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Report on the 4th Ottawa International Conference on Neuromuscular Disease and Biology - September 5-7, 2017, Ottawa, Canada.

Chardon JW, Jasmin BJ, Kothary R, Parks RJ.

J Neuromuscul Dis. 2018;5(4):539-552. doi: 10.3233/JND-180353. No abstract available.


Building immune tolerance through DNA vaccination.

Parks RJ, Gussoni E.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9652-9654. doi: 10.1073/pnas.1813461115. Epub 2018 Sep 6. No abstract available.


Cyclophilin D-mediated regulation of the permeability transition pore is altered in mice lacking the mitochondrial calcium uniporter.

Parks RJ, Menazza S, Holmström KM, Amanakis G, Fergusson M, Ma H, Aponte AM, Bernardi P, Finkel T, Murphy E.

Cardiovasc Res. 2019 Feb 1;115(2):385-394. doi: 10.1093/cvr/cvy218.


Human adenoviral DNA association with nucleosomes containing histone variant H3.3 during the early phase of infection is not dependent on viral transcription or replication.

Giberson AN, Saha B, Campbell K, Christou C, Poulin KL, Parks RJ.

Biochem Cell Biol. 2018 Dec;96(6):797-807. doi: 10.1139/bcb-2018-0117. Epub 2018 Jun 6.


Mitochondrial Permeability Transition Pore and Calcium Handling.

Parks RJ, Murphy E, Liu JC.

Methods Mol Biol. 2018;1782:187-196. doi: 10.1007/978-1-4939-7831-1_11.


Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy.

Nash LA, McFall ER, Perozzo AM, Turner M, Poulin KL, De Repentigny Y, Burns JK, McMillan HJ, Warman Chardon J, Burger D, Kothary R, Parks RJ.

Sci Rep. 2017 Oct 24;7(1):13859. doi: 10.1038/s41598-017-14313-z.


The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.

Sundaram M, Curtis KR, Amir Alipour M, LeBlond ND, Margison KD, Yaworski RA, Parks RJ, McIntyre AD, Hegele RA, Fullerton MD, Yao Z.

J Lipid Res. 2017 Nov;58(11):2188-2196. doi: 10.1194/jlr.M077313. Epub 2017 Sep 8.


HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques.

Han Q, Williams WB, Saunders KO, Seaton KE, Wiehe KJ, Vandergrift N, Von Holle TA, Trama AM, Parks RJ, Luo K, Gurley TC, Kepler TB, Marshall DJ, Montefiori DC, Sutherland LL, Alam MS, Whitesides JF, Bowman CM, Permar SR, Graham BS, Mascola JR, Seed PC, Van Rompay KKA, Tomaras GD, Moody MA, Haynes BF.

J Virol. 2017 Oct 13;91(21). pii: e00923-17. doi: 10.1128/JVI.00923-17. Print 2017 Nov 1.


Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.

Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF.

Sci Immunol. 2017 Jan 27;2(7). pii: eaal2200. doi: 10.1126/sciimmunol.aal2200.


The impact of ovariectomy on cardiac excitation-contraction coupling is mediated through cAMP/PKA-dependent mechanisms.

Parks RJ, Bogachev O, Mackasey M, Ray G, Rose RA, Howlett SE.

J Mol Cell Cardiol. 2017 Oct;111:51-60. doi: 10.1016/j.yjmcc.2017.07.118. Epub 2017 Aug 1.


mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells.

Eid W, Dauner K, Courtney KC, Gagnon A, Parks RJ, Sorisky A, Zha X.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7999-8004. doi: 10.1073/pnas.1705304114. Epub 2017 Jul 10.


The In Vivo Biology of the Mitochondrial Calcium Uniporter.

Liu JC, Parks RJ, Liu J, Stares J, Rovira II, Murphy E, Finkel T.

Adv Exp Med Biol. 2017;982:49-63. doi: 10.1007/978-3-319-55330-6_3. Review.


