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A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments.

Espada A, Haro R, Castañon J, Sayago C, Perez-Cozar F, Cano L, Redero P, Molina-Martin M, Broughton H, Stites RE, Pascal BD, Griffin PR, Dodge JA, Chalmers MJ.

J Am Soc Mass Spectrom. 2019 Nov 13. doi: 10.1007/s13361-019-02331-2. [Epub ahead of print]


HP1 reshapes nucleosome core to promote phase separation of heterochromatin.

Sanulli S, Trnka MJ, Dharmarajan V, Tibble RW, Pascal BD, Burlingame AL, Griffin PR, Gross JD, Narlikar GJ.

Nature. 2019 Nov;575(7782):390-394. doi: 10.1038/s41586-019-1669-2. Epub 2019 Oct 16.


Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry.

Zheng J, Strutzenberg T, Pascal BD, Griffin PR.

Curr Opin Struct Biol. 2019 Oct;58:305-313. doi: 10.1016/ Epub 2019 Jul 25. Review.


Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2019 Jul 11;178(2):507-508. doi: 10.1016/j.cell.2019.06.028. No abstract available.


Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.


Validation of a procedure to mix homogenous solutions in bags and syringes.

Pauline T, Lucie B, Pascal B.

Eur J Hosp Pharm. 2018 Oct;25(e2):e126-e129. doi: 10.1136/ejhpharm-2017-001284. Epub 2017 Aug 31.


Goals, Recommendations, and the How-To Strategies for Developing and Facilitating Patient Safety and System Integration Simulations.

Dubé M, Shultz J, Barnes S, Pascal B, Kaba A.

HERD. 2019 May 6:1937586719846586. doi: 10.1177/1937586719846586. [Epub ahead of print]


Protecting User Privacy and Rights in Academic Data-Sharing Partnerships: Principles From a Pilot Program at Crisis Text Line.

Pisani AR, Kanuri N, Filbin B, Gallo C, Gould M, Lehmann LS, Levine R, Marcotte JE, Pascal B, Rousseau D, Turner S, Yen S, Ranney ML.

J Med Internet Res. 2019 Jan 17;21(1):e11507. doi: 10.2196/11507.


HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.

Zheng J, Wang C, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J, Griffin PR.

Nat Commun. 2018 Dec 18;9(1):5366. doi: 10.1038/s41467-018-07780-z.


Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2018 Dec 13;175(7):1756-1768.e17. doi: 10.1016/j.cell.2018.10.025. Erratum in: Cell. 2019 Jul 11;178(2):507-508.


Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.

Patil DN, Rangarajan ES, Novick SJ, Pascal BD, Kojetin DJ, Griffin PR, Izard T, Martemyanov KA.

Elife. 2018 Dec 12;7. pii: e42150. doi: 10.7554/eLife.42150.


Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function.

Raveendra BL, Swarnkar S, Avchalumov Y, Liu XA, Grinman E, Badal K, Reich A, Pascal BD, Puthanveettil SV.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10197-E10205. doi: 10.1073/pnas.1722587115. Epub 2018 Oct 8.


A questionnaire-based analysis of parental perspectives on pediatric cochlear implant (CI) re/habilitation services: a pilot study from a developing CI service in India.

Dev AN, Lohith U, Pascal B, Dutt CS, Dutt SN.

Cochlear Implants Int. 2018 Nov;19(6):338-349. doi: 10.1080/14670100.2018.1489937. Epub 2018 Jun 29.


Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988.

Frkic RL, Chua BS, Shin Y, Pascal BD, Novick SJ, Kamenecka TM, Griffin PR, Bruning JB.

Nucl Receptor Res. 2018;5. pii: 101350. doi: 10.11131/2018/101350.


HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

Zheng J, Chang MR, Stites RE, Wang Y, Bruning JB, Pascal BD, Novick SJ, Garcia-Ordonez RD, Stayrook KR, Chalmers MJ, Dodge JA, Griffin PR.

Nat Commun. 2017 Oct 13;8(1):923. doi: 10.1038/s41467-017-00978-7.


Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.

Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA.

J Mol Biol. 2017 Nov 24;429(23):3696-3716. doi: 10.1016/j.jmb.2017.09.016. Epub 2017 Sep 29.


Comparative Evaluation of Veriflow®Listeria Species to USDA Culture-Based Method for the Detection of Listeria spp. in Food and Environmental Samples.

Joelsson AC, Terkhorn SP, Brown AS, Puri A, Pascal BJ, Gaudioso ZE, Siciliano NA.

J AOAC Int. 2017 Sep 1;100(5):1434-1444. doi: 10.5740/jaoacint.17-0080. Epub 2017 Jun 20.


RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.

Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S.

Sci Signal. 2016 Nov 15;9(454):ra111.


A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen-Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions.

Saltzberg DJ, Broughton HB, Pellarin R, Chalmers MJ, Espada A, Dodge JA, Pascal BD, Griffin PR, Humblet C, Sali A.

