Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 112

1.

Collagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1.

Lai SL, Tan ML, Hollows RJ, Robinson M, Ibrahim M, Margielewska S, Parkinson EK, Ramanathan A, Zain RB, Mehanna H, Spruce RJ, Wei W, Chung I, Murray PG, Yap LF, Paterson IC.

Cancers (Basel). 2019 Nov 9;11(11). pii: E1766. doi: 10.3390/cancers11111766.

2.

Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells.

Li X, Ahmad US, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G, McArthur S, Parkinson EK, Wan H.

Mech Ageing Dev. 2019 Dec;184:111174. doi: 10.1016/j.mad.2019.111174. Epub 2019 Oct 31.

3.

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy.

Veeramachaneni R, Walker T, Revil T, Weck A, Badescu D, O'Sullivan J, Higgins C, Elliott L, Liloglou T, Risk JM, Shaw R, Hampson L, Hampson I, Dearden S, Woodwards R, Prime S, Hunter K, Parkinson EK, Ragoussis J, Thakker N.

Sci Rep. 2019 Aug 19;9(1):11992. doi: 10.1038/s41598-019-48229-7.

4.

The induction of the fibroblast extracellular senescence metabolome is a dynamic process.

James ENL, Bennett MH, Parkinson EK.

Sci Rep. 2018 Aug 14;8(1):12148. doi: 10.1038/s41598-018-29809-5.

5.

Corrigendum: A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 Jul 30;39(8):1094. doi: 10.1093/carcin/bgy083. No abstract available.

PMID:
29982353
6.

A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 May 28;39(6):798-807. doi: 10.1093/carcin/bgy032. Erratum in: Carcinogenesis. 2018 Jul 30;39(8):1094.

7.

Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism.

James EL, Lane JA, Michalek RD, Karoly ED, Parkinson EK.

Sci Rep. 2016 Dec 7;6:38489. doi: 10.1038/srep38489.

8.

Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-β-dependent pathways in genotype-specific oral cancer.

Cirillo N, Hassona Y, Celentano A, Lim KP, Manchella S, Parkinson EK, Prime SS.

Carcinogenesis. 2017 Jan;38(1):76-85. doi: 10.1093/carcin/bgw113. Epub 2016 Nov 1.

PMID:
27803052
9.

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.

Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, Prime SS, Thomas GJ, Paterson IC, Zhou D, McCall J, Speight PM, Lambert DW.

Aging (Albany NY). 2016 Aug;8(8):1608-35. doi: 10.18632/aging.100987.

10.

Fibroblast activation and senescence in oral cancer.

Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James EN, Parkinson EK.

J Oral Pathol Med. 2017 Feb;46(2):82-88. doi: 10.1111/jop.12456. Epub 2016 May 30. Review.

PMID:
27237745
11.

Senescence-Derived Extracellular Molecules as Modulators of Oral Cancer Development: A Mini-Review.

Parkinson EK, James EL, Prime SS.

Gerontology. 2016;62(4):417-24. doi: 10.1159/000440954. Epub 2015 Dec 3. Review.

12.

Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression.

Rehman A, Ali S, Lone MA, Atif M, Hassona Y, Prime SS, Pitiyage GN, James EL, Parkinson EK.

J Oral Pathol Med. 2016 May;45(5):365-72. doi: 10.1111/jop.12370. Epub 2015 Sep 28.

PMID:
26414019
13.

Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner.

Dale TP, de Castro A, Kuiper NJ, Parkinson EK, Forsyth NR.

PLoS One. 2015 Jul 21;10(7):e0133745. doi: 10.1371/journal.pone.0133745. eCollection 2015.

14.

Serum metabolomics in animal models and human disease.

James EL, Parkinson EK.

Curr Opin Clin Nutr Metab Care. 2015 Sep;18(5):478-83. doi: 10.1097/MCO.0000000000000200. Review.

PMID:
26147529
15.

Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease.

James EL, Michalek RD, Pitiyage GN, de Castro AM, Vignola KS, Jones J, Mohney RP, Karoly ED, Prime SS, Parkinson EK.

J Proteome Res. 2015 Apr 3;14(4):1854-71. doi: 10.1021/pr501221g. Epub 2015 Feb 26.

16.

The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators.

de Castro A, Minty F, Hattinger E, Wolf R, Parkinson EK.

Longev Healthspan. 2014 Oct 17;3:8. doi: 10.1186/2046-2395-3-8. eCollection 2014.

17.

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion.