Sex Differences in Metabolic Cardiomyopathy.

Murphy E, Amanakis G, Fillmore N, Parks RJ, Sun J.

Cardiovasc Res. 2017 Feb 1. doi: 10.1093/cvr/cvx008. [Epub ahead of print]


Adenoviral Vectors Armed with Cell Fusion-Inducing Proteins as Anti-Cancer Agents.

Del Papa J, Parks RJ.

Viruses. 2017 Jan 19;9(1). pii: E13. doi: 10.3390/v9010013. Review.


Spinal Muscular Atrophy: More than a Disease of Motor Neurons?

Nash LA, Burns JK, Chardon JW, Kothary R, Parks RJ.

Curr Mol Med. 2016;16(9):779-792. doi: 10.2174/1566524016666161128113338. Review.


Report on the 3rd Ottawa International Conference on Neuromuscular Biology, Disease and Therapy - September 24-26, 2015, Ottawa, Canada.

Chardon JW, Jasmin BJ, Kothary R, Parks RJ.

J Neuromuscul Dis. 2016 Aug 30;3(3):431-442. No abstract available.


Expression of the fusogenic p14 FAST protein from a replication-defective adenovirus vector does not provide a therapeutic benefit in an immunocompetent mouse model of cancer.

Wong CM, Nash LA, Del Papa J, Poulin KL, Falls T, Bell JC, Parks RJ.

Cancer Gene Ther. 2016 Oct;23(10):355-364. doi: 10.1038/cgt.2016.41. Epub 2016 Oct 14.


Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.

Alvarez-Saavedra M, De Repentigny Y, Yang D, O'Meara RW, Yan K, Hashem LE, Racacho L, Ioshikhes I, Bulman DE, Parks RJ, Kothary R, Picketts DJ.

Cell Rep. 2016 Oct 11;17(3):862-875. doi: 10.1016/j.celrep.2016.09.030.


MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload.

Liu JC, Liu J, Holmström KM, Menazza S, Parks RJ, Fergusson MM, Yu ZX, Springer DA, Halsey C, Liu C, Murphy E, Finkel T.

Cell Rep. 2016 Aug 9;16(6):1561-1573. doi: 10.1016/j.celrep.2016.07.011. Epub 2016 Jul 28.


Temporal activation of XRCC1-mediated DNA repair is essential for muscle differentiation.

Al-Khalaf MH, Blake LE, Larsen BD, Bell RA, Brunette S, Parks RJ, Rudnicki MA, McKinnon PJ, Jeffrey Dilworth F, Megeney LA.

Cell Discov. 2016 Jan 12;2:15041. doi: 10.1038/celldisc.2015.41. eCollection 2016.


Opening the window: The case for carrier and perinatal screening for spinal muscular atrophy.

Burns JK, Kothary R, Parks RJ.

Neuromuscul Disord. 2016 Sep;26(9):551-9. doi: 10.1016/j.nmd.2016.06.459. Epub 2016 Jun 23. Review.


Adenovirus-Mediated Expression of the p14 Fusion-Associated Small Transmembrane Protein Promotes Cancer Cell Fusion and Apoptosis In Vitro but Does Not Provide Therapeutic Efficacy in a Xenograft Mouse Model of Cancer.

Wong CM, Poulin KL, Tong G, Christou C, Kennedy MA, Falls T, Bell JC, Parks RJ.

PLoS One. 2016 Mar 17;11(3):e0151516. doi: 10.1371/journal.pone.0151516. eCollection 2016.


Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase.

Smethells JR, Swalve N, Brimijoin S, Gao Y, Parks RJ, Greer A, Carroll ME.

J Pharmacol Exp Ther. 2016 May;357(2):375-81. doi: 10.1124/jpet.116.232504. Epub 2016 Mar 11.


Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.

Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C; NISC Comparative Sequencing Program, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF.

