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Cerebral Blood Perfusion Predicts Response to Sertraline versus Placebo for Major Depressive Disorder in the EMBARC Trial.

Cooper CM, Chin Fatt CR, Jha M, Fonzo GA, Grannemann BD, Carmody T, Ali A, Aslan S, Almeida JRC, Deckersbach T, Fava M, Kurian BT, McGrath PJ, McInnis M, Parsey RV, Weissman M, Phillips ML, Lu H, Etkin A, Trivedi MH.

EClinicalMedicine. 2019 May 18;10:32-41. doi: 10.1016/j.eclinm.2019.04.007. eCollection 2019 Apr.


Examining raphe-amygdala structural connectivity as a biological predictor of SSRI response.

Pillai RLI, Huang C, LaBella A, Zhang M, Yang J, Trivedi M, Weissman M, McGrath P, Fava M, Kurian B, Cooper C, McInnis M, Oquendo MA, Pizzagalli DA, Parsey RV, DeLorenzo C.

J Affect Disord. 2019 May 28;256:8-16. doi: 10.1016/j.jad.2019.05.055. [Epub ahead of print]


Childhood trauma history is linked to abnormal brain connectivity in major depression.

Yu M, Linn KA, Shinohara RT, Oathes DJ, Cook PA, Duprat R, Moore TM, Oquendo MA, Phillips ML, McInnis M, Fava M, Trivedi MH, McGrath P, Parsey R, Weissman MM, Sheline YI.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8582-8590. doi: 10.1073/pnas.1900801116. Epub 2019 Apr 8.


Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial.

Whitton AE, Webb CA, Dillon DG, Kayser J, Rutherford A, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello JM, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH, Pizzagalli DA.

Biol Psychiatry. 2019 May 15;85(10):872-880. doi: 10.1016/j.biopsych.2018.12.007. Epub 2018 Dec 19.


Anxiety and anhedonia in depression: Associations with neuroticism and cognitive control.

Liao A, Walker R, Carmody TJ, Cooper C, Shaw MA, Grannemann BD, Adams P, Bruder GE, McInnis MG, Webb CA, Dillon DG, Pizzagalli DA, Phillips ML, Kurian BT, Fava M, Parsey RV, McGrath PJ, Weissman MM, Trivedi MH.

J Affect Disord. 2019 Feb 15;245:1070-1078. doi: 10.1016/j.jad.2018.11.072. Epub 2018 Nov 14.


The Concise Health Risk Tracking-Self Report: Psychometrics within a placebo-controlled antidepressant trial among depressed outpatients.

Trombello JM, Killian MO, Grannemann BD, Rush AJ, Mayes TL, Parsey RV, McInnis M, Jha MK, Ali A, McGrath PJ, Adams P, Oquendo MA, Weissman MM, Carmody TJ, Trivedi MH.

J Psychopharmacol. 2019 Feb;33(2):185-193. doi: 10.1177/0269881118817156. Epub 2019 Jan 17.


Resting regional brain activity correlates of verbal learning deficit in major depressive disorder.

Milak MS, Potter WA, Pantazatos SP, Keilp JG, Zanderigo F, Schain M, Sublette ME, Oquendo MA, Malone KM, Brandenburg H, Parsey RV, Mann JJ.

Psychiatry Res Neuroimaging. 2019 Jan 30;283:96-103. doi: 10.1016/j.pscychresns.2018.12.006. Epub 2018 Dec 8.


Quantification of Positron Emission Tomography Data Using Simultaneous Estimation of the Input Function: Validation with Venous Blood and Replication of Clinical Studies.

Bartlett EA, Ananth M, Rossano S, Zhang M, Yang J, Lin SF, Nabulsi N, Huang Y, Zanderigo F, Parsey RV, DeLorenzo C.

Mol Imaging Biol. 2018 Dec 7. doi: 10.1007/s11307-018-1300-1. [Epub ahead of print]


In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons.

Kumar JSD, Zanderigo F, Prabhakaran J, Rubin-Falcone H, Parsey RV, Mann JJ.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3592-3595. doi: 10.1016/j.bmcl.2018.10.049. Epub 2018 Oct 31.


The Importance of Publishing Negative Findings in Science.

Parsey R.

Biol Psychiatry. 2018 Oct 15;84(8):550. doi: 10.1016/j.biopsych.2018.08.010. No abstract available.


Synthesis of Patient-Specific Transmission Data for PET Attenuation Correction for PET/MRI Neuroimaging Using a Convolutional Neural Network.

