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Items: 1 to 50 of 137

1.

ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis.

Foglia B, Cannito S, Bocca C, Parola M, Novo E.

Int J Mol Sci. 2019 Jun 1;20(11). pii: E2700. doi: 10.3390/ijms20112700. Review.

2.

Pathophysiology of Organ and Tissue Fibrosis.

Parola M, Pinzani M.

Mol Aspects Med. 2019 Feb;65:1. doi: 10.1016/j.mam.2019.02.001. No abstract available.

PMID:
30755310
3.

Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies.

Cannito S, Milani C, Cappon A, Parola M, Strazzabosco M, Cadamuro M.

Int J Mol Sci. 2018 Dec 4;19(12). pii: E3875. doi: 10.3390/ijms19123875. Review.

4.

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.

Parola M, Pinzani M.

Mol Aspects Med. 2019 Feb;65:37-55. doi: 10.1016/j.mam.2018.09.002. Epub 2018 Sep 13. Review.

PMID:
30213667
5.

B2-Lymphocyte responses to oxidative stress-derived antigens contribute to the evolution of nonalcoholic fatty liver disease (NAFLD).

Bruzzì S, Sutti S, Giudici G, Burlone ME, Ramavath NN, Toscani A, Bozzola C, Schneider P, Morello E, Parola M, Pirisi M, Albano E.

Free Radic Biol Med. 2018 Aug 20;124:249-259. doi: 10.1016/j.freeradbiomed.2018.06.015. Epub 2018 Jun 18.

6.

Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein.

Morello E, Sutti S, Foglia B, Novo E, Cannito S, Bocca C, Rajsky M, Bruzzì S, Abate ML, Rosso C, Bozzola C, David E, Bugianesi E, Albano E, Parola M.

Hepatology. 2018 Jun;67(6):2196-2214. doi: 10.1002/hep.29754. Epub 2018 Apr 19.

7.

Serpinb3 is overexpressed in the liver in presence of iron overload.

Turato C, Kent P, Sebastiani G, Cannito S, Morello E, Terrin L, Biasiolo A, Simonato D, Parola M, Pantopoulos K, Pontisso P.

J Investig Med. 2018 Jan;66(1):32-38. doi: 10.1136/jim-2017-000473. Epub 2017 Sep 20.

PMID:
28935635
8.

SerpinB3 Promotes Pro-fibrogenic Responses in Activated Hepatic Stellate Cells.

Novo E, Villano G, Turato C, Cannito S, Paternostro C, Busletta C, Biasiolo A, Quarta S, Morello E, Bocca C, Miglietta A, David E, Sutti S, Plebani M, Albano E, Parola M, Pontisso P.

Sci Rep. 2017 Jun 13;7(1):3420. doi: 10.1038/s41598-017-03744-3.

9.

Therapeutic pro-fibrogenic signaling pathways in fibroblasts.

Cannito S, Novo E, Parola M.

Adv Drug Deliv Rev. 2017 Nov 1;121:57-84. doi: 10.1016/j.addr.2017.05.017. Epub 2017 Jun 1. Review.

PMID:
28578015
10.

SENP1 activity sustains cancer stem cell in hypoxic HCC.

Conigliaro A, Tripodi M, Parola M.

Gut. 2017 Dec;66(12):2051-2052. doi: 10.1136/gutjnl-2017-313946. Epub 2017 Apr 13. No abstract available.

11.

Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis.

Cannito S, Morello E, Bocca C, Foglia B, Benetti E, Novo E, Chiazza F, Rogazzo M, Fantozzi R, Povero D, Sutti S, Bugianesi E, Feldstein AE, Albano E, Collino M, Parola M.

PLoS One. 2017 Mar 1;12(3):e0172575. doi: 10.1371/journal.pone.0172575. eCollection 2017.

12.

In vivo reprogramming of hepatic myofibroblasts into hepatocytes attenuates liver fibrosis: back to the future?

Novo E, Cannito S, Parola M.

Stem Cell Investig. 2016 Sep 29;3:53. eCollection 2016. No abstract available.

13.

Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data.

Sansoè G, Aragno M, Mastrocola R, Mengozzi G, Novo E, Parola M.

PLoS One. 2016 Sep 16;11(9):e0162644. doi: 10.1371/journal.pone.0162644. eCollection 2016.

