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Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1).

Nagarajan P, Agudelo Garcia PA, Iyer CC, Popova LV, Arnold WD, Parthun MR.

Aging Cell. 2019 Oct;18(5):e12992. doi: 10.1111/acel.12992. Epub 2019 Jul 10.


Isolation of Proteins on Nascent Chromatin and Characterization by Quantitative Mass Spectrometry.

Agudelo Garcia PA, Gardner M, Freitas MA, Parthun MR.

Methods Mol Biol. 2019;1983:17-27. doi: 10.1007/978-1-4939-9434-2_2.


Corrigenda: Replication-dependent histone isoforms: a new source of complexity in chromatin structure and function.

Singh R, Bassett E, Chakravarti A, Parthun MR.

Nucleic Acids Res. 2018 Oct 12;46(18):9893-9894. doi: 10.1093/nar/gky831. No abstract available.


Replication-dependent histone isoforms: a new source of complexity in chromatin structure and function.

Singh R, Bassett E, Chakravarti A, Parthun MR.

Nucleic Acids Res. 2018 Sep 28;46(17):8665-8678. doi: 10.1093/nar/gky768. Review. Erratum in: Nucleic Acids Res. 2018 Oct 12;46(18):9893-9894.


Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly.

Agudelo Garcia PA, Hoover ME, Zhang P, Nagarajan P, Freitas MA, Parthun MR.

Nucleic Acids Res. 2017 Sep 19;45(16):9319-9335. doi: 10.1093/nar/gkx545.


Linker histone H1 and H3K56 acetylation are antagonistic regulators of nucleosome dynamics.

Bernier M, Luo Y, Nwokelo KC, Goodwin M, Dreher SJ, Zhang P, Parthun MR, Fondufe-Mittendorf Y, Ottesen JJ, Poirier MG.

Nat Commun. 2015 Dec 9;6:10152. doi: 10.1038/ncomms10152.


Proteomic profiling identifies specific histone species associated with leukemic and cancer cells.

Singh R, Harshman SW, Ruppert AS, Mortazavi A, Lucas DM, Thomas-Ahner JM, Clinton SK, Byrd JC, Freitas MA, Parthun MR.

Clin Proteomics. 2015 Aug 27;12(1):22. doi: 10.1186/s12014-015-9095-4. eCollection 2015.


Spinal Muscular Atrophy Biomarker Measurements from Blood Samples in a Clinical Trial of Valproic Acid in Ambulatory Adults.

Renusch SR, Harshman S, Pi H, Workman E, Wehr A, Li X, Prior TW, Elsheikh BH, Swoboda KJ, Simard LR, Kissel JT, Battle D, Parthun MR, Freitas MA, Kolb SJ.

J Neuromuscul Dis. 2015 Jun 4;2(2):119-130.


The yeast histone chaperone hif1p functions with RNA in nucleosome assembly.

Knapp AR, Wang H, Parthun MR.

PLoS One. 2014 Jul 29;9(7):e100299. doi: 10.1371/journal.pone.0100299. eCollection 2014.


Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex.

Li Y, Zhang L, Liu T, Chai C, Fang Q, Wu H, Agudelo Garcia PA, Han Z, Zong S, Yu Y, Zhang X, Parthun MR, Chai J, Xu RM, Yang M.

Genes Dev. 2014 Jun 1;28(11):1217-27. doi: 10.1101/gad.240531.114. Epub 2014 May 16.


Histone acetyltransferase 1: more than just an enzyme?

Parthun MR.

Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):256-63. Review.


SILAC peptide ratio calculator: a tool for SILAC quantitation of peptides and post-translational modifications.

Guan X, Rastogi N, Parthun MR, Freitas MA.

J Proteome Res. 2014 Feb 7;13(2):506-16. doi: 10.1021/pr400675n. Epub 2014 Jan 9.


Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis.

Singh R, Mortazavi A, Telu KH, Nagarajan P, Lucas DM, Thomas-Ahner JM, Clinton SK, Byrd JC, Freitas MA, Parthun MR.

Nucleic Acids Res. 2013 Nov;41(20):9284-95. doi: 10.1093/nar/gkt736. Epub 2013 Aug 16.


H1 histones: current perspectives and challenges.

Harshman SW, Young NL, Parthun MR, Freitas MA.

Nucleic Acids Res. 2013 Nov;41(21):9593-609. doi: 10.1093/nar/gkt700. Epub 2013 Aug 14. Review.


