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Items: 1 to 50 of 403

1.

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.

Sernee MF, Ralton JE, Nero TL, Sobala LF, Kloehn J, Vieira-Lara MA, Cobbold SA, Stanton L, Pires DEV, Hanssen E, Males A, Ward T, Bastidas LM, van der Peet PL, Parker MW, Ascher DB, Williams SJ, Davies GJ, McConville MJ.

Cell Host Microbe. 2019 Sep 11;26(3):385-399.e9. doi: 10.1016/j.chom.2019.08.009.

PMID:
31513773
2.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Sep 9. pii: canres.1112.2019. doi: 10.1158/0008-5472.CAN-19-1112. [Epub ahead of print]

PMID:
31501192
3.

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals.

Spackman PR, Yu LJ, Morton CJ, Parker MW, Bond CS, Spackman MA, Jayatilaka D, Thomas SP.

Angew Chem Int Ed Engl. 2019 Aug 6. doi: 10.1002/anie.201906602. [Epub ahead of print]

PMID:
31385643
4.

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.

Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L.

Nat Microbiol. 2019 Aug 5. doi: 10.1038/s41564-019-0524-4. [Epub ahead of print]

PMID:
31384003
5.

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.

Miles LA, Hermans SJ, Crespi GAN, Gooi JH, Doughty L, Nero TL, Markulić J, Ebneth A, Wroblowski B, Oehlrich D, Trabanco AA, Rives ML, Royaux I, Hancock NC, Parker MW.

iScience. 2019 Jul 19;19:110-118. doi: 10.1016/j.isci.2019.07.023. [Epub ahead of print]

6.

Interleukin 9 alterations linked to alzheimer disease in african americans.

Wharton W, Kollhoff AL, Gangishetti U, Verble DD, Upadhya S, Zetterberg H, Kumar V, Watts KD, Kippels AJ, Gearing M, Howell JC, Parker MW, Hu WT.

Ann Neurol. 2019 Sep;86(3):407-418. doi: 10.1002/ana.25543. Epub 2019 Jul 22.

PMID:
31271450
7.

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin.

Burns JR, Morton CJ, Parker MW, Tweten RK.

MBio. 2019 Jul 2;10(4). pii: e01017-19. doi: 10.1128/mBio.01017-19.

8.

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.

Leaver DJ, Cleary B, Nguyen N, Priebbenow DL, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White KL, Katneni K, Cuellar M, Strasser JM, Dahlin JL, Walters MA, Street IP, Monahan BJ, Jarman KE, Sabroux HJ, Falk H, Chung MC, Hermans SJ, Parker MW, Thomas T, Baell JB.

J Med Chem. 2019 Aug 8;62(15):7146-7159. doi: 10.1021/acs.jmedchem.9b00665. Epub 2019 Jul 17.

PMID:
31256587
9.

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation.

Morton CJ, Sani MA, Parker MW, Separovic F.

Chem Rev. 2019 Jul 10;119(13):7721-7736. doi: 10.1021/acs.chemrev.9b00090. Epub 2019 Jun 17.

PMID:
31244002
10.

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.

De Luca A, Parker LJ, Ang WH, Rodolfo C, Gabbarini V, Hancock NC, Palone F, Mazzetti AP, Menin L, Morton CJ, Parker MW, Lo Bello M, Dyson PJ.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13943-13951. doi: 10.1073/pnas.1903297116. Epub 2019 Jun 20.

11.

Author Correction: EPO does not promote interaction between the erythropoietin and beta-common receptors.

Cheung Tung Shing KS, Broughton SE, Nero TL, Gillinder K, Ilsley MD, Ramshaw H, Lopez AF, Griffin MDW, Parker MW, Perkins AC, Dhagat U.

Sci Rep. 2019 May 21;9(1):7851. doi: 10.1038/s41598-019-43988-9.

12.

Retrospective fractional dose reduction in Tc-99m cardiac perfusion SPECT/CT patients: A human and model observer study.

Pretorius PH, Ramon AJ, King MA, Konik A, Dahlberg ST, Parker MW, Botkin NF, Johnson KL, Yang Y, Wernick MN.

J Nucl Cardiol. 2019 May 10. doi: 10.1007/s12350-019-01743-7. [Epub ahead of print]

PMID:
31077073
13.

Looking back on wartime service: Reminiscence by James G. Van Straten.

Martin JA, Clayton LA, Parker MW.

Aging Ment Health. 2019 Sep;23(9):1067-1073. doi: 10.1080/13607863.2019.1609904. Epub 2019 May 6.

