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Items: 1 to 50 of 285

1.

Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor.

Bashore AC, Liu M, Key CC, Boudyguina E, Wang X, Carroll CM, Sawyer JK, Mullick AE, Lee RG, Macauley SL, Parks JS.

Arterioscler Thromb Vasc Biol. 2019 Jun 6:ATVBAHA119312382. doi: 10.1161/ATVBAHA.119.312382. [Epub ahead of print]

PMID:
31167565
2.

Plasma apoM and S1P levels are inversely associated with mortality in African Americans with type 2 diabetes mellitus.

Liu M, Frej C, Langefeld CD, Divers J, Bowden DW, Carr JJ, Gebre AK, Xu J, Larsson B, Dahlbäck B, Freedman BI, Parks JS.

J Lipid Res. 2019 Aug;60(8):1425-1431. doi: 10.1194/jlr.P089409. Epub 2019 May 27.

PMID:
31133557
3.

Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans.

Sharma NK, Chuang Key CC, Civelek M, Wabitsch M, Comeau ME, Langefeld CD, Parks JS, Das SK.

Diabetes. 2019 Jul;68(7):1508-1522. doi: 10.2337/db18-1229. Epub 2019 Apr 22.

PMID:
31010960
4.

Genetic Polymorphisms Associated with Idiopathic Short Stature and First-Year Response to Growth Hormone Treatment.

Quigley CA, Li YG, Brown MR, Pillai SG, Banerjee P, Scott RS, Blum WF, Parks JS.

Horm Res Paediatr. 2019;91(3):164-174. doi: 10.1159/000496989. Epub 2019 Apr 10.

PMID:
30970347
5.

Gene Sequence and Production of Recombinant MetGH/hGH.

Parks JS.

Pediatr Endocrinol Rev. 2018 Sep;16(Suppl 1):17-27. doi: 10.17458/per.vol16.2018.p.sequenceproductionmetgh.

PMID:
30378779
6.

Screening a large pediatric cohort with GH deficiency for mutations in genes regulating pituitary development and GH secretion: Frequencies, phenotypes and growth outcomes.

Blum WF, Klammt J, Amselem S, Pfäffle HM, Legendre M, Sobrier ML, Luton MP, Child CJ, Jones C, Zimmermann AG, Quigley CA, Cutler GB Jr, Deal CL, Lebl J, Rosenfeld RG, Parks JS, Pfäffle RW.

EBioMedicine. 2018 Oct;36:390-400. doi: 10.1016/j.ebiom.2018.09.026. Epub 2018 Sep 25. No abstract available.

7.

Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain.

He H, Holl K, DeBehnke S, Yeo CT, Hansen P, Gebre AK, Leone-Kabler S, Ruas M, Parks JS, Parrington J, Solberg Woods LC.

Physiol Genomics. 2018 Aug 1;50(8):605-614. doi: 10.1152/physiolgenomics.00135.2017. Epub 2018 May 11.

8.

Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice.

Liu M, Chuang Key CC, Weckerle A, Boudyguina E, Sawyer JK, Gebre AK, Spoo W, Makwana O, Parks JS.

Food Chem Toxicol. 2018 Mar;113:287-295. doi: 10.1016/j.fct.2018.01.058. Epub 2018 Feb 5.

PMID:
29421645
9.

Congenital Hypopituitarism.

Parks JS.

Clin Perinatol. 2018 Mar;45(1):75-91. doi: 10.1016/j.clp.2017.11.001. Review.

PMID:
29406008
10.

Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.

Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):733-743. doi: 10.1161/ATVBAHA.117.309880. Epub 2018 Jan 18.

11.

Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

Divers J, Palmer ND, Langefeld CD, Brown WM, Lu L, Hicks PJ, Smith SC, Xu J, Terry JG, Register TC, Wagenknecht LE, Parks JS, Ma L, Chan GC, Buxbaum SG, Correa A, Musani S, Wilson JG, Taylor HA, Bowden DW, Carr JJ, Freedman BI.

BMC Genet. 2017 Dec 8;18(1):105. doi: 10.1186/s12863-017-0572-9.

12.

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.

Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, Parks JS, Hammer RE, Boucher P, Tsai S, Herz J.

Elife. 2017 Nov 16;6. pii: e29292. doi: 10.7554/eLife.29292.

13.

Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.

Gromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JM.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):218-231. doi: 10.1161/ATVBAHA.117.309660. Epub 2017 Oct 26.

14.

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.

Zamanian-Daryoush M, Lindner DJ, DiDonato JA, Wagner M, Buffa J, Rayman P, Parks JS, Westerterp M, Tall AR, Hazen SL.

Oncotarget. 2017 Jun 27;8(42):71965-71980. doi: 10.18632/oncotarget.18666. eCollection 2017 Sep 22.

15.

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.

Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR Jr, Post W, Hoeschele I, Bell DA, Herrington D, Parks JS, Tracy RP, McCall CE, Stein JH.

Nat Commun. 2017 Aug 30;8(1):393. doi: 10.1038/s41467-017-00517-4.

16.

Genetic regulation of adipose tissue transcript expression is involved in modulating serum triglyceride and HDL-cholesterol.

Sajuthi SP, Sharma NK, Comeau ME, Chou JW, Bowden DW, Freedman BI, Langefeld CD, Parks JS, Das SK.

Gene. 2017 Oct 20;632:50-58. doi: 10.1016/j.gene.2017.08.019. Epub 2017 Aug 26.

17.

Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.

Liu M, Chung S, Shelness GS, Parks JS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt A):1035-1043. doi: 10.1016/j.bbalip.2017.07.001. Epub 2017 Jul 8.

PMID:
28694219
18.

Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.

Omar I, Rom O, Aviram M, Cohen-Daniel L, Gebre AK, Parks JS, Berger M.

Immunology. 2017 Nov;152(3):484-493. doi: 10.1111/imm.12785. Epub 2017 Aug 2.

19.

Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.

Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS.

Cell Rep. 2017 Jun 6;19(10):2116-2129. doi: 10.1016/j.celrep.2017.05.032.

20.

Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes.

Lee SG, Parks JS, Kang HW.

J Nutr Biochem. 2017 Apr;42:62-71. doi: 10.1016/j.jnutbio.2016.12.018. Epub 2017 Jan 12.

PMID:
28131896
21.

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction.

Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI.

J Am Soc Nephrol. 2017 Apr;28(4):1093-1105. doi: 10.1681/ASN.2016050567. Epub 2016 Nov 7.

22.

In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.

Shewale SV, Brown AL, Bi X, Boudyguina E, Sawyer JK, Alexander-Miller MA, Parks JS.

J Lipid Res. 2017 Jan;58(1):236-246. doi: 10.1194/jlr.M072769. Epub 2016 Nov 3.

23.

Very Low Density Lipoprotein Assembly Is Required for cAMP-responsive Element-binding Protein H Processing and Hepatic Apolipoprotein A-IV Expression.

Cheng D, Xu X, Simon T, Boudyguina E, Deng Z, VerHague M, Lee AH, Shelness GS, Weinberg RB, Parks JS.

J Biol Chem. 2016 Nov 4;291(45):23793-23803. Epub 2016 Sep 21.

24.

MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.

Lai L, Azzam KM, Lin WC, Rai P, Lowe JM, Gabor KA, Madenspacher JH, Aloor JJ, Parks JS, Näär AM, Fessler MB.

J Biol Chem. 2016 Sep 9;291(37):19651-60. doi: 10.1074/jbc.M116.723056. Epub 2016 Jul 28.

25.

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.

Westerterp M, Tsuchiya K, Tattersall IW, Fotakis P, Bochem AE, Molusky MM, Ntonga V, Abramowicz S, Parks JS, Welch CL, Kitajewski J, Accili D, Tall AR.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1328-37. doi: 10.1161/ATVBAHA.115.306670. Epub 2016 May 19.

26.

Myeloid Deletion of α1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice.

Cao Q, Cui X, Wu R, Zha L, Wang X, Parks JS, Yu L, Shi H, Xue B.

Diabetes. 2016 Jun;65(6):1565-76. doi: 10.2337/db15-0917. Epub 2016 Jan 28.

27.

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.

Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL.

J Biol Chem. 2016 Mar 18;291(12):6386-95. doi: 10.1074/jbc.M115.696088. Epub 2016 Jan 21.

28.

Dietary cholesterol effects on adipose tissue inflammation.

Chung S, Parks JS.

Curr Opin Lipidol. 2016 Feb;27(1):19-25. doi: 10.1097/MOL.0000000000000260. Review.

29.

Characterization of circulating APOL1 protein complexes in African Americans.

Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.

J Lipid Res. 2016 Jan;57(1):120-30. doi: 10.1194/jlr.M063453. Epub 2015 Nov 18.

30.

Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.

Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y.

Diabetes. 2015 Oct;64(10):3464-74. doi: 10.2337/db14-1314. Epub 2015 Jul 7.

31.

Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.

Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, Freedman BI, Parks JS, Shelness GS.

J Lipid Res. 2015 Aug;56(8):1583-93. doi: 10.1194/jlr.M059733. Epub 2015 Jun 18.

32.

Genesis of two most prevalent PROP1 gene variants causing combined pituitary hormone deficiency in 21 populations.

Dusatkova P, Pfäffle R, Brown MR, Akulevich N, Arnhold IJ, Kalina MA, Kot K, Krzisnik C, Lemos MC, Malikova J, Navardauskaite R, Obermannova B, Pribilincova Z, Sallai A, Stipancic G, Verkauskiene R, Cinek O, Blum WF, Parks JS, Austerlitz F, Lebl J.

