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Items: 1 to 50 of 265

1.

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series.

Aspatwar A, Parvathaneni NK, Barker H, Anduran E, Supuran CT, Dubois L, Lambin P, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):109-117. doi: 10.1080/14756366.2019.1685510.

2.

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos.

Aspatwar A, Hammaren M, Parikka M, Parkkila S, Carta F, Bozdag M, Vullo D, Supuran CT.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):65-71. doi: 10.1080/14756366.2019.1683007.

3.

Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs.

Aspatwar A, Kairys V, Rala S, Parikka M, Bozdag M, Carta F, Supuran CT, Parkkila S.

Int J Mol Sci. 2019 Oct 17;20(20). pii: E5153. doi: 10.3390/ijms20205153. Review.

4.

A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors.

Llanos MA, Sbaraglini ML, Villalba ML, Ruiz MD, Carrillo C, Alba Soto C, Talevi A, Angeli A, Parkkila S, Supuran CT, Gavernet L.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):21-30. doi: 10.1080/14756366.2019.1677638.

5.

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos.

Aspatwar A, Hammaren MM, Parikka M, Parkkila S.

J Vis Exp. 2019 Aug 25;(150). doi: 10.3791/59315.

PMID:
31498322
6.

Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors.

Kazokaitė J, Kairys V, Smirnovienė J, Smirnov A, Manakova E, Tolvanen M, Parkkila S, Matulis D.

Sci Rep. 2019 Sep 3;9(1):12710. doi: 10.1038/s41598-019-49094-0.

7.

Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases.

Saghafi T, Taheri RA, Parkkila S, Emameh RZ.

Int J Mol Sci. 2019 Jun 15;20(12). pii: E2939. doi: 10.3390/ijms20122939. Review.

8.

Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1.

Aspatwar A, Tolvanen MEE, Schneider HP, Becker HM, Narkilahti S, Parkkila S, Deitmer JW.

FEBS Open Bio. 2019 Jul;9(7):1204-1211. doi: 10.1002/2211-5463.12647. Epub 2019 Jun 11.

9.

Discovery of new organoselenium compounds as antileishmanial agents.

Al-Tamimi AS, Etxebeste-Mitxeltorena M, Sanmartín C, Jiménez-Ruiz A, Syrjänen L, Parkkila S, Selleri S, Carta F, Angeli A, Supuran CT.

Bioorg Chem. 2019 May;86:339-345. doi: 10.1016/j.bioorg.2019.01.069. Epub 2019 Jan 31.

PMID:
30743174
10.

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica with Amino Acids and Amines.

Bua S, Haapanen S, Kuuslahti M, Parkkila S, Supuran CT.

Metabolites. 2019 Feb 1;9(2). pii: E26. doi: 10.3390/metabo9020026.

11.

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica.

Bua S, Haapanen S, Kuuslahti M, Parkkila S, Supuran CT.

Int J Mol Sci. 2018 Dec 8;19(12). pii: E3946. doi: 10.3390/ijms19123946.

12.

R-Ras regulates vascular permeability, but not overall healing in skin wounds.

Ketomäki T, Vähätupa M, May U, Pemmari T, Ruikka E, Hietamo J, Kaipiainen P, Barker H, Parkkila S, Uusitalo-Järvinen H, Järvinen TAH.

Exp Dermatol. 2019 Feb;28(2):202-206. doi: 10.1111/exd.13851. Epub 2018 Dec 21.

PMID:
30489650
13.

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica.

Haapanen S, Bua S, Kuuslahti M, Parkkila S, Supuran CT.

Molecules. 2018 Nov 28;23(12). pii: E3112. doi: 10.3390/molecules23123112.

14.

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies.

Aspatwar A, Winum JY, Carta F, Supuran CT, Hammaren M, Parikka M, Parkkila S.

Molecules. 2018 Nov 8;23(11). pii: E2911. doi: 10.3390/molecules23112911. Review.

15.

Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Karihtala P, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ.

APMIS. 2018 Nov;126(11):852-863. doi: 10.1111/apm.12894.

PMID:
30357962
16.

Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma.

Nortunen M, Huhta H, Helminen O, Parkkila S, Kauppila JH, Karttunen TJ, Saarnio J.

Virchows Arch. 2018 Nov;473(5):567-575. doi: 10.1007/s00428-018-2424-z. Epub 2018 Jul 31.

PMID:
30066203
17.

Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi.

Angeli A, Kuuslahti M, Parkkila S, Supuran CT.

Bioorg Med Chem. 2018 Aug 7;26(14):4187-4190. doi: 10.1016/j.bmc.2018.07.011. Epub 2018 Jul 7.

PMID:
30007565
18.

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ.

World J Surg Oncol. 2018 Jul 4;16(1):127. doi: 10.1186/s12957-018-1432-4.

