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Kinome expression profiling to target new therapeutic avenues in multiple myeloma.

de Boussac H, Bruyer A, Jourdan M, Maes A, Robert N, Gourzones C, Vincent L, Seckinger A, Cartron G, Hose D, De Bruyne E, Kassambara A, Pasero P, Moreaux J.

Haematologica. 2019 Jul 9. pii: haematol.2018.208306. doi: 10.3324/haematol.2018.208306. [Epub ahead of print]


EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.

Nieminuszczy J, Broderick R, Bellani MA, Smethurst E, Schwab RA, Cherdyntseva V, Evmorfopoulou T, Lin YL, Minczuk M, Pasero P, Gagos S, Seidman MM, Niedzwiedz W.

Mol Cell. 2019 Aug 8;75(3):605-619.e6. doi: 10.1016/j.molcel.2019.05.026. Epub 2019 Jun 26.


Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells.

Pasero P, Tourrière H.

Mol Cell Oncol. 2019 May 7;6(4):1607455. doi: 10.1080/23723556.2019.1607455. eCollection 2019.


qDSB-Seq is a general method for genome-wide quantification of DNA double-strand breaks using sequencing.

Zhu Y, Biernacka A, Pardo B, Dojer N, Forey R, Skrzypczak M, Fongang B, Nde J, Yousefi R, Pasero P, Ginalski K, Rowicka M.

Nat Commun. 2019 May 24;10(1):2313. doi: 10.1038/s41467-019-10332-8.


Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer.

Combès E, Andrade AF, Tosi D, Michaud HA, Coquel F, Garambois V, Desigaud D, Jarlier M, Coquelle A, Pasero P, Bonnefoy N, Moreaux J, Martineau P, Del Rio M, Beijersbergen RL, Vezzio-Vie N, Gongora C.

Cancer Res. 2019 Jun 1;79(11):2933-2946. doi: 10.1158/0008-5472.CAN-18-2807. Epub 2019 Apr 15.


Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.

Bianco JN, Bergoglio V, Lin YL, Pillaire MJ, Schmitz AL, Gilhodes J, Lusque A, Mazières J, Lacroix-Triki M, Roumeliotis TI, Choudhary J, Moreaux J, Hoffmann JS, Tourrière H, Pasero P.

Nat Commun. 2019 Feb 22;10(1):910. doi: 10.1038/s41467-019-08886-8.


DDR Inc., one business, two associates.

Moriel-Carretero M, Pasero P, Pardo B.

Curr Genet. 2019 Apr;65(2):445-451. doi: 10.1007/s00294-018-0908-7. Epub 2018 Nov 22. Review.


i-BLESS is an ultra-sensitive method for detection of DNA double-strand breaks.

Biernacka A, Zhu Y, Skrzypczak M, Forey R, Pardo B, Grzelak M, Nde J, Mitra A, Kudlicki A, Crosetto N, Pasero P, Rowicka M, Ginalski K.

Commun Biol. 2018 Oct 31;1:181. doi: 10.1038/s42003-018-0165-9. eCollection 2018.


SAMHD1 and the innate immune response to cytosolic DNA during DNA replication.

Coquel F, Neumayer C, Lin YL, Pasero P.

Curr Opin Immunol. 2019 Feb;56:24-30. doi: 10.1016/j.coi.2018.09.017. Epub 2018 Oct 5. Review.


Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage.

Bacal J, Moriel-Carretero M, Pardo B, Barthe A, Sharma S, Chabes A, Lengronne A, Pasero P.

EMBO J. 2018 Nov 2;37(21). pii: e99319. doi: 10.15252/embj.201899319. Epub 2018 Aug 29.


DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.

Sasi NK, Coquel F, Lin YL, MacKeigan JP, Pasero P, Weinreich M.

Neoplasia. 2018 Oct;20(10):985-995. doi: 10.1016/j.neo.2018.08.001. Epub 2018 Aug 26.


SAMHD1 acts at stalled replication forks to prevent interferon induction.

Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P.

Nature. 2018 May;557(7703):57-61. doi: 10.1038/s41586-018-0050-1. Epub 2018 Apr 18.


Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.

Cohen S, Puget N, Lin YL, Clouaire T, Aguirrebengoa M, Rocher V, Pasero P, Canitrot Y, Legube G.

Nat Commun. 2018 Feb 7;9(1):533. doi: 10.1038/s41467-018-02894-w.


Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing.

Fang D, Lengronne A, Shi D, Forey R, Skrzypczak M, Ginalski K, Yan C, Wang X, Cao Q, Pasero P, Lou H.

Genes Dev. 2017 Dec 1;31(23-24):2405-2415. doi: 10.1101/gad.306571.117. Epub 2018 Jan 12.


Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts.

Pasero P, Vindigni A.

