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Macrophage MMP10 Regulates TLR7-Mediated Tolerance.

Rohani MG, Dimitrova E, Beppu A, Wang Y, Jefferies CA, Parks WC.

Front Immunol. 2018 Dec 4;9:2817. doi: 10.3389/fimmu.2018.02817. eCollection 2018.


Transcriptional and functional diversity of human macrophage repolarization.

Gharib SA, McMahan RS, Eddy WE, Long ME, Parks WC, Aitken ML, Manicone AM.

J Allergy Clin Immunol. 2019 Apr;143(4):1536-1548. doi: 10.1016/j.jaci.2018.10.046. Epub 2018 Nov 14.


Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification.

Purroy A, Roncal C, Orbe J, Meilhac O, Belzunce M, Zalba G, Villa-Bellosta R, Andrés V, Parks WC, Páramo JA, Rodríguez JA.

Atherosclerosis. 2018 Nov;278:124-134. doi: 10.1016/j.atherosclerosis.2018.09.022. Epub 2018 Sep 19.


Macrophages, Wound Healing, and Fibrosis: Recent Insights.

Smigiel KS, Parks WC.

Curr Rheumatol Rep. 2018 Mar 17;20(4):17. doi: 10.1007/s11926-018-0725-5. Review.


Extracellular matrix in lung development, homeostasis and disease.

Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ.

Matrix Biol. 2018 Nov;73:77-104. doi: 10.1016/j.matbio.2018.03.005. Epub 2018 Mar 8. Review.


Matrix metalloproteinases in emphysema.

Gharib SA, Manicone AM, Parks WC.

Matrix Biol. 2018 Nov;73:34-51. doi: 10.1016/j.matbio.2018.01.018. Epub 2018 Mar 23. Review.


Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes.

Parimon T, Brauer R, Schlesinger SY, Xie T, Jiang D, Ge L, Huang Y, Birkland TP, Parks WC, Habiel DM, Hogaboam CM, Gharib SA, Deng N, Liu Z, Chen P.

Am J Pathol. 2018 Apr;188(4):1094-1103. doi: 10.1016/j.ajpath.2017.12.009. Epub 2018 Jan 31.


Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.

Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1069-L1086. doi: 10.1152/ajplung.00353.2017. Epub 2017 Sep 14.


Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

Eddy WE, Gong KQ, Bell B, Parks WC, Ziegler SF, Manicone AM.

J Immunol. 2017 Jun 15;198(12):4813-4822. doi: 10.4049/jimmunol.1601777. Epub 2017 May 12.


Matrix Metalloproteinases and Leukocyte Activation.

Smigiel KS, Parks WC.

Prog Mol Biol Transl Sci. 2017;147:167-195. doi: 10.1016/bs.pmbts.2017.01.003. Epub 2017 Mar 3. Review.


Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis.

Manicone AM, Gharib SA, Gong KQ, Eddy WE, Long ME, Frevert CW, Altemeier WA, Parks WC, Houghton AM.

Am J Pathol. 2017 Jun;187(6):1288-1300. doi: 10.1016/j.ajpath.2017.02.008. Epub 2017 Apr 8.


Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes.

Vandivort TC, Birkland TP, Domiciano TP, Mitra S, Kavanagh TJ, Parks WC.

Int J Nanomedicine. 2017 Feb 7;12:1019-1031. doi: 10.2147/IJN.S123484. eCollection 2017.


Lung pericyte-like cells are functional interstitial immune sentinel cells.

Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L556-L567. doi: 10.1152/ajplung.00349.2016. Epub 2017 Feb 10.


Interplay of extracellular matrix and leukocytes in lung inflammation.

Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SF.

Cell Immunol. 2017 Feb;312:1-14. doi: 10.1016/j.cellimm.2016.12.003. Epub 2016 Dec 23. Review.


Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo.

Secor PR, Michaels LA, Smigiel KS, Rohani MG, Jennings LK, Hisert KB, Arrigoni A, Braun KR, Birkland TP, Lai Y, Hallstrand TS, Bollyky PL, Singh PK, Parks WC.

Infect Immun. 2016 Dec 29;85(1). pii: e00648-16. doi: 10.1128/IAI.00648-16. Print 2017 Jan.


GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen.

Sheih A, Parks WC, Ziegler SF.

Mucosal Immunol. 2017 May;10(3):705-715. doi: 10.1038/mi.2016.90. Epub 2016 Oct 12.


Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.

McMahan RS, Birkland TP, Smigiel KS, Vandivort TC, Rohani MG, Manicone AM, McGuire JK, Gharib SA, Parks WC.

J Immunol. 2016 Aug 1;197(3):899-909. doi: 10.4049/jimmunol.1600502. Epub 2016 Jun 17.


An Improved Method for Rapid Intubation of the Trachea in Mice.

Vandivort TC, An D, Parks WC.

J Vis Exp. 2016 Feb 22;(108):53771. doi: 10.3791/53771.


Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis.

Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P.

Am J Respir Crit Care Med. 2016 Aug 1;194(3):333-44. doi: 10.1164/rccm.201509-1878OC.


Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation.

Gill SE, Nadler ST, Li Q, Frevert CW, Park PW, Chen P, Parks WC.

Am J Respir Cell Mol Biol. 2016 Aug;55(2):243-51. doi: 10.1165/rcmb.2015-0193OC.


Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection.

Gounder AP, Myers ND, Treuting PM, Bromme BA, Wilson SS, Wiens ME, Lu W, Ouellette AJ, Spindler KR, Parks WC, Smith JG.

PLoS Pathog. 2016 Mar 2;12(3):e1005474. doi: 10.1371/journal.ppat.1005474. eCollection 2016 Mar.


Nonhematopoietic Peroxisome Proliferator-Activated Receptor-α Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis.

Standage SW, Waworuntu RL, Delaney MA, Maskal SM, Bennion BG, Duffield JS, Parks WC, Liles WC, McGuire JK.

Crit Care Med. 2016 Aug;44(8):e594-603. doi: 10.1097/CCM.0000000000001585.


Biofilm assembly becomes crystal clear - filamentous bacteriophage organize the Pseudomonas aeruginosa biofilm matrix into a liquid crystal.

Secor PR, Jennings LK, Michaels LA, Sweere JM, Singh PK, Parks WC, Bollyky PL.

Microb Cell. 2015 Dec 31;3(1):49-52. doi: 10.15698/mic2016.01.475.


Filamentous Bacteriophage Promote Biofilm Assembly and Function.

Secor PR, Sweere JM, Michaels LA, Malkovskiy AV, Lazzareschi D, Katznelson E, Rajadas J, Birnbaum ME, Arrigoni A, Braun KR, Evanko SP, Stevens DA, Kaminsky W, Singh PK, Parks WC, Bollyky PL.

Cell Host Microbe. 2015 Nov 11;18(5):549-59. doi: 10.1016/j.chom.2015.10.013.


Integrative pathway genomics of lung function and airflow obstruction.

Gharib SA, Loth DW, Soler Artigas M, Birkland TP, Wilk JB, Wain LV, Brody JA, Obeidat M, Hancock DB, Tang W, Rawal R, Boezen HM, Imboden M, Huffman JE, Lahousse L, Alves AC, Manichaikul A, Hui J, Morrison AC, Ramasamy A, Smith AV, Gudnason V, Surakka I, Vitart V, Evans DM, Strachan DP, Deary IJ, Hofman A, Gläser S, Wilson JF, North KE, Zhao JH, Heckbert SR, Jarvis DL, Probst-Hensch N, Schulz H, Barr RG, Jarvelin MR, O'Connor GT, Kähönen M, Cassano PA, Hysi PG, Dupuis J, Hayward C, Psaty BM, Hall IP, Parks WC, Tobin MD, London SJ; CHARGE Consortium; SpiroMeta Consortium.

Hum Mol Genet. 2015 Dec 1;24(23):6836-48. doi: 10.1093/hmg/ddv378. Epub 2015 Sep 22.


CD11b(+) Mononuclear Cells Mitigate Hyperoxia-Induced Lung Injury in Neonatal Mice.

Eldredge LC, Treuting PM, Manicone AM, Ziegler SF, Parks WC, McGuire JK.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):273-83. doi: 10.1165/rcmb.2014-0395OC.


Correction: Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.

Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K.

PLoS One. 2015 May 21;10(5):e0128735. doi: 10.1371/journal.pone.0128735. eCollection 2015. No abstract available.


MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages.

Rohani MG, McMahan RS, Razumova MV, Hertz AL, Cieslewicz M, Pun SH, Regnier M, Wang Y, Birkland TP, Parks WC.

J Invest Dermatol. 2015 Oct;135(10):2377-2384. doi: 10.1038/jid.2015.167. Epub 2015 Apr 30.


Metalloproteinases: A parade of functions in matrix biology and an outlook for the future.

Apte SS, Parks WC.

Matrix Biol. 2015 May-Jul;44-46:1-6. doi: 10.1016/j.matbio.2015.04.005. Epub 2015 Apr 23. Review.


Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.

Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K.

PLoS One. 2015 Apr 13;10(4):e0123460. doi: 10.1371/journal.pone.0123460. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0128735.


Matrix remodeling by MMPs during wound repair.

Rohani MG, Parks WC.

Matrix Biol. 2015 May-Jul;44-46:113-21. doi: 10.1016/j.matbio.2015.03.002. Epub 2015 Mar 11. Review.


Mechanisms of tendon injury and repair.

Thomopoulos S, Parks WC, Rifkin DB, Derwin KA.

J Orthop Res. 2015 Jun;33(6):832-9. doi: 10.1002/jor.22806. Epub 2015 Mar 2. Review.


A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions.

Wilson SS, Tocchi A, Holly MK, Parks WC, Smith JG.

Mucosal Immunol. 2015 Mar;8(2):352-61. doi: 10.1038/mi.2014.72. Epub 2014 Aug 13.