19.

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.

Aspatwar A, Becker HM, Parvathaneni NK, Hammaren M, Svorjova A, Barker H, Supuran CT, Dubois L, Lambin P, Parikka M, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1064-1073. doi: 10.1080/14756366.2018.1482285.

20.

Involvement of β-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists.

Zolfaghari Emameh R, Barker HR, Hytönen VP, Parkkila S.

Appl Environ Microbiol. 2018 Jul 17;84(15). pii: e00771-18. doi: 10.1128/AEM.00771-18. Print 2018 Aug 1.

21.

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.

Karjalainen SL, Haapasalo HK, Aspatwar A, Barker H, Parkkila S, Haapasalo JA.

BMC Cancer. 2018 May 23;18(1):584. doi: 10.1186/s12885-018-4493-4.

22.

Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi.

Angeli A, Donald WA, Parkkila S, Supuran CT.

Bioorg Chem. 2018 Aug;78:406-410. doi: 10.1016/j.bioorg.2018.04.010. Epub 2018 Apr 16.

PMID:
29689418
23.

An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii.

Aspatwar A, Haapanen S, Parkkila S.

Metabolites. 2018 Mar 13;8(1). pii: E22. doi: 10.3390/metabo8010022. Review.

24.

Surveillance and diagnosis of zoonotic foodborne parasites.

Zolfaghari Emameh R, Purmonen S, Sukura A, Parkkila S.

Food Sci Nutr. 2017 Nov 12;6(1):3-17. doi: 10.1002/fsn3.530. eCollection 2018 Jan. Review.

25.

Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae.

Vullo D, Syrjänen L, Kuuslahti M, Parkkila S, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):359-363. doi: 10.1080/14756366.2017.1421182.

26.

Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase.

Patrikainen MS, Tolvanen MEE, Aspatwar A, Barker HR, Ortutay C, Jänis J, Laitaoja M, Hytönen VP, Azizi L, Manandhar P, Jáger E, Vullo D, Kukkurainen S, Hilvo M, Supuran CT, Parkkila S.

PeerJ. 2017 Dec 7;5:e4128. doi: 10.7717/peerj.4128. eCollection 2017.

27.

An update on anticancer drug development and delivery targeting carbonic anhydrase IX.

Kazokaitė J, Aspatwar A, Parkkila S, Matulis D.

PeerJ. 2017 Nov 23;5:e4068. doi: 10.7717/peerj.4068. eCollection 2017.

28.

β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis.

Aspatwar A, Hammarén M, Koskinen S, Luukinen B, Barker H, Carta F, Supuran CT, Parikka M, Parkkila S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):832-840. doi: 10.1080/14756366.2017.1332056.

29.

Role of carbonic anhydrases in skin wound healing.

Barker H, Aaltonen M, Pan P, Vähätupa M, Kaipiainen P, May U, Prince S, Uusitalo-Järvinen H, Waheed A, Pastoreková S, Sly WS, Parkkila S, Järvinen TA.

Exp Mol Med. 2017 May 19;49(5):e334. doi: 10.1038/emm.2017.60.

30.

Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei.

Järvinen P, Kivelä AJ, Nummela P, Lepistö A, Ristimäki A, Parkkila S.

APMIS. 2017 Mar;125(3):207-212. doi: 10.1111/apm.12653.

PMID:
28233447
31.

Anti-carbonic anhydrase autoantibodies and serum beta-2 microglobulin correlate with the ClinESSDAI score in patients with Sjögren's syndrome.

Pertovaara M, Parkkila S, Korpela M.

Clin Exp Rheumatol. 2017 Mar-Apr;35(2):351. Epub 2017 Jan 5. No abstract available.

PMID:
28079504
32.

Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.

Viikilä P, Kivelä AJ, Mustonen H, Koskensalo S, Waheed A, Sly WS, Pastorek J, Pastorekova S, Parkkila S, Haglund C.

World J Gastroenterol. 2016 Sep 28;22(36):8168-77. doi: 10.3748/wjg.v22.i36.8168.

33.

Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide.

Kazokaitė J, Aspatwar A, Kairys V, Parkkila S, Matulis D.

Drug Chem Toxicol. 2017 Jul;40(3):309-319. doi: 10.1080/01480545.2016.1223095. Epub 2016 Sep 6.

PMID:
27600313
34.

Identification and inhibition of carbonic anhydrases from nematodes.

Zolfaghari Emameh R, Barker HR, Syrjänen L, Urbański L, Supuran CT, Parkkila S.

J Enzyme Inhib Med Chem. 2016;31(sup4):176-184. Epub 2016 Aug 25. Review.

PMID:
27557594
35.

Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.

Patrikainen MS, Pan P, Barker HR, Parkkila S.