Annu Rev Genet. 2017 Nov 27;51:477-499. doi: 10.1146/annurev-genet-120116-024745. Review.


Transcription-Replication Conflicts: Orientation Matters.

Lin YL, Pasero P.

Cell. 2017 Aug 10;170(4):603-604. doi: 10.1016/j.cell.2017.07.040.


RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.

Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, Seckinger A, Goldschmidt H, Constantinou A, Pasero P, Hose D, Moreaux J.

Leukemia. 2017 Oct;31(10):2104-2113. doi: 10.1038/leu.2017.54. Epub 2017 Feb 10.


Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches.

Uzcanga G, Lara E, Gutiérrez F, Beaty D, Beske T, Teran R, Navarro JC, Pasero P, Benítez W, Poveda A.

Crit Rev Microbiol. 2017 Mar;43(2):156-177. doi: 10.1080/1040841X.2016.1188758. Epub 2016 Dec 14. Review.


Signaling pathways of replication stress in yeast.

Pardo B, Crabbé L, Pasero P.

FEMS Yeast Res. 2017 Mar 1;17(2). doi: 10.1093/femsyr/fow101. Review.


RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.

Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM.

Mol Cell. 2016 Dec 1;64(5):951-966. doi: 10.1016/j.molcel.2016.10.032. Epub 2016 Nov 23.


Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.

Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty BK, Bacal J, Langston LD, Pasero P, O'Donnell ME.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3639-48. doi: 10.1073/pnas.1607552113. Epub 2016 Jun 13. Erratum in: Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4577.


USP1 Regulates Cellular Senescence by Controlling Genomic Integrity.

Ogrunc M, Martinez-Zamudio RI, Sadoun PB, Dore G, Schwerer H, Pasero P, Lemaitre JM, Dejean A, Bischof O.

Cell Rep. 2016 May 17;15(7):1401-1411. doi: 10.1016/j.celrep.2016.04.033. Epub 2016 May 5.


RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.

Viziteu E, Kassambara A, Pasero P, Klein B, Moreaux J.

Biomark Res. 2016 Feb 13;4:3. doi: 10.1186/s40364-016-0057-4. eCollection 2016.


Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.

Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM.

Genes Dev. 2016 Feb 1;30(3):337-54. doi: 10.1101/gad.273813.115. Epub 2016 Jan 21.


Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance.

Menolfi D, Delamarre A, Lengronne A, Pasero P, Branzei D.

Mol Cell. 2015 Dec 17;60(6):835-46. doi: 10.1016/j.molcel.2015.10.023. Epub 2015 Nov 19.


Caught in the Act: R-loops are cleaved by structure-specific endonucleases to generate DSBs.

Lin YL, Pasero P.

Mol Cell. 2014 Dec 18;56(6):721-2. doi: 10.1016/j.molcel.2014.12.011.


Closing the MCM cycle at replication termination sites.

Lengronne A, Pasero P.

EMBO Rep. 2014 Dec;15(12):1226-7. doi: 10.15252/embr.201439774. Epub 2014 Nov 12.


DNA repair in diffuse large B-cell lymphoma: a molecular portrait.

Bret C, Klein B, Cartron G, Schved JF, Constantinou A, Pasero P, Moreaux J.

Br J Haematol. 2015 Apr;169(2):296-9. doi: 10.1111/bjh.13206. Epub 2014 Nov 5. No abstract available.


The replication timing program in the hands of two HDACs.

Yoshida K, Lengronne A, Pasero P.

Microb Cell. 2014 Jul 25;1(8):273-275. doi: 10.15698/mic2014.08.163.


The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.

Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P.

Mol Cell. 2014 May 22;54(4):691-7. doi: 10.1016/j.molcel.2014.04.032.


The causes of replication stress and their consequences on genome stability and cell fate.

Magdalou I, Lopez BS, Pasero P, Lambert SA.

Semin Cell Dev Biol. 2014 Jun;30:154-64. doi: 10.1016/j.semcdb.2014.04.035. Epub 2014 May 9. Review.


A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy.

Kassambara A, Gourzones-Dmitriev C, Sahota S, Rème T, Moreaux J, Goldschmidt H, Constantinou A, Pasero P, Hose D, Klein B.

Oncotarget. 2014 May 15;5(9):2487-98.


Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.

Sheu YJ, Kinney JB, Lengronne A, Pasero P, Stillman B.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1899-908. doi: 10.1073/pnas.1404063111. Epub 2014 Apr 16.


New histone supply regulates replication fork speed and PCNA unloading.

Mejlvang J, Feng Y, Alabert C, Neelsen KJ, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A.

J Cell Biol. 2014 Jan 6;204(1):29-43. doi: 10.1083/jcb.201305017. Epub 2013 Dec 30.


SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT, Wright Colopy G, Dreau H, Sigaux F, Judde JG, Rotger M, Telenti A, Lin YL, Pasero P, Maelfait J, Titsias M, Cohen DR, Henderson SJ, Ross MT, Bentley D, Hillmen P, Pettitt A, Rehwinkel J, Knight SJ, Taylor JC, Crow YJ, Benkirane M, Schuh A.

Blood. 2014 Feb 13;123(7):1021-31. doi: 10.1182/blood-2013-04-490847. Epub 2013 Dec 12.


DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells.

Sokol AM, Cruet-Hennequart S, Pasero P, Carty MP.

Sci Rep. 2013 Nov 20;3:3277. doi: 10.1038/srep03277.


Time to be versatile: regulation of the replication timing program in budding yeast.

Yoshida K, Poveda A, Pasero P.

J Mol Biol. 2013 Nov 29;425(23):4696-705. doi: 10.1016/j.jmb.2013.09.020. Epub 2013 Sep 25. Review.


DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment.

Gourzones-Dmitriev C, Kassambara A, Sahota S, Rème T, Moreaux J, Bourquard P, Hose D, Pasero P, Constantinou A, Klein B.

Cell Cycle. 2013 Sep 1;12(17):2760-73. doi: 10.4161/cc.25951. Epub 2013 Aug 9. Review.


Rescuing stalled or damaged replication forks.

Yeeles JT, Poli J, Marians KJ, Pasero P.

Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a012815. doi: 10.1101/cshperspect.a012815. Review.


Genetic and epigenetic determinants of DNA replication origins, position and activation.

Méchali M, Yoshida K, Coulombe P, Pasero P.

Curr Opin Genet Dev. 2013 Apr;23(2):124-31. doi: 10.1016/j.gde.2013.02.010. Epub 2013 Mar 28. Review.


Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing.

Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I.

Nat Methods. 2013 Apr;10(4):361-5. doi: 10.1038/nmeth.2408. Epub 2013 Mar 17.


Interference between DNA replication and transcription as a cause of genomic instability.

Lin YL, Pasero P.

Curr Genomics. 2012 Mar;13(1):65-73. doi: 10.2174/138920212799034767.


Cohesin association to replication sites depends on rad50 and promotes fork restart.

Tittel-Elmer M, Lengronne A, Davidson MB, Bacal J, François P, Hohl M, Petrini JHJ, Pasero P, Cobb JA.

Mol Cell. 2012 Oct 12;48(1):98-108. doi: 10.1016/j.molcel.2012.07.004. Epub 2012 Aug 9.


Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing.

Bianco JN, Poli J, Saksouk J, Bacal J, Silva MJ, Yoshida K, Lin YL, Tourrière H, Lengronne A, Pasero P.

Methods. 2012 Jun;57(2):149-57. doi: 10.1016/j.ymeth.2012.04.007. Epub 2012 May 3.


dNTP pools determine fork progression and origin usage under replication stress.

Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P.

EMBO J. 2012 Feb 15;31(4):883-94. doi: 10.1038/emboj.2011.470. Epub 2012 Jan 10.


DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.

Allera-Moreau C, Rouquette I, Lepage B, Oumouhou N, Walschaerts M, Leconte E, Schilling V, Gordien K, Brouchet L, Delisle MB, Mazieres J, Hoffmann JS, Pasero P, Cazaux C.

Oncogenesis. 2012 Oct 22;1:e30. doi: 10.1038/oncsis.2012.29.


Histone H3 lysine 56 acetylation and the response to DNA replication fork damage.

Wurtele H, Kaiser GS, Bacal J, St-Hilaire E, Lee EH, Tsao S, Dorn J, Maddox P, Lisby M, Pasero P, Verreault A.

Mol Cell Biol. 2012 Jan;32(1):154-72. doi: 10.1128/MCB.05415-11. Epub 2011 Oct 24.


New Topoisomerase I mutations are associated with resistance to camptothecin.

Gongora C, Vezzio-Vie N, Tuduri S, Denis V, Causse A, Auzanneau C, Collod-Beroud G, Coquelle A, Pasero P, Pourquier P, Martineau P, Del Rio M.

Mol Cancer. 2011 May 27;10:64. doi: 10.1186/1476-4598-10-64.


Transcription and replication: breaking the rules of the road causes genomic instability.

Poveda AM, Le Clech M, Pasero P.

Transcription. 2010 Sep-Oct;1(2):99-102. doi: 10.4161/trns.1.2.12665.


RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.

Piwko W, Olma MH, Held M, Bianco JN, Pedrioli PG, Hofmann K, Pasero P, Gerlich DW, Peter M.

EMBO J. 2010 Dec 15;29(24):4210-22. doi: 10.1038/emboj.2010.304. Epub 2010 Nov 26.

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