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Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection.

Wang H, Hoffman C, Yang X, Clapp B, Pascual DW.

PLoS Pathog. 2020 Jan 17;16(1):e1008176. doi: 10.1371/journal.ppat.1008176. eCollection 2020 Jan.


Optimized Mucosal Modified Vaccinia Virus Ankara Prime/Soluble gp120 Boost HIV Vaccination Regimen Induces Antibody Responses Similar to Those of an Intramuscular Regimen.

Jones DI, Pollara JJ, Johnson-Weaver BT, LaBranche CC, Montefiori DC, Pickup DJ, Permar SR, Abraham SN, Maddaloni M, Pascual DW, Staats HF.

J Virol. 2019 Jun 28;93(14). pii: e00475-19. doi: 10.1128/JVI.00475-19. Print 2019 Jul 15.


VirB10 vaccination for protection against Anaplasma phagocytophilum.

Crosby FL, Lundgren AM, Hoffman C, Pascual DW, Barbet AF.

BMC Microbiol. 2018 Dec 18;18(1):217. doi: 10.1186/s12866-018-1346-x.


Delivery of IL-35 by Lactococcus lactis Ameliorates Collagen-Induced Arthritis in Mice.

Maddaloni M, Kochetkova I, Hoffman C, Pascual DW.

Front Immunol. 2018 Nov 20;9:2691. doi: 10.3389/fimmu.2018.02691. eCollection 2018.


IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14).

Li X, Shao Y, Sha X, Fang P, Kuo YM, Andrews AJ, Li Y, Yang WY, Maddaloni M, Pascual DW, Luo JJ, Jiang X, Wang H, Yang X.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):599-609. doi: 10.1161/ATVBAHA.117.310626. Epub 2018 Jan 25.


Alternative strategies for vaccination to brucellosis.

Pascual DW, Yang X, Wang H, Goodwin Z, Hoffman C, Clapp B.

Microbes Infect. 2018 Oct - Nov;20(9-10):599-605. doi: 10.1016/j.micinf.2017.12.006. Epub 2017 Dec 26. Review.


Vaccination with a ΔnorD ΔznuA Brucella abortus mutant confers potent protection against virulent challenge.

Yang X, Clapp B, Thornburg T, Hoffman C, Pascual DW.

Vaccine. 2016 Oct 17;34(44):5290-5297. doi: 10.1016/j.vaccine.2016.09.004. Epub 2016 Sep 14.


Regulatory T Cell Dysfunction Acquiesces to BTLA+ Regulatory B Cells Subsequent to Oral Intervention in Experimental Autoimmune Encephalomyelitis.

Huarte E, Jun S, Rynda-Apple A, Golden S, Jackiw L, Hoffman C, Maddaloni M, Pascual DW.

J Immunol. 2016 Jun 15;196(12):5036-46. doi: 10.4049/jimmunol.1501973. Epub 2016 May 18.


Development of an Avirulent Salmonella Surrogate for Modeling Pathogen Behavior in Pre- and Postharvest Environments.

de Moraes MH, Chapin TK, Ginn A, Wright AC, Parker K, Hoffman C, Pascual DW, Danyluk MD, Teplitski M.

Appl Environ Microbiol. 2016 Jun 30;82(14):4100-4111. doi: 10.1128/AEM.00898-16. Print 2016 Jul 15.


Brucellosis vaccines for livestock.

Goodwin ZI, Pascual DW.

Vet Immunol Immunopathol. 2016 Nov 15;181:51-58. doi: 10.1016/j.vetimm.2016.03.011. Epub 2016 Mar 16. Review.


Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.

Clapp B, Yang X, Thornburg T, Walters N, Pascual DW.

Immunol Cell Biol. 2016 May;94(5):496-508. doi: 10.1038/icb.2016.5. Epub 2016 Jan 11.


Isolation of oxalotrophic bacteria associated with Varroa destructor mites.

Maddaloni M, Pascual DW.