Eur J Hum Genet. 2016 Mar;24(3):415-20. doi: 10.1038/ejhg.2015.126. Epub 2015 Jun 10.

33.

Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver.

Shewale SV, Boudyguina E, Zhu X, Shen L, Hutchins PM, Barkley RM, Murphy RC, Parks JS.

J Lipid Res. 2015 Jun;56(6):1191-205. doi: 10.1194/jlr.M059170. Epub 2015 Apr 28.

34.

Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.

Chowdhury SM, Zhu X, Aloor JJ, Azzam KM, Gabor KA, Ge W, Addo KA, Tomer KB, Parks JS, Fessler MB.

Mol Cell Proteomics. 2015 Jul;14(7):1859-70. doi: 10.1074/mcp.M114.045179. Epub 2015 Apr 24.

35.

Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.

Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS.

J Biol Chem. 2015 Mar 20;290(12):7861-70. doi: 10.1074/jbc.M114.631101. Epub 2015 Jan 27.

36.

Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.

Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B.

Endocrinology. 2014 Dec;155(12):4925-38. doi: 10.1210/en.2014-1595. Epub 2014 Sep 24.

37.

A novel TRPS1 gene mutation causing trichorhinophalangeal syndrome with growth hormone responsive short stature: a case report and review of the literature.

Merjaneh L, Parks JS, Muir AB, Fadoju D.

Int J Pediatr Endocrinol. 2014;2014(1):16. doi: 10.1186/1687-9856-2014-16. Epub 2014 Aug 15.

38.

Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development.

Cao Q, Rong S, Repa JJ, St Clair R, Parks JS, Mishra N.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1871-9. doi: 10.1161/ATVBAHA.114.303393. Epub 2014 Jul 17.

39.

Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.

Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, Cheng D, Saleem MA, Satchell SC, Banas B, Mathieson PW, Kretzler M, Hemal AK, Rudel LL, Petrovic S, Weckerle A, Pollak MR, Ross MD, Parks JS, Freedman BI.

J Am Soc Nephrol. 2015 Feb;26(2):339-48. doi: 10.1681/ASN.2013091017. Epub 2014 Jul 10.

40.

Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys.

Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1880-7. doi: 10.1161/ATVBAHA.114.303896. Epub 2014 Jun 26.

41.

Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.

Bi X, Zhu X, Gao C, Shewale S, Cao Q, Liu M, Boudyguina E, Gebre AK, Wilson MD, Brown AL, Parks JS.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1888-99. doi: 10.1161/ATVBAHA.114.303791. Epub 2014 May 15.

42.

An abundant dysfunctional apolipoprotein A1 in human atheroma.

Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL.

Nat Med. 2014 Feb;20(2):193-203. doi: 10.1038/nm.3459. Epub 2014 Jan 26.

43.

Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.

Liu M, Seo J, Allegood J, Bi X, Zhu X, Boudyguina E, Gebre AK, Avni D, Shah D, Sorci-Thomas MG, Thomas MJ, Shelness GS, Spiegel S, Parks JS.

J Biol Chem. 2014 Jan 31;289(5):2801-14. doi: 10.1074/jbc.M113.499913. Epub 2013 Dec 6.

44.

Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice.

Iqbal J, Parks JS, Hussain MM.

J Biol Chem. 2013 Oct 18;288(42):30432-44. doi: 10.1074/jbc.M113.501247. Epub 2013 Sep 9.

45.

Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models.

Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS.

J Lipid Res. 2013 Oct;54(10):2708-17. doi: 10.1194/jlr.M038943. Epub 2013 Jul 27.

46.

Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice.

Forrest LM, Lough CM, Chung S, Boudyguina EY, Gebre AK, Smith TL, Colvin PL, Parks JS.

Nutrients. 2013 Jul 12;5(7):2629-45. doi: 10.3390/nu5072629.

47.

Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis.

Bi X, Zhu X, Duong M, Boudyguina EY, Wilson MD, Gebre AK, Parks JS.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2288-96. doi: 10.1161/ATVBAHA.112.301110. Epub 2013 Jun 27.

48.

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation.

Cheng HY, Wu R, Gebre AK, Hanna RN, Smith DJ, Parks JS, Ley K, Hedrick CC.

PLoS One. 2013 May 21;8(5):e63746. doi: 10.1371/journal.pone.0063746. Print 2013.

49.

Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice.

Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR.

Circ Res. 2013 May 24;112(11):1456-65. doi: 10.1161/CIRCRESAHA.113.301086. Epub 2013 Apr 9.

50.

Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS.

Cell Metab. 2013 Apr 2;17(4):549-61. doi: 10.1016/j.cmet.2013.03.009.

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