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Items: 1 to 50 of 93

1.

An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding.

Oostdyk LT, Wang Z, Zang C, Li H, McConnell MJ, Paschal BM.

Sci Rep. 2020 Mar 16;10(1):4844. doi: 10.1038/s41598-020-61369-5.

2.

Characterization of the Importin-β binding domain in nuclear import receptor KPNA7.

Oostdyk LT, McConnell MJ, Paschal BM.

Biochem J. 2019 Nov 15;476(21):3413-3434. doi: 10.1042/BCJ20190717.

PMID:
31642884
3.

Detection of ADP-Ribosylation of the Androgen Receptor Using the Recombinant Macrodomain AF1521 from Archaeoglobus fulgidus.

Kamata T, Yang CS, Jividen K, Spencer A, Dworak N, Oostdyk LT, Paschal BM.

Methods Mol Biol. 2019;1966:107-124. doi: 10.1007/978-1-4939-9195-2_9.

PMID:
31041742
4.

Methods in Nuclear Architecture and Transport.

Paschal BM.

Methods. 2019 Mar 15;157:1-2. doi: 10.1016/j.ymeth.2019.02.020. No abstract available.

PMID:
30832896
5.

A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling.

Dworak N, Makosa D, Chatterjee M, Jividen K, Yang CS, Snow C, Simke WC, Johnson IG, Kelley JB, Paschal BM.

Aging Cell. 2019 Feb;18(1):e12851. doi: 10.1111/acel.12851. Epub 2018 Dec 19.

6.

Fluorescence-based quantification of nucleocytoplasmic transport.

Kelley JB, Paschal BM.

Methods. 2019 Mar 15;157:106-114. doi: 10.1016/j.ymeth.2018.11.002. Epub 2018 Nov 10.

7.

Towards improving proximity labeling by the biotin ligase BirA.

Oostdyk LT, Shank L, Jividen K, Dworak N, Sherman NE, Paschal BM.

Methods. 2019 Mar 15;157:66-79. doi: 10.1016/j.ymeth.2018.11.003. Epub 2018 Nov 10.

8.

Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer.

Yang J, Wei X, Tufan T, Kuscu C, Unlu H, Farooq S, Demirtas E, Paschal BM, Adli M.

Genome Biol. 2018 Nov 7;19(1):190. doi: 10.1186/s13059-018-1572-4.

9.

Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.

Jividen K, Kedzierska KZ, Yang CS, Szlachta K, Ratan A, Paschal BM.

BMC Cancer. 2018 Oct 10;18(1):960. doi: 10.1186/s12885-018-4848-x.

10.

The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.

Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF Jr, Wotton D, Paschal BM.

Prostate. 2017 Nov;77(15):1452-1467. doi: 10.1002/pros.23400. Epub 2017 Sep 6.

11.

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

Yang CS, Jividen K, Spencer A, Dworak N, Ni L, Oostdyk LT, Chatterjee M, Kuśmider B, Reon B, Parlak M, Gorbunova V, Abbas T, Jeffery E, Sherman NE, Paschal BM.

Mol Cell. 2017 May 18;66(4):503-516.e5. doi: 10.1016/j.molcel.2017.04.028.

12.

Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA.

Zboray L, Pluciennik A, Curtis D, Liu Y, Berman-Booty LD, Orr C, Kesler CT, Berger T, Gioeli D, Paschal BM, Merry DE.

Cell Rep. 2015 Dec 15;13(10):2312-23. doi: 10.1016/j.celrep.2015.11.019. Epub 2015 Dec 7.

13.

Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins.

Ng S, Lin E, Kitov PI, Tjhung KF, Gerlits OO, Deng L, Kasper B, Sood A, Paschal BM, Zhang P, Ling CC, Klassen JS, Noren CJ, Mahal LK, Woods RJ, Coates L, Derda R.

J Am Chem Soc. 2015 Apr 29;137(16):5248-51. doi: 10.1021/ja511237n. Epub 2015 Apr 16.

14.

De novo mutations in SIK1 cause a spectrum of developmental epilepsies.

Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR.

Am J Hum Genet. 2015 Apr 2;96(4):682-90. doi: 10.1016/j.ajhg.2015.02.013. Erratum in: Am J Hum Genet. 2015 Jun 4;96(6):1009.

15.

Chemical posttranslational modification of phage-displayed peptides.

