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Items: 1 to 50 of 82

1.

Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells.

Paquet-Fifield S, Koh SL, Cheng L, Beyit LM, Shembrey C, Mølck C, Behrenbruch C, Papin M, Gironella M, Guelfi S, Nasr R, Grillet F, Prudhomme M, Bourgaux JF, Castells A, Pascussi JM, Heriot AG, Puisieux A, Davis MJ, Pannequin J, Hill AF, Sloan EK, Hollande F.

Cancer Res. 2018 Jun 1;78(11):2925-2938. doi: 10.1158/0008-5472.CAN-17-1869. Epub 2018 Mar 6.

2.

[Mechanisms of resistance of cancer stem cells to chemotherapy].

Pascussi JM.

Bull Cancer. 2017 Dec;104(12):1080-1084. doi: 10.1016/j.bulcan.2017.10.013. Epub 2017 Nov 22. French. No abstract available.

PMID:
29173972
3.

Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.

Runtz L, Girard B, Toussenot M, Espallergues J, Fayd'Herbe De Maudave A, Milman A, deBock F, Ghosh C, Guérineau NC, Pascussi JM, Bertaso F, Marchi N.

Epilepsia. 2018 Jan;59(1):123-134. doi: 10.1111/epi.13942. Epub 2017 Nov 10.

4.

Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.

Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi JM, Gangarossa G, Marchi N.

Neuroscience. 2018 Feb 1;370:130-138. doi: 10.1016/j.neuroscience.2017.07.038. Epub 2017 Jul 23.

5.

Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.

Prieur A, Cappellini M, Habif G, Lefranc MP, Mazard T, Morency E, Pascussi JM, Flacelière M, Cahuzac N, Vire B, Dubuc B, Durochat A, Liaud P, Ollier J, Pfeiffer C, Poupeau S, Saywell V, Planque C, Assenat E, Bibeau F, Bourgaux JF, Pujol P, Sézeur A, Ychou M, Joubert D.

Clin Cancer Res. 2017 Sep 1;23(17):5267-5280. doi: 10.1158/1078-0432.CCR-17-0533. Epub 2017 Jun 9.

6.

The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism.

Mølck C, Ryall J, Failla LM, Coates JL, Pascussi JM, Heath JK, Stewart G, Hollande F.

Cancer Lett. 2016 Dec 1;383(1):135-143. doi: 10.1016/j.canlet.2016.09.018. Epub 2016 Sep 28.

PMID:
27693637
7.

Bases fondamentales du processus métastatique.

Pascussi JM, Giraud J, Samalin E, Grillet F, Pannequin J.

Bull Cancer. 2016 Jun;103(6 Suppl 1):S39-47. doi: 10.1016/S0007-4551(16)30144-8. Review. French.

PMID:
27494972
8.

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.

Grillet F, Bayet E, Villeronce O, Zappia L, Lagerqvist EL, Lunke S, Charafe-Jauffret E, Pham K, Molck C, Rolland N, Bourgaux JF, Prudhomme M, Philippe C, Bravo S, Boyer JC, Canterel-Thouennon L, Taylor GR, Hsu A, Pascussi JM, Hollande F, Pannequin J.

Gut. 2017 Oct;66(10):1802-1810. doi: 10.1136/gutjnl-2016-311447. Epub 2016 Jul 25.

9.

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse.

Planque C, Rajabi F, Grillet F, Finetti P, Bertucci F, Gironella M, Lozano JJ, Beucher B, Giraud J, Garambois V, Vincent C, Brown D, Caillo L, Kantar J, Pelegrin A, Prudhomme M, Ripoche J, Bourgaux JF, Ginestier C, Castells A, Hollande F, Pannequin J, Pascussi JM.

Oncotarget. 2016 Aug 30;7(35):56558-56573. doi: 10.18632/oncotarget.10646.

10.

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.

Boussadia B, Gangarossa G, Mselli-Lakhal L, Rousset MC, de Bock F, Lassere F, Ghosh C, Pascussi JM, Janigro D, Marchi N.

Exp Neurol. 2016 Sep;283(Pt A):39-48. doi: 10.1016/j.expneurol.2016.05.018. Epub 2016 May 27.

11.

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.

Giraud J, Failla LM, Pascussi JM, Lagerqvist EL, Ollier J, Finetti P, Bertucci F, Ya C, Gasmi I, Bourgaux JF, Prudhomme M, Mazard T, Ait-Arsa I, Houhou L, Birnbaum D, Pélegrin A, Vincent C, Ryall JG, Joubert D, Pannequin J, Hollande F.