14.

Nocturnal hypoxia in obese-related obstructive sleep apnea as a putative trigger of oxidative stress in pediatric NAFLD progression.

Parola M, Vajro P.

J Hepatol. 2016 Sep;65(3):470-2. doi: 10.1016/j.jhep.2016.05.042. Epub 2016 Aug 5. No abstract available.

15.

NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling.

Vivoli E, Cappon A, Milani S, Piombanti B, Provenzano A, Novo E, Masi A, Navari N, Narducci R, Mannaioni G, Moneti G, Oliveira CP, Parola M, Marra F.

Clin Sci (Lond). 2016 Oct 1;130(20):1793-806. doi: 10.1042/CS20160400. Epub 2016 Jul 20.

PMID:
27439970
16.

Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine.

Sansoè G, Aragno M, Mastrocola R, Mengozzi G, Parola M.

PLoS One. 2016 Jul 6;11(7):e0158486. doi: 10.1371/journal.pone.0158486. eCollection 2016.

17.

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity.

Turato C, Cannito S, Simonato D, Villano G, Morello E, Terrin L, Quarta S, Biasiolo A, Ruvoletto M, Martini A, Fasolato S, Zanus G, Cillo U, Gatta A, Parola M, Pontisso P.

Sci Rep. 2015 Dec 4;5:17701. doi: 10.1038/srep17701.

18.

Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?

Sansoè G, Aragno M, Mastrocola R, Parola M.

Clin Sci (Lond). 2016 Jan;130(2):117-24. doi: 10.1042/CS20150479. Epub 2015 Oct 30.

PMID:
26519424
19.

Age-dependent changes in extracellular matrix turnover: An under evaluated issue in the approach to chronic liver diseases.

Parola M.

J Hepatol. 2016 Jan;64(1):13-5. doi: 10.1016/j.jhep.2015.09.017. Epub 2015 Sep 30. No abstract available.

PMID:
26432685
20.

Angiogenesis and Fibrogenesis in Chronic Liver Diseases.

Bocca C, Novo E, Miglietta A, Parola M.

Cell Mol Gastroenterol Hepatol. 2015 Jul 13;1(5):477-488. doi: 10.1016/j.jcmgh.2015.06.011. eCollection 2015 Sep. Review.

21.

Dose-dependency of clonidine's effects in ascitic cirrhotic rats: comparison with α1-adrenergic agonist midodrine.

Sansoè G, Aragno M, Mastrocola R, Parola M.

Liver Int. 2016 Feb;36(2):205-11. doi: 10.1111/liv.12905. Epub 2015 Jul 22.

PMID:
26121993
22.

Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH).

Jindal A, Bruzzì S, Sutti S, Locatelli I, Bozzola C, Paternostro C, Parola M, Albano E.

Exp Mol Pathol. 2015 Aug;99(1):155-62. doi: 10.1016/j.yexmp.2015.06.015. Epub 2015 Jun 22.

23.

Hepatic myofibroblasts and fibrogenic progression of chronic liver diseases.

Novo E, Cannito S, Morello E, Paternostro C, Bocca C, Miglietta A, Parola M.

Histol Histopathol. 2015 Sep;30(9):1011-32. doi: 10.14670/HH-11-623. Epub 2015 Apr 21. Review.

24.

[Effects of alpha lipoic acid and pirfenidone on liver cells antioxidant modulation against oxidative damage].

Macias-Barragan J, Caligiuri A, García-Banuelos J, Parola M, Pinzani M, Armendariz-Borunda J.

Rev Med Chil. 2014 Dec;142(12):1553-64. doi: 10.4067/S0034-98872014001200009. Spanish.

25.

Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells.

Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, Quarta S, Novo E, Morello E, Villano G, Fasolato S, Musso T, David E, Tusa I, Rovida E, Autelli R, Smedile A, Cillo U, Pontisso P, Parola M.

Oncotarget. 2015 Feb 10;6(4):2206-21.

26.

Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid hormone injection.

Sansoe G, Mastrocola R, Aragno M, Parola M.

J Physiol Pharmacol. 2014 Oct;65(5):649-57.

27.

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.

Rovida E, Di Maira G, Tusa I, Cannito S, Paternostro C, Navari N, Vivoli E, Deng X, Gray NS, Esparís-Ogando A, David E, Pandiella A, Dello Sbarba P, Parola M, Marra F.

