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Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility.

Jones JC, Pascua PNQ, Fabrizio TP, Marathe BM, Seiler P, Barman S, Webby RJ, Webster RG, Govorkova EA.

Proc Natl Acad Sci U S A. 2020 Mar 26. pii: 201916825. doi: 10.1073/pnas.1916825117. [Epub ahead of print]


Influenza B viruses from different genetic backgrounds are variably impaired by neuraminidase inhibitor resistance-associated substitutions.

Pascua PNQ, Marathe BM, Bisen S, Webby RJ, Govorkova EA.

Antiviral Res. 2020 Jan;173:104669. doi: 10.1016/j.antiviral.2019.104669. Epub 2019 Nov 29.


A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus.

Kwon HI, Kim YI, Park SJ, Kim EH, Kim S, Si YJ, Song MS, Pascua PNQ, Govorkova EA, Webster RG, Webby RJ, Choi YK.

mBio. 2019 Nov 5;10(6). pii: e02369-19. doi: 10.1128/mBio.02369-19.


Optimizing T-705 (favipiravir) treatment of severe influenza B virus infection in the immunocompromised mouse model.

Pascua PNQ, Marathe BM, Vogel P, Webby RJ, Govorkova EA.

J Antimicrob Chemother. 2019 May 1;74(5):1333-1341. doi: 10.1093/jac/dky560.


A pharmacologically immunosuppressed mouse model for assessing influenza B virus pathogenicity and oseltamivir treatment.

Marathe BM, Mostafa HH, Vogel P, Pascua PNQ, Jones JC, Russell CJ, Webby RJ, Govorkova EA.

Antiviral Res. 2017 Dec;148:20-31. doi: 10.1016/j.antiviral.2017.10.021. Epub 2017 Oct 31.


Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection.

Pascua PNQ, Mostafa HH, Marathe BM, Vogel P, Russell CJ, Webby RJ, Govorkova EA.

Sci Rep. 2017 Aug 4;7(1):7345. doi: 10.1038/s41598-017-07433-z.


Avian Influenza A Viruses: Evolution and Zoonotic Infection.

Kim SM, Kim YI, Pascua PN, Choi YK.

Semin Respir Crit Care Med. 2016 Aug;37(4):501-11. doi: 10.1055/s-0036-1584953. Epub 2016 Aug 3. Review.


Competitive Fitness of Influenza B Viruses Possessing E119A and H274Y Neuraminidase Inhibitor Resistance-Associated Substitutions in Ferrets.

Pascua PN, Marathe BM, Burnham AJ, Vogel P, Webby RJ, Webster RG, Govorkova EA.

PLoS One. 2016 Jul 28;11(7):e0159847. doi: 10.1371/journal.pone.0159847. eCollection 2016.


A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro.

Jones JC, Marathe BM, Lerner C, Kreis L, Gasser R, Pascua PN, Najera I, Govorkova EA.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5504-14. doi: 10.1128/AAC.00888-16. Print 2016 Sep.


Mouse adaptation of influenza B virus increases replication in the upper respiratory tract and results in droplet transmissibility in ferrets.

Kim EH, Park SJ, Kwon HI, Kim SM, Kim YI, Song MS, Choi EJ, Pascua PN, Choi YK.

Sci Rep. 2015 Nov 3;5:15940. doi: 10.1038/srep15940.


Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses.

Song MS, Baek YH, Pascua PN, Kwon HI, Kim EH, Park SJ, Kim SM, Kim YI, Choi WS, Kim EG, Kim CJ, Choi YK.

J Virol. 2015 Oct 21;90(1):616-23. doi: 10.1128/JVI.01572-15. Print 2016 Jan 1.


Evaluation of the zoonotic potential of a novel reassortant H1N2 swine influenza virus with gene constellation derived from multiple viral sources.

Lee JH, Pascua PN, Decano AG, Kim SM, Park SJ, Kwon HI, Kim EH, Kim YI, Kim H, Kim SY, Song MS, Jang HK, Park BK, Choi YK.

