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Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus.

Frolinger T, Herman F, Sharma A, Sims S, Wang J, Pasinetti GM.

Biol Open. 2018 Jul 3. pii: bio.035196. doi: 10.1242/bio.035196. [Epub ahead of print]


Principles of inflammasome priming and inhibition: Implications for psychiatric disorders.

Herman FJ, Pasinetti GM.

Brain Behav Immun. 2018 Jun 11. pii: S0889-1591(18)30226-5. doi: 10.1016/j.bbi.2018.06.010. [Epub ahead of print] Review.


Prevalence of dry eye in video display terminal users: a cross-sectional Caucasian study in Italy.

Rossi GCM, Scudeller L, Bettio F, Pasinetti GM, Bianchi PE.

Int Ophthalmol. 2018 Jun 7. doi: 10.1007/s10792-018-0947-6. [Epub ahead of print]


An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression.

Wang J, Fernández AE, Tiano S, Huang J, Floyd E, Poulev A, Ribnicky D, Pasinetti GM.

Oxid Med Cell Longev. 2018 May 13;2018:7418681. doi: 10.1155/2018/7418681. eCollection 2018.


Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation.

Frolinger T, Smith C, Cobo CF, Sims S, Brathwaite J, de Boer S, Huang J, Pasinetti GM.

FASEB J. 2018 Apr 27:fj201800030R. doi: 10.1096/fj.201800030R. [Epub ahead of print]


The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice.

Pasinetti GM, Singh R, Westfall S, Herman F, Faith J, Ho L.

J Alzheimers Dis. 2018;63(2):409-421. doi: 10.3233/JAD-171151.


Endoscopic retrograde cholangiopancreatography in the elderly: results of a retrospective study and a geriatricians' point of view.

Galeazzi M, Mazzola P, Valcarcel B, Bellelli G, Dinelli M, Pasinetti GM, Annoni G.

BMC Gastroenterol. 2018 Mar 14;18(1):38. doi: 10.1186/s12876-018-0764-4.


Polyphenolic Compounds Alter Stress-Induced Patterns of Global DNA Methylation in Brain and Blood.

Blaze J, Wang J, Ho L, Mendelev N, Haghighi F, Pasinetti GM.

Mol Nutr Food Res. 2018 Apr;62(8):e1700722. doi: 10.1002/mnfr.201700722. Epub 2018 Mar 22.


Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice.

Wang J, Hodes GE, Zhang H, Zhang S, Zhao W, Golden SA, Bi W, Menard C, Kana V, Leboeuf M, Xie M, Bregman D, Pfau ML, Flanigan ME, Esteban-Fernández A, Yemul S, Sharma A, Ho L, Dixon R, Merad M, Han MH, Russo SJ, Pasinetti GM.

Nat Commun. 2018 Feb 2;9(1):477. doi: 10.1038/s41467-017-02794-5.


Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms.

Ho L, Ono K, Tsuji M, Mazzola P, Singh R, Pasinetti GM.

Expert Rev Neurother. 2018 Jan;18(1):83-90. doi: 10.1080/14737175.2018.1400909. Epub 2017 Nov 14.


A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols.

Ho L, Cheng H, Wang J, Simon JE, Wu Q, Zhao D, Carry E, Ferruzzi MG, Faith J, Valcarcel B, Hao K, Pasinetti GM.

Mol Pharm. 2018 Mar 5;15(3):840-850. doi: 10.1021/acs.molpharmaceut.7b00412. Epub 2018 Feb 5.


The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans.

Novotny JA, Chen TY, Terekhov AI, Gebauer SK, Baer DJ, Ho L, Pasinetti GM, Ferruzzi MG.

Mol Nutr Food Res. 2017 Nov;61(11). doi: 10.1002/mnfr.201700043. Epub 2017 Aug 29.


Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat.

Chen TY, Ferruzzi MG, Wu QL, Simon JE, Talcott ST, Wang J, Ho L, Todd G, Cooper B, Pasinetti GM, Janle EM.

Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700111. Epub 2017 Aug 14.


Association Between Preoperative Malnutrition and Postoperative Delirium After Hip Fracture Surgery in Older Adults.

Mazzola P, Ward L, Zazzetta S, Broggini V, Anzuini A, Valcarcel B, Brathwaite JS, Pasinetti GM, Bellelli G, Annoni G.

J Am Geriatr Soc. 2017 Jun;65(6):1222-1228. doi: 10.1111/jgs.14764. Epub 2017 Mar 6.


Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.

Varghese M, Santa-Maria I, Ho L, Ward L, Yemul S, Dubner L, Księżak-Reding H, Pasinetti GM.

J Alzheimers Dis. 2016 Sep 6;54(2):477-96. doi: 10.3233/JAD-160166.


Recommendations for Development of Botanical Polyphenols as "Natural Drugs" for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment.

Ward L, Pasinetti GM.

Neuromolecular Med. 2016 Sep;18(3):487-95. doi: 10.1007/s12017-016-8418-6. Epub 2016 Jun 24. Review.


Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer's Patients.

Ho L, Bloom PA, Vega JG, Yemul S, Zhao W, Ward L, Savage E, Rooney R, Patel DH, Pasinetti GM.

Neuromolecular Med. 2016 Jun;18(2):177-89. doi: 10.1007/s12017-016-8388-8. Epub 2016 Mar 17.


In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy.

Zhao W, Ho L, Wang J, Bi W, Yemul S, Ward L, Freire D, Mazzola P, Brathwaite J, Mezei M, Sanchez R, Elder GA, Pasinetti GM.

J Cell Biochem. 2016 Oct;117(10):2241-8. doi: 10.1002/jcb.25521. Epub 2016 Jul 12.


Hip Fracture Surgery and Survival in Centenarians.

Mazzola P, Rea F, Merlino L, Bellelli G, Dubner L, Corrao G, Pasinetti GM, Annoni G.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1514-1518. Epub 2016 Feb 16.


Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease.

Wang J, Bi W, Zhao W, Varghese M, Koch RJ, Walker RH, Chandraratna RA, Sanders ME, Janesick A, Blumberg B, Ward L, Ho L, Pasinetti GM.

Oncotarget. 2016 Feb 16;7(7):7469-79. doi: 10.18632/oncotarget.7191.


REMOVED: Insulin resistance and obesity in childhood and long term consequences during aging.

Pasinetti GM.

Int J Dev Neurosci. 2015 Dec;47(Pt A):88. doi: 10.1016/j.ijdevneu.2015.04.241. Epub 2015 Nov 5.


Towards prevention and therapy of Alzheimer's disease.

Pasinetti GM.

Mol Aspects Med. 2015 Jun-Oct;43-44:1-2. doi: 10.1016/j.mam.2015.09.001. No abstract available.


Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction.

Zhao W, Wang J, Bi W, Ferruzzi M, Yemul S, Freire D, Mazzola P, Ho L, Dubner L, Pasinetti GM.

Neurochem Int. 2015 Oct;89:191-7. doi: 10.1016/j.neuint.2015.07.023. Epub 2015 Jul 30.


Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols.

Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB.

J Neurochem. 2015 Oct;135(2):416-30. doi: 10.1111/jnc.13270. Epub 2015 Sep 2.


Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes.

Hao K, Di Narzo AF, Ho L, Luo W, Li S, Chen R, Li T, Dubner L, Pasinetti GM.

Mol Aspects Med. 2015 Jun-Oct;43-44:66-76. doi: 10.1016/j.mam.2015.06.006. Epub 2015 Jun 23. Review.


Childhood and adolescent obesity and long-term cognitive consequences during aging.

Wang J, Freire D, Knable L, Zhao W, Gong B, Mazzola P, Ho L, Levine S, Pasinetti GM.

J Comp Neurol. 2015 Jul 1;523(10):1587. doi: 10.1002/cne.23799. No abstract available.