PMID:
31056937
14.

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin.

Wade KR, Lawrence SL, Farrand AJ, Hotze EM, Kuiper MJ, Gorman MA, Christie MP, Panjikar S, Morton CJ, Parker MW, Tweten RK.

MBio. 2019 Apr 23;10(2). pii: e00538-19. doi: 10.1128/mBio.00538-19.

15.

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Thilakasiri P, Huynh J, Poh AR, Tan CW, Nero TL, Tran K, Parslow AC, Afshar-Sterle S, Baloyan D, Hannan NJ, Buchert M, Scott AM, Griffin MD, Hollande F, Parker MW, Putoczki TL, Ernst M, Chand AL.

EMBO Mol Med. 2019 Apr;11(4). pii: e9539. doi: 10.15252/emmm.201809539.

16.

Management of Pediatric Gastroesophageal Reflux Disease.

Barfield E, Parker MW.

JAMA Pediatr. 2019 May 1;173(5):485-486. doi: 10.1001/jamapediatrics.2019.0170. No abstract available.

PMID:
30882857
17.

Clinical Guideline Highlights for the Hospitalist: Maintenance Intravenous Fluids in Infants and Children.

Girdwood ST, Parker MW, Shaughnessy EE.

J Hosp Med. 2019 Mar;14(3):170-171. doi: 10.12788/jhm.3177. Review.

PMID:
30811323
18.

Estimation of Mean Left Atrial Pressure in Patients with Acute Coronary Syndromes: A Doppler Echocardiographic and Cardiac Catheterization Study.

Tachjian A, Sanghai SR, Stencel J, Parker MW, Kakouros N, Aurigemma GP.

J Am Soc Echocardiogr. 2019 Mar;32(3):365-374.e1. doi: 10.1016/j.echo.2018.11.002. Epub 2019 Jan 16.

PMID:
30660349
19.

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis.

Tvorogov D, Thomas D, Liau NPD, Dottore M, Barry EF, Lathi M, Kan WL, Hercus TR, Stomski F, Hughes TP, Tergaonkar V, Parker MW, Ross DM, Majeti R, Babon JJ, Lopez AF.

Sci Adv. 2018 Nov 28;4(11):eaat3834. doi: 10.1126/sciadv.aat3834. eCollection 2018 Nov.

20.

The presbycardia phenotype: Cardiac remodeling and valvular degeneration in nonagenarians.

Iskandar A, Mowakeaa S, Sardana M, Fitzgibbons TP, Tighe DA, Parker MW, Kakouros N, McManus D, Aurigemma GP.

Echocardiography. 2018 Dec;35(12):1974-1981. doi: 10.1111/echo.14160. Epub 2018 Nov 15.

PMID:
30431175
21.

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations.

Molakarimi M, Gorman MA, Mohseni A, Pashandi Z, Taghdir M, Naderi-Manesh H, Sajedi RH, Parker MW.

J Biol Chem. 2019 Jan 4;294(1):20-27. doi: 10.1074/jbc.RA118.006053. Epub 2018 Nov 12.

PMID:
30420427
22.

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.

Hanson AL, Morton CJ, Parker MW, Bessette D, Kenna TJ.

Hum Immunol. 2019 May;80(5):281-289. doi: 10.1016/j.humimm.2018.11.002. Epub 2018 Nov 9. Review.

PMID:
30419264
23.

Protein structure and computational drug discovery.

Nero TL, Parker MW, Morton CJ.

Biochem Soc Trans. 2018 Oct 19;46(5):1367-1379. doi: 10.1042/BST20180202. Epub 2018 Sep 20. Review.

PMID:
30242117
24.

EPO does not promote interaction between the erythropoietin and beta-common receptors.

Cheung Tung Shing KS, Broughton SE, Nero TL, Gillinder K, Ilsley MD, Ramshaw H, Lopez AF, Griffin MDW, Parker MW, Perkins AC, Dhagat U.

Sci Rep. 2018 Aug 20;8(1):12457. doi: 10.1038/s41598-018-29865-x. Erratum in: Sci Rep. 2019 May 21;9(1):7851.

25.

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore.

Christie MP, Johnstone BA, Tweten RK, Parker MW, Morton CJ.

Biophys Rev. 2018 Oct;10(5):1337-1348. doi: 10.1007/s12551-018-0448-x. Epub 2018 Aug 16. Review.

26.

New Method, Same Answer: We Do Not Know if Hypertonic Saline Helps Bronchiolitis.