Cell. 2016 Apr 7;165(2):449-63. doi: 10.1016/j.cell.2016.02.022. Epub 2016 Mar 3.


Regulation of Macropinocytosis by Diacylglycerol Kinase ζ.

Ard R, Mulatz K, Pomoransky JL, Parks RJ, Trinkle-Mulcahy L, Bell JC, Gee SH.

PLoS One. 2015 Dec 23;10(12):e0144942. doi: 10.1371/journal.pone.0144942. eCollection 2015.


Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.

Holmström KM, Pan X, Liu JC, Menazza S, Liu J, Nguyen TT, Pan H, Parks RJ, Anderson S, Noguchi A, Springer D, Murphy E, Finkel T.

J Mol Cell Cardiol. 2015 Aug;85:178-82. doi: 10.1016/j.yjmcc.2015.05.022. Epub 2015 Jun 6.


The ins and outs of mitochondrial calcium.

Finkel T, Menazza S, Holmström KM, Parks RJ, Liu J, Sun J, Liu J, Pan X, Murphy E.

Circ Res. 2015 May 22;116(11):1810-9. doi: 10.1161/CIRCRESAHA.116.305484. Review.


Plasma butyrylcholinesterase regulates ghrelin to control aggression.

Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2251-6. doi: 10.1073/pnas.1421536112. Epub 2015 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1510.


The adenovirus genome contributes to the structural stability of the virion.

Saha B, Wong CM, Parks RJ.

Viruses. 2014 Sep 24;6(9):3563-83. doi: 10.3390/v6093563. Review.


A reduction in the human adenovirus virion size through use of a shortened fibre protein does not enhance muscle transduction following systemic or localised delivery in mice.

McFall ER, Murray LM, Lunde JA, Jasmin BJ, Kothary R, Parks RJ.

Virology. 2014 Nov;468-470:444-453. doi: 10.1016/j.virol.2014.08.026. Epub 2014 Sep 20.


Sex differences in SR Ca(2+) release in murine ventricular myocytes are regulated by the cAMP/PKA pathway.

Parks RJ, Ray G, Bienvenu LA, Rose RA, Howlett SE.

J Mol Cell Cardiol. 2014 Oct;75:162-73. doi: 10.1016/j.yjmcc.2014.07.006. Epub 2014 Jul 24.


Retinal transduction profiles by high-capacity viral vectors.

Puppo A, Cesi G, Marrocco E, Piccolo P, Jacca S, Shayakhmetov DM, Parks RJ, Davidson BL, Colloca S, Brunetti-Pierri N, Ng P, Donofrio G, Auricchio A.

Gene Ther. 2014 Oct;21(10):855-65. doi: 10.1038/gt.2014.57. Epub 2014 Jul 3.


Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice.

Murthy V, Gao Y, Geng L, LeBrasseur NK, White TA, Parks RJ, Brimijoin S.

Vaccine. 2014 Jul 16;32(33):4155-62. doi: 10.1016/j.vaccine.2014.05.067. Epub 2014 Jun 2.


An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF.

J Clin Invest. 2014 Apr;124(4):1835-43. doi: 10.1172/JCI73441. Epub 2014 Mar 10.


Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: evidence for enzymatic activity.

Zlebnik NE, Brimijoin S, Gao Y, Saykao AT, Parks RJ, Carroll ME.

Neuropsychopharmacology. 2014 May;39(6):1538-46. doi: 10.1038/npp.2014.3. Epub 2014 Jan 10.


Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression.

Holterman CE, Thibodeau JF, Towaij C, Gutsol A, Montezano AC, Parks RJ, Cooper ME, Touyz RM, Kennedy CR.

J Am Soc Nephrol. 2014 Apr;25(4):784-97. doi: 10.1681/ASN.2013040371. Epub 2013 Nov 21.