Transgenic Res. 2016 Oct;25(5):649-64. doi: 10.1007/s11248-016-9961-5. Epub 2016 May 21.

PMID:
27209317
36.

Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation.

Niinimaki E, Muola P, Parkkila S, Kholová I, Haapasalo H, Pastorekova S, Pastorek J, Paavonen T, Mennander A.

Scand Cardiovasc J. 2016 Jun;50(3):162-6. doi: 10.3109/14017431.2016.1158416. Epub 2016 May 9.

PMID:
27157093
37.

Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes.

Zolfaghari Emameh R, Barker HR, Tolvanen ME, Parkkila S, Hytönen VP.

Parasit Vectors. 2016 Mar 16;9:152. doi: 10.1186/s13071-016-1415-7.

38.

Innovative molecular diagnosis of Trichinella species based on β-carbonic anhydrase genomic sequence.

Zolfaghari Emameh R, Kuuslahti M, Näreaho A, Sukura A, Parkkila S.

Microb Biotechnol. 2016 Mar;9(2):172-9. doi: 10.1111/1751-7915.12327. Epub 2015 Dec 7.

39.

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

La Regina G, Coluccia A, Famiglini V, Pelliccia S, Monti L, Vullo D, Nuti E, Alterio V, De Simone G, Monti SM, Pan P, Parkkila S, Supuran CT, Rossello A, Silvestri R.

J Med Chem. 2015 Nov 12;58(21):8564-72. doi: 10.1021/acs.jmedchem.5b01144. Epub 2015 Nov 4.

PMID:
26497049
40.

Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis.

Zolfaghari Emameh R, Kuuslahti M, Vullo D, Barker HR, Supuran CT, Parkkila S.

Parasit Vectors. 2015 Sep 18;8:479. doi: 10.1186/s13071-015-1098-5.

41.

β carbonic anhydrase is required for female fertility in Drosophila melanogaster.

Syrjänen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Rämet M, Parkkila S.

Front Zool. 2015 Aug 22;12:19. doi: 10.1186/s12983-015-0111-3. eCollection 2015.

42.

Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish.

Aspatwar A, Tolvanen ME, Ojanen MJ, Barker HR, Saralahti AK, Bäuerlein CA, Ortutay C, Pan P, Kuuslahti M, Parikka M, Rämet M, Parkkila S.

PLoS One. 2015 Jul 28;10(7):e0134263. doi: 10.1371/journal.pone.0134263. eCollection 2015.

43.

The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.

Syrjänen L, Kuuslahti M, Tolvanen M, Vullo D, Parkkila S, Supuran CT.

Bioorg Med Chem. 2015 May 15;23(10):2303-9. doi: 10.1016/j.bmc.2015.03.081. Epub 2015 Apr 7.

PMID:
25882523
44.

A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi.

Alafeefy AM, Ceruso M, Al-Jaber NA, Parkkila S, Vermelho AB, Supuran CT.

J Enzyme Inhib Med Chem. 2015;30(4):581-5. doi: 10.3109/14756366.2014.956309. Epub 2014 Nov 6.

PMID:
25373503
45.

Drosophila melanogaster: a model organism for controlling Dipteran vectors and pests.

Zolfaghari Emameh R, Syrjänen L, Barker H, Supuran CT, Parkkila S.

J Enzyme Inhib Med Chem. 2015 Jun;30(3):505-13. doi: 10.3109/14756366.2014.944178. Epub 2014 Sep 8. Review.

PMID:
25198895
46.

Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry.

Zolfaghari Emameh R, Barker H, Hytönen VP, Tolvanen ME, Parkkila S.

Parasit Vectors. 2014 Aug 29;7:403. doi: 10.1186/1756-3305-7-403.

47.

The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6⁻/⁻ mouse model.

Patrikainen M, Pan P, Kulesskaya N, Voikar V, Parkkila S.

J Biomed Sci. 2014 Aug 19;21:82. doi: 10.1186/s12929-014-0082-2.

48.

Development and characterization of new monoclonal antibodies against human recombinant CA XII.

Dekaminaviciute D, Lasickiene R, Parkkila S, Jogaite V, Matuliene J, Matulis D, Zvirbliene A.

Biomed Res Int. 2014;2014:309307. doi: 10.1155/2014/309307. Epub 2014 May 20.

49.

Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster.

Syrjänen L, Parkkila S, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2797-801. doi: 10.1016/j.bmcl.2014.04.117. Epub 2014 May 9.

PMID:
24852120
50.

Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation.

Reibring CG, El Shahawy M, Hallberg K, Kannius-Janson M, Nilsson J, Parkkila S, Sly WS, Waheed A, Linde A, Gritli-Linde A.

PLoS One. 2014 May 1;9(5):e96007. doi: 10.1371/journal.pone.0096007. eCollection 2014.

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