Lett Appl Microbiol. 2015 Nov;61(5):411-7. doi: 10.1111/lam.12486. Epub 2015 Oct 5.


Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway.

Sha X, Meng S, Li X, Xi H, Maddaloni M, Pascual DW, Shan H, Jiang X, Wang H, Yang XF.

J Biol Chem. 2015 Jul 31;290(31):19307-18. doi: 10.1074/jbc.M115.663286. Epub 2015 Jun 17.


Milk-based nutraceutical for treating autoimmune arthritis via the stimulation of IL-10- and TGF-β-producing CD39+ regulatory T cells.

Maddaloni M, Kochetkova I, Jun S, Callis G, Thornburg T, Pascual DW.

PLoS One. 2015 Jan 28;10(1):e0117825. doi: 10.1371/journal.pone.0117825. eCollection 2015.


Paratransgenesis feasibility in the honeybee (Apis mellifera) using Fructobacillus fructosus commensal.

Maddaloni M, Hoffman C, Pascual DW.

J Appl Microbiol. 2014 Dec;117(6):1572-84. doi: 10.1111/jam.12650. Epub 2014 Oct 13.


Regulatory T-cell vaccination independent of auto-antigen.

Pascual DW, Yang X, Holderness K, Jun S, Maddaloni M, Kochetkova I.

Exp Mol Med. 2014 Mar 14;46:e82. doi: 10.1038/emm.2014.4. Review.


Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.

Kochetkova I, Thornburg T, Callis G, Holderness K, Maddaloni M, Pascual DW.

J Immunol. 2014 Jan 15;192(2):804-16. doi: 10.4049/jimmunol.1302018. Epub 2013 Dec 11.


Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis.

Kouakou K, Schepetkin IA, Jun S, Kirpotina LN, Yapi A, Khramova DS, Pascual DW, Ovodov YS, Jutila MA, Quinn MT.

BMC Complement Altern Med. 2013 Jun 28;13:149. doi: 10.1186/1472-6882-13-149.


Interleukin-17 protects against the Francisella tularensis live vaccine strain but not against a virulent F. tularensis type A strain.

Skyberg JA, Rollins MF, Samuel JW, Sutherland MD, Belisle JT, Pascual DW.

Infect Immun. 2013 Sep;81(9):3099-105. doi: 10.1128/IAI.00203-13. Epub 2013 Jun 17.


Progress in Brucella vaccine development.

Yang X, Skyberg JA, Cao L, Clapp B, Thornburg T, Pascual DW.

Front Biol (Beijing). 2013 Feb 1;8(1):60-77.


Attenuating gene expression (AGE) for vaccine development.

Pascual DW, Suo Z, Cao L, Avci R, Yang X.

Virulence. 2013 Jul 1;4(5):384-90. doi: 10.4161/viru.24886. Epub 2013 May 7. Review.


A polymer/oil based nanovaccine as a single-dose immunization approach.

Vicente S, Diaz-Freitas B, Peleteiro M, Sanchez A, Pascual DW, Gonzalez-Fernandez A, Alonso MJ.

PLoS One. 2013 Apr 22;8(4):e62500. doi: 10.1371/journal.pone.0062500. Print 2013.


18β-glycyrrhetinic acid delivered orally induces isolated lymphoid follicle maturation at the intestinal mucosa and attenuates rotavirus shedding.

Hendricks JM, Hoffman C, Pascual DW, Hardy ME.

PLoS One. 2012;7(11):e49491. doi: 10.1371/journal.pone.0049491. Epub 2012 Nov 13.


Flagella overexpression attenuates Salmonella pathogenesis.

Yang X, Thornburg T, Suo Z, Jun S, Robison A, Li J, Lim T, Cao L, Hoyt T, Avci R, Pascual DW.

PLoS One. 2012;7(10):e46828. doi: 10.1371/journal.pone.0046828. Epub 2012 Oct 3.


IFN-γ-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis.

Skyberg JA, Thornburg T, Kochetkova I, Layton W, Callis G, Rollins MF, Riccardi C, Becker T, Golden S, Pascual DW.