J Phys Chem B. 2017 Apr 20;121(15):3493-3501. doi: 10.1021/acs.jpcb.6b09358. Epub 2016 Dec 1.


Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.

Cummins DJ, Espada A, Novick SJ, Molina-Martin M, Stites RE, Espinosa JF, Broughton H, Goswami D, Pascal BD, Dodge JA, Chalmers MJ, Griffin PR.

Anal Chem. 2016 Jun 21;88(12):6607-14. doi: 10.1021/acs.analchem.6b01650. Epub 2016 Jun 13.


Identification of Bexarotene as a PPARγ Antagonist with HDX.

Marciano DP, Kuruvilla DS, Pascal BD, Griffin PR.

PPAR Res. 2015;2015:254560. doi: 10.1155/2015/254560. Epub 2015 Sep 15.


SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex.

Mari Y, West GM, Scharager-Tapia C, Pascal BD, Garcia-Ordonez RD, Griffin PR.

J Proteome Res. 2015 Nov 6;14(11):4571-80. doi: 10.1021/acs.jproteome.5b00379. Epub 2015 Oct 7.


Software Analysis of Uncorrelated MS1 Peaks for Discovery of Post-Translational Modifications.

Pascal BD, West GM, Scharager-Tapia C, Flefil R, Moroni T, Martinez-Acedo P, Griffin PR, Carvalloza AC.

J Am Soc Mass Spectrom. 2015 Dec;26(12):2133-40. doi: 10.1007/s13361-015-1229-4. Epub 2015 Aug 12.


Conformational states of the full-length glucagon receptor.

Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yang H, Wang MW, Stevens RC, Jiang H.

Nat Commun. 2015 Jul 31;6:7859. doi: 10.1038/ncomms8859.


Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE.

Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22.


Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry.

Goswami D, Tuske S, Pascal BD, Bauman JD, Patel D, Arnold E, Griffin PR.

Anal Chem. 2015 Apr 7;87(7):4015-4022. doi: 10.1021/acs.analchem.5b00372. Epub 2015 Mar 25.


New approach to capture and characterize synaptic proteome.

Liu XA, Kadakkuzha B, Pascal B, Steckler C, Akhmedov K, Yan L, Chalmers M, Puthanveettil SV.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16154-9. doi: 10.1073/pnas.1401483111. Epub 2014 Oct 28.


Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain.

West GM, Willard FS, Sloop KW, Showalter AD, Pascal BD, Griffin PR.

PLoS One. 2014 Sep 2;9(9):e105683. doi: 10.1371/journal.pone.0105683. eCollection 2014.


Veriflow Campylobacter. Performance tested method 101201.

Joelsson AC, Brown AS, Puri A, Keough MP, Pascal BJ, Gaudioso ZE.

J AOAC Int. 2014 May-Jun;97(3):820-8.


Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry.

Goswami D, Callaway C, Pascal BD, Kumar R, Edwards DP, Griffin PR.

Structure. 2014 Jul 8;22(7):961-73. doi: 10.1016/j.str.2014.04.013. Epub 2014 Jun 5.


Nitric oxide-induced conformational changes in soluble guanylate cyclase.

Underbakke ES, Iavarone AT, Chalmers MJ, Pascal BD, Novick S, Griffin PR, Marletta MA.

Structure. 2014 Apr 8;22(4):602-11. doi: 10.1016/j.str.2014.01.008. Epub 2014 Feb 20.


The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARγ, RORs, and Rev-erbs.

Marciano DP, Chang MR, Corzo CA, Goswami D, Lam VQ, Pascal BD, Griffin PR.

Cell Metab. 2014 Feb 4;19(2):193-208. doi: 10.1016/j.cmet.2013.12.009. Epub 2014 Jan 16. Review.


Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.

Landgraf RR, Goswami D, Rajamohan F, Harris MS, Calabrese MF, Hoth LR, Magyar R, Pascal BD, Chalmers MJ, Busby SA, Kurumbail RG, Griffin PR.

Structure. 2013 Nov 5;21(11):1942-53. doi: 10.1016/j.str.2013.08.023. Epub 2013 Sep 26.


Time window expansion for HDX analysis of an intrinsically disordered protein.

Goswami D, Devarakonda S, Chalmers MJ, Pascal BD, Spiegelman BM, Griffin PR.

J Am Soc Mass Spectrom. 2013 Oct;24(10):1584-92. doi: 10.1007/s13361-013-0669-y. Epub 2013 Jul 25.


Suicide attempts in the county of Basel: results from the WHO/EURO Multicentre Study on Suicidal Behaviour.

Flavio M, Martin E, Pascal B, Stephanie C, Gabriela S, Merle K, Anita RR.

Swiss Med Wkly. 2013 May 28;143:w13759. doi: 10.4414/smw.2013.13759. eCollection 2013.


