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Items: 7


Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol.

Teitelbaum AM, McDonald MG, Kowalski JP, Parkinson OT, Scian M, Whittington D, Roellecke K, Hanenberg H, Wiek C, Rettie AE.

J Pharmacol Exp Ther. 2019 Feb;368(2):308-316. doi: 10.1124/jpet.118.249771. Epub 2018 Nov 8.


Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity.

Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE.

Drug Metab Dispos. 2016 Oct;44(10):1598-602. doi: 10.1124/dmd.116.070003. Epub 2016 Jul 28.


Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, Hanenberg H.

PLoS One. 2015 Sep 10;10(9):e0137110. doi: 10.1371/journal.pone.0137110. eCollection 2015.


Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.

Parkinson OT, Liggitt HD, Rettie AE, Kelly EJ.

Toxicol Sci. 2013 Aug;134(2):243-50. doi: 10.1093/toxsci/kft123. Epub 2013 Jun 7.


Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016.

Parkinson OT, Kelly EJ, Bezabih E, Whittington D, Rettie AE.

J Vet Pharmacol Ther. 2012 Aug;35(4):402-5. doi: 10.1111/j.1365-2885.2011.01339.x. Epub 2011 Sep 15. No abstract available.


CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, Hall JE.

Drug Metab Dispos. 2006 Dec;34(12):1985-94. Epub 2006 Sep 22.


P450 2C18 catalyzes the metabolic bioactivation of phenytoin.

Kinobe RT, Parkinson OT, Mitchell DJ, Gillam EM.

Chem Res Toxicol. 2005 Dec;18(12):1868-75.


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