Spuhler KD, Gardus J 3rd, Gao Y, DeLorenzo C, Parsey R, Huang C.

J Nucl Med. 2019 Apr;60(4):555-560. doi: 10.2967/jnumed.118.214320. Epub 2018 Aug 30.


Development and evaluation of a multimodal marker of major depressive disorder.

Yang J, Zhang M, Ahn H, Zhang Q, Jin TB, Li I, Nemesure M, Joshi N, Jiang H, Miller JM, Ogden RT, Petkova E, Milak MS, Sublette ME, Sullivan GM, Trivedi MH, Weissman M, McGrath PJ, Fava M, Kurian BT, Pizzagalli DA, Cooper CM, McInnis M, Oquendo MA, Mann JJ, Parsey RV, DeLorenzo C.

Hum Brain Mapp. 2018 Nov;39(11):4420-4439. doi: 10.1002/hbm.24282. Epub 2018 Aug 16.


A Novel Strategy to Identify Placebo Responders: Prediction Index of Clinical and Biological Markers in the EMBARC Trial.

Trivedi MH, South C, Jha MK, Rush AJ, Cao J, Kurian B, Phillips M, Pizzagalli DA, Trombello JM, Oquendo MA, Cooper C, Dillon DG, Webb C, Grannemann BD, Bruder G, McGrath PJ, Parsey R, Weissman M, Fava M.

Psychother Psychosom. 2018;87(5):285-295. doi: 10.1159/000491093. Epub 2018 Aug 15.


In Vivo Brain Imaging, Biodistribution, and Radiation Dosimetry Estimation of [11C]Celecoxib, a COX-2 PET Ligand, in Nonhuman Primates.

Kumar JSD, Bai B, Zanderigo F, DeLorenzo C, Prabhakaran J, Parsey RV, Mann JJ.

Molecules. 2018 Aug 2;23(8). pii: E1929. doi: 10.3390/molecules23081929.


Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study.

Webb CA, Trivedi MH, Cohen ZD, Dillon DG, Fournier JC, Goer F, Fava M, McGrath PJ, Weissman M, Parsey R, Adams P, Trombello JM, Cooper C, Deldin P, Oquendo MA, McInnis MG, Huys Q, Bruder G, Kurian BT, Jha M, DeRubeis RJ, Pizzagalli DA.

Psychol Med. 2019 May;49(7):1118-1127. doi: 10.1017/S0033291718001708. Epub 2018 Jul 2.


Pretreatment and early-treatment cortical thickness is associated with SSRI treatment response in major depressive disorder.

Bartlett EA, DeLorenzo C, Sharma P, Yang J, Zhang M, Petkova E, Weissman M, McGrath PJ, Fava M, Ogden RT, Kurian BT, Malchow A, Cooper CM, Trombello JM, McInnis M, Adams P, Oquendo MA, Pizzagalli DA, Trivedi M, Parsey RV.

Neuropsychopharmacology. 2018 Oct;43(11):2221-2230. doi: 10.1038/s41386-018-0122-9. Epub 2018 Jun 19.


Kappa opioid receptor binding in major depression: A pilot study.

Miller JM, Zanderigo F, Purushothaman PD, DeLorenzo C, Rubin-Falcone H, Ogden RT, Keilp J, Oquendo MA, Nabulsi N, Huang YH, Parsey RV, Carson RE, Mann JJ.

Synapse. 2018 Sep;72(9):e22042. doi: 10.1002/syn.22042. Epub 2018 Jul 17.


Radiosynthesis and in vivo evaluation of [11C]MOV as a PET imaging agent for COX-2.

Prabhakaran J, Underwood M, Zanderigo F, Simpson NR, Cooper AR, Matthew J, Rubin-Falcone H, Parsey RV, Mann JJ, Dileep Kumar JS.

Bioorg Med Chem Lett. 2018 Aug 1;28(14):2432-2435. doi: 10.1016/j.bmcl.2018.06.015. Epub 2018 Jun 12.


Higher 5-HT1A autoreceptor binding as an endophenotype for major depressive disorder identified in high risk offspring - A pilot study.

Milak MS, Pantazatos S, Rashid R, Zanderigo F, DeLorenzo C, Hesselgrave N, Ogden RT, Oquendo MA, Mulhern ST, Miller JM, Burke AK, Parsey RV, Mann JJ.

Psychiatry Res Neuroimaging. 2018 Jun 30;276:15-23. doi: 10.1016/j.pscychresns.2018.04.002. Epub 2018 Apr 13.