Infect Genet Evol. 2015 Aug;34:378-93. doi: 10.1016/j.meegid.2015.06.005. Epub 2015 Jun 4.


Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus.

Kim YI, Pascua PN, Kwon HI, Lim GJ, Kim EH, Yoon SW, Park SJ, Kim SM, Choi EJ, Si YJ, Lee OJ, Shim WS, Kim SW, Mo IP, Bae Y, Lim YT, Sung MH, Kim CJ, Webby RJ, Webster RG, Choi YK.

Emerg Microbes Infect. 2014 Oct;3(10):e75. doi: 10.1038/emi.2014.75. Epub 2014 Oct 22.


Development of a dual-protective live attenuated vaccine against H5N1 and H9N2 avian influenza viruses by modifying the NS1 gene.

Choi EH, Song MS, Park SJ, Pascua PN, Baek YH, Kwon HI, Kim EH, Kim S, Jang HK, Poo H, Kim CJ, Choi YK.

Arch Virol. 2015 Jul;160(7):1729-40. doi: 10.1007/s00705-015-2442-y. Epub 2015 May 12.


Profiling and characterization of influenza virus N1 strains potentially resistant to multiple neuraminidase inhibitors.

Baek YH, Song MS, Lee EY, Kim YI, Kim EH, Park SJ, Park KJ, Kwon HI, Pascua PN, Lim GJ, Kim S, Yoon SW, Kim MH, Webby RJ, Choi YK.

J Virol. 2015 Jan;89(1):287-99. doi: 10.1128/JVI.02485-14. Epub 2014 Oct 15.


Differential microRNA expression following infection with a mouse-adapted, highly virulent avian H5N2 virus.

Choi EJ, Kim HB, Baek YH, Kim EH, Pascua PN, Park SJ, Kwon HI, Lim GJ, Kim S, Kim YI, Choi YK.

BMC Microbiol. 2014 Sep 30;14:252. doi: 10.1186/s12866-014-0252-0.


Zoonotic infections with avian influenza A viruses and vaccine preparedness: a game of "mix and match".

Pascua PN, Choi YK.

Clin Exp Vaccine Res. 2014 Jul;3(2):140-8. doi: 10.7774/cevr.2014.3.2.140. Epub 2014 Jun 20. Review.


Evaluation of heterosubtypic cross-protection against highly pathogenic H5N1 by active infection with human seasonal influenza A virus or trivalent inactivated vaccine immunization in ferret models.

Park SJ, Kim EH, Pascua PNQ, Kwon HI, Lim GJ, Decano A, Kim SM, Song MK, Shin EC, Choi YK.

J Gen Virol. 2014 Apr;95(Pt 4):793-798. doi: 10.1099/vir.0.058636-0. Epub 2014 Jan 13.


Avian-derived NS gene segments alter pathogenicity of the A/Puerto Rico/8/34 virus.

Park SJ, Lee EH, Choi EH, Pascua PN, Kwon HI, Kim EH, Lim GJ, Decano A, Kim SM, Choi YK.

Virus Res. 2014 Jan 22;179:64-72. doi: 10.1016/j.virusres.2013.11.011. Epub 2013 Nov 21.


Adjuvant efficacy of mOMV against avian influenza virus infection in mice.

Lee BJ, Lee SH, Song MS, Pascua PN, Kwon HI, Park SJ, Kim EH, Decano A, Kim SM, Lim GJ, Kim DJ, Chang KT, Kim SH, Choi YK.

J Microbiol. 2013 Oct;51(5):682-8. doi: 10.1007/s12275-013-3411-3. Epub 2013 Oct 31.


Emergence of H3N2pM-like and novel reassortant H3N1 swine viruses possessing segments derived from the A (H1N1)pdm09 influenza virus, Korea.

Pascua PN, Lim GJ, Kwon HI, Park SJ, Kim EH, Song MS, Kim CJ, Choi YK.