Decoding split and pool combinatorial libraries with electron-transfer dissociation tandem mass spectrometry.

Sarkar M, Pascal BD, Steckler C, Aquino C, Micalizio GC, Kodadek T, Chalmers MJ.

J Am Soc Mass Spectrom. 2013 Jul;24(7):1026-36. doi: 10.1007/s13361-013-0633-x. Epub 2013 May 2.


Perforated duodenal diverticulum, a rare complication of a common pathology: A seven-patient case series.

Rossetti A, Christian BN, Pascal B, Stephane D, Philippe M.

World J Gastrointest Surg. 2013 Mar 27;5(3):47-50. doi: 10.4240/wjgs.v5.i3.47.


Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities.

West GM, Pascal BD, Ng LM, Soon FF, Melcher K, Xu HE, Chalmers MJ, Griffin PR.

Structure. 2013 Feb 5;21(2):229-35. doi: 10.1016/j.str.2012.12.001. Epub 2013 Jan 3.


HDX workbench: software for the analysis of H/D exchange MS data.

Pascal BD, Willis S, Lauer JL, Landgraf RR, West GM, Marciano D, Novick S, Goswami D, Chalmers MJ, Griffin PR.

J Am Soc Mass Spectrom. 2012 Sep;23(9):1512-21. doi: 10.1007/s13361-012-0419-6. Epub 2012 Jun 13.


Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data.

Chalmers MJ, Pascal BD, Willis S, Zhang J, Iturria SJ, Dodge JA, Griffin PR.

Int J Mass Spectrom. 2011 Apr 30;302(1-3):59-68.


DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Wang Y, Busby SA, Pascal BD, Garcia-Ordonez RD, Bruning JB, Istrate MA, Kojetin DJ, Dodge JA, Burris TP, Griffin PR.

Nat Struct Mol Biol. 2011 May;18(5):556-63. doi: 10.1038/nsmb.2046. Epub 2011 Apr 10.


Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, West GM, Griffin PR.

Expert Rev Proteomics. 2011 Feb;8(1):43-59. doi: 10.1586/epr.10.109. Review.


Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Garcia-Ordonez RD, Pascal BD, Burris TP, Dodge JA, Griffin PR.

Structure. 2010 Oct 13;18(10):1332-41. doi: 10.1016/j.str.2010.07.007.


A conceptual framework for analyzing how Canadian physicians are using electronic medical records in clinical care.

Paterson G, Shaw N, Grant A, Leonard K, Delisle E, Mitchell S, McCarrey M, Pascal B, Kraetschmer N.

Stud Health Technol Inform. 2010;160(Pt 1):141-5.


Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange.

Zhang X, Chien EY, Chalmers MJ, Pascal BD, Gatchalian J, Stevens RC, Griffin PR.

Anal Chem. 2010 Feb 1;82(3):1100-8. doi: 10.1021/ac902484p.


Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.

Dai SY, Burris TP, Dodge JA, Montrose-Rafizadeh C, Wang Y, Pascal BD, Chalmers MJ, Griffin PR.

Biochemistry. 2009 Oct 13;48(40):9668-76. doi: 10.1021/bi901149t.


HD desktop: an integrated platform for the analysis and visualization of H/D exchange data.

Pascal BD, Chalmers MJ, Busby SA, Griffin PR.

J Am Soc Mass Spectrom. 2009 Apr;20(4):601-10. doi: 10.1016/j.jasms.2008.11.019. Epub 2008 Dec 6.


[Evaluation of accuracy of three assays for human papillomavirus detection and typing: Hybrid Capture 2, HPV Consensus kit and Amplicor HPV].

Hantz S, Caly H, Decroisette E, Dutrop A, Bakeland D, Pascal B, Darreye G, Dussartre C, Renaudie J, Rogez S, Aubard Y, Denis F, Alain S.

Pathol Biol (Paris). 2008 Feb;56(1):29-35. doi: 10.1016/j.patbio.2007.09.006. Epub 2008 Jan 4. French.


Prostate-specific genes and their regulation by dihydrotestosterone.

Ma C, Yoshioka M, Boivin A, Belleau P, Gan L, Takase Y, Labrie F, St-Amand J.

Prostate. 2008 Feb 15;68(3):241-54. Erratum in: Prostate. 2008 Sep 1;68(12):1372. Ci, Ma [corrected to Ma, Ci]; Mayumi, Yoshioka [corrected to Yoshioka, Mayumi]; André, Boivin [corrected to Boivin, André]; Pascal, Belleau [corrected to Belleau, Pascal]; Lin, Gan [corrected to Gan, Lin]; Yasukazu, Takase [corrected to Takase, Yasukazu].


A two-stage differential hydrogen deuterium exchange method for the rapid characterization of protein/ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, Southern MR, Griffin PR.

J Biomol Tech. 2007 Sep;18(4):194-204.

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