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Complete structure of the chemosensory array core signalling unit in an E. coli minicell strain.

Burt A, Cassidy CK, Ames P, Bacia-Verloop M, Baulard M, Huard K, Luthey-Schulten Z, Desfosses A, Stansfeld PJ, Margolin W, Parkinson JS, Gutsche I.

Nat Commun. 2020 Feb 6;11(1):743. doi: 10.1038/s41467-020-14350-9.


Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations.

Cassidy CK, Himes BA, Sun D, Ma J, Zhao G, Parkinson JS, Stansfeld PJ, Luthey-Schulten Z, Zhang P.

Commun Biol. 2020 Jan 10;3(1):24. doi: 10.1038/s42003-019-0748-0.


Under Elevated c-di-GMP in Escherichia coli, YcgR Alters Flagellar Motor Bias and Speed Sequentially, with Additional Negative Control of the Flagellar Regulon via the Adaptor Protein RssB.

Nieto V, Partridge JD, Severin GB, Lai RZ, Waters CM, Parkinson JS, Harshey RM.

J Bacteriol. 2019 Dec 6;202(1). pii: e00578-19. doi: 10.1128/JB.00578-19. Print 2019 Dec 6.


Identification of a Kinase-Active CheA Conformation in Escherichia coli Chemoreceptor Signaling Complexes.

Piñas GE, Parkinson JS.

J Bacteriol. 2019 Nov 5;201(23). pii: e00543-19. doi: 10.1128/JB.00543-19. Print 2019 Dec 1.


Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli.

Gao Q, Cheng A, Parkinson JS.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15651-15660. doi: 10.1073/pnas.1902521116. Epub 2019 Jul 17.


In Situ Conformational Changes of the Escherichia coli Serine Chemoreceptor in Different Signaling States.

Yang W, Cassidy CK, Ames P, Diebolder CA, Schulten K, Luthey-Schulten Z, Parkinson JS, Briegel A.

mBio. 2019 Jul 2;10(4). pii: e00973-19. doi: 10.1128/mBio.00973-19.


A zipped-helix cap potentiates HAMP domain control of chemoreceptor signaling.

Flack CE, Parkinson JS.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3519-E3528. doi: 10.1073/pnas.1721554115. Epub 2018 Mar 26.


Noncritical Signaling Role of a Kinase-Receptor Interaction Surface in the Escherichia coli Chemosensory Core Complex.

Piñas GE, DeSantis MD, Parkinson JS.

J Mol Biol. 2018 Mar 30;430(7):1051-1064. doi: 10.1016/j.jmb.2018.02.004. Epub 2018 Feb 14.


Monitoring Two-Component Sensor Kinases with a Chemotaxis Signal Readout.

Lai RZ, Parkinson JS.

Methods Mol Biol. 2018;1729:127-135. doi: 10.1007/978-1-4939-7577-8_12.


All-Codon Mutagenesis for Structure-Function Studies of Chemotaxis Signaling Proteins.

Ames P, Parkinson JS.

Methods Mol Biol. 2018;1729:79-85. doi: 10.1007/978-1-4939-7577-8_8.


Paradoxical enhancement of chemoreceptor detection sensitivity by a sensory adaptation enzyme.

Lai RZ, Han XS, Dahlquist FW, Parkinson JS.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7583-E7591. doi: 10.1073/pnas.1709075114. Epub 2017 Aug 21.


Classic Spotlights: Selected Highlights from the First 100 Years of the Journal of Bacteriology.

Armitage JP, Becker A, Christie PJ, de Boer PAJ, DiRita VJ, Gourse RL, Henkin TM, Margolin W, Metcalf WW, Mullineaux CW, O'Toole GA, Parkinson JS, Schneewind O, Silhavy TJ, Stock AM, Zhulin IB.

J Bacteriol. 2017 Jun 13;199(13). pii: e00062-17. doi: 10.1128/JB.00062-17. Print 2017 Jul 1. No abstract available.


Signaling Consequences of Structural Lesions that Alter the Stability of Chemoreceptor Trimers of Dimers.

Lai RZ, Gosink KK, Parkinson JS.

J Mol Biol. 2017 Mar 24;429(6):823-835. doi: 10.1016/j.jmb.2017.02.007. Epub 2017 Feb 16.


Networked Chemoreceptors Benefit Bacterial Chemotaxis Performance.