Auger KA, Parker MW, Huang B.

Pediatrics. 2018 Sep;142(3). pii: e20181868. doi: 10.1542/peds.2018-1868. Epub 2018 Aug 16. No abstract available.

27.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

Baell JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, Bergamasco MI, May RE, Davey BK, Morgan KJ, Sealey AJ, Wang B, Zamudio N, Wilcox S, Garnham AL, Sheikh BN, Aubrey BJ, Doggett K, Chung MC, de Silva M, Bentley J, Pilling P, Hattarki M, Dolezal O, Dennis ML, Falk H, Ren B, Charman SA, White KL, Rautela J, Newbold A, Hawkins ED, Johnstone RW, Huntington ND, Peat TS, Heath JK, Strasser A, Parker MW, Smyth GK, Street IP, Monahan BJ, Voss AK, Thomas T.

Nature. 2018 Aug;560(7717):253-257. doi: 10.1038/s41586-018-0387-5. Epub 2018 Aug 1.

PMID:
30069049
28.

Linking Education to Action: A Program to Increase Research Participation Among African American Women.

Radecki Breitkopf C, Williams KP, Ridgeway JL, Parker MW, Strong-Simmons A, Hayes SN, Halyard MY.

J Womens Health (Larchmt). 2018 Oct;27(10):1242-1249. doi: 10.1089/jwh.2017.6791. Epub 2018 Jul 5.

PMID:
29975586
29.

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

Dhagat U, Hercus TR, Broughton SE, Nero TL, Cheung Tung Shing KS, Barry EF, Thomson CA, Bryson S, Pai EF, McClure BJ, Schrader JW, Lopez AF, Parker MW.

MAbs. 2018 Oct;10(7):1018-1029. doi: 10.1080/19420862.2018.1494107. Epub 2018 Sep 12.

30.

Diagnosis and Management of Infectious Diarrhea.

Parker MW, Unaka N.

JAMA Pediatr. 2018 Aug 1;172(8):775-776. doi: 10.1001/jamapediatrics.2018.1172. No abstract available.

PMID:
29889925
31.

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis.

Márquez CL, Lau D, Walsh J, Shah V, McGuinness C, Wong A, Aggarwal A, Parker MW, Jacques DA, Turville S, Böcking T.

Elife. 2018 Jun 7;7. pii: e34772. doi: 10.7554/eLife.34772.

32.

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase.

Northfield SE, Wielens J, Headey SJ, Williams-Noonan BJ, Mulcair M, Scanlon MJ, Parker MW, Thompson PE, Chalmers DK.

ChemMedChem. 2018 Aug 10;13(15):1555-1565. doi: 10.1002/cmdc.201800129. Epub 2018 Jul 6.

PMID:
29862651
33.

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA.

Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24.

34.

Effect of an Educational Intervention on the Accuracy of Data Submitted to a National Quality Registry.

Gulati V, Elsaid O, Parker MW, Thorns M, Ling T, Zweibel S.

Conn Med. 2017 Apr;81(4):197-202.

PMID:
29714403
35.

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

Ngoei KRW, Langendorf CG, Ling NXY, Hoque A, Varghese S, Camerino MA, Walker SR, Bozikis YE, Dite TA, Ovens AJ, Smiles WJ, Jacobs R, Huang H, Parker MW, Scott JW, Rider MH, Foitzik RC, Kemp BE, Baell JB, Oakhill JS.

Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. doi: 10.1016/j.chembiol.2018.03.008. Epub 2018 Apr 12.

36.

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

Broughton SE, Hercus TR, Nero TL, Kan WL, Barry EF, Dottore M, Cheung Tung Shing KS, Morton CJ, Dhagat U, Hardy MP, Wilson NJ, Downton MT, Schieber C, Hughes TP, Lopez AF, Parker MW.

Nat Commun. 2018 Jan 26;9(1):386. doi: 10.1038/s41467-017-02633-7.

37.

Impact of Nuclear Laboratory Personnel Credentials & Continuing Education on Nuclear Cardiology Laboratory Quality Operations.

Malhotra S, Sobieraj DM, Mann A, Parker MW.

J Nucl Med Technol. 2017 Dec 22. pii: jnmt.117.202234. doi: 10.2967/jnmt.117.202234. [Epub ahead of print]

PMID:
29273701
38.

AMP and adenosine are both ligands for adenosine 2B receptor signaling.

Holien JK, Seibt B, Roberts V, Salvaris E, Parker MW, Cowan PJ, Dwyer KM.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206. doi: 10.1016/j.bmcl.2017.11.019. Epub 2017 Nov 20.

