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Items: 1 to 50 of 208

1.

Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.

Flemming S, Luissint AC, Nusrat A, Parkos CA.

JCI Insight. 2018 Oct 18;3(20). pii: 99722. doi: 10.1172/jci.insight.99722. [Epub ahead of print]

2.

Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans.

Salinas-Muñoz L, Campos-Fernández R, Mercader E, Olivera-Valle I, Fernández-Pacheco C, Matilla L, García-Bordas J, Brazil JC, Parkos CA, Asensio F, Muñoz-Fernández MA, Hidalgo A, Sánchez-Mateos P, Samaniego R, Relloso M.

Front Immunol. 2018 May 24;9:1033. doi: 10.3389/fimmu.2018.01033. eCollection 2018.

3.

Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines.

Yulis M, Quiros M, Hilgarth R, Parkos CA, Nusrat A.

Cell Death Dis. 2018 Mar 9;9(3):389. doi: 10.1038/s41419-018-0380-9.

4.

Role of negative regulation of immune signaling pathways in neutrophil function.

Azcutia V, Parkos CA, Brazil JC.

J Leukoc Biol. 2017 Dec 19. doi: 10.1002/JLB.3MIR0917-374R. [Epub ahead of print] Review.

PMID:
29345376
5.

Bioengineering Bacterially Derived Immunomodulants: A Therapeutic Approach to Inflammatory Bowel Disease.

Herrera Estrada L, Wu H, Ling K, Zhang G, Sumagin R, Parkos CA, Jones RM, Champion JA, Neish AS.

ACS Nano. 2017 Oct 24;11(10):9650-9662. doi: 10.1021/acsnano.7b03239. Epub 2017 Sep 5.

PMID:
28872828
6.

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.

Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A.

J Clin Invest. 2017 Sep 1;127(9):3510-3520. doi: 10.1172/JCI90229. Epub 2017 Aug 7.

7.

Expression of Lewis-a glycans on polymorphonuclear leukocytes augments function by increasing transmigration.

Brazil JC, Sumagin R, Stowell SR, Lee G, Louis NA, Cummings RD, Parkos CA.

J Leukoc Biol. 2017 Sep;102(3):753-762. doi: 10.1189/jlb.1MA0117-013R. Epub 2017 Jun 9.

8.

Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.

Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW.

J Leukoc Biol. 2017 Feb;101(2):493-505. doi: 10.1189/jlb.3A1215-546RR. Epub 2016 Dec 13.

PMID:
27965383
9.

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL.

Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14.

10.

Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades.

Lili LN, Farkas AE, Gerner-Smidt C, Overgaard CE, Moreno CS, Parkos CA, Capaldo CT, Nusrat A.

Tissue Barriers. 2016 Jul 19;4(3):e1214038. doi: 10.1080/21688370.2016.1214038. eCollection 2016 Jul-Sep.

11.

Pathobiology of neutrophil-epithelial interactions.

Brazil JC, Parkos CA.

Immunol Rev. 2016 Sep;273(1):94-111. doi: 10.1111/imr.12446. Review.

12.

Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration.

Butin-Israeli V, Houser MC, Feng M, Thorp EB, Nusrat A, Parkos CA, Sumagin R.

FASEB J. 2016 Dec;30(12):4007-4020. Epub 2016 Aug 23.

13.

Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair.

Luissint AC, Parkos CA, Nusrat A.

Gastroenterology. 2016 Oct;151(4):616-32. doi: 10.1053/j.gastro.2016.07.008. Epub 2016 Jul 18. Review.

14.

Redox control of Cas phosphorylation requires Abl kinase in regulation of intestinal epithelial cell spreading and migration.

Matthews JD, Sumagin R, Hinrichs B, Nusrat A, Parkos CA, Neish AS.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G458-65. doi: 10.1152/ajpgi.00189.2016. Epub 2016 Jul 14.

15.

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol.

Rahman K, Desai C, Iyer SS, Thorn NE, Kumar P, Liu Y, Smith T, Neish AS, Li H, Tan S, Wu P, Liu X, Yu Y, Farris AB, Nusrat A, Parkos CA, Anania FA.

Gastroenterology. 2016 Oct;151(4):733-746.e12. doi: 10.1053/j.gastro.2016.06.022. Epub 2016 Jun 21.

16.

Neutrophil-Epithelial Interactions: A Double-Edged Sword.

Parkos CA.

Am J Pathol. 2016 Jun;186(6):1404-16. doi: 10.1016/j.ajpath.2016.02.001. Epub 2016 Apr 12. Review.

17.

Norovirus in symptomatic and asymptomatic individuals: cytokines and viral shedding.

Newman KL, Moe CL, Kirby AE, Flanders WD, Parkos CA, Leon JS.

Clin Exp Immunol. 2016 Jun;184(3):347-57. doi: 10.1111/cei.12772. Epub 2016 Feb 25.

18.

Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing.