Influenza Other Respir Viruses. 2013 Nov;7(6):1283-91. doi: 10.1111/irv.12154. Epub 2013 Aug 30.


Complete Genome Sequences of Novel Reassortant H1N2 Swine Influenza Viruses Isolated from Pigs in the Republic of Korea.

Pascua PN, Lim GJ, Kwon HI, Kim YI, Kim EH, Park SJ, Kim SM, Decano AG, Choi EJ, Jeon HY, Kim CJ, Choi YK.

Genome Announc. 2013 Aug 8;1(4). pii: e00552-13. doi: 10.1128/genomeA.00552-13.


Increased virulence of neuraminidase inhibitor-resistant pandemic H1N1 virus in mice: potential emergence of drug-resistant and virulent variants.

Song MS, Hee Baek Y, Kim EH, Park SJ, Kim S, Lim GJ, Kwon HI, Pascua PN, Decano AG, Lee BJ, Kim YI, Webby RJ, Choi YK.

Virulence. 2013 Aug 15;4(6):489-93. doi: 10.4161/viru.25952. Epub 2013 Aug 2.


The homologous tripartite viral RNA polymerase of A/swine/Korea/CT1204/2009(H1N2) influenza virus synergistically drives efficient replication and promotes respiratory droplet transmission in ferrets.

Pascua PN, Song MS, Kwon HI, Lim GJ, Kim EH, Park SJ, Lee OJ, Kim CJ, Webby RJ, Webster RG, Choi YK.

J Virol. 2013 Oct;87(19):10552-62. doi: 10.1128/JVI.01333-13. Epub 2013 Jul 17.


Immunomodulaton and attenuation of lethal influenza A virus infection by oral administration with KIOM-C.

Kim EH, Pascua PN, Song MS, Baek YH, Kwon HI, Park SJ, Lim GJ, Kim SM, Decano A, Lee KJ, Cho WK, Ma JY, Choi YK.

Antiviral Res. 2013 Jun;98(3):386-93. doi: 10.1016/j.antiviral.2013.04.006. Epub 2013 Apr 13.


Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza A virus in mice.

Kim EH, Lee JH, Pascua PN, Song MS, Baek YH, Kwon HI, Park SJ, Lim GJ, Decano A, Chowdhury MY, Seo SK, Song MK, Kim CJ, Choi YK.

Virol J. 2013 Apr 3;10:104. doi: 10.1186/1743-422X-10-104.


Establishment of Vero cell RNA polymerase I-driven reverse genetics for Influenza A virus and its application for pandemic (H1N1) 2009 influenza virus vaccine production.

Song MS, Baek YH, Pascua PNQ, Kwon HI, Park SJ, Kim EH, Lim GJ, Choi YK.

J Gen Virol. 2013 Jun;94(Pt 6):1230-1235. doi: 10.1099/vir.0.051284-0. Epub 2013 Mar 13.


Early regulation of viral infection reduces inflammation and rescues mx-positive mice from lethal avian influenza infection.

Song MS, Cho YH, Park SJ, Pascua PN, Baek YH, Kwon HI, Lee OJ, Kong BW, Kim H, Shin EC, Kim CJ, Choi YK.

Am J Pathol. 2013 Apr;182(4):1308-21. doi: 10.1016/j.ajpath.2012.12.022. Epub 2013 Feb 8.


Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses.

Pascua PN, Song MS, Lee JH, Baek YH, Kwon HI, Park SJ, Choi EH, Lim GJ, Lee OJ, Kim SW, Kim CJ, Sung MH, Kim MH, Yoon SW, Govorkova EA, Webby RJ, Webster RG, Choi YK.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15900-5. Epub 2012 Sep 10.


Evaluation of the efficacy of a pre-pandemic H5N1 vaccine (MG1109) in mouse and ferret models.

Song MS, Moon HJ, Kwon HI, Pascua PN, Lee JH, Baek YH, Woo GJ, Choi J, Lee S, Yoo H, Oh I, Yoon Y, Rho JB, Sung MH, Hong SP, Kim CJ, Choi YK.