Ng S, Tjhung KF, Paschal BM, Noren CJ, Derda R.

Methods Mol Biol. 2015;1248:155-72. doi: 10.1007/978-1-4939-2020-4_11. Review.

PMID:
25616332
16.

Disruption of the ran system by cysteine oxidation of the nucleotide exchange factor RCC1.

Chatterjee M, Paschal BM.

Mol Cell Biol. 2015 Feb;35(3):566-81. doi: 10.1128/MCB.01133-14. Epub 2014 Dec 1.

17.

Discovery and characterization of small molecules that target the GTPase Ral.

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D.

Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14.

18.

Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.

Bjerke GA, Pietrzak K, Melhuish TA, Frierson HF Jr, Paschal BM, Wotton D.

PLoS One. 2014 Mar 20;9(3):e92800. doi: 10.1371/journal.pone.0092800. eCollection 2014.

19.

Roles of the nucleoporin Tpr in cancer and aging.

Snow CJ, Paschal BM.

Adv Exp Med Biol. 2014;773:309-22. doi: 10.1007/978-1-4899-8032-8_14. Review.

PMID:
24563354
20.

A pathway linking oxidative stress and the Ran GTPase system in progeria.

Datta S, Snow CJ, Paschal BM.

Mol Biol Cell. 2014 Apr;25(8):1202-15. doi: 10.1091/mbc.E13-07-0430. Epub 2014 Feb 12.

21.

Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen receptor.

Ni L, Llewellyn R, Kesler CT, Kelley JB, Spencer A, Snow CJ, Shank L, Paschal BM.

Mol Cell Biol. 2013 Dec;33(24):4766-78. doi: 10.1128/MCB.00647-13. Epub 2013 Oct 7.

22.

Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation.

Paciorkowski AR, Weisenberg J, Kelley JB, Spencer A, Tuttle E, Ghoneim D, Thio LL, Christian SL, Dobyns WB, Paschal BM.

Eur J Hum Genet. 2014 May;22(5):587-93. doi: 10.1038/ejhg.2013.196. Epub 2013 Sep 18.

23.

Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis.

Bjerke GA, Yang CS, Frierson HF, Paschal BM, Wotton D.

Oncogene. 2014 Jul 10;33(28):3660-7. doi: 10.1038/onc.2013.342. Epub 2013 Sep 2.

24.

Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.

Snow CJ, Dar A, Dutta A, Kehlenbach RH, Paschal BM.

J Cell Biol. 2013 May 13;201(4):541-57. doi: 10.1083/jcb.201212117. Epub 2013 May 6.

25.

Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells.

Sun D, Layer R, Mueller AC, Cichewicz MA, Negishi M, Paschal BM, Dutta A.

Oncogene. 2014 Mar 13;33(11):1448-57. doi: 10.1038/onc.2013.77. Epub 2013 Mar 18.

26.

Post-translational modification of the androgen receptor.

Gioeli D, Paschal BM.

Mol Cell Endocrinol. 2012 Apr 16;352(1-2):70-8. doi: 10.1016/j.mce.2011.07.004. Epub 2011 Jul 24.

PMID:
21820033
27.

The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.

Kelley JB, Datta S, Snow CJ, Chatterjee M, Ni L, Spencer A, Yang CS, Cubeñas-Potts C, Matunis MJ, Paschal BM.

Mol Cell Biol. 2011 Aug;31(16):3378-95. doi: 10.1128/MCB.05087-11. Epub 2011 Jun 13.

28.

Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.

Kelley JB, Talley AM, Spencer A, Gioeli D, Paschal BM.

BMC Cell Biol. 2010 Aug 11;11:63. doi: 10.1186/1471-2121-11-63.

29.

Petty syndrome and Fontaine-Farriaux syndrome: Delineation of a single syndrome.

Braddock SR, Ardinger HH, Yang CS, Paschal BM, Hall BD.

Am J Med Genet A. 2010 Jul;152A(7):1718-23. doi: 10.1002/ajmg.a.33468.

PMID:
20583180
30.

FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.

Ni L, Yang CS, Gioeli D, Frierson H, Toft DO, Paschal BM.

Mol Cell Biol. 2010 Mar;30(5):1243-53. doi: 10.1128/MCB.01891-08. Epub 2010 Jan 4.

31.

Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1.

Chen S, Kesler CT, Paschal BM, Balk SP.

