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Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose dehydratase.

Eisemann T, Langelier MF, Pascal JM.

J Biol Chem. 2019 Aug 2. pii: jbc.RA119.009200. doi: 10.1074/jbc.RA119.009200. [Epub ahead of print]


Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.

Caron MC, Sharma AK, O'Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY.

Nat Commun. 2019 Jul 4;10(1):2954. doi: 10.1038/s41467-019-10741-9.


Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.

Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT.

J Med Chem. 2019 Jun 13;62(11):5330-5357. doi: 10.1021/acs.jmedchem.8b01709. Epub 2019 May 24.


Signal-induced PARP1-Erk synergism mediates IEG expression.

Cohen-Armon M, Yeheskel A, Pascal JM.

Signal Transduct Target Ther. 2019 Apr 12;4:8. doi: 10.1038/s41392-019-0042-0. eCollection 2019. Review.


PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification.

Langelier MF, Eisemann T, Riccio AA, Pascal JM.

Curr Opin Struct Biol. 2018 Dec;53:187-198. doi: 10.1016/ Epub 2018 Nov 24. Review.


The comings and goings of PARP-1 in response to DNA damage.

Pascal JM.

DNA Repair (Amst). 2018 Nov;71:177-182. doi: 10.1016/j.dnarep.2018.08.022. Epub 2018 Aug 23. Review.


Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS.

Gagné JP, Langelier MF, Pascal JM, Poirier GG.

J Proteome Res. 2018 Jul 6;17(7):2542-2551. doi: 10.1021/acs.jproteome.8b00146. Epub 2018 Jun 11.


NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains.

Langelier MF, Zandarashvili L, Aguiar PM, Black BE, Pascal JM.

Nat Commun. 2018 Feb 27;9(1):844. doi: 10.1038/s41467-018-03234-8.


The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.

Karch KR, Langelier MF, Pascal JM, Garcia BA.

Mol Biosyst. 2017 Nov 21;13(12):2660-2671. doi: 10.1039/c7mb00498b.


Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy.

Sultanov DC, Gerasimova NS, Kudryashova KS, Maluchenko NV, Kotova EY, Langelier MF, Pascal JM, Kirpichnikov MP, Feofanov AV, Studitsky VM.

AIMS Genet. 2017;4(1):21-31. doi: 10.3934/genet.2017.1.21. Epub 2017 Jan 5.


Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis.

Langelier MF, Steffen JD, Riccio AA, McCauley M, Pascal JM.

Methods Mol Biol. 2017;1608:431-444. doi: 10.1007/978-1-4939-6993-7_27.


Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

Chand SN, Zarei M, Schiewer MJ, Kamath AR, Romeo C, Lal S, Cozzitorto JA, Nevler A, Scolaro L, Londin E, Jiang W, Meisner-Kober N, Pishvaian MJ, Knudsen KE, Yeo CJ, Pascal JM, Winter JM, Brody JR.

Cancer Res. 2017 Sep 15;77(18):5011-5025. doi: 10.1158/0008-5472.CAN-16-2704. Epub 2017 Jul 7.


Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.

Jeronimo C, Langelier MF, Bataille AR, Pascal JM, Pugh BF, Robert F.

Mol Cell. 2016 Nov 3;64(3):455-466. doi: 10.1016/j.molcel.2016.09.002. Epub 2016 Oct 20.


Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

Eisemann T, McCauley M, Langelier MF, Gupta K, Roy S, Van Duyne GD, Pascal JM.

Structure. 2016 Oct 4;24(10):1679-1692. doi: 10.1016/j.str.2016.07.014. Epub 2016 Sep 1.


Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.

Steffen JD, McCauley MM, Pascal JM.

Nucleic Acids Res. 2016 Nov 16;44(20):9771-9783. Epub 2016 Aug 16.


Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.

Riccio AA, McCauley M, Langelier MF, Pascal JM.

Structure. 2016 Sep 6;24(9):1573-81. doi: 10.1016/j.str.2016.06.022. Epub 2016 Aug 4.