J Leukoc Biol. 2012 Aug;92(2):375-87. doi: 10.1189/jlb.1211626. Epub 2012 May 25.


Loss of sialic acid binding domain redirects protein σ1 to enhance M cell-directed vaccination.

Zlotkowska D, Maddaloni M, Riccardi C, Walters N, Holderness K, Callis G, Rynda-Apple A, Pascual DW.

PLoS One. 2012;7(4):e36182. doi: 10.1371/journal.pone.0036182. Epub 2012 Apr 30.


Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections.

Skyberg JA, Rollins MF, Holderness JS, Marlenee NL, Schepetkin IA, Goodyear A, Dow SW, Jutila MA, Pascual DW.

PLoS Pathog. 2012;8(3):e1002587. doi: 10.1371/journal.ppat.1002587. Epub 2012 Mar 15.


Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Hanks TS, Kochetkova I, Pascual DW, Jutila MA, Quinn MT.

Mol Pharmacol. 2012 Jun;81(6):832-45. doi: 10.1124/mol.111.077446. Epub 2012 Mar 20.


Bystander-mediated stimulation of proteolipid protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-β.

Jun S, Ochoa-Repáraz J, Zlotkowska D, Hoyt T, Pascual DW.

J Neuroimmunol. 2012 Apr;245(1-2):39-47. doi: 10.1016/j.jneuroim.2012.02.003. Epub 2012 Mar 13.


Expression of Escherichia coli virulence usher protein attenuates wild-type Salmonella.

Yang X, Suo Z, Thornburg T, Holderness K, Cao L, Lim T, Walters N, Kellerman L, Loetterle L, Avci R, Pascual DW.

Virulence. 2012 Jan-Feb;3(1):29-42. doi: 10.4161/viru.3.1.18447. Epub 2012 Jan 1.


Sublingual immunization with adenovirus F protein-based vaccines stimulates protective immunity against botulinum neurotoxin A intoxication.

Jun S, Clapp B, Zlotkowska D, Hoyt T, Holderness K, Maddaloni M, Pascual DW.

Int Immunol. 2012 Feb;24(2):117-28. doi: 10.1093/intimm/dxr106. Epub 2011 Dec 29.


Tolerogen-induced interferon-producing killer dendritic cells (IKDCs) protect against EAE.

Huarte E, Rynda-Apple A, Riccardi C, Skyberg JA, Golden S, Rollins MF, Ramstead AG, Jackiw LO, Maddaloni M, Pascual DW.

J Autoimmun. 2011 Dec;37(4):328-41. doi: 10.1016/j.jaut.2011.09.005. Epub 2011 Oct 22.


Serum antibodies protect against intraperitoneal challenge with enterotoxigenic Escherichia coli.

Yang X, Thornburg T, Holderness K, Suo Z, Cao L, Lim T, Avci R, Pascual DW.

J Biomed Biotechnol. 2011;2011:632396. doi: 10.1155/2011/632396. Epub 2011 Oct 9.


Segregated regulatory CD39+CD4+ T cell function: TGF-β-producing Foxp3- and IL-10-producing Foxp3+ cells are interdependent for protection against collagen-induced arthritis.

Kochetkova I, Thornburg T, Callis G, Pascual DW.

J Immunol. 2011 Nov 1;187(9):4654-66. doi: 10.4049/jimmunol.1100530. Epub 2011 Oct 3.


Protective live oral brucellosis vaccines stimulate Th1 and th17 cell responses.

Clapp B, Skyberg JA, Yang X, Thornburg T, Walters N, Pascual DW.

Infect Immun. 2011 Oct;79(10):4165-74. doi: 10.1128/IAI.05080-11. Epub 2011 Jul 18.


Murine and bovine γδ T cells enhance innate immunity against Brucella abortus infections.

Skyberg JA, Thornburg T, Rollins M, Huarte E, Jutila MA, Pascual DW.