Hassona Y, Cirillo N, Heesom K, Parkinson EK, Prime SS.

Br J Cancer. 2014 Sep 9;111(6):1230-7. doi: 10.1038/bjc.2014.438. Epub 2014 Aug 12.

18.

Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2.

Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT, Parkinson EK.

Carcinogenesis. 2013 Dec;34(12):2716-25. doi: 10.1093/carcin/bgt257. Epub 2013 Jul 26.

19.

The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin.

Nikolakopoulou Z, Shaikh MH, Dehlawi H, Michael-Titus AT, Parkinson EK.

Toxicol Lett. 2013 Apr 12;218(2):150-8. doi: 10.1016/j.toxlet.2013.01.021. Epub 2013 Feb 4.

PMID:
23391486
20.

Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β.

Hassona Y, Cirillo N, Lim KP, Herman A, Mellone M, Thomas GJ, Pitiyage GN, Parkinson EK, Prime SS.

Carcinogenesis. 2013 Jun;34(6):1286-95. doi: 10.1093/carcin/bgt035. Epub 2013 Jan 27.

PMID:
23358854
21.

Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageing.

Pitiyage GN, Lim KP, Gemenitzidis E, Teh MT, Waseem A, Prime SS, Tilakaratne WM, Fortune F, Parkinson EK.

J Oral Pathol Med. 2012 Jul;41(6):454-62. doi: 10.1111/j.1600-0714.2012.01129.x. Epub 2012 Mar 3.

PMID:
22385081
22.

An overview of the molecular pathology of head and neck cancer, and its clinical implications.

Hunter K, Parkinson EK, Thakker N.

Periodontol 2000. 2011 Oct;57(1):132-49. doi: 10.1111/j.1600-0757.2011.00387.x. Review. No abstract available.

PMID:
21781184
23.

Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases.

Pitiyage GN, Slijepcevic P, Gabrani A, Chianea YG, Lim KP, Prime SS, Tilakaratne WM, Fortune F, Parkinson EK.

J Pathol. 2011 Apr;223(5):604-17. doi: 10.1002/path.2839. Epub 2011 Feb 21.

PMID:
21341274
24.

Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma.

Lim KP, Cirillo N, Hassona Y, Wei W, Thurlow JK, Cheong SC, Pitiyage G, Parkinson EK, Prime SS.

J Pathol. 2011 Mar;223(4):459-69. doi: 10.1002/path.2841. Epub 2011 Jan 17.

PMID:
21294120
25.

Induction of human epithelial stem/progenitor expansion by FOXM1.

Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT.

Cancer Res. 2010 Nov 15;70(22):9515-26. doi: 10.1158/0008-5472.CAN-10-2173. Epub 2010 Nov 9. Erratum in: Cancer Res. 2011 Jan 1;71(1):290.

26.

Senescence as a modulator of oral squamous cell carcinoma development.

Parkinson EK.

Oral Oncol. 2010 Dec;46(12):840-53. doi: 10.1016/j.oraloncology.2009.09.009. Epub 2010 Nov 2. Review.

PMID:
21050803
27.

A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma.

Teh MT, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H.

J Oral Pathol Med. 2011 Jan;40(1):67-76. doi: 10.1111/j.1600-0714.2010.00951.x. Epub 2010 Oct 4.

PMID:
20923451
28.

Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma.

Thurlow JK, Peña Murillo CL, Hunter KD, Buffa FM, Patiar S, Betts G, West CM, Harris AL, Parkinson EK, Harrison PR, Ozanne BW, Partridge M, Kalna G.

J Clin Oncol. 2010 Jun 10;28(17):2881-8. doi: 10.1200/JCO.2009.24.8724. Epub 2010 May 10. Erratum in: J Clin Oncol. 2010 Oct 20;28(30):4664.

PMID:
20458058
29.

Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.

Syed MI, Syed S, Minty F, Harrower S, Singh J, Chin A, McLellan DR, Parkinson EK, Clark LJ.

Otolaryngol Head Neck Surg. 2009 Apr;140(4):498-504. doi: 10.1016/j.otohns.2008.12.049.

PMID:
19328337
30.

FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation.

Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK, Cheong SC, Teo SH, Wan H, Waseem A, Parkinson EK, Fortune F, Teh MT.

PLoS One. 2009;4(3):e4849. doi: 10.1371/journal.pone.0004849. Epub 2009 Mar 16.

31.

Dissecting the non-canonical functions of telomerase.

Parkinson EK, Fitchett C, Cereser B.

