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Items: 37

1.

Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy.

Zhang Q, Green MD, Lang X, Lazarus J, Parsels JD, Wei S, Parsels LA, Shi J, Ramnath N, Wahl DR, Pasca di Magliano M, Frankel TL, Kryczek I, Lei YL, Lawrence TS, Zou W, Morgan MA.

Cancer Res. 2019 Aug 1;79(15):3940-3951. doi: 10.1158/0008-5472.CAN-19-0761. Epub 2019 May 17.

PMID:
31101760
2.

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA.

Cell Metab. 2019 Jun 4;29(6):1390-1399.e6. doi: 10.1016/j.cmet.2019.02.001. Epub 2019 Feb 28.

PMID:
30827862
3.

Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis.

Crawford HC, Pasca di Magliano M, Banerjee S.

Gastroenterology. 2019 May;156(7):2073-2084. doi: 10.1053/j.gastro.2018.12.042. Epub 2019 Feb 1. Review.

4.

Spatial and phenotypic immune profiling of metastatic colon cancer.

Lazarus J, Maj T, Smith JJ, Perusina Lanfranca M, Rao A, D'Angelica MI, Delrosario L, Girgis A, Schukow C, Shia J, Kryczek I, Shi J, Wasserman I, Crawford H, Nathan H, Pasca Di Magliano M, Zou W, Frankel TL.

JCI Insight. 2018 Nov 15;3(22). pii: 121932. doi: 10.1172/jci.insight.121932.

5.

Epithelial-Stromal Interactions in Pancreatic Cancer.

Zhang Y, Crawford HC, Pasca di Magliano M.

Annu Rev Physiol. 2019 Feb 10;81:211-233. doi: 10.1146/annurev-physiol-020518-114515. Epub 2018 Nov 12.

PMID:
30418798
6.

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.

Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M.

Cell Mol Gastroenterol Hepatol. 2017 Nov 10;5(2):169-185.e2. doi: 10.1016/j.jcmgh.2017.10.008. eCollection 2018.

7.

Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer.

Halbrook CJ, Pasca di Magliano M, Lyssiotis CA.

Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G27-G35. doi: 10.1152/ajpgi.00416.2017. Epub 2018 Mar 15. Review.

8.

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, Lyssiotis CA, Ljungman M, Morton JP, Galbán S, Fearon ER, Pasca di Magliano M.

JCI Insight. 2018 Jan 25;3(2). pii: 97422. doi: 10.1172/jci.insight.97422. eCollection 2018 Jan 25.

9.

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice.

Zhang Y, Yan W, Mathew E, Kane KT, Brannon A 3rd, Adoumie M, Vinta A, Crawford HC, Pasca di Magliano M.

Elife. 2017 Oct 5;6. pii: e27388. doi: 10.7554/eLife.27388.

10.

Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma.

Kim SH, Li M, Trousil S, Zhang Y, Pasca di Magliano M, Swanson KD, Zheng B.

J Invest Dermatol. 2017 Aug;137(8):1740-1748. doi: 10.1016/j.jid.2017.03.033. Epub 2017 Apr 19.

11.

Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation.

Zhang Q, Zhang Y, Parsels JD, Lohse I, Lawrence TS, Pasca di Magliano M, Sun Y, Morgan MA.

Neoplasia. 2016 Nov;18(11):666-673. doi: 10.1016/j.neo.2016.08.009. Epub 2016 Oct 18.

12.

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.

Zhang Y, Velez-Delgado A, Mathew E, Li D, Mendez FM, Flannagan K, Rhim AD, Simeone DM, Beatty GL, Pasca di Magliano M.

Gut. 2017 Jan;66(1):124-136. doi: 10.1136/gutjnl-2016-312078. Epub 2016 Jul 8.

13.

Early pancreatic islet fate and maturation is controlled through RBP-Jκ.

Cras-Méneur C, Conlon M, Zhang Y, Pasca Di Magliano M, Bernal-Mizrachi E.

Sci Rep. 2016 May 31;6:26874. doi: 10.1038/srep26874.

14.

GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer.

Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, Schradle KA, Urs S, Pasca Di Magliano M, Welling TH, Palmbos PL, Abel EV, Sahai V, Nagrath S, Wang L, Simeone DM.

Cancer Discov. 2016 Aug;6(8):886-99. doi: 10.1158/2159-8290.CD-15-0947. Epub 2016 May 16.

15.

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

Yang S, Imamura Y, Jenkins RW, Cañadas I, Kitajima S, Aref A, Brannon A, Oki E, Castoreno A, Zhu Z, Thai T, Reibel J, Qian Z, Ogino S, Wong KK, Baba H, Kimmelman AC, Pasca Di Magliano M, Barbie DA.

Cancer Immunol Res. 2016 Jun;4(6):520-30. doi: 10.1158/2326-6066.CIR-15-0235. Epub 2016 Apr 11.

16.

Change isn't always better.

Schofield H, Pasca di Magliano M.

Elife. 2015 Aug 14;4. doi: 10.7554/eLife.10054.

17.

Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.

Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M.

Carcinogenesis. 2015 Jul;36(7):730-8. doi: 10.1093/carcin/bgv058. Epub 2015 May 4.

18.

ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.

Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM.