Erratum. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.

Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR.

FASEB J. 2015 Jun;29(6):2679. doi: 10.1096/fj.13-239509ERR. No abstract available.


Correction to Survey of polyphenol constituents in grapes and grape-derived products.

Xu Y, Simon JE, Welch C, Wightman JD, Ferruzzi MG, Ho L, Pasinetti GM, Wu Q.

J Agric Food Chem. 2015 Apr 15;63(14):3804. doi: 10.1021/acs.jafc.5b01552. Epub 2015 Apr 6. No abstract available.


Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects.

Zhao W, Wang J, Varghese M, Ho L, Mazzola P, Haroutunian V, Katsel PL, Gibson GE, Levine S, Dubner L, Pasinetti GM.

Neuropsychiatr Dis Treat. 2015 Mar 5;11:565-74. doi: 10.2147/NDT.S74898. eCollection 2015.


Novel role of red wine-derived polyphenols in the prevention of Alzheimer's disease dementia and brain pathology: experimental approaches and clinical implications.

Pasinetti GM.

Planta Med. 2012 Oct;78(15):E24. doi: 10.1055/s-0035-1545846. Epub 2015 Mar 11. No abstract available.


From benzalkonium chloride-preserved Latanoprost to Polyquad-preserved Travoprost: a 6-month study on ocular surface safety and tolerability.

Rossi GC, Scudeller L, Rolle T, Pasinetti GM, Bianchi PE.

Expert Opin Drug Saf. 2015 May;14(5):619-23. doi: 10.1517/14740338.2015.1017467. Epub 2015 Mar 10.


Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization.

Wang D, Ho L, Faith J, Ono K, Janle EM, Lachcik PJ, Cooper BR, Jannasch AH, D'Arcy BR, Williams BA, Ferruzzi MG, Levine S, Zhao W, Dubner L, Pasinetti GM.

Mol Nutr Food Res. 2015 Jun;59(6):1025-40. doi: 10.1002/mnfr.201400544. Epub 2015 Apr 27. Erratum in: Mol Nutr Food Res. 2015 Jun;59(6):1222. Mol Nutr Food Res. 2015 Nov;59(11):2337.


Select small nucleolar RNAs in blood components as novel biomarkers for improved identification of comorbid traumatic brain injury and post-traumatic stress disorder in veterans of the conflicts in Afghanistan and Iraq.

Ho L, Lange G, Zhao W, Wang J, Rooney R, Patel DH, Fobler MM, Helmer DA, Elder G, Shaughness MC, Ahlers ST, Russo SJ, Pasinetti GM.

Am J Neurodegener Dis. 2014 Dec 5;3(3):170-81. eCollection 2014.


Simultaneous bilateral femoral neck fracture and end-stage renal disease in a 76-year-old woman: a case report.

Mazzola P, Anzuini A, Picone D, De Filippi F, Dubner L, Bellelli G, Zatti G, Pasinetti GM, Annoni G.

Aging Clin Exp Res. 2015 Aug;27(4):555-9. doi: 10.1007/s40520-014-0312-1. Epub 2015 Jan 10.


The science of cocoa flavanols: bioavailability, emerging evidence, and proposed mechanisms.

Blumberg JB, Ding EL, Dixon R, Pasinetti GM, Villarreal F.

Adv Nutr. 2014 Sep;5(5):547-9.


Childhood and adolescent obesity and long-term cognitive consequences during aging.

Wang J, Freire D, Knable L, Zhao W, Gong B, Mazzola P, Ho L, Levine S, Pasinetti GM.

J Comp Neurol. 2015 Apr 1;523(5):757-68. doi: 10.1002/cne.23708. Epub 2014 Dec 26. Erratum in: J Comp Neurol. 2015 Jul 1;523(10):1587.


Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment.

Pasinetti GM, Wang J, Ho L, Zhao W, Dubner L.