A PARP1-ERK2 synergism is required for the induction of LTP.

Visochek L, Grigoryan G, Kalal A, Milshtein-Parush H, Gazit N, Slutsky I, Yeheskel A, Shainberg A, Castiel A, Seger R, Langelier MF, Dantzer F, Pascal JM, Segal M, Cohen-Armon M.

Sci Rep. 2016 Apr 28;6:24950. doi: 10.1038/srep24950.


PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.

Riccio AA, Cingolani G, Pascal JM.

Nucleic Acids Res. 2016 Feb 29;44(4):1691-702. doi: 10.1093/nar/gkv1376. Epub 2015 Dec 23.


PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.

Dawicki-McKenna JM, Langelier MF, DeNizio JE, Riccio AA, Cao CD, Karch KR, McCauley M, Steffen JD, Black BE, Pascal JM.

Mol Cell. 2015 Dec 3;60(5):755-768. doi: 10.1016/j.molcel.2015.10.013. Epub 2015 Nov 25.


Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.

Eustermann S, Wu WF, Langelier MF, Yang JC, Easton LE, Riccio AA, Pascal JM, Neuhaus D.

Mol Cell. 2015 Dec 3;60(5):742-754. doi: 10.1016/j.molcel.2015.10.032. Epub 2015 Nov 25.


Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.

Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB.

Biochem J. 2015 Oct 1;471(1):37-51. doi: 10.1042/BJ20150325. Epub 2015 Jul 22.


The rise and fall of poly(ADP-ribose): An enzymatic perspective.

Pascal JM, Ellenberger T.

DNA Repair (Amst). 2015 Aug;32:10-16. doi: 10.1016/j.dnarep.2015.04.008. Epub 2015 May 1. Review.


Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs.

Gagné JP, Ethier C, Defoy D, Bourassa S, Langelier MF, Riccio AA, Pascal JM, Moon KM, Foster LJ, Ning Z, Figeys D, Droit A, Poirier GG.

DNA Repair (Amst). 2015 Jun;30:68-79. doi: 10.1016/j.dnarep.2015.02.004. Epub 2015 Feb 19.


Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.

Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF.

Nat Chem Biol. 2014 Sep;10(9):753-9. doi: 10.1038/nchembio.1592. Epub 2014 Aug 10.


PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.

Langelier MF, Riccio AA, Pascal JM.

Nucleic Acids Res. 2014 Jul;42(12):7762-75. doi: 10.1093/nar/gku474. Epub 2014 Jun 13.


Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.

Patel MR, Bhatt A, Steffen JD, Chergui A, Murai J, Pommier Y, Pascal JM, Trombetta LD, Fronczek FR, Talele TT.

J Med Chem. 2014 Jul 10;57(13):5579-601. doi: 10.1021/jm5002502. Epub 2014 Jun 25.


Structural Implications for Selective Targeting of PARPs.

Steffen JD, Brody JR, Armen RS, Pascal JM.

Front Oncol. 2013 Dec 20;3:301. doi: 10.3389/fonc.2013.00301. Review.


Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Steffen JD, Tholey RM, Langelier MF, Planck JL, Schiewer MJ, Lal S, Bildzukewicz NA, Yeo CJ, Knudsen KE, Brody JR, Pascal JM.

Cancer Res. 2014 Jan 1;74(1):31-7. doi: 10.1158/0008-5472.CAN-13-1701. Epub 2013 Nov 4.


New players to the field of ADP-ribosylation make the final cut.

Steffen JD, Pascal JM.

EMBO J. 2013 May 2;32(9):1205-7. doi: 10.1038/emboj.2013.83. Epub 2013 Apr 9. No abstract available.


Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca²⁺-sensing and SK channel activation.

Zhang M, Pascal JM, Zhang JF.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4828-33. doi: 10.1073/pnas.1220253110. Epub 2013 Mar 4.


Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.

Karlberg T, Langelier MF, Pascal JM, Schüler H.