In vitro approaches to assessing the toxicity of quantum dots.

McMahan RS, Lee V, Parks WC, Kavanagh TJ, Eaton DL.

Methods Mol Biol. 2014;1199:155-63. doi: 10.1007/978-1-4939-1280-3_12.


Amphiphilic polymer-coated CdSe/ZnS quantum dots induce pro-inflammatory cytokine expression in mouse lung epithelial cells and macrophages.

Lee V, McMahan RS, Hu X, Gao X, Faustman EM, Griffith WC, Kavanagh TJ, Eaton DL, McGuire JK, Parks WC.

Nanotoxicology. 2015 May;9(3):336-43. doi: 10.3109/17435390.2014.930532. Epub 2014 Jul 1.


Diverse functions of matrix metalloproteinases during fibrosis.

Giannandrea M, Parks WC.

Dis Model Mech. 2014 Feb;7(2):193-203. doi: 10.1242/dmm.012062. Review.


Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.

Yoo J, Manicone AM, McGuire JK, Wang Y, Parks WC.

J Inflamm Res. 2014 Feb 20;7:29-38. doi: 10.2147/JIR.S55672. eCollection 2014.


Cdc42 inhibits ERK-mediated collagenase-1 (MMP-1) expression in collagen-activated human keratinocytes.

Rohani MG, Pilcher BK, Chen P, Parks WC.

J Invest Dermatol. 2014 May;134(5):1230-1237. doi: 10.1038/jid.2013.499. Epub 2013 Nov 25.


Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair.

Garcia-Irigoyen O, Carotti S, Latasa MU, Uriarte I, Fernández-Barrena MG, Elizalde M, Urtasun R, Vespasiani-Gentilucci U, Morini S, Banales JM, Parks WC, Rodriguez JA, Orbe J, Prieto J, Páramo JA, Berasain C, Ávila MA.

Liver Int. 2014 Aug;34(7):e257-70. doi: 10.1111/liv.12337. Epub 2013 Oct 16.


Matrix metalloproteinase-10 plays an active role in microvascular complications in type 1 diabetic patients.

Toni M, Hermida J, Goñi MJ, Fernández P, Parks WC, Toledo E, Montes R, Díez N.

Diabetologia. 2013 Dec;56(12):2743-52.


MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis.

Gharib SA, Johnston LK, Huizar I, Birkland TP, Hanson J, Wang Y, Parks WC, Manicone AM.

J Leukoc Biol. 2014 Jan;95(1):9-18. doi: 10.1189/jlb.1112587. Epub 2013 Aug 20. Erratum in: J Leukoc Biol. 2016 Nov;100(5):1225.


Changes in macrophage phenotype as the immune response evolves.

Lichtnekert J, Kawakami T, Parks WC, Duffield JS.

Curr Opin Pharmacol. 2013 Aug;13(4):555-64. doi: 10.1016/j.coph.2013.05.013. Epub 2013 Jun 7. Review.


Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.

Gill SE, Gharib SA, Bench EM, Sussman SW, Wang RT, Rims C, Birkland TP, Wang Y, Manicone AM, McGuire JK, Parks WC.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):768-77. doi: 10.1165/rcmb.2012-0377OC.


The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.

McConnachie LA, Botta D, White CC, Weldy CS, Wilkerson HW, Yu J, Dills R, Yu X, Griffith WC, Faustman EM, Farin FM, Gill SE, Parks WC, Hu X, Gao X, Eaton DL, Kavanagh TJ.

PLoS One. 2013 May 27;8(5):e64165. doi: 10.1371/journal.pone.0064165. Print 2013.


Macrophage migration and invasion is regulated by MMP10 expression.

Murray MY, Birkland TP, Howe JD, Rowan AD, Fidock M, Parks WC, Gavrilovic J.

PLoS One. 2013 May 14;8(5):e63555. doi: 10.1371/journal.pone.0063555. Print 2013.


Functional interactions between matrix metalloproteinases and glycosaminoglycans.

Tocchi A, Parks WC.

FEBS J. 2013 May;280(10):2332-41. doi: 10.1111/febs.12198. Epub 2013 Mar 8. Review.


Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells.

Gharib SA, Altemeier WA, Van Winkle LS, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, Chen P.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):390-6. doi: 10.1165/rcmb.2012-0083OC. Epub 2012 Dec 20.


Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia.

Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B.

Lab Invest. 2012 Dec;92(12):1749-59. doi: 10.1038/labinvest.2012.141. Epub 2012 Oct 8.


Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion.

Altemeier WA, Schlesinger SY, Buell CA, Brauer R, Rapraeger AC, Parks WC, Chen P.

J Biol Chem. 2012 Oct 12;287(42):34927-35. doi: 10.1074/jbc.M112.376814. Epub 2012 Aug 30.


Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly.

Altemeier WA, Schlesinger SY, Buell CA, Parks WC, Chen P.

J Cell Sci. 2012 Nov 1;125(Pt 21):5188-95. doi: 10.1242/jcs.109884. Epub 2012 Aug 16.

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