Cytogenet Genome Res. 2008;122(3-4):273-80. doi: 10.1159/000167813. Epub 2009 Jan 30. Review.

PMID:
19188696
32.

Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion.

MacIntyre A, Brouilette SW, Lamb K, Radhakrishnan K, McGlynn L, Chee MM, Parkinson EK, Freeman D, Madhok R, Shiels PG.

Ann Rheum Dis. 2008 Dec;67(12):1780-2. doi: 10.1136/ard.2007.086652. Epub 2008 Jul 28.

PMID:
18662931
33.

Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile.

Minty F, Thurlow JK, Harrison PR, Parkinson EK.

Exp Cell Res. 2008 Aug 1;314(13):2434-47. doi: 10.1016/j.yexcr.2008.05.007. Epub 2008 May 27.

PMID:
18589416
34.

Upregulation of HIF-1alpha in malignant transformation of oral submucous fibrosis.

Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E, Lalli A, Waseem A, Parkinson EK, Fortune F.

J Oral Pathol Med. 2008 Jul;37(6):372-7. doi: 10.1111/j.1600-0714.2007.00625.x. Epub 2008 Jan 19.

PMID:
18221327
35.

An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity.

Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK, Teh MT, Fortune F, Waseem A.

J Oral Pathol Med. 2008 Apr;37(4):211-20. doi: 10.1111/j.1600-0714.2007.00609.x. Epub 2008 Jan 17.

PMID:
18205743
36.

Anticancer therapy targeting telomeres and telomerase : current status.

Parkinson EK, Minty F.

BioDrugs. 2007;21(6):375-85. Review.

PMID:
18020621
37.

Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells.

McCaul JA, Gordon KE, Minty F, Fleming J, Parkinson EK.

Oral Oncol. 2008 Mar;44(3):261-9. Epub 2007 May 1.

PMID:
17475542
38.

Divergent routes to oral cancer.

Hunter KD, Thurlow JK, Fleming J, Drake PJ, Vass JK, Kalna G, Higham DJ, Herzyk P, Macdonald DG, Parkinson EK, Harrison PR.

Cancer Res. 2006 Aug 1;66(15):7405-13.

40.

Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression.

Sedghizadeh PP, Mallery SR, Thompson SJ, Kresty L, Beck FM, Parkinson EK, Biancamano J, Lang JC.

Head Neck. 2006 May;28(5):432-40.

PMID:
16320362
41.

Profiling early head and neck cancer.

Hunter KD, Parkinson EK, Harrison PR.

Nat Rev Cancer. 2005 Feb;5(2):127-35. doi: 10.1038/nrc1549. Review.

PMID:
15685196
42.

Analysis of telomerase activity and telomere function in cancer.

Gordon KE, Parkinson EK.

Methods Mol Biol. 2004;281:333-48.

PMID:
15220541
43.

Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock.

Munro J, Barr NI, Ireland H, Morrison V, Parkinson EK.

Exp Cell Res. 2004 May 1;295(2):525-38.

PMID:
15093749
44.

Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.

Scott LA, Vass JK, Parkinson EK, Gillespie DA, Winnie JN, Ozanne BW.

Mol Cell Biol. 2004 Feb;24(4):1540-59.

45.

Telomerase as a novel and potentially selective target for cancer chemotherapy.

Parkinson EK.

Ann Med. 2003;35(7):466-75. Review.

PMID:
14649329
47.

Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability.

Wootton M, Steeghs K, Watt D, Munro J, Gordon K, Ireland H, Morrison V, Behan W, Parkinson EK.

Hum Gene Ther. 2003 Oct 10;14(15):1473-87.

PMID:
14577927
48.

Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15.

Fitzsimmons SA, Ireland H, Barr NI, Cuthbert AP, Going JJ, Newbold RF, Parkinson EK.

Oncogene. 2003 Mar 20;22(11):1737-46.

PMID:
12642877
49.

High levels of telomere dysfunction bestow a selective disadvantage during the progression of human oral squamous cell carcinoma.

Gordon KE, Ireland H, Roberts M, Steeghs K, McCaul JA, MacDonald DG, Parkinson EK.

Cancer Res. 2003 Jan 15;63(2):458-67.

50.

A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23.

Bryce SD, Morrison V, Craig NJ, Forsyth NR, Fitzsimmons SA, Ireland H, Cuthbert AP, Newbold RF, Parkinson EK.

Neoplasia. 2002 Nov-Dec;4(6):544-50.

Supplemental Content

Loading ...
Support Center