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Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes.

Gros A, Tran E, Parkhurst MR, Ilyas S, Pasetto A, Groh EM, Robbins PF, Yossef R, Garcia-Garijo A, Fajardo CA, Prickett TD, Jia L, Gartner JJ, Ray S, Ngo L, Wunderllich JR, Yang JC, Rosenberg SA.

J Clin Invest. 2019 Nov 1;129(11):4992-5004. doi: 10.1172/JCI127967.


Editorial: HBV-the naked truth?

Pasetto A, Ahlén G, Sällberg M.

Aliment Pharmacol Ther. 2019 Oct;50(8):963-964. doi: 10.1111/apt.15428. No abstract available.


Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers.

Parkhurst MR, Robbins PF, Tran E, Prickett TD, Gartner JJ, Jia L, Ivey G, Li YF, El-Gamil M, Lalani A, Crystal JS, Sachs A, Groh E, Ray S, Ngo LT, Kivitz S, Pasetto A, Yossef R, Lowery FJ, Goff SL, Lo W, Cafri G, Deniger DC, Malekzadeh P, Ahmadzadeh M, Wunderlich JR, Somerville RPT, Rosenberg SA.

Cancer Discov. 2019 Aug;9(8):1022-1035. doi: 10.1158/2159-8290.CD-18-1494. Epub 2019 Jun 4.


Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers.

Malekzadeh P, Pasetto A, Robbins PF, Parkhurst MR, Paria BC, Jia L, Gartner JJ, Hill V, Yu Z, Restifo NP, Sachs A, Tran E, Lo W, Somerville RP, Rosenberg SA, Deniger DC.

J Clin Invest. 2019 Mar 1;129(3):1109-1114. doi: 10.1172/JCI123791. Epub 2019 Feb 4. No abstract available.


Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer.

Lo W, Parkhurst M, Robbins PF, Tran E, Lu YC, Jia L, Gartner JJ, Pasetto A, Deniger D, Malekzadeh P, Shelton TE, Prickett T, Ray S, Kivitz S, Paria BC, Kriley I, Schrump DS, Rosenberg SA.

Cancer Immunol Res. 2019 Apr;7(4):534-543. doi: 10.1158/2326-6066.CIR-18-0686. Epub 2019 Feb 1. Review.


Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients.

Cafri G, Yossef R, Pasetto A, Deniger DC, Lu YC, Parkhurst M, Gartner JJ, Jia L, Ray S, Ngo LT, Jafferji M, Sachs A, Prickett T, Robbins PF, Rosenberg SA.

Nat Commun. 2019 Jan 25;10(1):449. doi: 10.1038/s41467-019-08304-z.


Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity.

Ahmadzadeh M, Pasetto A, Jia L, Deniger DC, Stevanović S, Robbins PF, Rosenberg SA.

Sci Immunol. 2019 Jan 11;4(31). pii: eaao4310. doi: 10.1126/sciimmunol.aao4310.


Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.

Yossef R, Tran E, Deniger DC, Gros A, Pasetto A, Parkhurst MR, Gartner JJ, Prickett TD, Cafri G, Robbins PF, Rosenberg SA.

JCI Insight. 2018 Oct 4;3(19). pii: 122467. doi: 10.1172/jci.insight.122467.


Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer.

Zacharakis N, Chinnasamy H, Black M, Xu H, Lu YC, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, Gartner J, Jia L, Trebska-McGowan K, Somerville RP, Robbins PF, Rosenberg SA, Goff SL, Feldman SA.

Nat Med. 2018 Jun;24(6):724-730. doi: 10.1038/s41591-018-0040-8. Epub 2018 Jun 4.


T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers.

Deniger DC, Pasetto A, Robbins PF, Gartner JJ, Prickett TD, Paria BC, Malekzadeh P, Jia L, Yossef R, Langhan MM, Wunderlich JR, Danforth DN, Somerville RPT, Rosenberg SA.

Clin Cancer Res. 2018 Nov 15;24(22):5562-5573. doi: 10.1158/1078-0432.CCR-18-0573. Epub 2018 May 31.


Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer.

Stevanović S, Pasetto A, Helman SR, Gartner JJ, Prickett TD, Howie B, Robins HS, Robbins PF, Klebanoff CA, Rosenberg SA, Hinrichs CS.

Science. 2017 Apr 14;356(6334):200-205. doi: 10.1126/science.aak9510.


Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.

