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Items: 12

1.

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches.

Guo Y, Chu X, Parrott NJ, Brouwer KLR, Hsu V, Nagar S, Matsson P, Sharma P, Snoeys J, Sugiyama Y, Tatosian D, Unadkat JD, Huang SM, Galetin A; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):865-889. doi: 10.1002/cpt.1183. Epub 2018 Sep 12.

PMID:
30059145
2.

Importance of target-mediated drug disposition for small molecules.

Smith DA, van Waterschoot RAB, Parrott NJ, Olivares-Morales A, Lavé T, Rowland M.

Drug Discov Today. 2018 Dec;23(12):2023-2030. doi: 10.1016/j.drudis.2018.06.010. Epub 2018 Jun 19. Review.

PMID:
29928850
3.

Impact of target interactions on small-molecule drug disposition: an overlooked area.

van Waterschoot RAB, Parrott NJ, Olivares-Morales A, Lavé T, Rowland M, Smith DA.

Nat Rev Drug Discov. 2018 Apr;17(4):299. doi: 10.1038/nrd.2018.26. Epub 2018 Feb 23. No abstract available.

PMID:
29472637
4.

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

Kratochwil NA, Triyatni M, Mueller MB, Klammers F, Leonard B, Turley D, Schmaler J, Ekiciler A, Molitor B, Walter I, Gonsard PA, Tournillac CA, Durrwell A, Marschmann M, Jones R, Ullah M, Boess F, Ottaviani G, Jin Y, Parrott NJ, Fowler S.

J Pharmacol Exp Ther. 2018 May;365(2):237-248. doi: 10.1124/jpet.117.245712. Epub 2018 Feb 16.

PMID:
29453199
5.

A novel orally available small molecule that inhibits hepatitis B virus expression.

Mueller H, Wildum S, Luangsay S, Walther J, Lopez A, Tropberger P, Ottaviani G, Lu W, Parrott NJ, Zhang JD, Schmucki R, Racek T, Hoflack JC, Kueng E, Point F, Zhou X, Steiner G, Lütgehetmann M, Rapp G, Volz T, Dandri M, Yang S, Young JAT, Javanbakht H.

J Hepatol. 2018 Mar;68(3):412-420. doi: 10.1016/j.jhep.2017.10.014. Epub 2017 Oct 25.

6.

Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing.

Stillhart C, Parrott NJ, Lindenberg M, Chalus P, Bentley D, Szepes A.

AAPS J. 2017 May;19(3):827-836. doi: 10.1208/s12248-017-0060-1. Epub 2017 Feb 24.

PMID:
28236228
7.

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.

Kratochwil NA, Meille C, Fowler S, Klammers F, Ekiciler A, Molitor B, Simon S, Walter I, McGinnis C, Walther J, Leonard B, Triyatni M, Javanbakht H, Funk C, Schuler F, Lavé T, Parrott NJ.

AAPS J. 2017 Mar;19(2):534-550. doi: 10.1208/s12248-016-0019-7. Epub 2017 Jan 3.

PMID:
28050713
8.

Physiologically Based Absorption Modeling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Alectinib.

Parrott NJ, Yu LJ, Takano R, Nakamura M, Morcos PN.

AAPS J. 2016 Nov;18(6):1464-1474. Epub 2016 Jul 22.

PMID:
27450228
9.

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs.

Kristoffersson AN, David-Pierson P, Parrott NJ, Kuhlmann O, Lave T, Friberg LE, Nielsen EI.

Pharm Res. 2016 May;33(5):1115-25. doi: 10.1007/s11095-016-1856-x. Epub 2016 Jan 19.

PMID:
26786016
10.

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.

PMID:
25665805
11.

Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state.

Arndt M, Chokshi H, Tang K, Parrott NJ, Reppas C, Dressman JB.

Eur J Pharm Biopharm. 2013 Aug;84(3):633-41. doi: 10.1016/j.ejpb.2013.01.010. Epub 2013 Feb 19.

PMID:
23434923
12.

Expression profiles of metabolic enzymes and drug transporters in the liver and along the intestine of beagle dogs.

Haller S, Schuler F, Lazic SE, Bachir-Cherif D, Krämer SD, Parrott NJ, Steiner G, Belli S.

Drug Metab Dispos. 2012 Aug;40(8):1603-10. doi: 10.1124/dmd.112.045443. Epub 2012 May 17.

PMID:
22596220

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