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Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein.

Gomez W, Morales R, Maracaja-Coutinho V, Parra V, Nassif M.

Aging (Albany NY). 2020 Jan 9;12(1):1011-1033. doi: 10.18632/aging.102677. Epub 2020 Jan 9.


Emerging role of mitophagy in cardiovascular physiology and pathology.

Morales PE, Arias-Durán C, Ávalos-Guajardo Y, Aedo G, Verdejo HE, Parra V, Lavandero S.

Mol Aspects Med. 2019 Oct 3:100822. doi: 10.1016/j.mam.2019.09.006. [Epub ahead of print] Review.


Polycystin-2 Is Required for Starvation- and Rapamycin-Induced Atrophy in Myotubes.

Kretschmar C, Peña-Oyarzun D, Hernando C, Hernández-Moya N, Molina-Berríos A, Hernández-Cáceres MP, Lavandero S, Budini M, Morselli E, Parra V, Troncoso R, Criollo A.

Front Endocrinol (Lausanne). 2019 May 8;10:280. doi: 10.3389/fendo.2019.00280. eCollection 2019.


Dermoscopic Features of Spiradenocylindroma.

Senarega A, Flores L, Innocenti AC, Parra V.

Actas Dermosifiliogr. 2019 Sep;110(7):604-606. doi: 10.1016/ Epub 2019 Apr 16. English, Spanish. No abstract available.


Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.

Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S.

Cell Death Differ. 2019 Nov;26(11):2494. doi: 10.1038/s41418-019-0279-8.


Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.

Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA.

EMBO Rep. 2018 Dec;19(12). pii: e44706. doi: 10.15252/embr.201744706. Epub 2018 Nov 2.


Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.

Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S.

Cell Death Differ. 2019 Jul;26(7):1195-1212. doi: 10.1038/s41418-018-0197-1. Epub 2018 Sep 12. Erratum in: Cell Death Differ. 2019 Feb 11;:.


[Spinal subacute combined degeneration after intrathecal chemotherapy. Report of two cases].

Cartier R L, Parra V J, Puga B, Cardemil D.

Rev Med Chil. 2018 Jun;146(6):802-807. doi: 10.4067/s0034-98872018000600802. Spanish.


Correction to: Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both.

Olloquequi J, Jaime S, Parra V, Cornejo-Córdova E, Valdivia G, Agustí À, Silva RO.

Respir Res. 2018 Apr 30;19(1):77. doi: 10.1186/s12931-018-0765-4.


Polycystin-2-dependent control of cardiomyocyte autophagy.

Criollo A, Altamirano F, Pedrozo Z, Schiattarella GG, Li DL, Rivera-Mejías P, Sotomayor-Flores C, Parra V, Villalobos E, Battiprolu PK, Jiang N, May HI, Morselli E, Somlo S, de Smedt H, Gillette TG, Lavandero S, Hill JA.

J Mol Cell Cardiol. 2018 May;118:110-121. doi: 10.1016/j.yjmcc.2018.03.002. Epub 2018 Mar 6.


Narrowband UV-B Phototherapy in the Treatment of Generalized Hailey-Hailey Disease.

Abaca MC, Flores L, Parra V.

Actas Dermosifiliogr. 2018 Dec;109(10):924-927. doi: 10.1016/ Epub 2018 Feb 18. English, Spanish. No abstract available.


Chronic Diarrhea as the Only Symptom in a Patient With Duodenal-Colo-Renal Primary Fistula.

Parra V, Preciado Aponte J, Huertas Quintero M, Garcia S, Carlos Sabbagh L.

ACG Case Rep J. 2018 Jan 17;5:e7. doi: 10.14309/crj.2018.7. eCollection 2018. No abstract available.


Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network.

Parra V, Altamirano F, Hernández-Fuentes CP, Tong D, Kyrychenko V, Rotter D, Pedrozo Z, Hill JA, Eisner V, Lavandero S, Schneider JW, Rothermel BA.

Circ Res. 2018 Mar 16;122(6):e20-e33. doi: 10.1161/CIRCRESAHA.117.311522. Epub 2018 Jan 23.


Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both.

Olloquequi J, Jaime S, Parra V, Cornejo-Córdova E, Valdivia G, Agustí À, Silva O R.

Respir Res. 2018 Jan 18;19(1):13. doi: 10.1186/s12931-018-0718-y. Erratum in: Respir Res. 2018 Apr 30;19(1):77.


The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.