Sites of acetylation on newly synthesized histone H4 are required for chromatin assembly and DNA damage response signaling.

Ge Z, Nair D, Guan X, Rastogi N, Freitas MA, Parthun MR.

Mol Cell Biol. 2013 Aug;33(16):3286-98. doi: 10.1128/MCB.00460-13. Epub 2013 Jun 17.


Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.

Nagarajan P, Ge Z, Sirbu B, Doughty C, Agudelo Garcia PA, Schlederer M, Annunziato AT, Cortez D, Kenner L, Parthun MR.

PLoS Genet. 2013 Jun;9(6):e1003518. doi: 10.1371/journal.pgen.1003518. Epub 2013 Jun 6.


Discovery of histone modification crosstalk networks by stable isotope labeling of amino acids in cell culture mass spectrometry (SILAC MS).

Guan X, Rastogi N, Parthun MR, Freitas MA.

Mol Cell Proteomics. 2013 Aug;12(8):2048-59. doi: 10.1074/mcp.M112.026716. Epub 2013 Apr 15.


miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.

Sandhu SK, Volinia S, Costinean S, Galasso M, Neinast R, Santhanam R, Parthun MR, Perrotti D, Marcucci G, Garzon R, Croce CM.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20047-52. doi: 10.1073/pnas.1213764109. Epub 2012 Nov 19.


CENP-A exceeds microtubule attachment sites in centromere clusters of both budding and fission yeast.

Coffman VC, Wu P, Parthun MR, Wu JQ.

J Cell Biol. 2011 Nov 14;195(4):563-72. doi: 10.1083/jcb.201106078.


The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms.

Wang H, Ge Z, Walsh ST, Parthun MR.

Nucleic Acids Res. 2012 Jan;40(2):660-9. doi: 10.1093/nar/gkr781. Epub 2011 Sep 29.


Histone acetyltransferase 1: More than just an enzyme?

Parthun MR.

Biochim Biophys Acta. 2012 Mar;1819(3-4):256-63. doi: 10.1016/j.bbagrm.2011.07.006. Epub 2011 Jul 18.


Genetic interactions between POB3 and the acetylation of newly synthesized histones.

Nair DM, Ge Z, Mersfelder EL, Parthun MR.

Curr Genet. 2011 Aug;57(4):271-86. doi: 10.1007/s00294-011-0347-1. Epub 2011 Jun 9.


Nuclear Hat1p complex (NuB4) components participate in DNA repair-linked chromatin reassembly.

Ge Z, Wang H, Parthun MR.

J Biol Chem. 2011 May 13;286(19):16790-9. doi: 10.1074/jbc.M110.216846. Epub 2011 Mar 17.


The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.

Lucas DM, Alinari L, West DA, Davis ME, Edwards RB, Johnson AJ, Blum KA, Hofmeister CC, Freitas MA, Parthun MR, Wang D, Lehman A, Zhang X, Jarjoura D, Kulp SK, Croce CM, Grever MR, Chen CS, Baiocchi RA, Byrd JC.

PLoS One. 2010 Jun 3;5(6):e10941. doi: 10.1371/journal.pone.0010941.


Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia.

Su X, Lucas DM, Zhang L, Xu H, Zabrouskov V, Davis ME, Knapp AR, Young DC, Payne PR, Parthun MR, Marcucci G, Grever MR, Byrd JC, Freitas MA.

Proteomics. 2009 Mar;9(5):1197-206. doi: 10.1002/pmic.200800333.


Expanded binding specificity of the human histone chaperone NASP.

Wang H, Walsh ST, Parthun MR.

Nucleic Acids Res. 2008 Oct;36(18):5763-72. doi: 10.1093/nar/gkn574. Epub 2008 Sep 9.


Involvement of Hat1p (Kat1p) catalytic activity and subcellular localization in telomeric silencing.

Mersfelder EL, Parthun MR.

J Biol Chem. 2008 Oct 24;283(43):29060-8. doi: 10.1074/jbc.M802564200. Epub 2008 Aug 26.


Hat1: the emerging cellular roles of a type B histone acetyltransferase.

Parthun MR.

Oncogene. 2007 Aug 13;26(37):5319-28. Review.


Quantitative profiling of histone post-translational modifications by stable isotope labeling.