PLoS One. 2011;6(7):e21978. doi: 10.1371/journal.pone.0021978. Epub 2011 Jul 12.


DNA vaccination of bison to brucellar antigens elicits elevated antibody and IFN-γ responses.

Clapp B, Walters N, Thornburg T, Hoyt T, Yang X, Pascual DW.

J Wildl Dis. 2011 Jul;47(3):501-10.


Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression.

Skyberg JA, Robison A, Golden S, Rollins MF, Callis G, Huarte E, Kochetkova I, Jutila MA, Pascual DW.

J Leukoc Biol. 2011 Dec;90(6):1043-54. doi: 10.1189/jlb.0311168. Epub 2011 Jun 21.


M cell-targeted mucosal vaccine strategies.

Yamamoto M, Pascual DW, Kiyono H.

Curr Top Microbiol Immunol. 2012;354:39-52. doi: 10.1007/82_2011_134. Review.


Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits.

Staats HF, Fielhauer JR, Thompson AL, Tripp AA, Sobel AE, Maddaloni M, Abraham SN, Pascual DW.

PLoS One. 2011 Jan 27;6(1):e16532. doi: 10.1371/journal.pone.0016532.


Active immunization using a single dose immunotherapeutic abates established EAE via IL-10 and regulatory T cells.

Rynda-Apple A, Huarte E, Maddaloni M, Callis G, Skyberg JA, Pascual DW.

Eur J Immunol. 2011 Feb;41(2):313-23. doi: 10.1002/eji.201041104. Epub 2010 Dec 29.


Adenovirus F protein as a delivery vehicle for botulinum B.

Clapp B, Golden S, Maddaloni M, Staats HF, Pascual DW.

BMC Immunol. 2010 Jul 7;11:36. doi: 10.1186/1471-2172-11-36.


IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10.

Kochetkova I, Golden S, Holderness K, Callis G, Pascual DW.

J Immunol. 2010 Jun 15;184(12):7144-53. doi: 10.4049/jimmunol.0902739. Epub 2010 May 10.


A parenteral DNA vaccine protects against pneumonic plague.

Yamanaka H, Hoyt T, Yang X, Bowen R, Golden S, Crist K, Becker T, Maddaloni M, Pascual DW.

Vaccine. 2010 Apr 19;28(18):3219-30. doi: 10.1016/j.vaccine.2010.02.022. Epub 2010 Mar 1.


IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).

Rynda A, Maddaloni M, Ochoa-Repáraz J, Callis G, Pascual DW.

PLoS One. 2010 Jan 14;5(1):e8720. doi: 10.1371/journal.pone.0008720.


DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate.

Yang X, Thornburg T, Walters N, Pascual DW.

Vaccine. 2010 Jan 22;28(4):1069-74. doi: 10.1016/j.vaccine.2009.10.113. Epub 2009 Nov 13.


Antibody selection for immobilizing living bacteria.

Suo Z, Yang X, Avci R, Deliorman M, Rugheimer P, Pascual DW, Idzerda Y.

Anal Chem. 2009 Sep 15;81(18):7571-8. doi: 10.1021/ac9014484.


Bacteria survive multiple puncturings of their cell walls.

Suo Z, Avci R, Deliorman M, Yang X, Pascual DW.

Langmuir. 2009 Apr 21;25(8):4588-94. doi: 10.1021/la8033319.


Distal IgA immunity can be sustained by alphaEbeta7+ B cells in L-selectin-/- mice following oral immunization.

Pascual DW, Riccardi C, Csencsits-Smith K.

Mucosal Immunol. 2008 Jan;1(1):68-77. doi: 10.1038/mi.2007.2.


An IL-12 DNA vaccine co-expressing Yersinia pestis antigens protects against pneumonic plague.

Yamanaka H, Hoyt T, Bowen R, Yang X, Crist K, Golden S, Maddaloni M, Pascual DW.

Vaccine. 2009 Jan 1;27(1):80-7. doi: 10.1016/j.vaccine.2008.10.021. Epub 2008 Oct 26.

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