Characterizing anxiety subtypes and the relationship to behavioral phenotyping in major depression: Results from the EMBARC study.

Trombello JM, Pizzagalli DA, Weissman MM, Grannemann BD, Cooper CM, Greer TL, Malchow AL, Jha MK, Carmody TJ, Kurian BT, Webb CA, Dillon DG, McGrath PJ, Bruder G, Fava M, Parsey RV, McInnis MG, Adams P, Trivedi MH.

J Psychiatr Res. 2018 Jul;102:207-215. doi: 10.1016/j.jpsychires.2018.04.003. Epub 2018 Apr 6.


Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres.

Nørgaard M, Ganz M, Svarer C, Feng L, Ichise M, Lanzenberger R, Lubberink M, Parsey RV, Politis M, Rabiner EA, Slifstein M, Sossi V, Suhara T, Talbot PS, Turkheimer F, Strother SC, Knudsen GM.

J Cereb Blood Flow Metab. 2019 Feb;39(2):210-222. doi: 10.1177/0271678X18770107. Epub 2018 Apr 13.


Pretreatment Rostral Anterior Cingulate Cortex Theta Activity in Relation to Symptom Improvement in Depression: A Randomized Clinical Trial.

Pizzagalli DA, Webb CA, Dillon DG, Tenke CE, Kayser J, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello J, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH.

JAMA Psychiatry. 2018 Jun 1;75(6):547-554. doi: 10.1001/jamapsychiatry.2018.0252.


Molecular connectivity disruptions in males with major depressive disorder.

Pillai RL, Zhang M, Yang J, Mann JJ, Oquendo MA, Parsey RV, DeLorenzo C.

J Cereb Blood Flow Metab. 2018 Mar 9:271678X18764053. doi: 10.1177/0271678X18764053. [Epub ahead of print]


[11C]Harmine Binding to Brain Monoamine Oxidase A: Test-Retest Properties and Noninvasive Quantification.

Zanderigo F, D'Agostino AE, Joshi N, Schain M, Kumar D, Parsey RV, DeLorenzo C, Mann JJ.

Mol Imaging Biol. 2018 Aug;20(4):667-681. doi: 10.1007/s11307-018-1165-3.


Will imaging individual raphe nuclei in males with major depressive disorder enhance diagnostic sensitivity and specificity?

Pillai RLI, Zhang M, Yang J, Boldrini M, Mann JJ, Oquendo MA, Parsey RV, DeLorenzo C.

Depress Anxiety. 2018 May;35(5):411-420. doi: 10.1002/da.22721. Epub 2018 Jan 24.


Relations between cortical thickness, serotonin 1A receptor binding, and structural connectivity: A multimodal imaging study.

Pillai RLI, Malhotra A, Rupert DD, Weschler B, Williams JC, Zhang M, Yang J, Mann JJ, Oquendo MA, Parsey RV, DeLorenzo C.

Hum Brain Mapp. 2018 Feb;39(2):1043-1055. doi: 10.1002/hbm.23903. Epub 2017 Nov 27.


Noise contamination from PET blood sampling pump: Effects on structural MRI image quality in simultaneous PET/MR studies.

Bartlett E, DeLorenzo C, Parsey R, Huang C.

Med Phys. 2018 Feb;45(2):678-686. doi: 10.1002/mp.12715. Epub 2017 Dec 22.


Utility of Molecular and Structural Brain Imaging to Predict Progression from Mild Cognitive Impairment to Dementia.

Lan MJ, Ogden RT, Kumar D, Stern Y, Parsey RV, Pelton GH, Rubin-Falcone H, Pradhaban G, Zanderigo F, Miller JM, Mann JJ, Devanand DP.

J Alzheimers Dis. 2017;60(3):939-947. doi: 10.3233/JAD-161284.


Neuroticism and Individual Differences in Neural Function in Unmedicated Major Depression: Findings from the EMBARC Study.

Fournier JC, Chase HW, Greenberg T, Etkin A, Almeida JR, Stiffler R, Deckersbach T, Weyandt S, Cooper C, Toups M, Carmody T, Kurian B, Peltier S, Adams P, McInnis MG, Oquendo MA, McGrath PJ, Fava M, Weissman M, Parsey R, Trivedi MH, Phillips ML.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):138-148. doi: 10.1016/j.bpsc.2016.11.008. Epub 2016 Dec 6.


Diffusion Entropy: A Potential Neuroimaging Biomarker of Bipolar Disorder in the Temporal Pole.