Cancer Res. 2016 Jun 15;76(12):3618-28. doi: 10.1158/0008-5472.CAN-15-1497. Epub 2016 May 4.

12.

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L.

Toxicol Appl Pharmacol. 2016 Jul 15;303:90-100. doi: 10.1016/j.taap.2016.05.006. Epub 2016 May 11.

PMID:
27180240
13.

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W.

Nat Commun. 2015 Sep 3;6:8089. doi: 10.1038/ncomms9089.

14.

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

Briolotti P, Chaloin L, Balaguer P, Da Silva F, Tománková V, Pascussi JM, Duret C, Fabre JM, Ramos J, Klieber S, Maurel P, Daujat-Chavanieu M, Gerbal-Chaloin S.

Toxicol Sci. 2015 Nov;148(1):261-75. doi: 10.1093/toxsci/kfv177. Epub 2015 Aug 10.

PMID:
26259606
15.

Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.

Boussadia B, Ghosh C, Plaud C, Pascussi JM, de Bock F, Rousset MC, Janigro D, Marchi N.

Neuroscience. 2014 Dec 5;281:124-34. doi: 10.1016/j.neuroscience.2014.09.055. Epub 2014 Oct 2.

16.

Characterization of a novel PXR isoform with potential dominant-negative properties.

Breuker C, Planque C, Rajabi F, Nault JC, Couchy G, Zucman-Rossi J, Evrard A, Kantar J, Chevet E, Bioulac-Sage P, Ramos J, Assenat E, Joubert D, Pannequin J, Hollande F, Pascussi JM.

J Hepatol. 2014 Sep;61(3):609-16. doi: 10.1016/j.jhep.2014.04.030. Epub 2014 May 2.

PMID:
24798619
17.

The effects of rosuvastatin and the CYP51A1 inhibitor LEK-935 on the proteome of primary human hepatocytes.

Wörner M, Melchior K, Monostory K, Pascussi JM, Huber CG, Bernhardt R.

Drug Metab Dispos. 2012 Mar;40(3):414-8. doi: 10.1124/dmd.111.040402. Epub 2011 Dec 16.

PMID:
22180046
18.

Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.

Ayed-Boussema I, Pascussi JM, Maurel P, Bacha H, Hassen W.

Int J Toxicol. 2012 Jan-Feb;31(1):86-93. doi: 10.1177/1091581811422453. Epub 2011 Oct 12.

PMID:
21994236
19.

The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.

Ayed-Boussema I, Pascussi JM, Rjiba K, Maurel P, Bacha H, Hassen W.

Drug Chem Toxicol. 2012 Jul;35(3):241-50. doi: 10.3109/01480545.2011.592194. Epub 2011 Sep 22.

PMID:
21939362
20.

The human primary hepatocyte transcriptome reveals novel insights into atorvastatin and rosuvastatin action.

Hafner M, Juvan P, Rezen T, Monostory K, Pascussi JM, Rozman D.

Pharmacogenet Genomics. 2011 Nov;21(11):741-50. doi: 10.1097/FPC.0b013e32834a5585.

PMID:
21869732
21.

Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.

Ayed-Boussema I, Pascussi JM, Zaied C, Maurel P, Bacha H, Hassen W.

Drug Chem Toxicol. 2012 Jan;35(1):71-80. doi: 10.3109/01480545.2011.589438. Epub 2011 Aug 11.

PMID:
21834667
22.

Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes.

Ayed-Boussema I, Pascussi JM, Maurel P, Bacha H, Hassen W.

Environ Toxicol Pharmacol. 2011 Jan;31(1):79-87. doi: 10.1016/j.etap.2010.09.008. Epub 2010 Sep 15.

PMID:
21787672
23.

CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site.

Villard PH, Barlesi F, Armand M, Dao TM, Pascussi JM, Fouchier F, Champion S, Dufour C, Giniès C, Khalil A, Amiot MJ, Barra Y, Seree E.

PLoS One. 2011 Jan 31;6(1):e14629. doi: 10.1371/journal.pone.0014629.

24.

Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.

Funakoshi N, Duret C, Pascussi JM, Blanc P, Maurel P, Daujat-Chavanieu M, Gerbal-Chaloin S.