Shaikh S, Troncoso R, Mondaca-Ruff D, Parra V, Garcia L, Chiong M, Lavandero S.

Toxicol In Vitro. 2018 Apr;48:121-127. doi: 10.1016/j.tiv.2018.01.005. Epub 2018 Jan 12.


Inonotosis in Patient with Hematologic Malignancy.

Fernández-Cruz A, Kwon M, Guinea J, Escribano P, Jiménez MDCM, Pulido A, Parra V, Serrano D, Gayoso J, Martín JLD, Bouza E.

Emerg Infect Dis. 2018 Jan;24(1):180-182. doi: 10.3201/eid2401.171265.


Chile Crece Contigo: Implementation, results, and scaling-up lessons.

Torres A, Lopez Boo F, Parra V, Vazquez C, Segura-Pérez S, Cetin Z, Pérez-Escamilla R.

Child Care Health Dev. 2018 Jan;44(1):4-11. doi: 10.1111/cch.12519. Review.


Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis.

Romero-Sánchez C, Bautista-Molano W, Parra V, De Avila J, Rueda JC, Bello-Gualtero JM, Londoño J, Valle-Oñate R.

Int J Rheumatol. 2017;2017:4029584. doi: 10.1155/2017/4029584. Epub 2017 Oct 29.


Endoscopic Sleeve Gastroplasty, Laparoscopic Sleeve Gastrectomy, and Laparoscopic Band for Weight Loss: How Do They Compare?

Novikov AA, Afaneh C, Saumoy M, Parra V, Shukla A, Dakin GF, Pomp A, Dawod E, Shah S, Aronne LJ, Sharaiha RZ.

J Gastrointest Surg. 2018 Feb;22(2):267-273. doi: 10.1007/s11605-017-3615-7. Epub 2017 Nov 6.


Low-cost technique for resection of a large duodenal lipoma with the aid of a modified polypectomy snare.

Parra V, Preciado J, Huertas M, Acero F, Aponte DM, Sabbagh LC.

Endoscopy. 2018 Jan;50(1):E22. doi: 10.1055/s-0043-120265. Epub 2017 Nov 3. No abstract available.


Novel management of a necrotic pancreatic fluid collection with staged cystgastrostomy followed by cystgastrojejunostomy: the Lizzie Grace maneuver.

Xu MM, Kumta N, Marfatia P, Parra V, Silva G, Brown EG, Tyberg A, Sharaiha R, Kahaleh M.

Endoscopy. 2017 Nov;49(11):E290-E291. doi: 10.1055/s-0043-117999. Epub 2017 Sep 13. No abstract available.


Gastric peroral endoscopic myotomy for gastroparesis, after botulinum toxin injection.

Saumoy M, Nassani N, Ortiz J, Parra V, Tyberg A, Kahaleh M.

Endoscopy. 2017 Oct;49(10):E256-E257. doi: 10.1055/s-0043-115888. Epub 2017 Jul 31. No abstract available.


Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells.

Parra V, Bravo-Sagua R, Norambuena-Soto I, Hernández-Fuentes CP, Gómez-Contreras AG, Verdejo HE, Mellado R, Chiong M, Lavandero S, Castro PF.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2891-2903. doi: 10.1016/j.bbadis.2017.07.018. Epub 2017 Jul 22.


Calcium Transport and Signaling in Mitochondria.

Bravo-Sagua R, Parra V, López-Crisosto C, Díaz P, Quest AF, Lavandero S.

Compr Physiol. 2017 Mar 16;7(2):623-634. doi: 10.1002/cphy.c160013. Review.


Calcineurin signaling in the heart: The importance of time and place.

Parra V, Rothermel BA.

J Mol Cell Cardiol. 2017 Feb;103:121-136. doi: 10.1016/j.yjmcc.2016.12.006. Epub 2016 Dec 20. Review.


The binding effectiveness of anti-r-disintegrin polyclonal antibodies against disintegrins and PII and PIII metalloproteases: An immunological survey of type A, B and A+B venoms from Mohave rattlesnakes.

Cantú E Jr, Mallela S, Nyguen M, Báez R, Parra V, Johnson R, Wilson K, Suntravat M, Lucena S, Rodríguez-Acosta A, Sánchez EE.

Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jan;191:168-176. doi: 10.1016/j.cbpc.2016.10.009. Epub 2016 Oct 28.


mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

Bravo-Sagua R, López-Crisosto C, Parra V, Rodriguez-Peña M, Rothermel BA, Quest AF, Lavandero S.

