater. 2014 Jul;10(7):3354-62. doi: 10.1016/j.actbio.2014.04.005. Epub 2014 Apr 13.

PMID:
24732634
43.

Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia.

Karjalainen K, Pasqualini R, Cortes JE, Kornblau SM, Lichtiger B, O'Brien S, Kantarjian HM, Sidman RL, Arap W, Koivunen E.

Cancer. 2014 Feb 15;120(4):589-602. doi: 10.1002/cncr.28419. Epub 2013 Oct 25.

44.

Bacteriophage Associated Silicon Particles: Design and Characterization of a Novel Theranostic Vector with Improved Payload Carrying Potential.

Srinivasan S, Alexander JF, Driessen WH, Leonard F, Ye H, Liu X, Arap W, Pasqualini R, Ferrari M, Godin B.

J Mater Chem B. 2013 Oct 21;1(39). doi: 10.1039/C3TB20595A.

45.

CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis.

Dondossola E, Rangel R, Guzman-Rojas L, Barbu EM, Hosoya H, St John LS, Molldrem JJ, Corti A, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20717-22. doi: 10.1073/pnas.1321139110. Epub 2013 Dec 2.

46.

Mixed tridentate π -donor and monodentate π -acceptor ligands as chelating systems for rhenium-188 and technetium-99m nitrido radiopharmaceuticals.

Boschi A, Uccelli L, Pasquali M, Pasqualini R, Guerrini R, Duatti A.

Curr Radiopharm. 2013 Sep;6(3):137-45.

PMID:
24106999
47.

An antimicrobial peptidomimetic induces Mucorales cell death through mitochondria-mediated apoptosis.

Barbu EM, Shirazi F, McGrath DM, Albert N, Sidman RL, Pasqualini R, Arap W, Kontoyiannis DP.

PLoS One. 2013 Oct 3;8(10):e76981. doi: 10.1371/journal.pone.0076981. eCollection 2013.

48.

Targeting mammalian organelles with internalizing phage (iPhage) libraries.

Rangel R, Dobroff AS, Guzman-Rojas L, Salmeron CC, Gelovani JG, Sidman RL, Pasqualini R, Arap W.

Nat Protoc. 2013 Oct;8(10):1916-39. doi: 10.1038/nprot.2013.119. Epub 2013 Sep 12.

49.

Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity.

Chintalgattu V, Rees ML, Culver JC, Goel A, Jiffar T, Zhang J, Dunner K Jr, Pati S, Bankson JA, Pasqualini R, Arap W, Bryan NS, Taegtmeyer H, Langley RR, Yao H, Kupferman ME, Entman ML, Dickinson ME, Khakoo AY.

Sci Transl Med. 2013 May 29;5(187):187ra69. doi: 10.1126/scitranslmed.3005066.

50.

Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings.

Loi M, Di Paolo D, Soster M, Brignole C, Bartolini A, Emionite L, Sun J, Becherini P, Curnis F, Petretto A, Sani M, Gori A, Milanese M, Gambini C, Longhi R, Cilli M, Allen TM, Bussolino F, Arap W, Pasqualini R, Corti A, Ponzoni M, Marchiò S, Pastorino F.

J Control Release. 2013 Sep 10;170(2):233-41. doi: 10.1016/j.jconrel.2013.04.029. Epub 2013 May 25.

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