Stem Cell Rev Rep. 2011 Sep;7(3):518-31. doi: 10.1007/s12015-010-9225-3.

25.

Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.

Acimovic J, Korosec T, Seliskar M, Bjorkhem I, Monostory K, Szabo P, Pascussi JM, Belic A, Urleb U, Kocjan D, Rozman D.

Drug Metab Dispos. 2011 Jan;39(1):39-46. doi: 10.1124/dmd.110.035840. Epub 2010 Oct 15.

PMID:
20952551
26.

Metabonomic studies on human hepatocyte in primary culture.

Croixmarie V, Umbdenstock T, Cloarec O, Moreau A, Pascussi JM, Parmentier Y, Boursier-Neyret C, Walther B.

Methods Mol Biol. 2010;640:355-74. doi: 10.1007/978-1-60761-688-7_19.

PMID:
20645062
27.

Interplay between cholesterol and drug metabolism.

Rezen T, Rozman D, Pascussi JM, Monostory K.

Biochim Biophys Acta. 2011 Jan;1814(1):146-60. doi: 10.1016/j.bbapap.2010.05.014. Epub 2010 Jun 4. Review.

PMID:
20570756
28.

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

Raynal C, Pascussi JM, Leguelinel G, Breuker C, Kantar J, Lallemant B, Poujol S, Bonnans C, Joubert D, Hollande F, Lumbroso S, Brouillet JP, Evrard A.

Mol Cancer. 2010 Mar 2;9:46. doi: 10.1186/1476-4598-9-46.

29.

Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).

Breuker C, Moreau A, Lakhal L, Tamasi V, Parmentier Y, Meyer U, Maurel P, Lumbroso S, Vilarem MJ, Pascussi JM.

Endocrinology. 2010 Apr;151(4):1653-61. doi: 10.1210/en.2009-1435. Epub 2010 Feb 25.

PMID:
20185760
30.

Hormonal regulation of CYP1A expression.

Monostory K, Pascussi JM, Kóbori L, Dvorak Z.

Drug Metab Rev. 2009;41(4):547-72. doi: 10.1080/03602530903112284. Review.

PMID:
19627176
31.

Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures.

Croixmarie V, Umbdenstock T, Cloarec O, Moreau A, Pascussi JM, Boursier-Neyret C, Walther B.

Anal Chem. 2009 Aug 1;81(15):6061-9. doi: 10.1021/ac900333e.

PMID:
19588937
32.

Identification of proteomic changes during human liver development by 2D-DIGE and mass spectrometry.

Brizard JP, Ramos J, Robert A, Lafitte D, Bigi N, Sarda P, Laoudj-Chenivesse D, Navarro F, Blanc P, Assenat E, Maurel P, Pascussi JM, Vilarem MJ.

J Hepatol. 2009 Jul;51(1):114-26. doi: 10.1016/j.jhep.2009.02.029. Epub 2009 Apr 17.

PMID:
19443070
33.

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.

Moreau A, Téruel C, Beylot M, Albalea V, Tamasi V, Umbdenstock T, Parmentier Y, Sa-Cunha A, Suc B, Fabre JM, Navarro F, Ramos J, Meyer U, Maurel P, Vilarem MJ, Pascussi JM.

Hepatology. 2009 Jun;49(6):2068-79. doi: 10.1002/hep.22907.

PMID:
19437491
34.

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates.

Eveillard A, Mselli-Lakhal L, Mogha A, Lasserre F, Polizzi A, Pascussi JM, Guillou H, Martin PG, Pineau T.

Biochem Pharmacol. 2009 Jun 1;77(11):1735-46. doi: 10.1016/j.bcp.2009.02.023. Epub 2009 Mar 11.

PMID:
19428328
35.

Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent.

Monostory K, Pascussi JM, Szabó P, Temesvári M, Köhalmy K, Acimovic J, Kocjan D, Kuzman D, Wilzewski B, Bernhardt R, Kóbori L, Rozman D.

Drug Metab Dispos. 2009 Feb;37(2):375-85. doi: 10.1124/dmd.108.023887. Epub 2008 Oct 29.

PMID:
18971317
36.

[Crosstalk between cholesterol homeostasis and drug metabolism].

Kohalmy K, Rozman D, Pascussi JM, Sárváry E, Monostory K.

Orv Hetil. 2008 Jul 6;149(27):1283-9. doi: 10.1556/OH.2008.28329. Review. Hungarian.

PMID:
18579468
37.

Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.

