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Items: 31


Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture.

Priyanka A, Solanki V, Parkesh R, Thakur KG.

Proteins. 2016 Oct;84(10):1558-63. doi: 10.1002/prot.25085. Epub 2016 Jun 23.


ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery.

Nanduri R, Bhutani I, Somavarapu AK, Mahajan S, Parkesh R, Gupta P.

Database (Oxford). 2015 Dec 4;2015. pii: bav112. doi: 10.1093/database/bav112. Print 2015.


Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248. Epub 2015 Jul 7.


Structure, dynamics, and interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 examined by molecular modeling, simulation, and electrostatic studies.

Bhutani I, Loharch S, Gupta P, Madathil R, Parkesh R.

PLoS One. 2015 Mar 19;10(3):e0119771. doi: 10.1371/journal.pone.0119771. eCollection 2015.


EpiDBase: a manually curated database for small molecule modulators of epigenetic landscape.

Loharch S, Bhutani I, Jain K, Gupta P, Sahoo DK, Parkesh R.

Database (Oxford). 2015 Mar 16;2015. pii: bav013. doi: 10.1093/database/bav013. Print 2015.


Transcription factors and cognate signalling cascades in the regulation of autophagy.

Chandra V, Bhagyaraj E, Parkesh R, Gupta P.

Biol Rev Camb Philos Soc. 2016 May;91(2):429-51. doi: 10.1111/brv.12177. Epub 2015 Feb 4. Review.


Discovery of Mycobacterium tuberculosis α-1,4-glucan branching enzyme (GlgB) inhibitors by structure- and ligand-based virtual screening.

Dkhar HK, Gopalsamy A, Loharch S, Kaur A, Bhutani I, Saminathan K, Bhagyaraj E, Chandra V, Swaminathan K, Agrawal P, Parkesh R, Gupta P.

J Biol Chem. 2015 Jan 2;290(1):76-89. doi: 10.1074/jbc.M114.589200. Epub 2014 Nov 10.


α-Glucan pathway as a novel Mtb drug target: structural insights and cues for polypharmcological targeting of GlgB and GlgE.

Agrawal P, Gupta P, Swaminathan K, Parkesh R.

Curr Med Chem. 2014;21(35):4074-84. Review.


Mechanistic insight into the enzymatic reduction of truncated hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A motif in electron cycling.

Singh S, Thakur N, Oliveira A, Petruk AA, Hade MD, Sethi D, Bidon-Chanal A, Martí MA, Datta H, Parkesh R, Estrin DA, Luque FJ, Dikshit KL.

J Biol Chem. 2014 Aug 1;289(31):21573-83. doi: 10.1074/jbc.M114.578187. Epub 2014 Jun 13.


Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: a case of a heterologous and noncanonical ligand-receptor pair.

Dkhar HK, Nanduri R, Mahajan S, Dave S, Saini A, Somavarapu AK, Arora A, Parkesh R, Thakur KG, Mayilraj S, Gupta P.

J Immunol. 2014 Jul 1;193(1):295-305. doi: 10.4049/jimmunol.1400092. Epub 2014 Jun 6.


SMMRNA: a database of small molecule modulators of RNA.

Mehta A, Sonam S, Gouri I, Loharch S, Sharma DK, Parkesh R.

Nucleic Acids Res. 2014 Jan;42(Database issue):D132-41. doi: 10.1093/nar/gkt976. Epub 2013 Oct 24.


Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1.

Childs-Disney JL, Parkesh R, Nakamori M, Thornton CA, Disney MD.

ACS Chem Biol. 2012 Dec 21;7(12):1984-93. doi: 10.1021/cb3001606. Epub 2012 Nov 7.


Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.

Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD.

J Am Chem Soc. 2012 Mar 14;134(10):4731-42. doi: 10.1021/ja210088v. Epub 2012 Mar 5.


Synthesis and use of cell-permeant cyclic ADP-ribose.

Rosen D, Bloor-Young D, Squires J, Parkesh R, Waters G, Vasudevan SR, Lewis AM, Churchill GC.