Frank V, Piñas GE, Cohen H, Parkinson JS, Vaknin A.

mBio. 2016 Dec 20;7(6). pii: e01824-16. doi: 10.1128/mBio.01824-16.


Classic Spotlight: the Discovery of Bacterial Transduction.

Parkinson JS.

J Bacteriol. 2016 Oct 7;198(21):2899-2900. Print 2016 Nov 1. No abstract available.


Classic Spotlight: Look, Max-No Math Required!

Parkinson JS.

J Bacteriol. 2016 Aug 11;198(17):2281-2. doi: 10.1128/JB.00525-16. Print 2016 Sep 1. No abstract available.


Classic Spotlight: Dawn of the Molecular Era of Bacterial Chemotaxis.

Parkinson JS.

J Bacteriol. 2016 Jun 13;198(13):1796. doi: 10.1128/JB.00297-16. Print 2016 Jul 1. No abstract available.


Evidence for a Helix-Clutch Mechanism of Transmembrane Signaling in a Bacterial Chemoreceptor.

Ames P, Hunter S, Parkinson JS.

J Mol Biol. 2016 Sep 25;428(19):3776-88. doi: 10.1016/j.jmb.2016.03.017. Epub 2016 Mar 24.


The source of high signal cooperativity in bacterial chemosensory arrays.

Piñas GE, Frank V, Vaknin A, Parkinson JS.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3335-40. doi: 10.1073/pnas.1600216113. Epub 2016 Mar 7.


Chemotactic Signaling by Single-Chain Chemoreceptors.

Mowery P, Ames P, Reiser RH, Parkinson JS.

PLoS One. 2015 Dec 28;10(12):e0145267. doi: 10.1371/journal.pone.0145267. eCollection 2015.


A Trigger Residue for Transmembrane Signaling in the Escherichia coli Serine Chemoreceptor.

Kitanovic S, Ames P, Parkinson JS.

J Bacteriol. 2015 Aug 1;197(15):2568-79. doi: 10.1128/JB.00274-15. Epub 2015 May 26.


Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update.

Parkinson JS, Hazelbauer GL, Falke JJ.

Trends Microbiol. 2015 May;23(5):257-66. doi: 10.1016/j.tim.2015.03.003. Epub 2015 Mar 30. Review.


Functional suppression of HAMP domain signaling defects in the E. coli serine chemoreceptor.

Lai RZ, Parkinson JS.

J Mol Biol. 2014 Oct 23;426(21):3642-55. doi: 10.1016/j.jmb.2014.08.003. Epub 2014 Aug 15.


Signalling-dependent interactions between the kinase-coupling protein CheW and chemoreceptors in living cells.

Pedetta A, Parkinson JS, Studdert CA.

Mol Microbiol. 2014 Sep;93(6):1144-55. doi: 10.1111/mmi.12727. Epub 2014 Aug 5.


A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors.

Ortega DR, Yang C, Ames P, Baudry J, Parkinson JS, Zhulin IB.

Nat Commun. 2013;4:2881. doi: 10.1038/ncomms3881.


An unorthodox sensory adaptation site in the Escherichia coli serine chemoreceptor.

Han XS, Parkinson JS.

J Bacteriol. 2014 Feb;196(3):641-9. doi: 10.1128/JB.01164-13. Epub 2013 Nov 22.


HAMP domain structural determinants for signalling and sensory adaptation in Tsr, the Escherichia coli serine chemoreceptor.

Ames P, Zhou Q, Parkinson JS.

Mol Microbiol. 2014 Mar;91(5):875-86. doi: 10.1111/mmi.12443. Epub 2013 Nov 10.


Mutational analysis of the P1 phosphorylation domain in Escherichia coli CheA, the signaling kinase for chemotaxis.

Nishiyama S, Garzón A, Parkinson JS.

J Bacteriol. 2014 Jan;196(2):257-64. doi: 10.1128/JB.01167-13. Epub 2013 Oct 25.


The mobility of two kinase domains in the Escherichia coli chemoreceptor array varies with signalling state.

Briegel A, Ames P, Gumbart JC, Oikonomou CM, Parkinson JS, Jensen GJ.

Mol Microbiol. 2013 Sep;89(5):831-41. doi: 10.1111/mmi.12309. Epub 2013 Jul 30.


Alexander Böhm (1971-2012).

Boos W, Parkinson JS, Jenal U, Vogel J, Søgaard-Andersen L.

Mol Microbiol. 2013 Apr;88(2):219-21. doi: 10.1111/mmi.12198.