J Microbiol. 2012 Jun;50(3):478-88. doi: 10.1007/s12275-012-1573-z. Epub 2012 Jun 30. Erratum in: J Microbiol. 2012 Aug;50(4):715. Woo, Kyu-Jin [corrected to Woo, Gyu-Jin].


Prevalence and genetic characterization of respiratory syncytial virus (RSV) in hospitalized children in Korea.

Baek YH, Choi EH, Song MS, Pascua PN, Kwon HI, Park SJ, Lee JH, Woo SI, Ahn BH, Han HS, Hahn YS, Shin KS, Jang HL, Kim SY, Choi YK.

Arch Virol. 2012 Jun;157(6):1039-50. doi: 10.1007/s00705-012-1267-1. Epub 2012 Mar 9.


Swine influenza viruses: an Asian perspective.

Choi YK, Pascua PN, Song MS.

Curr Top Microbiol Immunol. 2013;370:147-72. Review.


Role of the p21-activated kinases (PAKs) in influenza A virus replication.

Pascua PN, Lee JH, Song MS, Park SJ, Baek YH, Ann BH, Shin EY, Kim EG, Choi YK.

Biochem Biophys Res Commun. 2011 Oct 28;414(3):569-74. doi: 10.1016/j.bbrc.2011.09.119. Epub 2011 Oct 1.


Impairment of the Staufen1-NS1 interaction reduces influenza viral replication.

Lee JH, Oh JY, Pascua PN, Kim EG, Choi YK, Kim HK.

Biochem Biophys Res Commun. 2011 Oct 14;414(1):153-8. doi: 10.1016/j.bbrc.2011.09.042. Epub 2011 Sep 16.


Virulence of pandemic (H1N1) 2009 influenza A polymerase reassortant viruses.

Song MS, Pascua PN, Choi YK.

Virulence. 2011 Sep-Oct;2(5):422-6. doi: 10.4161/viru.2.5.17267. Epub 2011 Sep 1. Review.


Genetic characterization and pathogenicity assessment of highly pathogenic H5N1 avian influenza viruses isolated from migratory wild birds in 2011, South Korea.

Kwon HI, Song MS, Pascua PN, Baek YH, Lee JH, Hong SP, Rho JB, Kim JK, Poo H, Kim CJ, Choi YK.

Virus Res. 2011 Sep;160(1-2):305-15. doi: 10.1016/j.virusres.2011.07.003. Epub 2011 Jul 12.


Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses.

Song MS, Pascua PN, Lee JH, Baek YH, Park KJ, Kwon HI, Park SJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2011 Jul;85(13):6275-86. doi: 10.1128/JVI.02125-10. Epub 2011 Apr 20.


Rapid evolution of low-pathogenic H9N2 avian influenza viruses following poultry vaccination programmes.

Park KJ, Kwon HI, Song MS, Pascua PN, Baek YH, Lee JH, Jang HL, Lim JY, Mo IP, Moon HJ, Kim CJ, Choi YK.

J Gen Virol. 2011 Jan;92(Pt 1):36-50. doi: 10.1099/vir.0.024992-0. Epub 2010 Sep 22.


Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea.

Song MS, Lee JH, Pascua PN, Baek YH, Kwon HI, Park KJ, Choi HW, Shin YK, Song JY, Kim CJ, Choi YK.

J Clin Microbiol. 2010 Sep;48(9):3204-11. doi: 10.1128/JCM.00053-10. Epub 2010 Jul 7.


Surveillance and characterization of low pathogenic H5 avian influenza viruses isolated from wild migratory birds in Korea.

Baek YH, Pascua PN, Song MS, Park KJ, Kwon HI, Lee JH, Kim SY, Moon HJ, Kim CJ, Choi YK.

Virus Res. 2010 Jun;150(1-2):119-28. doi: 10.1016/j.virusres.2010.03.002. Epub 2010 Mar 21.