Sumagin R, Brazil JC, Nava P, Nishio H, Alam A, Luissint AC, Weber DA, Neish AS, Nusrat A, Parkos CA.

Mucosal Immunol. 2016 Sep;9(5):1151-62. doi: 10.1038/mi.2015.135. Epub 2016 Jan 6.

19.

Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation.

Brazil JC, Sumagin R, Cummings RD, Louis NA, Parkos CA.

Am J Pathol. 2016 Feb;186(2):297-311. doi: 10.1016/j.ajpath.2015.10.015. Epub 2015 Dec 10.

20.

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, Nusrat A, Denning TL.

J Immunol. 2016 Jan 1;196(1):34-8. doi: 10.4049/jimmunol.1501312. Epub 2015 Nov 20.

21.

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier.

Kamekura R, Nava P, Feng M, Quiros M, Nishio H, Weber DA, Parkos CA, Nusrat A.

Mol Biol Cell. 2015 Sep 15;26(18):3165-77. doi: 10.1091/mbc.E15-03-0147. Epub 2015 Jul 29.

22.

HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.

Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA, Nusrat A.

Am J Pathol. 2015 Aug;185(8):2206-18. doi: 10.1016/j.ajpath.2015.04.023.

23.

Human norovirus infection and the acute serum cytokine response.

Newman KL, Moe CL, Kirby AE, Flanders WD, Parkos CA, Leon JS.

Clin Exp Immunol. 2015 Nov;182(2):195-203. doi: 10.1111/cei.12681. Epub 2015 Sep 22.

24.

Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration.

Sumagin R, Parkos CA.

Tissue Barriers. 2015 Apr 3;3(1-2):e969100. doi: 10.4161/21688362.2014.969100. eCollection 2015.

25.

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS, Nusrat A.

J Clin Invest. 2015 Mar 2;125(3):1215-27. doi: 10.1172/JCI76693. Epub 2015 Feb 9.

26.

Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function.

Mitchell LA, Ward C, Kwon M, Mitchell PO, Quintero DA, Nusrat A, Parkos CA, Koval M.

Am J Pathol. 2015 Feb;185(2):372-86. doi: 10.1016/j.ajpath.2014.10.010. Epub 2014 Nov 28.

27.

Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response.

Leoni G, Gripentrog J, Lord C, Riesselman M, Sumagin R, Parkos CA, Nusrat A, Jesaitis AJ.

J Leukoc Biol. 2015 Jan;97(1):87-101. doi: 10.1189/jlb.4A0314-153R. Epub 2014 Nov 13.

28.

Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination.

Lai CM, Boehme KW, Pruijssers AJ, Parekh VV, Van Kaer L, Parkos CA, Dermody TS.

J Infect Dis. 2015 Feb 1;211(3):383-93. doi: 10.1093/infdis/jiu476. Epub 2014 Aug 22.

29.

IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ.

Nava P, Kamekura R, Quirós M, Medina-Contreras O, Hamilton RW, Kolegraff KN, Koch S, Candelario A, Romo-Parra H, Laur O, Hilgarth RS, Denning TL, Parkos CA, Nusrat A.

Mol Biol Cell. 2014 Oct 1;25(19):2894-904. doi: 10.1091/mbc.E13-09-0512. Epub 2014 Jul 30.

30.

Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface.

Monteiro AC, Luissint AC, Sumagin R, Lai C, Vielmuth F, Wolf MF, Laur O, Reiss K, Spindler V, Stehle T, Dermody TS, Nusrat A, Parkos CA.

Mol Biol Cell. 2014 May;25(10):1574-85. doi: 10.1091/mbc.E14-01-0018. Epub 2014 Mar 26.

31.

JAM-related proteins in mucosal homeostasis and inflammation.

Luissint AC, Nusrat A, Parkos CA.

Semin Immunopathol. 2014 Mar;36(2):211-26. doi: 10.1007/s00281-014-0421-0. Epub 2014 Mar 26. Review.

32.

Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation.

Weber DA, Sumagin R, McCall IC, Leoni G, Neumann PA, Andargachew R, Brazil JC, Medina-Contreras O, Denning TL, Nusrat A, Parkos CA.

Mucosal Immunol. 2014 Sep;7(5):1221-32. doi: 10.1038/mi.2014.12. Epub 2014 Mar 12.

33.

Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion.

Jiang K, Rankin CR, Nava P, Sumagin R, Kamekura R, Stowell SR, Feng M, Parkos CA, Nusrat A.

J Biol Chem. 2014 Apr 11;289(15):10510-7. doi: 10.1074/jbc.M113.538538. Epub 2014 Feb 24.

34.

Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression.

Wise SK, Laury AM, Katz EH, Den Beste KA, Parkos CA, Nusrat A.

Int Forum Allergy Rhinol. 2014 May;4(5):361-70. doi: 10.1002/alr.21298. Epub 2014 Feb 7.

35.

Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment.

Sumagin R, Robin AZ, Nusrat A, Parkos CA.