Balasiddaiah A, Davanian H, Aleman S, Pasetto A, Frelin L, Sällberg M, Lohmann V, Koh S, Bertoletti A, Chen M.

J Virol. 2017 Apr 13;91(9). pii: e00010-17. doi: 10.1128/JVI.00010-17. Print 2017 May 1.


A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma.

Deniger DC, Kwong ML, Pasetto A, Dudley ME, Wunderlich JR, Langhan MM, Lee CR, Rosenberg SA.

Clin Cancer Res. 2017 Jan 15;23(2):351-362. doi: 10.1158/1078-0432.CCR-16-0906. Epub 2016 Oct 7.


T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.

Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, Jia L, Pasetto A, Zheng Z, Ray S, Groh EM, Kriley IR, Rosenberg SA.

N Engl J Med. 2016 Dec 8;375(23):2255-2262.


Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.

Parkhurst M, Gros A, Pasetto A, Prickett T, Crystal JS, Robbins P, Rosenberg SA.

Clin Cancer Res. 2017 May 15;23(10):2491-2505. doi: 10.1158/1078-0432.CCR-16-2680. Epub 2016 Nov 8.


Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor.

Pasetto A, Gros A, Robbins PF, Deniger DC, Prickett TD, Matus-Nicodemos R, Douek DC, Howie B, Robins H, Parkhurst MR, Gartner J, Trebska-McGowan K, Crystal JS, Rosenberg SA.

Cancer Immunol Res. 2016 Sep 2;4(9):734-43. doi: 10.1158/2326-6066.CIR-16-0001. Epub 2016 Jun 28.


Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens.

Prickett TD, Crystal JS, Cohen CJ, Pasetto A, Parkhurst MR, Gartner JJ, Yao X, Wang R, Gros A, Li YF, El-Gamil M, Trebska-McGowan K, Rosenberg SA, Robbins PF.

Cancer Immunol Res. 2016 Aug;4(8):669-78. doi: 10.1158/2326-6066.CIR-15-0215. Epub 2016 Jun 16.


Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System.

Deniger DC, Pasetto A, Tran E, Parkhurst MR, Cohen CJ, Robbins PF, Cooper LJ, Rosenberg SA.

Mol Ther. 2016 Jun;24(6):1078-1089. doi: 10.1038/mt.2016.51. Epub 2016 Mar 5.


Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients.

Gros A, Parkhurst MR, Tran E, Pasetto A, Robbins PF, Ilyas S, Prickett TD, Gartner JJ, Crystal JS, Roberts IM, Trebska-McGowan K, Wunderlich JR, Yang JC, Rosenberg SA.

Nat Med. 2016 Apr;22(4):433-8. doi: 10.1038/nm.4051. Epub 2016 Feb 22.


Checklist for anesthesiological process: analysis of risks.

Ghirardini AM, Guerra E, Serio L, Girardis M, Pasetto A, Busani S.

Minerva Anestesiol. 2014 Aug;80(8):913-21. Epub 2013 Dec 17.


Functional attributes of responding T cells in HCV infection: the recent advances in engineering functional antiviral T cells.

Pasetto A, Aleman S, Chen M.

Arch Immunol Ther Exp (Warsz). 2014 Feb;62(1):23-30. doi: 10.1007/s00005-013-0248-8. Epub 2013 Aug 18. Review.


The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.

Knudsen ML, Johansson DX, Kostic L, Nordström EK, Tegerstedt K, Pasetto A, Applequist SE, Ljungberg K, Sirard JC, Liljeström P.

PLoS One. 2013 Jun 13;8(6):e65964. doi: 10.1371/journal.pone.0065964. Print 2013.


A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice.

Holmström F, Pasetto A, Nähr V, Brass A, Kriegs M, Hildt E, Broderick KE, Chen M, Ahlén G, Frelin L.

J Immunol. 2013 Feb 1;190(3):1113-24. doi: 10.4049/jimmunol.1201497. Epub 2013 Jan 2.


Levosimendan in a case of severe peri-myocarditis associated with influenza A/H1N1 virus.

Busani S, Pasetto A, Ligabue G, Malavasi V, Lugli R, Girardis M.

Br J Anaesth. 2012 Dec;109(6):1011-3. doi: 10.1093/bja/aes413. No abstract available.


TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity.

Pasetto A, Frelin L, Aleman S, Holmström F, Brass A, Ahlén G, Brenndörfer ED, Lohmann V, Bartenschlager R, Sällberg M, Bertoletti A, Chen M.