Extensive mammalian ancestry of pandemic (H1N1) 2009 virus.

Ilyushina NA, Kim JK, Negovetich NJ, Choi YK, Lang V, Bovin NV, Forrest HL, Song MS, Pascua PN, Kim CJ, Webster RG, Webby RJ.

Emerg Infect Dis. 2010 Feb;16(2):314-7. doi: 10.3201/eid1602.091141.


Evaluation of the efficacy and cross-protectivity of recent human and swine vaccines against the pandemic (H1N1) 2009 virus infection.

Pascua PN, Song MS, Lee JH, Park KJ, Kwon HI, Baek YH, Hong SP, Rho JB, Kim CJ, Poo H, Ryoo TS, Sung MH, Choi YK.

PLoS One. 2009 Dec 23;4(12):e8431. doi: 10.1371/journal.pone.0008431.


Active reassortment of H9 influenza viruses between wild birds and live-poultry markets in Korea.

Moon HJ, Song MS, Cruz DJ, Park KJ, Pascua PN, Lee JH, Baek YH, Choi DH, Choi YK, Kim CJ.

Arch Virol. 2010 Feb;155(2):229-41. doi: 10.1007/s00705-009-0577-4. Epub 2009 Dec 22.


Direct interaction of cellular hnRNP-F and NS1 of influenza A virus accelerates viral replication by modulation of viral transcriptional activity and host gene expression.

Lee JH, Kim SH, Pascua PN, Song MS, Baek YH, Jin X, Choi JK, Kim CJ, Kim H, Choi YK.

Virology. 2010 Feb 5;397(1):89-99. doi: 10.1016/j.virol.2009.10.041. Epub 2009 Nov 18. Retraction in: Virology. 2013 Feb 5;436(1):245.


The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model.

Song MS, Pascua PN, Lee JH, Baek YH, Lee OJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2009 Dec;83(23):12325-35. doi: 10.1128/JVI.01373-09. Epub 2009 Sep 30.


Investigation of the biological indicator for vaccine efficacy against highly pathogenic avian influenza (HPAI) H5N1 virus challenge in mice and ferrets.

Song MS, Oh TK, Pascua PN, Moon HJ, Lee JH, Baek YH, Woo KJ, Yoon Y, Sung MH, Poo H, Kim CJ, Choi YK.

Vaccine. 2009 May 21;27(24):3145-52. doi: 10.1016/j.vaccine.2009.03.061. Epub 2009 Apr 9.


Isolation and genetic characterization of H5N2 influenza viruses from pigs in Korea.

Lee JH, Pascua PN, Song MS, Baek YH, Kim CJ, Choi HW, Sung MH, Webby RJ, Webster RG, Poo H, Choi YK.

J Virol. 2009 May;83(9):4205-15. doi: 10.1128/JVI.02403-09.


Molecular characterization and phylogenetic analysis of H3N2 human influenza A viruses in Cheongju, South Korea.

Baek YH, Park JH, Song YJ, Song MS, Pascua PN, Hahn YS, Han HS, Lee OJ, Kim KS, Kang C, Choi YK.

J Microbiol. 2009 Feb;47(1):91-100. doi: 10.1007/s12275-008-0207-y. Epub 2009 Feb 20.


Emergence of amantadine-resistant H3N2 avian influenza A virus in South Korea.

Lee J, Song YJ, Park JH, Lee JH, Baek YH, Song MS, Oh TK, Han HS, Pascua PN, Choi YK.

J Clin Microbiol. 2008 Nov;46(11):3788-90. doi: 10.1128/JCM.01427-08. Epub 2008 Sep 24.


Seroprevalence and genetic evolutions of swine influenza viruses under vaccination pressure in Korean swine herds.

Pascua PN, Song MS, Lee JH, Choi HW, Han JH, Kim JH, Yoo GJ, Kim CJ, Choi YK.

Virus Res. 2008 Dec;138(1-2):43-9. doi: 10.1016/j.virusres.2008.08.005. Epub 2008 Oct 28.


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