Gut. 2015 Sep;64(9):1454-65. doi: 10.1136/gutjnl-2014-306761. Epub 2014 Sep 2.

28.

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.

Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S, Parola M, Paternostro C, Bugianesi E, McArthur S, Albano E, Perretti M.

Hepatology. 2014 Aug;60(2):531-44. doi: 10.1002/hep.27141. Epub 2014 May 12.

29.

Cellular and molecular mechanisms in liver fibrogenesis.

Novo E, Cannito S, Paternostro C, Bocca C, Miglietta A, Parola M.

Arch Biochem Biophys. 2014 Apr 15;548:20-37. doi: 10.1016/j.abb.2014.02.015. Epub 2014 Mar 11. Review.

30.

n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis.

Provenzano A, Milani S, Vizzutti F, Delogu W, Navari N, Novo E, Maggiora M, Maurino V, Laffi G, Parola M, Marra F.

Liver Int. 2014 Jul;34(6):918-30. doi: 10.1111/liv.12500. Epub 2014 Mar 15.

31.

Hepatic progenitor cells express SerpinB3.

Villano G, Turato C, Quarta S, Ruvoletto M, Ciscato F, Terrin L, Semeraro R, Paternostro C, Parola M, Alvaro D, Bernardi P, Gatta A, Pontisso P.

BMC Cell Biol. 2014 Feb 11;15:5. doi: 10.1186/1471-2121-15-5.

32.

Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness.

Bocca C, Ievolella M, Autelli R, Motta M, Mosso L, Torchio B, Bozzo F, Cannito S, Paternostro C, Colombatto S, Parola M, Miglietta A.

Expert Opin Ther Targets. 2014 Feb;18(2):121-35. doi: 10.1517/14728222.2014.860447. Epub 2013 Dec 11.

33.

Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.

Povero D, Eguchi A, Niesman IR, Andronikou N, de Mollerat du Jeu X, Mulya A, Berk M, Lazic M, Thapaliya S, Parola M, Patel HH, Feldstein AE.

Sci Signal. 2013 Oct 8;6(296):ra88. doi: 10.1126/scisignal.2004512.

34.

Hypoxia, hypoxia-inducible factors and fibrogenesis in chronic liver diseases.

Cannito S, Paternostro C, Busletta C, Bocca C, Colombatto S, Miglietta A, Novo E, Parola M.

Histol Histopathol. 2014 Jan;29(1):33-44. doi: 10.14670/HH-29.33. Epub 2013 Sep 2. Review.

35.

Calcium receptors located in fibrotic septa: a new target to reduce portal pressure in liver cirrhosis.

Sansoè G, Aragno M, Mastrocola R, Paternostro C, Parola M.

Clin Sci (Lond). 2013 Jul 1;125(2):67-75. doi: 10.1042/CS20120476.

PMID:
23384153
36.

The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis.

Novo E, Parola M.

Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S4. doi: 10.1186/1755-1536-5-S1-S4. eCollection 2012.

37.

Myogenic potential of whole bone marrow mesenchymal stem cells in vitro and in vivo for usage in urinary incontinence.

Gunetti M, Tomasi S, Giammò A, Boido M, Rustichelli D, Mareschi K, Errichiello E, Parola M, Ferrero I, Fagioli F, Vercelli A, Carone R.

PLoS One. 2012;7(9):e45538. doi: 10.1371/journal.pone.0045538. Epub 2012 Sep 21.

38.

Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis.

Galastri S, Zamara E, Milani S, Novo E, Provenzano A, Delogu W, Vizzutti F, Sutti S, Locatelli I, Navari N, Vivoli E, Caligiuri A, Pinzani M, Albano E, Parola M, Marra F.

Clin Sci (Lond). 2012 Oct;123(7):459-71. doi: 10.1042/CS20110515.

39.

Stem cells in liver failure.

Russo FP, Parola M.

Best Pract Res Clin Gastroenterol. 2012 Feb;26(1):35-45. doi: 10.1016/j.bpg.2012.01.001. Review.

PMID:
22482524
40.

Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.

Salamone F, Galvano F, Marino Gammazza A, Paternostro C, Tibullo D, Bucchieri F, Mangiameli A, Parola M, Bugianesi E, Li Volti G.