PMID:
29191553
39.

Race modifies the relationship between cognition and Alzheimer's disease cerebrospinal fluid biomarkers.

Howell JC, Watts KD, Parker MW, Wu J, Kollhoff A, Wingo TS, Dorbin CD, Qiu D, Hu WT.

Alzheimers Res Ther. 2017 Nov 2;9(1):88. doi: 10.1186/s13195-017-0315-1.

40.

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment.

Flierl U, Nero TL, Lim B, Andrews RK, Parker MW, Gardiner EE, Peter K.

J Thromb Haemost. 2018 Jan;16(1):181-185. doi: 10.1111/jth.13877. Epub 2017 Nov 16. No abstract available.

PMID:
29052937
41.

Implementation of a Communication Bundle for High-Risk Patients.

Parker MW, Carroll M, Bolser B, Ballinger J, Brewington J, Campanella S, Davis-Sandfoss A, Tucker K, Brady PW.

Hosp Pediatr. 2017 Sep;7(9):523-529. doi: 10.1542/hpeds.2016-0170.

42.

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407.

Hodson C, Yang J, Hocking DM, Azzopardi K, Chen Q, Holien JK, Parker MW, Tauschek M, Robins-Browne RM.

Front Microbiol. 2017 Aug 11;8:1525. doi: 10.3389/fmicb.2017.01525. eCollection 2017.

43.

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins.

Molakarimi M, Mohseni A, Taghdir M, Pashandi Z, Gorman MA, Parker MW, Naderi-Manesh H, Sajedi RH.

PLoS One. 2017 Aug 4;12(8):e0182317. doi: 10.1371/journal.pone.0182317. eCollection 2017.

44.

Role of the β Common (βc) Family of Cytokines in Health and Disease.

Hercus TR, Kan WLT, Broughton SE, Tvorogov D, Ramshaw HS, Sandow JJ, Nero TL, Dhagat U, Thompson EJ, Shing KSCT, McKenzie DR, Wilson NJ, Owczarek CM, Vairo G, Nash AD, Tergaonkar V, Hughes T, Ekert PG, Samuel MS, Bonder CS, Grimbaldeston MA, Parker MW, Lopez AF.

Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6). pii: a028514. doi: 10.1101/cshperspect.a028514. Review.

PMID:
28716883
45.

Fear and Uncertainty Do Not Influence Reported Willingness to Undergo Lumbar Punctures in a U.S. Multi-Cultural Cohort.

Tsvetkova DZ, Bergquist SH, Parker MW, Jarrett TL, Howell JC, Watts KD, Kollhoff A, Roberts DL, Hu WT.

Front Aging Neurosci. 2017 Feb 10;9:22. doi: 10.3389/fnagi.2017.00022. eCollection 2017.

46.

Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway.

Portelius E, Mattsson N, Pannee J, Zetterberg H, Gisslén M, Vanderstichele H, Gkanatsiou E, Crespi GA, Parker MW, Miles LA, Gobom J, Blennow K.

Mol Neurodegener. 2017 Feb 20;12(1):18. doi: 10.1186/s13024-017-0152-5.

47.

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability.

Gillinder KR, Ilsley MD, Nébor D, Sachidanandam R, Lajoie M, Magor GW, Tallack MR, Bailey T, Landsberg MJ, Mackay JP, Parker MW, Miles LA, Graber JH, Peters LL, Bieker JJ, Perkins AC.

Nucleic Acids Res. 2017 Feb 17;45(3):1130-1143. doi: 10.1093/nar/gkw1014.

48.

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites.

Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, Morton CJ, Zeller J, Kiefer J, Potempa LA, Mellett NA, Miles LA, Du XJ, Meikle PJ, Huber-Lang M, Stark GB, Parker MW, Peter K, Eisenhardt SU.

Nat Commun. 2017 Jan 23;8:14188. doi: 10.1038/ncomms14188.

49.

Mechanisms and regulation of DNA replication initiation in eukaryotes.

Parker MW, Botchan MR, Berger JM.

Crit Rev Biochem Mol Biol. 2017 Apr;52(2):107-144. doi: 10.1080/10409238.2016.1274717. Epub 2017 Jan 17. Review.

50.

A Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17.

Holien JK, Parker MW, Conley AJ, Corbin CJ, Rodgers RJ, Martin LL.

Curr Protein Pept Sci. 2017;18(5):515-521. doi: 10.2174/1389203717666161220142957. Review.

PMID:
28000554

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