Genes Dev. 2015 Jan 15;29(2):171-83. doi: 10.1101/gad.253591.114.

19.

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models.

DeCant BT, Principe DR, Guerra C, Pasca di Magliano M, Grippo PJ.

Front Physiol. 2014 Dec 4;5:464. doi: 10.3389/fphys.2014.00464. eCollection 2014. Review.

20.

Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis.

Thomas MM, Zhang Y, Mathew E, Kane KT, Maillard I, Pasca di Magliano M.

BMC Cancer. 2014 Nov 22;14:862. doi: 10.1186/1471-2407-14-862.

21.

Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling.

Mathew E, Zhang Y, Holtz AM, Kane KT, Song JY, Allen BL, Pasca di Magliano M.

Cell Rep. 2014 Oct 23;9(2):484-94. doi: 10.1016/j.celrep.2014.09.010. Epub 2014 Oct 9.

22.

Immune cells in pancreatic cancer: Joining the dark side.

Zhang Y, McAllister F, Pasca di Magliano M.

Oncoimmunology. 2014 Jun 5;3:e29125. eCollection 2014.

23.

Kras as a key oncogene and therapeutic target in pancreatic cancer.

Collins MA, Pasca di Magliano M.

Front Physiol. 2014 Jan 21;4:407. doi: 10.3389/fphys.2013.00407. eCollection 2013. Review.

24.

MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice.

Collins MA, Yan W, Sebolt-Leopold JS, Pasca di Magliano M.

Gastroenterology. 2014 Mar;146(3):822-834.e7. doi: 10.1053/j.gastro.2013.11.052. Epub 2013 Dec 6.

25.

Canonical wnt signaling is required for pancreatic carcinogenesis.

Zhang Y, Morris JP 4th, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M.

Cancer Res. 2013 Aug 1;73(15):4909-22. doi: 10.1158/0008-5472.CAN-12-4384. Epub 2013 Jun 12.

26.

Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.

Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME.

J Biol Chem. 2013 Apr 26;288(17):11786-94. doi: 10.1074/jbc.M112.438846. Epub 2013 Mar 12.

27.

Advances in acute and chronic pancreatitis: from development to inflammation and repair.

Pasca di Magliano M, Forsmark C, Freedman S, Hebrok M, Pasricha PJ, Saluja A, Stanger BZ, Holt J, Serrano J, James SP, Rustgi AK.

Gastroenterology. 2013 Jan;144(1):e1-4. doi: 10.1053/j.gastro.2012.11.018. Epub 2012 Nov 15. No abstract available.

28.

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.

Collins MA, Bednar F, Zhang Y, Brisset JC, Galbán S, Galbán CJ, Rakshit S, Flannagan KS, Adsay NV, Pasca di Magliano M.

J Clin Invest. 2012 Feb;122(2):639-53. doi: 10.1172/JCI59227. Epub 2012 Jan 9.

29.

c-Met is a marker of pancreatic cancer stem cells and therapeutic target.

Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, Pasca di Magliano M, Simeone DM.

Gastroenterology. 2011 Dec;141(6):2218-2227.e5. doi: 10.1053/j.gastro.2011.08.009. Epub 2011 Aug 22.

PMID:
21864475
30.

Pancreatic cancer and hedgehog pathway signaling: new insights.

Dosch JS, Pasca di Magliano M, Simeone DM.

Pancreatology. 2010;10(2-3):151-7. doi: 10.1159/000225923. Epub 2010 May 7.

PMID:
20453550
31.

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.

Decker T, Pasca di Magliano M, McManus S, Sun Q, Bonifer C, Tagoh H, Busslinger M.

Immunity. 2009 Apr 17;30(4):508-20. doi: 10.1016/j.immuni.2009.01.012. Epub 2009 Apr 2.

32.

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Pasca di Magliano M, Biankin AV, Heiser PW, Cano DA, Gutierrez PJ, Deramaudt T, Segara D, Dawson AC, Kench JG, Henshall SM, Sutherland RL, Dlugosz A, Rustgi AK, Hebrok M.

PLoS One. 2007 Nov 7;2(11):e1155.

33.

A small-molecule antagonist of the hedgehog signaling pathway.

Lee J, Wu X, Pasca di Magliano M, Peters EC, Wang Y, Hong J, Hebrok M, Ding S, Cho CY, Schultz PG.

Chembiochem. 2007 Nov 5;8(16):1916-9. No abstract available.

PMID:
17886323
34.

Hedgehog/Ras interactions regulate early stages of pancreatic cancer.

Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M.

Genes Dev. 2006 Nov 15;20(22):3161-73.

35.

Hedgehog signalling in cancer formation and maintenance.

Pasca di Magliano M, Hebrok M.

Nat Rev Cancer. 2003 Dec;3(12):903-11. Review. No abstract available.

PMID:
14737121
36.

Pax8 has a key role in thyroid cell differentiation.

Pasca di Magliano M, Di Lauro R, Zannini M.

Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13144-9.

37.

The thyroid transcription factor 2 (TTF-2) is a promoter-specific DNA-binding independent transcriptional repressor.

Perrone L, Pasca di Magliano M, Zannini M, Di Lauro R.

Biochem Biophys Res Commun. 2000 Aug 18;275(1):203-8.

PMID:
10944465

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