Dig Liver Dis. 2012 Apr;44(4):334-42. doi: 10.1016/j.dld.2011.11.010. Epub 2011 Dec 24. Erratum in: Dig Liver Dis. 2012 Aug;44(8):709. Marino, Antonella [corrected to Marino Gammazza, Antonella].

PMID:
22197629
41.

The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells.

Novo E, Povero D, Busletta C, Paternostro C, di Bonzo LV, Cannito S, Compagnone A, Bandino A, Marra F, Colombatto S, David E, Pinzani M, Parola M.

J Pathol. 2012 Mar;226(4):588-97. doi: 10.1002/path.3005. Epub 2011 Dec 5.

42.

Chronic exposure to agmatine results in the selection of agmatine-resistant hepatoma cells.

Bandino A, Battaglia V, Bravoco V, Busletta C, Compagnone A, Cravanzola C, Meli F, Agostinelli E, Parola M, Colombatto S.

Amino Acids. 2012 Feb;42(2-3):769-74. doi: 10.1007/s00726-011-0993-0. Epub 2011 Sep 7. Erratum in: Amino Acids. 2012 Jun;42(6):2533. Andrea, Bandino [corrected to Bandino, Andrea]; Valentina, Battaglia [corrected to Battaglia, Valentina]; Vittoria, Bravoco [corrected to Bravoco, Vittoria]; Chiara, Busletta [corrected to Busletta, Chiara]; Alessandra, Compagnone [corrected to Compagnone,.

PMID:
21901471
43.

Polyamines modulate epithelial-to-mesenchymal transition.

Compagnone A, Bandino A, Meli F, Bravoco V, Cravanzola C, Parola M, Colombatto S.

Amino Acids. 2012 Feb;42(2-3):783-9. doi: 10.1007/s00726-011-0995-y. Epub 2011 Sep 7. Erratum in: Amino Acids. 2012 Jun;42(6):2535. Alessandra, Compagnone [corrected to Compagnone, Alessandra]; Andrea, Bandino [ corrected to Bandino, Andrea]; Floriana, Meli [corrected to Meli, Floriana]; Vittoria, Bravoco [corrected to Bravoco, Vittoria]; Carlo, Cravanzola [corrected to Cravanzola, Car.

PMID:
21901470
44.

Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells.

Bocca C, Bozzo F, Cannito S, Parola M, Miglietta A.

Mol Carcinog. 2012 Oct;51(10):783-95. doi: 10.1002/mc.20846. Epub 2011 Aug 31.

45.

Human-induced pluripotent stem cells as a source of hepatocyte-like cells: new kids on the block.

Busletta C, Novo E, Parola M.

Hepatol Int. 2013 Jun;7(2):299-305. doi: 10.1007/s12072-011-9300-0. Epub 2011 Jul 23. No abstract available.

46.

Dissection of the biphasic nature of hypoxia-induced motogenic action in bone marrow-derived human mesenchymal stem cells.

Busletta C, Novo E, Valfrè Di Bonzo L, Povero D, Paternostro C, Ievolella M, Mareschi K, Ferrero I, Cannito S, Compagnone A, Bandino A, Colombatto S, Fagioli F, Parola M.

Stem Cells. 2011 Jun;29(6):952-63. doi: 10.1002/stem.642.

47.

Liver fibrogenic cells.

Forbes SJ, Parola M.

Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):207-17. doi: 10.1016/j.bpg.2011.02.006. Review.

PMID:
21497739
48.

Mammalian target of rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells.

Aleffi S, Navari N, Delogu W, Galastri S, Novo E, Rombouts K, Pinzani M, Parola M, Marra F.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G210-9. doi: 10.1152/ajpgi.00047.2010. Epub 2011 Jan 20.

49.

Stem and progenitor cells in liver regeneration and repair.

Russo FP, Parola M.

Cytotherapy. 2011 Feb;13(2):135-44. doi: 10.3109/14653249.2010.545386. Review.

PMID:
21235295
50.

Adipokines and redox signaling: impact on fatty liver disease.

Parola M, Marra F.

Antioxid Redox Signal. 2011 Jul 15;15(2):461-83. doi: 10.1089/ars.2010.3848. Epub 2011 May 5. Review.

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