Pax7 is critical for the normal function of satellite cells in adult skeletal muscle.

von Maltzahn J, Jones AE, Parks RJ, Rudnicki MA.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16474-9. doi: 10.1073/pnas.1307680110. Epub 2013 Sep 24.


Supraphysiological expression of survival motor neuron protein from an adenovirus vector does not adversely affect cell function.

Goulet BB, McFall ER, Wong CM, Kothary R, Parks RJ.

Biochem Cell Biol. 2013 Aug;91(4):252-64. doi: 10.1139/bcb-2012-0094. Epub 2013 Apr 8.


Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.

Geng L, Gao Y, Chen X, Hou S, Zhan CG, Radic Z, Parks RJ, Russell SJ, Pham L, Brimijoin S.

PLoS One. 2013 Jun 28;8(6):e67446. doi: 10.1371/journal.pone.0067446. Print 2013.


The role of chromatin in adenoviral vector function.

Wong CM, McFall ER, Burns JK, Parks RJ.

Viruses. 2013 Jun 14;5(6):1500-15. doi: 10.3390/v5061500. Review.


Sex differences in mechanisms of cardiac excitation-contraction coupling.

Parks RJ, Howlett SE.

Pflugers Arch. 2013 May;465(5):747-63. doi: 10.1007/s00424-013-1233-0. Epub 2013 Feb 17. Review.


Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Liao HX, Bonsignori M, Alam SM, McLellan JS, Tomaras GD, Moody MA, Kozink DM, Hwang KK, Chen X, Tsao CY, Liu P, Lu X, Parks RJ, Montefiori DC, Ferrari G, Pollara J, Rao M, Peachman KK, Santra S, Letvin NL, Karasavvas N, Yang ZY, Dai K, Pancera M, Gorman J, Wiehe K, Nicely NI, Rerks-Ngarm S, Nitayaphan S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Sinangil F, Kim JH, Michael NL, Kepler TB, Kwong PD, Mascola JR, Nabel GJ, Pinter A, Zolla-Pazner S, Haynes BF.

Immunity. 2013 Jan 24;38(1):176-86. doi: 10.1016/j.immuni.2012.11.011. Epub 2013 Jan 11.


Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways.

Conte D, Huh M, Goodall E, Delorme M, Parks RJ, Picketts DJ.

PLoS One. 2012;7(12):e52167. doi: 10.1371/journal.pone.0052167. Epub 2012 Dec 17.


Snapshots: chromatin control of viral infection.

Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM.

Virology. 2013 Jan 5;435(1):141-56. doi: 10.1016/j.virol.2012.09.023. Review.


Compromised genomic integrity impedes muscle growth after Atrx inactivation.

Huh MS, Price O'Dea T, Ouazia D, McKay BC, Parise G, Parks RJ, Rudnicki MA, Picketts DJ.

J Clin Invest. 2012 Dec;122(12):4412-23. doi: 10.1172/JCI63765. Epub 2012 Nov 1.


Diacylglycerol kinase ζ regulates RhoA activation via a kinase-independent scaffolding mechanism.

Ard R, Mulatz K, Abramovici H, Maillet JC, Fottinger A, Foley T, Byham MR, Iqbal TA, Yoneda A, Couchman JR, Parks RJ, Gee SH.

Mol Biol Cell. 2012 Oct;23(20):4008-19. doi: 10.1091/mbc.E12-01-0026. Epub 2012 Aug 23.


Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.

Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X, Kinsey B, Parks RJ, Gao Y, Brimijoin S.

PLoS One. 2012;7(8):e43536. doi: 10.1371/journal.pone.0043536. Epub 2012 Aug 17.


H-89 decreases the gain of excitation-contraction coupling and attenuates calcium sparks in the absence of beta-adrenergic stimulation.

Parks RJ, Howlett SE.

Eur J Pharmacol. 2012 Sep 15;691(1-3):163-72. doi: 10.1016/j.ejphar.2012.07.012. Epub 2012 Jul 14.


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