Sci Rep. 2016 Nov 3;6:36394. doi: 10.1038/srep36394.


Conditioning the Heart: Thirty Years of Research and Still Far from Humans.

Domenech RJ, Macho P, Parra V.

Curr Treat Options Cardiovasc Med. 2016 Dec;18(12):71. Review. No abstract available.


[Ventricular contractility: Physiology and clinical projection].

Domenech RJ, Parra VM.

Rev Med Chil. 2016 Jun;144(6):767-71. doi: 10.4067/S0034-98872016000600012. Review. Spanish.


A case of mucinous cystic neoplasm from a gastric ectopic pancreas.

Parra V, Acero F, Alvarez E, Aponte DM, Sabbagh LC.

Gastrointest Endosc. 2017 May;85(5):1096-1097. doi: 10.1016/j.gie.2016.06.010. Epub 2016 Jun 18. No abstract available.


International collaborative study on EUS-guided gallbladder drainage: Are we ready for prime time?

Kahaleh M, Perez-Miranda M, Artifon EL, Sharaiha RZ, Kedia P, Peñas I, De la Serna C, Kumta NA, Marson F, Gaidhane M, Boumitri C, Parra V, Rondon Clavo CM, Giovannini M.

Dig Liver Dis. 2016 Sep;48(9):1054-7. doi: 10.1016/j.dld.2016.05.021. Epub 2016 Jun 3.


Endoscopic Therapy With Lumen-apposing Metal Stents Is Safe and Effective for Patients With Pancreatic Walled-off Necrosis.

Sharaiha RZ, Tyberg A, Khashab MA, Kumta NA, Karia K, Nieto J, Siddiqui UD, Waxman I, Joshi V, Benias PC, Darwin P, DiMaio CJ, Mulder CJ, Friedland S, Forcione DG, Sejpal DV, Gonda TA, Gress FG, Gaidhane M, Koons A, DeFilippis EM, Salgado S, Weaver KR, Poneros JM, Sethi A, Ho S, Kumbhari V, Singh VK, Tieu AH, Parra V, Likhitsup A, Womeldorph C, Casey B, Jonnalagadda SS, Desai AP, Carr-Locke DL, Kahaleh M, Siddiqui AA.

Clin Gastroenterol Hepatol. 2016 Dec;14(12):1797-1803. doi: 10.1016/j.cgh.2016.05.011. Epub 2016 May 14.


[Transcatheter aortic valve implantation.Experience in 26 patients].

Pineda F, Sarango B, Sore L, Deck C, Turner E, Parra V, Bórquez E, Bernal S, Silva J, GonzÁlez S, Uriarte P.

Rev Med Chil. 2015 Dec;143(12):1512-20. doi: 10.4067/S0034-98872015001200002. Spanish.


Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling.

Inserte J, Cardona M, Poncelas-Nozal M, Hernando V, Vilardosa Ú, Aluja D, Parra VM, Sanchis D, Garcia-Dorado D.

Basic Res Cardiol. 2016 Mar;111(2):18. doi: 10.1007/s00395-016-0537-6. Epub 2016 Feb 16.


Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.

García-Rúa V, Feijóo-Bandín S, Rodríguez-Penas D, Mosquera-Leal A, Abu-Assi E, Beiras A, María Seoane L, Lear P, Parrington J, Portolés M, Roselló-Lletí E, Rivera M, Gualillo O, Parra V, Hill JA, Rothermel B, González-Juanatey JR, Lago F.

J Physiol. 2016 Jun 1;594(11):3061-77. doi: 10.1113/JP271332. Epub 2016 Feb 4.


BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism.

Rodríguez AE, López-Crisosto C, Peña-Oyarzún D, Salas D, Parra V, Quiroga C, Morawe T, Chiong M, Behl C, Lavandero S.

Autophagy. 2016;12(2):287-96. doi: 10.1080/15548627.2015.1124225.


HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor.

Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S.

Free Radic Biol Med. 2016 Jan;90:206-18. doi: 10.1016/j.freeradbiomed.2015.11.024. Epub 2015 Nov 23.


Mitochondrial dynamics, mitophagy and cardiovascular disease.

Vásquez-Trincado C, García-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA, Lavandero S.

J Physiol. 2016 Feb 1;594(3):509-25. doi: 10.1113/JP271301. Epub 2016 Jan 15. Review.