Mucosal Immunol. 2014 Jul;7(4):905-15. doi: 10.1038/mi.2013.106. Epub 2013 Dec 18.

36.

Leukocyte-epithelial interactions and mucosal homeostasis.

Matthews JD, Weight CM, Parkos CA.

Toxicol Pathol. 2014 Jan;42(1):91-8. doi: 10.1177/0192623313511336. Epub 2013 Nov 27. Review.

37.

Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signaling.

Kamekura R, Kolegraff KN, Nava P, Hilgarth RS, Feng M, Parkos CA, Nusrat A.

Oncogene. 2014 Sep 4;33(36):4531-6. doi: 10.1038/onc.2013.442. Epub 2013 Oct 28.

38.

α3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration.

Brazil JC, Liu R, Sumagin R, Kolegraff KN, Nusrat A, Cummings RD, Parkos CA, Louis NA.

J Immunol. 2013 Nov 1;191(9):4804-17. doi: 10.4049/jimmunol.1301307. Epub 2013 Sep 25.

39.

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.

Azcutia V, Routledge M, Williams MR, Newton G, Frazier WA, Manica A, Croce KJ, Parkos CA, Schmider AB, Turman MV, Soberman RJ, Luscinskas FW.

Mol Biol Cell. 2013 Nov;24(21):3358-68. doi: 10.1091/mbc.E13-01-0063. Epub 2013 Sep 4.

40.

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.

Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA.

Mol Biol Cell. 2013 Sep;24(18):2849-60. doi: 10.1091/mbc.E13-06-0298. Epub 2013 Jul 24.

41.

Neutrophils enlist IL-22 to restore order in the gut.

Denning TL, Parkos CA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12509-10. doi: 10.1073/pnas.1310907110. Epub 2013 Jul 19. No abstract available.

42.

The role of polymorphonuclear leukocyte trafficking in the perpetuation of inflammation during inflammatory bowel disease.

Brazil JC, Louis NA, Parkos CA.

Inflamm Bowel Dis. 2013 Jun;19(7):1556-65. doi: 10.1097/MIB.0b013e318281f54e. Review.

43.

House dust mite allergen Der p 1 effects on sinonasal epithelial tight junctions.

Henriquez OA, Den Beste K, Hoddeson EK, Parkos CA, Nusrat A, Wise SK.

Int Forum Allergy Rhinol. 2013 Aug;3(8):630-5. doi: 10.1002/alr.21168. Epub 2013 Apr 16.

44.

Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration.

Rankin CR, Hilgarth RS, Leoni G, Kwon M, Den Beste KA, Parkos CA, Nusrat A.

J Biol Chem. 2013 May 24;288(21):15229-39. doi: 10.1074/jbc.M112.440909. Epub 2013 Apr 4.

45.

Sinonasal epithelial wound resealing in an in vitro model: inhibition of wound closure with IL-4 exposure.

Wise SK, Den Beste KA, Hoddeson EK, Parkos CA, Nusrat A.

Int Forum Allergy Rhinol. 2013 Jun;3(6):439-49. doi: 10.1002/alr.21158. Epub 2013 Mar 6.

46.

Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda.

Denson LA, Long MD, McGovern DP, Kugathasan S, Wu GD, Young VB, Pizarro TT, de Zoeten EF, Stappenbeck TS, Plevy SE, Abraham C, Nusrat A, Jobin C, McCole DF, Siegel CA, Higgins PD, Herfarth HH, Hyams J, Sandborn WJ, Loftus EV Jr, Kappelman MD, Lewis JD, Parkos CA, Sartor RB; Challenges Workgroup.

Inflamm Bowel Dis. 2013 Mar-Apr;19(4):677-82. doi: 10.1097/MIB.0b013e31828134b3. No abstract available.

47.

Activation of PKCβII by PMA facilitates enhanced epithelial wound repair through increased cell spreading and migration.

Sumagin R, Robin AZ, Nusrat A, Parkos CA.

PLoS One. 2013;8(2):e55775. doi: 10.1371/journal.pone.0055775. Epub 2013 Feb 11.

48.

Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice.

Shashidharamurthy R, Machiah D, Aitken JD, Putty K, Srinivasan G, Chassaing B, Parkos CA, Selvaraj P, Vijay-Kumar M.

Arthritis Rheum. 2013 Apr;65(4):1064-73. doi: 10.1002/art.37840.

49.

Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit.

Mirpuri J, Sotnikov I, Myers L, Denning TL, Yarovinsky F, Parkos CA, Denning PW, Louis NA.

PLoS One. 2012;7(12):e51955. doi: 10.1371/journal.pone.0051955. Epub 2012 Dec 18.

50.

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.

Leoni G, Alam A, Neumann PA, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Neish AS, Nusrat A.

J Clin Invest. 2013 Jan;123(1):443-54. doi: 10.1172/JCI65831. Epub 2012 Dec 17.

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