Knapp AR, Ren C, Su X, Lucas DM, Byrd JC, Freitas MA, Parthun MR.

Methods. 2007 Mar;41(3):312-9.


Histone H4 acetylation dynamics determined by stable isotope labeling with amino acids in cell culture and mass spectrometry.

Su X, Zhang L, Lucas DM, Davis ME, Knapp AR, Green-Church KB, Marcucci G, Parthun MR, Byrd JC, Freitas MA.

Anal Biochem. 2007 Apr 1;363(1):22-34. Epub 2006 Dec 20.


Liquid chromatography mass spectrometry profiling of histones.

Su X, Jacob NK, Amunugama R, Lucas DM, Knapp AR, Ren C, Davis ME, Marcucci G, Parthun MR, Byrd JC, Fishel R, Freitas MA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):440-54. Epub 2007 Jan 7.


Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

Benson LJ, Phillips JA, Gu Y, Parthun MR, Hoffman CS, Annunziato AT.

J Biol Chem. 2007 Jan 12;282(2):836-42. Epub 2006 Oct 19.


Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repression.

Lindstrom KC, Vary JC Jr, Parthun MR, Delrow J, Tsukiyama T.

Mol Cell Biol. 2006 Aug;26(16):6117-29.


The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure.

Mersfelder EL, Parthun MR.

Nucleic Acids Res. 2006 May 19;34(9):2653-62. Print 2006. Review.


Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors.

Ren C, Zhang L, Freitas MA, Ghoshal K, Parthun MR, Jacob ST.

J Am Soc Mass Spectrom. 2005 Oct;16(10):1641-53.


Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly.

Ye J, Ai X, Eugeni EE, Zhang L, Carpenter LR, Jelinek MA, Freitas MA, Parthun MR.

Mol Cell. 2005 Apr 1;18(1):123-30.


Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder.

Roychowdhury S, Baiocchi RA, Vourganti S, Bhatt D, Blaser BW, Freud AG, Chou J, Chen CS, Xiao JJ, Parthun M, Chan KK, Eisenbeis CF, Ferketich AK, Grever MR, Chen CS, Caligiuri MA.

J Natl Cancer Inst. 2004 Oct 6;96(19):1447-57.


A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

Byrd JC, Marcucci G, Parthun MR, Xiao JJ, Klisovic RB, Moran M, Lin TS, Liu S, Sklenar AR, Davis ME, Lucas DM, Fischer B, Shank R, Tejaswi SL, Binkley P, Wright J, Chan KK, Grever MR.

Blood. 2005 Feb 1;105(3):959-67. Epub 2004 Oct 5.


Application of mass spectrometry to the identification and quantification of histone post-translational modifications.

Freitas MA, Sklenar AR, Parthun MR.

J Cell Biochem. 2004 Jul 1;92(4):691-700. Review.


The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells.

Lucas DM, Davis ME, Parthun MR, Mone AP, Kitada S, Cunningham KD, Flax EL, Wickham J, Reed JC, Byrd JC, Grever MR.

Leukemia. 2004 Jul;18(7):1207-14.


Differential expression of histone post-translational modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry.

Zhang L, Freitas MA, Wickham J, Parthun MR, Klisovic MI, Marcucci G, Byrd JC.

J Am Soc Mass Spectrom. 2004 Jan;15(1):77-86.


Identification of novel histone post-translational modifications by peptide mass fingerprinting.

Zhang L, Eugeni EE, Parthun MR, Freitas MA.

Chromosoma. 2003 Aug;112(2):77-86. Epub 2003 Jul 9.


Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines.

Klisovic DD, Katz SE, Effron D, Klisovic MI, Wickham J, Parthun MR, Guimond M, Marcucci G.

Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2390-8.


Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein.

Aron JL, Parthun MR, Marcucci G, Kitada S, Mone AP, Davis ME, Shen T, Murphy T, Wickham J, Kanakry C, Lucas DM, Reed JC, Grever MR, Byrd JC.

Blood. 2003 Jul 15;102(2):652-8. Epub 2003 Mar 20.


Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells.

Klisovic MI, Maghraby EA, Parthun MR, Guimond M, Sklenar AR, Whitman SP, Chan KK, Murphy T, Anon J, Archer KJ, Rush LJ, Plass C, Grever MR, Byrd JC, Marcucci G.

Leukemia. 2003 Feb;17(2):350-8.


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