Spuhler K, Bartlett E, Ding J, DeLorenzo C, Parsey R, Huang C.

Synapse. 2018 Feb;72(2). doi: 10.1002/syn.22015. Epub 2017 Oct 7.


Decreased Pretreatment Amygdalae Serotonin Transporter Binding in Unipolar Depression Remitters: A Prospective PET Study.

Ananth MR, DeLorenzo C, Yang J, Mann JJ, Parsey RV.

J Nucl Med. 2018 Apr;59(4):665-670. doi: 10.2967/jnumed.117.189654. Epub 2017 Sep 21. Erratum in: J Nucl Med. 2018 May;59(5):858.


Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling: Findings from the EMBARC study.

Almeida JRC, Greenberg T, Lu H, Chase HW, Fournier JC, Cooper CM, Deckersbach T, Adams P, Carmody T, Fava M, Kurian B, McGrath PJ, McInnis MG, Oquendo MA, Parsey R, Weissman M, Trivedi M, Phillips ML.

Magn Reson Imaging. 2018 Jan;45:26-33. doi: 10.1016/j.mri.2017.09.004. Epub 2017 Sep 6.


A positron emission tomography study of the serotonergic system in relation to anxiety in depression.

Iscan Z, Rakesh G, Rossano S, Yang J, Zhang M, Miller J, Sullivan GM, Sharma P, McClure M, Oquendo MA, Mann JJ, Parsey RV, DeLorenzo C.

Eur Neuropsychopharmacol. 2017 Oct;27(10):1011-1021. doi: 10.1016/j.euroneuro.2017.07.009. Epub 2017 Aug 12.


Statistical Analysis Plan for Stage 1 EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care) Study.

Petkova E, Ogden RT, Tarpey T, Ciarleglio A, Jiang B, Su Z, Carmody T, Adams P, Kraemer HC, Grannemann BD, Oquendo MA, Parsey R, Weissman M, McGrath PJ, Fava M, Trivedi MH.

Contemp Clin Trials Commun. 2017 Jun;6:22-30. doi: 10.1016/j.conctc.2017.02.007. Epub 2017 Feb 24.


Cortical thickness is not associated with current depression in a clinical treatment study.

Perlman G, Bartlett E, DeLorenzo C, Weissman M, McGrath P, Ogden T, Jin T, Adams P, Trivedi M, Kurian B, Oquendo M, McInnis M, Weyandt S, Fava M, Cooper C, Malchow A, Parsey R.

Hum Brain Mapp. 2017 Sep;38(9):4370-4385. doi: 10.1002/hbm.23664. Epub 2017 Jun 8.


Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression.

Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C.

Mol Psychiatry. 2018 Apr;23(4):824-832. doi: 10.1038/mp.2017.58. Epub 2017 Apr 11.


A comparison of structural connectivity in anxious depression versus non-anxious depression.

Delaparte L, Yeh FC, Adams P, Malchow A, Trivedi MH, Oquendo MA, Deckersbach T, Ogden T, Pizzagalli DA, Fava M, Cooper C, McInnis M, Kurian BT, Weissman MM, McGrath PJ, Klein DN, Parsey RV, DeLorenzo C.

J Psychiatr Res. 2017 Jun;89:38-47. doi: 10.1016/j.jpsychires.2017.01.012. Epub 2017 Jan 24.


Demonstrating test-retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response.

Tenke CE, Kayser J, Pechtel P, Webb CA, Dillon DG, Goer F, Murray L, Deldin P, Kurian BT, McGrath PJ, Parsey R, Trivedi M, Fava M, Weissman MM, McInnis M, Abraham K, E Alvarenga J, Alschuler DM, Cooper C, Pizzagalli DA, Bruder GE.

Psychophysiology. 2017 Jan;54(1):34-50. doi: 10.1111/psyp.12758.


In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB.

DeLorenzo C, Gallezot JD, Gardus J, Yang J, Planeta B, Nabulsi N, Ogden RT, Labaree DC, Huang YH, Mann JJ, Gasparini F, Lin X, Javitch JA, Parsey RV, Carson RE, Esterlis I.

J Cereb Blood Flow Metab. 2017 Aug;37(8):2716-2727. doi: 10.1177/0271678X16673646. Epub 2016 Jan 1.


Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults.

Strupp-Levitsky M, Miller JM, Rubin-Falcone H, Zanderigo F, Milak MS, Sullivan G, Ogden RT, Oquendo MA, DeLorenzo C, Simpson N, Parsey RV, Mann JJ.