J Biol Chem. 2009 Sep 18;284(38):25576-84. doi: 10.1074/jbc.M109.043133. Epub 2009 Jul 21.

32.

PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma.

Galgano MT, Conaway M, Spencer AM, Paschal BM, Frierson HF Jr.

Hum Pathol. 2009 Oct;40(10):1434-40. doi: 10.1016/j.humpath.2009.02.008. Epub 2009 May 7.

33.

SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.

Kaikkonen S, Jääskeläinen T, Karvonen U, Rytinki MM, Makkonen H, Gioeli D, Paschal BM, Palvimo JJ.

Mol Endocrinol. 2009 Mar;23(3):292-307. doi: 10.1210/me.2008-0219. Epub 2008 Dec 30.

34.

RNA polymerases.

Paschal BM, McReynolds LA, Noren CJ, Nichols NM.

Curr Protoc Mol Biol. 2008 Oct;Chapter 3:Unit3.8. doi: 10.1002/0471142727.mb0308s84.

PMID:
18972390
35.

Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro.

Shank LC, Kelley JB, Gioeli D, Yang CS, Spencer A, Allison LA, Paschal BM.

J Biol Chem. 2008 Apr 18;283(16):10568-80. doi: 10.1074/jbc.M800810200. Epub 2008 Feb 12.

36.

Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP.

Kelley JB, Paschal BM.

Mol Biol Cell. 2007 Nov;18(11):4365-76. Epub 2007 Aug 29.

37.

Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor.

Kesler CT, Gioeli D, Conaway MR, Weber MJ, Paschal BM.

Mol Endocrinol. 2007 Sep;21(9):2071-84. Epub 2007 Jun 19.

PMID:
17579212
38.

Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.

Sun K, Montana V, Chellappa K, Brelivet Y, Moras D, Maeda Y, Parpura V, Paschal BM, Sladek FM.

Mol Endocrinol. 2007 Jun;21(6):1297-311. Epub 2007 Mar 27.

PMID:
17389749
39.

Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions.

Yang CS, Xin HW, Kelley JB, Spencer A, Brautigan DL, Paschal BM.

Mol Cell Biol. 2007 May;27(9):3390-404. Epub 2007 Feb 26.

40.

Scientists share nuclear secrets at Jekyll Island.

Pemberton LF, Paschal BM.

Traffic. 2006 Jun;7(6):751-60. Epub 2006 Apr 21. No abstract available.

41.

Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.

Lévesque L, Bor YC, Matzat LH, Jin L, Berberoglu S, Rekosh D, Hammarskjöld ML, Paschal BM.

Mol Biol Cell. 2006 Feb;17(2):931-43. Epub 2005 Nov 28.

42.

Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization.

Gioeli D, Black BE, Gordon V, Spencer A, Kesler CT, Eblen ST, Paschal BM, Weber MJ.

Mol Endocrinol. 2006 Mar;20(3):503-15. Epub 2005 Nov 10.

PMID:
16282370
43.
44.

Nuclear transport of steroid hormone receptors.

Shank LC, Paschal BM.

Crit Rev Eukaryot Gene Expr. 2005;15(1):49-73. Review.

PMID:
15831078
45.

Mechanisms of receptor-mediated nuclear import and nuclear export.

Pemberton LF, Paschal BM.

Traffic. 2005 Mar;6(3):187-98. Review.

46.

Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor.

Yang CS, Vitto MJ, Busby SA, Garcia BA, Kesler CT, Gioeli D, Shabanowitz J, Hunt DF, Rundell K, Brautigan DL, Paschal BM.

Mol Cell Biol. 2005 Feb;25(4):1298-308.

47.

Intranuclear organization and function of the androgen receptor.

Black BE, Paschal BM.

Trends Endocrinol Metab. 2004 Nov;15(9):411-7. Review.

PMID:
15519887
49.

The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain.

Meller N, Irani-Tehrani M, Ratnikov BI, Paschal BM, Schwartz MA.

J Biol Chem. 2004 Sep 3;279(36):37470-6. Epub 2004 Jul 6.

50.

Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions.

Black BE, Vitto MJ, Gioeli D, Spencer A, Afshar N, Conaway MR, Weber MJ, Paschal BM.

Mol Endocrinol. 2004 Apr;18(4):834-50. Epub 2003 Dec 18.

PMID:
14684849

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