J Immunol. 2012 Nov 1;189(9):4510-9. doi: 10.4049/jimmunol.1201613. Epub 2012 Sep 28.


Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3.

Pasetto A, Frelin L, Brass A, Yasmeen A, Koh S, Lohmann V, Bartenschlager R, Magalhaes I, Maeurer M, Sällberg M, Chen M.

J Gen Virol. 2012 Feb;93(Pt 2):247-58. doi: 10.1099/vir.0.037903-0. Epub 2011 Nov 9.


ITalian Observational Study of the management of mild-to-moderate Post-Operative Pain (ITOSPOP).

Tufano R, Puntillo F, Draisci G, Pasetto A, Pietropaoli P, Pinto G, Catarci S, Cardone A, Varrassi G.

Minerva Anestesiol. 2012 Jan;78(1):15-25. Epub 2011 Jun 30.


The Helsinki Declaration on Patient Safety in Anesthesiology: a way forward with the European Board and the European Society of Anesthesiology.

Petrini F, Solca M, De Robertis E, Peduto VA, Pasetto A, Conti G, Antonelli M, Pelosi P; SIAARTI-ESA Task Force.

Minerva Anestesiol. 2010 Nov;76(11):971-7.


Surfactant therapy and intravenous zanamivir in severe respiratory failure due to persistent influenza A/H1N1 2009 virus infection.

Busani S, Girardis M, Biagioni E, Pasetto A, Sambri V.

Am J Respir Crit Care Med. 2010 Nov 15;182(10):1334. No abstract available.


Pulmonary hypertension as a predictor of postoperative complications and mortality after liver transplantation.

De Pietri L, Montalti R, Begliomini B, Reggiani A, Lancellotti L, Giovannini S, Di Benedetto F, Guerrini G, Serra V, Rompianesi G, Pasetto A, Gerunda GE.

Transplant Proc. 2010 May;42(4):1188-90. doi: 10.1016/j.transproceed.2010.03.068.


Levosimendan in cardiac failure after subarachnoid hemorrhage.

Busani S, Rinaldi L, Severino C, Cobelli M, Pasetto A, Girardis M.

J Trauma. 2010 May;68(5):E108-10. doi: 10.1097/TA.0b013e31817c4284.


Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients: a randomized controlled trial.

Terragni PP, Antonelli M, Fumagalli R, Faggiano C, Berardino M, Pallavicini FB, Miletto A, Mangione S, Sinardi AU, Pastorelli M, Vivaldi N, Pasetto A, Della Rocca G, Urbino R, Filippini C, Pagano E, Evangelista A, Ciccone G, Mascia L, Ranieri VM.

JAMA. 2010 Apr 21;303(15):1483-9. doi: 10.1001/jama.2010.447.


Thromboelastographic changes in liver and pancreatic cancer surgery: hypercoagulability, hypocoagulability or normocoagulability?

De Pietri L, Montalti R, Begliomini B, Scaglioni G, Marconi G, Reggiani A, Di Benedetto F, Aiello S, Pasetto A, Rompianesi G, Gerunda GE.

Eur J Anaesthesiol. 2010 Jul;27(7):608-16. doi: 10.1097/EJA.0b013e328334df31.


Usutu virus infection in a patient who underwent orthotropic liver transplantation, Italy, August-September 2009.

Cavrini F, Gaibani P, Longo G, Pierro AM, Rossini G, Bonilauri P, Gerunda GE, Di Benedetto F, Pasetto A, Girardis M, Dottori M, Landini MP, Sambri V.

Euro Surveill. 2009 Dec 17;14(50). pii: 19448. Erratum in: Euro Surveill. 2012;17(37). pii: 20267. Gerundi, G E [corrected to Gerunda, G E].


Two-stage liver transplantation: an effective procedure in urgent conditions.

Montalti R, Busani S, Masetti M, Girardis M, Di Benedetto F, Begliomini B, Rompianesi G, Rinaldi L, Ballarin R, Pasetto A, Gerunda GE.

Clin Transplant. 2010 Jan-Feb;24(1):122-6. doi: 10.1111/j.1399-0012.2009.01118.x. Epub 2009 Oct 15.


Use of recombinant factor IX and thromboelastography in a patient with hemophilia B undergoing liver transplantation: a case report.

De Pietri L, Masetti M, Montalti R, Begliomini B, Reggiani A, Barbieri E, Biagioni E, Marietta M, Romano A, Pasetto A, Gerunda GE.