Psychiatry Res Neuroimaging. 2016 Sep 30;255:81-6. doi: 10.1016/j.pscychresns.2016.08.002. Epub 2016 Aug 8.


Positron Emission Tomographic Imaging of the Serotonergic System and Prediction of Risk and Lethality of Future Suicidal Behavior.

Oquendo MA, Galfalvy H, Sullivan GM, Miller JM, Milak MM, Sublette ME, Cisneros-Trujillo S, Burke AK, Parsey RV, Mann JJ.

JAMA Psychiatry. 2016 Oct 1;73(10):1048-1055. doi: 10.1001/jamapsychiatry.2016.1478.


Autoradiographic Evaluation of [(18)F]FECUMI-101, a High Affinity 5-HT1AR Ligand in Human Brain.

Kumar JS, Underwood MD, Simpson NR, Kassir SA, Prabhakaran J, Majo VJ, Bakalian MJ, Parsey RV, Mann JJ, Arango V.

ACS Med Chem Lett. 2016 Mar 13;7(5):482-6. doi: 10.1021/acsmedchemlett.5b00499. eCollection 2016 May 12.


Utility of positron emission tomography for drug development for heart failure.

Papadimitriou L, Smith-Jones PM, Sarwar CM, Marti CN, Yaddanapudi K, Skopicki HA, Gheorghiade M, Parsey R, Butler J.

Am Heart J. 2016 May;175:142-52. doi: 10.1016/j.ahj.2016.02.016. Epub 2016 Feb 27. Review.


Developing New Treatments for Heart Failure: Focus on the Heart.

Gheorghiade M, Larson CJ, Shah SJ, Greene SJ, Cleland JG, Colucci WS, Dunnmon P, Epstein SE, Kim RJ, Parsey RV, Stockbridge N, Carr J, Dinh W, Krahn T, Kramer F, Wahlander K, Deckelbaum LI, Crandall D, Okada S, Senni M, Sikora S, Sabbah HN, Butler J.

Circ Heart Fail. 2016 May;9(5). pii: e002727. doi: 10.1161/CIRCHEARTFAILURE.115.002727.


Establishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): Rationale and design.

Trivedi MH, McGrath PJ, Fava M, Parsey RV, Kurian BT, Phillips ML, Oquendo MA, Bruder G, Pizzagalli D, Toups M, Cooper C, Adams P, Weyandt S, Morris DW, Grannemann BD, Ogden RT, Buckner R, McInnis M, Kraemer HC, Petkova E, Carmody TJ, Weissman MM.

J Psychiatr Res. 2016 Jul;78:11-23. doi: 10.1016/j.jpsychires.2016.03.001. Epub 2016 Mar 15.


Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic Disorders.

Mukherjee P, Sabharwal A, Kotov R, Szekely A, Parsey R, Barch DM, Mohanty A.

Schizophr Bull. 2016 Jul;42(4):1056-67. doi: 10.1093/schbul/sbw012. Epub 2016 Feb 23.


Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers.

Kumar JS, Walker M, Packiarajan M, Jubian V, Prabhakaran J, Chandrasena G, Pratap M, Parsey RV, Mann JJ.

ACS Chem Neurosci. 2016 May 18;7(5):540-5. doi: 10.1021/acschemneuro.5b00315. Epub 2016 Feb 22.


The 5-HT1A receptor in Major Depressive Disorder.

Kaufman J, DeLorenzo C, Choudhury S, Parsey RV.

Eur Neuropsychopharmacol. 2016 Mar;26(3):397-410. doi: 10.1016/j.euroneuro.2015.12.039. Epub 2016 Jan 11. Review.


Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [¹¹C]ABP688.

DeLorenzo C, Sovago J, Gardus J, Xu J, Yang J, Behrje R, Kumar JS, Devanand DP, Pelton GH, Mathis CA, Mason NS, Gomez-Mancilla B, Aizenstein H, Mann JJ, Parsey RV.

Transl Psychiatry. 2015 Dec 8;5:e693. doi: 10.1038/tp.2015.189.


Relationship of the serotonin transporter gene promoter polymorphism (5-HTTLPR) genotype and serotonin transporter binding to neural processing of negative emotional stimuli.

Schneck N, Miller JM, Delorenzo C, Kikuchi T, Sublette ME, Oquendo MA, Mann JJ, Parsey RV.

J Affect Disord. 2016 Jan 15;190:494-498. doi: 10.1016/j.jad.2015.10.047. Epub 2015 Nov 4.

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