Biochem Biophys Res Commun. 2012 Feb 10;418(2):353-8. doi: 10.1016/j.bbrc.2012.01.025. Epub 2012 Jan 17.


Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.

Kumar A, Parkesh R, Sznajder LJ, Childs-Disney JL, Sobczak K, Disney MD.

ACS Chem Biol. 2012 Mar 16;7(3):496-505. doi: 10.1021/cb200413a. Epub 2012 Jan 17.


Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations.

Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD.

Biochemistry. 2011 Nov 15;50(45):9928-35. doi: 10.1021/bi2013068. Epub 2011 Oct 20.


NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1.

Parkesh R, Fountain M, Disney MD.

Biochemistry. 2011 Feb 8;50(5):599-601. doi: 10.1021/bi101896j. Epub 2011 Jan 13.


Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure.

Brailoiu GC, Gurzu B, Gao X, Parkesh R, Aley PK, Trifa DI, Galione A, Dun NJ, Madesh M, Patel S, Churchill GC, Brailoiu E.

J Biol Chem. 2010 Nov 26;285(48):37133-7. doi: 10.1074/jbc.C110.169763. Epub 2010 Sep 27.


Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.

Rosen D, Lewis AM, Mizote A, Thomas JM, Aley PK, Vasudevan SR, Parkesh R, Galione A, Izumi M, Ganesan A, Churchill GC.

J Biol Chem. 2009 Dec 11;284(50):34930-4. doi: 10.1074/jbc.M109.016519. Epub 2009 Oct 13.


Identification of a chemical probe for NAADP by virtual screening.

Naylor E, Arredouani A, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A, Churchill GC.

Nat Chem Biol. 2009 Apr;5(4):220-6. doi: 10.1038/nchembio.150. Epub 2009 Feb 22.


NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata.

Brailoiu GC, Brailoiu E, Parkesh R, Galione A, Churchill GC, Patel S, Dun NJ.

Biochem J. 2009 Apr 1;419(1):91-7, 2 p following 97. doi: 10.1042/BJ20081138.


Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells.

Parkesh R, Lewis AM, Aley PK, Arredouani A, Rossi S, Tavares R, Vasudevan SR, Rosen D, Galione A, Dowden J, Churchill GC.

Cell Calcium. 2008 Jun;43(6):531-8. Epub 2007 Nov 1.


NAADP controls cross-talk between distinct Ca2+ stores in the heart.

Macgregor A, Yamasaki M, Rakovic S, Sanders L, Parkesh R, Churchill GC, Galione A, Terrar DA.

J Biol Chem. 2007 May 18;282(20):15302-11. Epub 2007 Mar 26.


Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).

Parkesh R, Vasudevan SR, Berry A, Galione A, Dowden J, Churchill GC.

Org Biomol Chem. 2007 Feb 7;5(3):441-3. Epub 2006 Dec 11.


Microdamage and bone mechanobiology.

Lee TC, O'Brien FJ, Gunnlaugsson T, Parkesh R, Taylor D.

Technol Health Care. 2006;14(4-5):359-65. Review.


Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis.

Parkesh R, Gowin W, Lee TC, Gunnlaugsson T.

Org Biomol Chem. 2006 Oct 7;4(19):3611-7. Epub 2006 Aug 15.


Microdamage in bone: surface analysis and radiological detection.

Parkesh R, Clive Lee T, Gunnlaugsson T, Gowin W.

J Biomech. 2006;39(8):1552-6. Epub 2005 May 31.


A highly selective and sensitive fluorescent PET (photoinduced electron transfer) chemosensor for Zn(II).

Gunnlaugsson T, Lee TC, Parkesh R.

Org Biomol Chem. 2003 Oct 7;1(19):3265-7.


Cd(II) sensing in water using novel aromatic iminodiacetate based fluorescent chemosensors.

Gunnlaugsson T, Lee TC, Parkesh R.

Org Lett. 2003 Oct 30;5(22):4065-8.


Detecting microdamage in bone.

Lee TC, Mohsin S, Taylor D, Parkesh R, Gunnlaugsson T, O'Brien FJ, Giehl M, Gowin W.

J Anat. 2003 Aug;203(2):161-72. Review.

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