Transplant Proc. 2008 Jul-Aug;40(6):2077-9. doi: 10.1016/j.transproceed.2008.05.054.


Strategies to control massive abdominal bleeding.

Busani S, Cavazzuti I, Marietta M, Pasetto A, Girardis M.

Transplant Proc. 2008 May;40(4):1212-5. doi: 10.1016/j.transproceed.2008.03.119.


Introduction to the 9th LAIC Meeting.

Busani S, Pasetto A.

Transplant Proc. 2008 May;40(4):1161-2. doi: 10.1016/j.transproceed.2008.03.067. No abstract available.


Thymoglobulin-induced severe cardiovascular reaction and acute renal failure in a patient scheduled for orthotopic liver transplantation.

Busani S, Rinaldi L, Begliomini B, Pasetto A, Girardis M.

Minerva Anestesiol. 2006 Apr;72(4):243-8. English, Italian.


The use of intrathecal morphine for postoperative pain relief after liver resection: a comparison with epidural analgesia.

De Pietri L, Siniscalchi A, Reggiani A, Masetti M, Begliomini B, Gazzi M, Gerunda GE, Pasetto A.

Anesth Analg. 2006 Apr;102(4):1157-63.


Rectal amputation sparing by haemostatic therapy with recombinant factor VIIa in a patient with cytomegalovirus-related colitis.

Girardis M, Marietta M, Busani S, Codeluppi M, Villa E, Pasetto A.

Thromb Haemost. 2006 Mar;95(3):579-80. No abstract available.


Posttransplant cerebral hemorrhage in a patient with familial amyloidotic polyneuropathy.

Rinaldi L, Busani S, Pasetto A, Girardis M.

Transplantation. 2006 Jan 15;81(1):134-5. No abstract available.


Wernicke's encephalopathy in a malnourished surgical patient: clinical features and magnetic resonance imaging.

Nolli M, Barbieri A, Pinna C, Pasetto A, Nicosia F.

Acta Anaesthesiol Scand. 2005 Nov;49(10):1566-70.


Use of recombinant factor VIIa in a thrombocytopenic patient with spontaneous intracerebral haemorrhage.

Busani S, Marietta M, Pasetto A, Girardis M.

Thromb Haemost. 2005 Feb;93(2):381-2. No abstract available.


Modifications of plasma concentrations of hormonal and tissue factors during mechanical ventilation with positive end-expiratory pressure.

Barbieri A, Siniscalchi A, De Pietri L, Pasetto A, Torsello A, Nolli M.

Int Angiol. 2004 Jun;23(2):177-84.


Increased prothrombin time and platelet counts in living donor right hepatectomy: implications for epidural anesthesia.

Siniscalchi A, Begliomini B, De Pietri L, Braglia V, Gazzi M, Masetti M, Di Benedetto F, Pinna AD, Miller CM, Pasetto A.

Liver Transpl. 2004 Sep;10(9):1144-9.


Intraoperative effects of combined versus general anesthesia during major liver surgery.

Siniscalchi A, Begliomini B, Matteo G, De Pietri L, Pasetto A.

Minerva Anestesiol. 2003 Dec;69(12):885-95. English, Italian.


SIAARTI recommendations on the assessment and treatment of chronic cancer pain.

Ambrosio F, Paoletti F, Savoia G, Amantea B, Arcuri E, Avogaro F, Barbati A, Beltrutti D, Branca L, Camaioni D, De Conno F, De Luca A, Di Massa A, Evangelista M, Finco G, Ischia S, Mattia C, Mascaro A, Mercadante S, Orlandini G, Palomba R, Pasetto A, Polati E, Raffaelli W, Varrassi G, Visentin M, Zucco E; SIAARTI.

Minerva Anestesiol. 2003 Sep;69(9):697-716, 717-29. English, Italian. No abstract available.


Muscle perfusion and oxygen consumption by near-infrared spectroscopy in septic-shock and non-septic-shock patients.

Girardis M, Rinaldi L, Busani S, Flore I, Mauro S, Pasetto A.

Intensive Care Med. 2003 Jul;29(7):1173-6. Epub 2003 May 28.


Pain management after small bowel/multivisceral transplantation.

Siniscalchi A, Begliomini B, De Pietri L, Ivagnes Petracca S, Braglia V, Girardis M, Pasetto A, Masetti M, Cautero N, Jovine E, Pinna AD.

Transplant Proc. 2002 May;34(3):969-70. No abstract available.


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