Mol Aspects Med. 2013 Dec;34(6):1088-108. doi: 10.1016/j.mam.2013.02.002. Epub 2013 Feb 28. Review.


PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.

Langelier MF, Pascal JM.

Curr Opin Struct Biol. 2013 Feb;23(1):134-43. doi: 10.1016/ Epub 2013 Jan 16. Review.


Dual roles of PARP-1 promote cancer growth and progression.

Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, Pascal JM, Centenera MM, Butler LM, Tilley WD, Feng FY, Knudsen KE.

Cancer Discov. 2012 Dec;2(12):1134-49. doi: 10.1158/2159-8290.CD-12-0120. Epub 2012 Sep 19.


Identification of the functional binding pocket for compounds targeting small-conductance Ca²⁺-activated potassium channels.

Zhang M, Pascal JM, Schumann M, Armen RS, Zhang JF.

Nat Commun. 2012;3:1021. doi: 10.1038/ncomms2017.


Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.

Langelier MF, Planck JL, Roy S, Pascal JM.

Science. 2012 May 11;336(6082):728-32. doi: 10.1126/science.1216338.


Structural basis for calmodulin as a dynamic calcium sensor.

Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, Chen Y, Loll PJ, Pascal JM, Zhang JF.

Structure. 2012 May 9;20(5):911-23. doi: 10.1016/j.str.2012.03.019.


Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.

Chan TO, Pascal JM, Armen RS, Rodeck U.

Cell Cycle. 2012 Feb 1;11(3):475-8. doi: 10.4161/cc.11.3.19059. Epub 2012 Feb 1. Review.


Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases.

Liu C, Sanders JM, Pascal JM, Hou YM.

RNA. 2012 Feb;18(2):213-21. doi: 10.1261/rna.029983.111. Epub 2011 Dec 19.


Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1120-7. doi: 10.1073/pnas.1109879108. Epub 2011 Oct 26.


Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis.

Langelier MF, Planck JL, Servent KM, Pascal JM.

Methods Mol Biol. 2011;780:209-26. doi: 10.1007/978-1-61779-270-0_13.


Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.

Langelier MF, Planck JL, Roy S, Pascal JM.

J Biol Chem. 2011 Mar 25;286(12):10690-701. doi: 10.1074/jbc.M110.202507. Epub 2011 Jan 13.


The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.

Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM.

J Biol Chem. 2010 Jun 11;285(24):18877-87. doi: 10.1074/jbc.M110.105668. Epub 2010 Apr 13.


The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.

Song W, Pascal JM, Ellenberger T, Tomkinson AE.

DNA Repair (Amst). 2009 Aug 6;8(8):912-9. doi: 10.1016/j.dnarep.2009.05.002. Epub 2009 Jun 11.


DNA and RNA ligases: structural variations and shared mechanisms.

Pascal JM.

Curr Opin Struct Biol. 2008 Feb;18(1):96-105. doi: 10.1016/ Epub 2008 Feb 8. Review.


A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation.

Langelier MF, Servent KM, Rogers EE, Pascal JM.

J Biol Chem. 2008 Feb 15;283(7):4105-14. Epub 2007 Nov 30. Erratum in: J Biol Chem. 2008 Aug 15;283(33):22884.


RNA ligase does the AMP shuffle.

Pascal JM, Ellenberger T.

Nat Struct Mol Biol. 2006 Nov;13(11):950-1. No abstract available.


A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T.

Mol Cell. 2006 Oct 20;24(2):279-91.


DNA ligases: structure, reaction mechanism, and function.

Tomkinson AE, Vijayakumar S, Pascal JM, Ellenberger T.

Chem Rev. 2006 Feb;106(2):687-99. Review. No abstract available.


Human DNA ligase I completely encircles and partially unwinds nicked DNA.

Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T.

Nature. 2004 Nov 25;432(7016):473-8.


Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.

Pascal JM, Hart PJ, Hecht NB, Robertus JD.

J Mol Biol. 2002 Jun 21;319(5):1049-57.


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