Exclusion criteria vs reality: dual BRAF/MEK inhibition and radiotherapy in a patient with melanoma metastatic to the brain and ECOG 3.

Márquez-Rodas I, Avilés-Izquierdo JA, Parra V, Álvarez-González A, Borrego P, Fernández-García P, Guzmán-de-Villoria JA, Jerez Y, Martin M.

Tumori. 2016 Nov 11;102(Suppl. 2). doi: 10.5301/tj.5000408.


FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes.

Oyarzún AP, Westermeier F, Pennanen C, López-Crisosto C, Parra V, Sotomayor-Flores C, Sánchez G, Pedrozo Z, Troncoso R, Lavandero S.

Biochem Pharmacol. 2015 Nov 1;98(1):92-101. doi: 10.1016/j.bcp.2015.08.097. Epub 2015 Aug 20.


Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.

Westermeier F, Navarro-Marquez M, López-Crisosto C, Bravo-Sagua R, Quiroga C, Bustamante M, Verdejo HE, Zalaquett R, Ibacache M, Parra V, Castro PF, Rothermel BA, Hill JA, Lavandero S.

Biochim Biophys Acta. 2015 May;1853(5):1113-8. doi: 10.1016/j.bbamcr.2015.02.005. Epub 2015 Feb 14. Review.


Exercise preconditioning of myocardial infarct size in dogs is triggered by calcium.

Parra VM, Macho P, Sánchez G, Donoso P, Domenech RJ.

J Cardiovasc Pharmacol. 2015 Mar;65(3):276-81. doi: 10.1097/FJC.0000000000000191.


Drainage of infected pancreatic necrosis by using 2 lumen-apposing metal stents, a nasocystic drain, and hydrogen peroxide.

Parra V, Kedia P, Zerbo S, Sharaiha RZ, Kahaleh M.

Gastrointest Endosc. 2015 May;81(5):1261. doi: 10.1016/j.gie.2014.08.009. Epub 2014 Oct 31. No abstract available.


Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes.

Gutiérrez T, Parra V, Troncoso R, Pennanen C, Contreras-Ferrat A, Vasquez-Trincado C, Morales PE, Lopez-Crisosto C, Sotomayor-Flores C, Chiong M, Rothermel BA, Lavandero S.

Cell Commun Signal. 2014 Nov 7;12:68. doi: 10.1186/s12964-014-0068-4.


Metastatic melanoma with spontaneous regression, psoriasis and HLA-Cw6: case report and a hypothesis to explore.

Pérez Ramírez S, Parra V, Avilés Izquierdo JA, Vicario JL, Martín M, Márquez-Rodas I.

Tumori. 2014 Jul-Aug;100(4):144e-7e. doi: 10.1700/1636.17932.


Endoscopic optical coherence tomography as a tool to evaluate successful myotomy after a peroral endoscopic myotomy.

Parra V, Kedia P, Minami H, Sharaiha RZ, Kahaleh M.

Gastrointest Endosc. 2015 May;81(5):1251. doi: 10.1016/j.gie.2014.07.011. Epub 2014 Oct 5. No abstract available.


Cleaning the paracolic gutter: transcutaneous endoscopic necrosectomy through a fully covered metal esophageal stent.

Kedia P, Parra V, Zerbo S, Sharaiha RZ, Kahaleh M.

Gastrointest Endosc. 2015 May;81(5):1252. doi: 10.1016/j.gie.2014.07.043. Epub 2014 Oct 1. No abstract available.


Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes.

Kuzmicic J, Parra V, Verdejo HE, López-Crisosto C, Chiong M, García L, Jensen MD, Bernlohr DA, Castro PF, Lavandero S.

Biochem Pharmacol. 2014 Oct 1;91(3):323-36. doi: 10.1016/j.bcp.2014.07.022. Epub 2014 Aug 1.


Hemorrhagic pancreatic necrosis drainage by using an esophageal stent.

Parra V, Boumitri C, Kedia P, Sharaiha RZ, Kahaleh M.

Gastrointest Endosc. 2015 Feb;81(2):458-9. doi: 10.1016/j.gie.2014.05.325. Epub 2014 Jul 15. No abstract available.


Salvage cryotherapy in portal hypertensive gastropathy.

Patel J, Parra V, Kedia P, Sharaiha RZ, Kahaleh M.

Gastrointest Endosc. 2015 Apr;81(4):1003. doi: 10.1016/j.gie.2014.05.326. Epub 2014 Jul 12. No abstract available.


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