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Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster.

Weigelt CM, Hahn O, Arlt K, Gruhn M, Jahn AJ, Eßer J, Werner JA, Klein C, Büschges A, Grönke S, Partridge L.

Life Sci Alliance. 2019 Jan 22;2(1). pii: e201800149. doi: 10.26508/lsa.201800149. Print 2019 Feb.


Using the drug-protein interactome to identify anti-ageing compounds for humans.

Fuentealba M, Dönertaş HM, Williams R, Labbadia J, Thornton JM, Partridge L.

PLoS Comput Biol. 2019 Jan 9;15(1):e1006639. doi: 10.1371/journal.pcbi.1006639. eCollection 2019 Jan.


C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.

Moens TG, Niccoli T, Wilson KM, Atilano ML, Birsa N, Gittings LM, Holbling BV, Dyson MC, Thoeng A, Neeves J, Glaria I, Yu L, Bussmann J, Storkebaum E, Pardo M, Choudhary JS, Fratta P, Partridge L, Isaacs AM.

Acta Neuropathol. 2019 Jan 2. doi: 10.1007/s00401-018-1946-4. [Epub ahead of print]


Identifying Potential Ageing-Modulating Drugs In Silico.

Dönertaş HM, Fuentealba M, Partridge L, Thornton JM.

Trends Endocrinol Metab. 2019 Feb;30(2):118-131. doi: 10.1016/j.tem.2018.11.005. Epub 2018 Dec 20. Review.


Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity.

Hahn O, Stubbs TM, Reik W, Grönke S, Beyer A, Partridge L.

PLoS Genet. 2018 Nov 21;14(11):e1007766. doi: 10.1371/journal.pgen.1007766. eCollection 2018 Nov.


Early Progressive Mobilization of Patients with External Ventricular Drains: Safety and Feasibility.

Yataco RA, Arnold SM, Brown SM, David Freeman W, Carmen Cononie C, Heckman MG, Partridge LW, Stucky CM, Mellon LN, Birst JL, Daron KL, Zapata-Cooper MH, Schudlich DM.

Neurocrit Care. 2018 Oct 24. doi: 10.1007/s12028-018-0632-7. [Epub ahead of print]


Mutations of mitochondrial DNA are not major contributors to aging of fruit flies.

Kauppila TES, Bratic A, Jensen MB, Baggio F, Partridge L, Jasper H, Grönke S, Larsson NG.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9620-E9629. doi: 10.1073/pnas.1721683115. Epub 2018 Sep 24.


Facing up to the global challenges of ageing.

Partridge L, Deelen J, Slagboom PE.

Nature. 2018 Sep;561(7721):45-56. doi: 10.1038/s41586-018-0457-8. Epub 2018 Sep 5. Review.


Horizons in the evolution of aging.

Flatt T, Partridge L.

BMC Biol. 2018 Aug 20;16(1):93. doi: 10.1186/s12915-018-0562-z. Review.


Gene expression-based drug repurposing to target aging.

Dönertaş HM, Fuentealba Valenzuela M, Partridge L, Thornton JM.

Aging Cell. 2018 Oct;17(5):e12819. doi: 10.1111/acel.12819. Epub 2018 Aug 9.


Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button.

Woodling NS, Partridge L.

Neuron. 2018 Jun 27;98(6):1059-1061. doi: 10.1016/j.neuron.2018.06.025.


Monocyte Subsets Have Distinct Patterns of Tetraspanin Expression and Different Capacities to Form Multinucleate Giant Cells.

Champion TC, Partridge LJ, Ong SM, Malleret B, Wong SC, Monk PN.

Front Immunol. 2018 Jun 8;9:1247. doi: 10.3389/fimmu.2018.01247. eCollection 2018.


Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension.

Catterson JH, Khericha M, Dyson MC, Vincent AJ, Callard R, Haveron SM, Rajasingam A, Ahmad M, Partridge L.

Curr Biol. 2018 Jun 4;28(11):1714-1724.e4. doi: 10.1016/j.cub.2018.04.015. Epub 2018 May 17.


Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster.

Augustin H, McGourty K, Allen MJ, Adcott J, Wong CT, Boucrot E, Partridge L.

