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Items: 33


Regulating behavior with the flip of a translational switch.

Ceh-Pavia E, Partch CL.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13151-13153. doi: 10.1073/pnas.1819247116. Epub 2018 Dec 13. No abstract available.


CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.

Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5986-5991. doi: 10.1073/pnas.1721076115. Epub 2018 May 21.


Structure, function, and mechanism of the core circadian clock in cyanobacteria.

Swan JA, Golden SS, LiWang A, Partch CL.

J Biol Chem. 2018 Apr 6;293(14):5026-5034. doi: 10.1074/jbc.TM117.001433. Epub 2018 Feb 13. Review.


Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms.

Fong JC, Rogers A, Michael AK, Parsley NC, Cornell WC, Lin YC, Singh PK, Hartmann R, Drescher K, Vinogradov E, Dietrich LE, Partch CL, Yildiz FH.

Elife. 2017 Aug 1;6. pii: e26163. doi: 10.7554/eLife.26163.


Assembly and function of bHLH-PAS complexes.

Fribourgh JL, Partch CL.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5330-5332. doi: 10.1073/pnas.1705408114. Epub 2017 May 15. No abstract available.


A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms.

Gustafson CL, Parsley NC, Asimgil H, Lee HW, Ahlbach C, Michael AK, Xu H, Williams OL, Davis TL, Liu AC, Partch CL.

Mol Cell. 2017 May 18;66(4):447-457.e7. doi: 10.1016/j.molcel.2017.04.011. Epub 2017 May 11.


Structural basis of the day-night transition in a bacterial circadian clock.

Tseng R, Goularte NF, Chavan A, Luu J, Cohen SE, Chang YG, Heisler J, Li S, Michael AK, Tripathi S, Golden SS, LiWang A, Partch CL.

Science. 2017 Mar 17;355(6330):1174-1180. doi: 10.1126/science.aag2516. Epub 2017 Mar 16.


Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.

Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny D, Tripathi SM, Takahashi JS, Partch CL.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1560-1565. doi: 10.1073/pnas.1615310114. Epub 2017 Jan 31.


Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond.

Michael AK, Fribourgh JL, Van Gelder RN, Partch CL.

Photochem Photobiol. 2017 Jan;93(1):128-140. doi: 10.1111/php.12677. Epub 2017 Jan 18. Review.


Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.

Militi S, Maywood ES, Sandate CR, Chesham JE, Barnard AR, Parsons MJ, Vibert JL, Joynson GM, Partch CL, Hastings MH, Nolan PM.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2756-61. doi: 10.1073/pnas.1517549113. Epub 2016 Feb 22.


Cytosolic BMAL1 moonlights as a translation factor.

Michael AK, Asimgil H, Partch CL.

Trends Biochem Sci. 2015 Sep;40(9):489-90. doi: 10.1016/j.tibs.2015.07.006. Epub 2015 Aug 7.


Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus.

Xu H, Gustafson CL, Sammons PJ, Khan SK, Parsley NC, Ramanathan C, Lee HW, Liu AC, Partch CL.

Nat Struct Mol Biol. 2015 Jun;22(6):476-484. doi: 10.1038/nsmb.3018. Epub 2015 May 11.


Cancer/Testis Antigen PASD1 Silences the Circadian Clock.

Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL.

Mol Cell. 2015 Jun 4;58(5):743-54. doi: 10.1016/j.molcel.2015.03.031. Epub 2015 Apr 30.


Analysis of protein stability and ligand interactions by thermal shift assay.

Huynh K, Partch CL.

Curr Protoc Protein Sci. 2015 Feb 2;79:28.9.1-14. doi: 10.1002/0471140864.ps2809s79.


Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.

Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH.

J Biol Chem. 2015 Mar 20;290(12):7707-21. doi: 10.1074/jbc.M114.632786. Epub 2015 Jan 27.


Emerging models for the molecular basis of mammalian circadian timing.

Gustafson CL, Partch CL.

Biochemistry. 2015 Jan 20;54(2):134-49. doi: 10.1021/bi500731f. Epub 2014 Dec 30. Review.


An imPERfect link to cancer?

Kopalle HM, Partch CL.

Cell Cycle. 2014;13(4):507. doi: 10.4161/cc.27862. Epub 2014 Jan 20. No abstract available.


Antibacterial membrane attack by a pore-forming intestinal C-type lectin.

Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV.

Nature. 2014 Jan 2;505(7481):103-7. doi: 10.1038/nature12729. Epub 2013 Nov 20.


Molecular architecture of the mammalian circadian clock.

Partch CL, Green CB, Takahashi JS.

Trends Cell Biol. 2014 Feb;24(2):90-9. doi: 10.1016/j.tcb.2013.07.002. Epub 2013 Aug 1. Review.


Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.

Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH.

ACS Chem Biol. 2013 Mar 15;8(3):626-35. doi: 10.1021/cb300604u. Epub 2012 Dec 26.


Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

Partch CL, Gardner KH.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7739-44. doi: 10.1073/pnas.1101357108. Epub 2011 Apr 21.


The three Rs of transcription: recruit, retain, and recycle.

Motta-Mena LB, Partch CL, Gardner KH.

Mol Cell. 2010 Dec 22;40(6):855-8. doi: 10.1016/j.molcel.2010.12.010.


Molecular basis for peptidoglycan recognition by a bactericidal lectin.

Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7722-7. doi: 10.1073/pnas.0909449107. Epub 2010 Apr 9.


Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family.

Partch CL, Gardner KH.

J Cell Physiol. 2010 Jun;223(3):553-7. doi: 10.1002/jcp.22067. Review.


Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).

Partch CL, Card PB, Amezcua CA, Gardner KH.

J Biol Chem. 2009 May 29;284(22):15184-92. doi: 10.1074/jbc.M808479200. Epub 2009 Mar 26.


Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.

Mukherjee S, Partch CL, Lehotzky RE, Whitham CV, Chu H, Bevins CL, Gardner KH, Hooper LV.

J Biol Chem. 2009 Feb 20;284(8):4881-8. doi: 10.1074/jbc.M808077200. Epub 2008 Dec 18.


Purification and characterization of a type III photolyase from Caulobacter crescentus.

Oztürk N, Kao YT, Selby CP, Kavakli IH, Partch CL, Zhong D, Sancar A.

Biochemistry. 2008 Sep 30;47(39):10255-61. doi: 10.1021/bi801085a. Epub 2008 Sep 5.


Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implications for photolyase activity.

Huang Y, Baxter R, Smith BS, Partch CL, Colbert CL, Deisenhofer J.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17701-6. Epub 2006 Nov 13.


Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

Partch CL, Shields KF, Thompson CL, Selby CP, Sancar A.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10467-10472. doi: 10.1073/pnas.0604138103. Epub 2006 Jun 21.


Photochemistry and photobiology of cryptochrome blue-light photopigments: the search for a photocycle.

Partch CL, Sancar A.

Photochem Photobiol. 2005 Nov-Dec;81(6):1291-304. Review.


Cryptochromes and circadian photoreception in animals.

Partch CL, Sancar A.

Methods Enzymol. 2005;393:726-45.


Role of structural plasticity in signal transduction by the cryptochrome blue-light photoreceptor.

Partch CL, Clarkson MW, Ozgür S, Lee AL, Sancar A.

Biochemistry. 2005 Mar 15;44(10):3795-805.


Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction.

Thompson CL, Selby CP, Partch CL, Plante DT, Thresher RJ, Araujo F, Sancar A.

Brain Res Mol Brain Res. 2004 Mar 30;122(2):158-66.


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