Mutational analysis of N381, a key trimer contact residue in Tsr, the Escherichia coli serine chemoreceptor.

Gosink KK, Zhao Y, Parkinson JS.

J Bacteriol. 2011 Dec;193(23):6452-60. doi: 10.1128/JB.05887-11. Epub 2011 Sep 30.


Phenol sensing by Escherichia coli chemoreceptors: a nonclassical mechanism.

Pham HT, Parkinson JS.

J Bacteriol. 2011 Dec;193(23):6597-604. doi: 10.1128/JB.05987-11. Epub 2011 Sep 30.


Mutational analysis of the control cable that mediates transmembrane signaling in the Escherichia coli serine chemoreceptor.

Kitanovic S, Ames P, Parkinson JS.

J Bacteriol. 2011 Oct;193(19):5062-72. doi: 10.1128/JB.05683-11. Epub 2011 Jul 29.


Biphasic control logic of HAMP domain signalling in the Escherichia coli serine chemoreceptor.

Zhou Q, Ames P, Parkinson JS.

Mol Microbiol. 2011 May;80(3):596-611. doi: 10.1111/j.1365-2958.2011.07577.x. Epub 2011 Feb 24.


Cross-linking evidence for motional constraints within chemoreceptor trimers of dimers.

Massazza DA, Parkinson JS, Studdert CA.

Biochemistry. 2011 Feb 8;50(5):820-7. doi: 10.1021/bi101483r. Epub 2011 Jan 13.


Signaling mechanisms of HAMP domains in chemoreceptors and sensor kinases.

Parkinson JS.

Annu Rev Microbiol. 2010;64:101-22. doi: 10.1146/annurev.micro.112408.134215. Review.


Disruption of chemoreceptor signalling arrays by high levels of CheW, the receptor-kinase coupling protein.

Cardozo MJ, Massazza DA, Parkinson JS, Studdert CA.

Mol Microbiol. 2010 Mar;75(5):1171-81. doi: 10.1111/j.1365-2958.2009.07032.x.


Mutational analyses of HAMP helices suggest a dynamic bundle model of input-output signalling in chemoreceptors.

Zhou Q, Ames P, Parkinson JS.

Mol Microbiol. 2009 Sep;73(5):801-14. doi: 10.1111/j.1365-2958.2009.06819.x. Epub 2009 Jul 28.


Different signaling roles of two conserved residues in the cytoplasmic hairpin tip of Tsr, the Escherichia coli serine chemoreceptor.

Mowery P, Ostler JB, Parkinson JS.

J Bacteriol. 2008 Dec;190(24):8065-74. doi: 10.1128/JB.01121-08. Epub 2008 Oct 17.


Mutational analysis of the connector segment in the HAMP domain of Tsr, the Escherichia coli serine chemoreceptor.

Ames P, Zhou Q, Parkinson JS.

J Bacteriol. 2008 Oct;190(20):6676-85. doi: 10.1128/JB.00750-08. Epub 2008 Jul 11.


Bacterial chemoreceptors: high-performance signaling in networked arrays.

Hazelbauer GL, Falke JJ, Parkinson JS.

Trends Biochem Sci. 2008 Jan;33(1):9-19. doi: 10.1016/j.tibs.2007.09.014. Epub 2007 Dec 31. Review.


A "bucket of light" for viewing bacterial colonies in soft agar.

Parkinson JS.

Methods Enzymol. 2007;423:432-5.


Ancient chemoreceptors retain their flexibility.

Parkinson JS.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2559-60. Epub 2007 Feb 14. No abstract available.


Conformational suppression of inter-receptor signaling defects.

Ames P, Parkinson JS.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9292-7. Epub 2006 Jun 2.


Differential activation of Escherichia coli chemoreceptors by blue-light stimuli.

Wright S, Walia B, Parkinson JS, Khan S.

J Bacteriol. 2006 Jun;188(11):3962-71.


Signaling interactions between the aerotaxis transducer Aer and heterologous chemoreceptors in Escherichia coli.

Gosink KK, Burón-Barral MC, Parkinson JS.

J Bacteriol. 2006 May;188(10):3487-93.


Loss- and gain-of-function mutations in the F1-HAMP region of the Escherichia coli aerotaxis transducer Aer.

Burón-Barral MC, Gosink KK, Parkinson JS.

J Bacteriol. 2006 May;188(10):3477-86.

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