Neurobiol Aging. 2018 Jun;66:149-157. doi: 10.1016/j.neurobiolaging.2018.02.027. Epub 2018 Mar 6.


Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Moens TG, Mizielinska S, Niccoli T, Mitchell JS, Thoeng A, Ridler CE, Grönke S, Esser J, Heslegrave A, Zetterberg H, Partridge L, Isaacs AM.

Acta Neuropathol. 2018 Mar;135(3):445-457. doi: 10.1007/s00401-017-1798-3. Epub 2018 Jan 29.


G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM.

EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850.


The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations.

Rust A, Partridge LJ, Davletov B, Hautbergue GM.

Toxins (Basel). 2017 Oct 27;9(11). pii: E344. doi: 10.3390/toxins9110344. Review.


Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity.

Bolukbasi E, Khericha M, Regan JC, Ivanov DK, Adcott J, Dyson MC, Nespital T, Thornton JM, Alic N, Partridge L.

Cell Rep. 2017 Oct 17;21(3):641-653. doi: 10.1016/j.celrep.2017.09.042.


Ageing as a risk factor for ALS/FTD.

Niccoli T, Partridge L, Isaacs AM.

Hum Mol Genet. 2017 Oct 1;26(R2):R105-R113. doi: 10.1093/hmg/ddx247. Review.


Drosophila as a model for ageing.

Piper MDW, Partridge L.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2707-2717. doi: 10.1016/j.bbadis.2017.09.016. Epub 2017 Sep 28. Review.


A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.

Tain LS, Sehlke R, Jain C, Chokkalingam M, Nagaraj N, Essers P, Rassner M, Grönke S, Froelich J, Dieterich C, Mann M, Alic N, Beyer A, Partridge L.

Mol Syst Biol. 2017 Sep 15;13(9):939. doi: 10.15252/msb.20177663.


Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.

Augustin H, McGourty K, Allen MJ, Madem SK, Adcott J, Kerr F, Wong CT, Vincent A, Godenschwege T, Boucrot E, Partridge L.

PLoS Biol. 2017 Sep 13;15(9):e2001655. doi: 10.1371/journal.pbio.2001655. eCollection 2017 Sep.


Novel Rbfox2 isoforms associated with alternative exon usage in rat cortex and suprachiasmatic nucleus.

Partridge LMM, Carter DA.

Sci Rep. 2017 Aug 30;7(1):9929. doi: 10.1038/s41598-017-10535-3.


Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity.

Gorsky MK, Burnouf S, Sofola-Adesakin O, Dols J, Augustin H, Weigelt CM, Grönke S, Partridge L.

Sci Rep. 2017 Aug 30;7(1):9984. doi: 10.1038/s41598-017-10225-0.


Small nucleoli are a cellular hallmark of longevity.

Tiku V, Jain C, Raz Y, Nakamura S, Heestand B, Liu W, Späth M, Suchiman HED, Müller RU, Slagboom PE, Partridge L, Antebi A.

Nat Commun. 2017 Aug 30;8:16083. doi: 10.1038/ncomms16083.


Complex roles of myoglianin in regulating adult performance and lifespan.

Augustin H, Adcott J, Elliott CJH, Partridge L.

Fly (Austin). 2017 Oct 2;11(4):284-289. doi: 10.1080/19336934.2017.1369638. Epub 2017 Aug 24.


Good Ol' Fat: Links between Lipid Signaling and Longevity.

Bustos V, Partridge L.

Trends Biochem Sci. 2017 Oct;42(10):812-823. doi: 10.1016/j.tibs.2017.07.001. Epub 2017 Aug 9. Review.


Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.

Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W.

Elife. 2017 Jul 12;6. pii: e24662. doi: 10.7554/eLife.24662.


Drug repurposing for aging research using model organisms.

Ziehm M, Kaur S, Ivanov DK, Ballester PJ, Marcus D, Partridge L, Thornton JM.

Aging Cell. 2017 Oct;16(5):1006-1015. doi: 10.1111/acel.12626. Epub 2017 Jun 16.


A role for the tetraspanin proteins in Salmonella infection of human macrophages.

Hassuna NA, Monk PN, Ali F, Read RC, Partridge LJ.