Biochim Biophys Acta. 2015 Jun;1852(6):1202-8. doi: 10.1016/j.bbadis.2014.10.006. Epub 2014 Oct 12. Review.


Chemical investigation of commercial grape seed derived products to assess quality and detect adulteration.

Villani TS, Reichert W, Ferruzzi MG, Pasinetti GM, Simon JE, Wu Q.

Food Chem. 2015 Mar 1;170:271-80. doi: 10.1016/j.foodchem.2014.08.084. Epub 2014 Aug 26.


Role of complement systems in IVIG mediated attenuation of cognitive deterioration in Alzheimer's disease.

Gong B, Levine S, Barnum SR, Pasinetti GM.

Curr Alzheimer Res. 2014;11(7):637-44. Review.


Cocoa extracts reduce oligomerization of amyloid-β: implications for cognitive improvement in Alzheimer's disease.

Wang J, Varghese M, Ono K, Yamada M, Levine S, Tzavaras N, Gong B, Hurst WJ, Blitzer RD, Pasinetti GM.

J Alzheimers Dis. 2014;41(2):643-50. doi: 10.3233/JAD-132231.


Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications.

Wang J, Bi W, Cheng A, Freire D, Vempati P, Zhao W, Gong B, Janle EM, Chen TY, Ferruzzi MG, Schmeidler J, Ho L, Pasinetti GM.

Front Aging Neurosci. 2014 Mar 14;6:42. doi: 10.3389/fnagi.2014.00042. eCollection 2014.


Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer's disease.

Wang J, Land D, Ono K, Galvez J, Zhao W, Vempati P, Steele JW, Cheng A, Yamada M, Levine S, Mazzola P, Pasinetti GM.

PLoS One. 2014 Mar 26;9(3):e92750. doi: 10.1371/journal.pone.0092750. eCollection 2014.


The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.

Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR.

FASEB J. 2014 May;28(5):2120-33. doi: 10.1096/fj.13-239509. Epub 2014 Feb 4. Erratum in: FASEB J. 2015 Jun;29(6):2679.


Epigenetic mechanisms linking diabetes and synaptic impairments.

Wang J, Gong B, Zhao W, Tang C, Varghese M, Nguyen T, Bi W, Bilski A, Begum S, Vempati P, Knable L, Ho L, Pasinetti GM.

Diabetes. 2014 Feb;63(2):645-54. doi: 10.2337/db13-1063. Epub 2013 Oct 23.


Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model.

Wang J, Tang C, Ferruzzi MG, Gong B, Song BJ, Janle EM, Chen TY, Cooper B, Varghese M, Cheng A, Freire D, Bilski A, Roman J, Nguyen T, Ho L, Talcott ST, Simon JE, Wu Q, Pasinetti GM.

Mol Nutr Food Res. 2013 Dec;57(12):2091-102. doi: 10.1002/mnfr.201300230. Epub 2013 Aug 21.


Effect of preservative-free tafluprost on keratocytes, sub-basal nerves, and endothelium: a single-blind one-year confocal study on naïve or treated glaucoma and hypertensive patients versus a control group.

Rossi GC, Blini M, Scudeller L, Ricciardelli G, Depolo L, Amisano A, Bossolesi L, Pasinetti GM, Bianchi PE.

J Ocul Pharmacol Ther. 2013 Nov;29(9):821-5. doi: 10.1089/jop.2013.0069. Epub 2013 Aug 14.


IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway.

Gong B, Pan Y, Zhao W, Knable L, Vempati P, Begum S, Ho L, Wang J, Yemul S, Barnum S, Bilski A, Gong BY, Pasinetti GM.

Mol Immunol. 2013 Dec;56(4):619-29. doi: 10.1016/j.molimm.2013.06.016. Epub 2013 Aug 1.


Sirtuins as therapeutic targets of ALS.

Pasinetti GM, Bilski AE, Zhao W.

Cell Res. 2013 Sep;23(9):1073-4. doi: 10.1038/cr.2013.94. Epub 2013 Jul 16.

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