Milagre I, Nunes MJ, Gama MJ, Silva RF, Pascussi JM, Lechner MC, Rodrigues E.

J Neurochem. 2008 Jul;106(2):835-49. doi: 10.1111/j.1471-4159.2008.05442.x. Epub 2008 Apr 28. Erratum in: J Neurochem. 2008 Nov;107(4):1168.

38.

[[Inflammation and drug metabolism: NF-kappB and the CAR and PXR xeno-receptors].

Pascussi JM, Vilarem MJ.

Med Sci (Paris). 2008 Mar;24(3):301-5. doi: 10.1051/medsci/2008243301. Review. French.

39.

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

Benod C, Subra G, Nahoum V, Mallavialle A, Guichou JF, Milhau J, Roblés S, Bourguet W, Pascussi JM, Balaguer P, Chavanieu A.

Bioorg Med Chem. 2008 Apr 1;16(7):3537-49. doi: 10.1016/j.bmc.2008.02.020. Epub 2008 Feb 13.

PMID:
18304819
40.

Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.

Vrzal R, Daujat-Chavanieu M, Pascussi JM, Ulrichova J, Maurel P, Dvorak Z.

Eur J Pharmacol. 2008 Mar 10;581(3):244-54. doi: 10.1016/j.ejphar.2007.11.059. Epub 2007 Dec 3.

PMID:
18177856
41.

Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

Moreau A, Vilarem MJ, Maurel P, Pascussi JM.

Mol Pharm. 2008 Jan-Feb;5(1):35-41. Epub 2007 Dec 27. Review.

PMID:
18159929
42.

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter.

Onica T, Nichols K, Larin M, Ng L, Maslen A, Dvorak Z, Pascussi JM, Vilarem MJ, Maurel P, Kirby GM.

Mol Pharmacol. 2008 Feb;73(2):451-60. Epub 2007 Oct 31.

PMID:
17978169
43.

Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent.

Molina S, Castet V, Pichard-Garcia L, Wychowski C, Meurs E, Pascussi JM, Sureau C, Fabre JM, Sacunha A, Larrey D, Dubuisson J, Coste J, McKeating J, Maurel P, Fournier-Wirth C.

J Virol. 2008 Jan;82(1):569-74. Epub 2007 Oct 17.

44.

Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes.

González R, Collado JA, Nell S, Briceño J, Tamayo MJ, Fraga E, Bernardos A, López-Cillero P, Pascussi JM, Rufián S, Vilarem MJ, De la Mata M, Brigelius-Flohe R, Maurel P, Muntané J.

Free Radic Biol Med. 2007 Nov 15;43(10):1439-52. Epub 2007 Aug 3.

PMID:
17936189
45.

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

Pascussi JM, Gerbal-Chaloin S, Duret C, Daujat-Chavanieu M, Vilarem MJ, Maurel P.

Annu Rev Pharmacol Toxicol. 2008;48:1-32. Review.

PMID:
17608617
46.

Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor.

Kohalmy K, Tamási V, Kóbori L, Sárváry E, Pascussi JM, Porrogi P, Rozman D, Prough RA, Meyer UA, Monostory K.

Drug Metab Dispos. 2007 Sep;35(9):1495-501. Epub 2007 Jun 25.

47.

Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression.

Moreau A, Maurel P, Vilarem MJ, Pascussi JM.

Biochem Biophys Res Commun. 2007 Aug 17;360(1):76-82. Epub 2007 Jun 13.

PMID:
17585873
48.

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

Lemaire G, Benod C, Nahoum V, Pillon A, Boussioux AM, Guichou JF, Subra G, Pascussi JM, Bourguet W, Chavanieu A, Balaguer P.

Mol Pharmacol. 2007 Sep;72(3):572-81. Epub 2007 Jun 15.

PMID:
17573484
49.

Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms.

Pascussi JM, Robert A, Moreau A, Ramos J, Bioulac-Sage P, Navarro F, Blanc P, Assenat E, Maurel P, Vilarem MJ.

Hepatology. 2007 May;45(5):1146-53.

PMID:
17464991
50.

Estrogens and antiestrogens activate hPXR.

Mnif W, Pascussi JM, Pillon A, Escande A, Bartegi A, Nicolas JC, Cavaillès V, Duchesne MJ, Balaguer P.

Toxicol Lett. 2007 Apr 5;170(1):19-29. Epub 2007 Feb 16.

PMID:
17379461

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