J Infect. 2017 Aug;75(2):115-124. doi: 10.1016/j.jinf.2017.06.003. Epub 2017 Jun 8.


Two forms of death in ageing Caenorhabditis elegans.

Zhao Y, Gilliat AF, Ziehm M, Turmaine M, Wang H, Ezcurra M, Yang C, Phillips G, McBay D, Zhang WB, Partridge L, Pincus Z, Gems D.

Nat Commun. 2017 May 23;8:15458. doi: 10.1038/ncomms15458.


Myostatin-like proteins regulate synaptic function and neuronal morphology.

Augustin H, McGourty K, Steinert JR, Cochemé HM, Adcott J, Cabecinha M, Vincent A, Halff EF, Kittler JT, Boucrot E, Partridge L.

Development. 2017 Jul 1;144(13):2445-2455. doi: 10.1242/dev.152975. Epub 2017 May 22.


Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.

Piper MDW, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L.

Cell Metab. 2017 May 2;25(5):1206. doi: 10.1016/j.cmet.2017.04.020. No abstract available.


2nd interventions in aging conference.

Kennedy BK, Partridge L.

Aging (Albany NY). 2017 Apr;9(4):1090-1095. doi: 10.18632/aging.101221. No abstract available.


Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.

Mizielinska S, Ridler CE, Balendra R, Thoeng A, Woodling NS, Grässer FA, Plagnol V, Lashley T, Partridge L, Isaacs AM.

Acta Neuropathol Commun. 2017 Apr 18;5(1):29. doi: 10.1186/s40478-017-0432-x.


Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis.

Yaseen IH, Monk PN, Partridge LJ.

Biochem Soc Trans. 2017 Apr 15;45(2):465-475. doi: 10.1042/BST20160022. Review.


Genetic models of C9orf72: what is toxic?

Moens TG, Partridge L, Isaacs AM.

Curr Opin Genet Dev. 2017 Jun;44:92-101. doi: 10.1016/j.gde.2017.01.006. Epub 2017 Mar 29. Review.


Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L.

Genome Biol. 2017 Mar 28;18(1):56. doi: 10.1186/s13059-017-1187-1.


Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.

Piper MDW, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L.

Cell Metab. 2017 Mar 7;25(3):610-621. doi: 10.1016/j.cmet.2017.02.005. Erratum in: Cell Metab. 2017 May 2;25(5):1206.


Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L.

PLoS Genet. 2017 Mar 2;13(3):e1006593. doi: 10.1371/journal.pgen.1006593. eCollection 2017 Mar.


Physical and functional outcomes following multidisciplinary residential rehabilitation for prearthritic hip pain among young active UK military personnel.

Coppack RJ, Bilzon JL, Wills AK, McCurdie IM, Partridge LK, Nicol AM, Bennett AN.

BMJ Open Sport Exerc Med. 2016 Apr 1;2(1):e000107. eCollection 2016.


A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin.

Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L.

J Neurosci. 2016 Nov 16;36(46):11654-11670.


mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA.

Nat Commun. 2016 Oct 27;7:13226. doi: 10.1038/ncomms13226.


Protocols to Study Aging in Drosophila.

Piper MD, Partridge L.

Methods Mol Biol. 2016;1478:291-302. Review.


pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity.

Sofola-Adesakin O, Khericha M, Snoeren I, Tsuda L, Partridge L.

Acta Neuropathol Commun. 2016 Oct 7;4(1):109.


Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing.

Kakanj P, Moussian B, Grönke S, Bustos V, Eming SA, Partridge L, Leptin M.

Nat Commun. 2016 Oct 7;7:12972. doi: 10.1038/ncomms12972.


Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.

Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L.

Curr Biol. 2016 Sep 26;26(18):2550. doi: 10.1016/j.cub.2016.09.018. Epub 2016 Sep 26. No abstract available.


Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.

Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L.

Curr Biol. 2016 Sep 12;26(17):2291-300. doi: 10.1016/j.cub.2016.07.017. Epub 2016 Aug 11. Erratum in: Curr Biol. 2016 Sep 26;26(18):2550.


Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications.

Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L.

Brain. 2016 Dec;139(Pt 12):e68. Epub 2016 Aug 6. No abstract available.


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