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Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis.

Morgan SR, Pilia N, Hewitt M, Moses RL, Moseley R, Lewis PN, Morrison PWJ, Kelly SL, Parker JE, Whitaker D, Quantock AJ, Heard CM.

Int J Pharm. 2020 Jan 31;579:119102. doi: 10.1016/j.ijpharm.2020.119102. [Epub ahead of print]


The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.

Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latgé JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ.

Nat Commun. 2020 Jan 22;11(1):427. doi: 10.1038/s41467-019-14191-1.


Arabidopsis EDR1 Protein Kinase Regulates the Association of EDS1 and PAD4 to Inhibit Cell Death.

Neubauer M, Serrano I, Rodibaugh N, Bhandari DD, Bautor J, Parker JE, Innes RW.

Mol Plant Microbe Interact. 2020 Feb 7:MPMI12190339R. doi: 10.1094/MPMI-12-19-0339-R. [Epub ahead of print]


Barrier bednets target malaria vectors and expand the range of usable insecticides.

Murray GPD, Lissenden N, Jones J, Voloshin V, Toé KH, Sherrard-Smith E, Foster GM, Churcher TS, Parker JEA, Towers CE, N'Falé S, Guelbeogo WM, Ranson H, Towers D, McCall PJ.

Nat Microbiol. 2020 Jan;5(1):40-47. doi: 10.1038/s41564-019-0607-2. Epub 2019 Dec 2.


The Arabidopsis PAD4 Lipase-Like Domain Is Sufficient for Resistance to Green Peach Aphid.

Dongus JA, Bhandari DD, Patel M, Archer L, Dijkgraaf L, Deslandes L, Shah J, Parker JE.

Mol Plant Microbe Interact. 2020 Feb;33(2):328-335. doi: 10.1094/MPMI-08-19-0245-R. Epub 2019 Dec 27.


Genetic strategies for improving crop yields.

Bailey-Serres J, Parker JE, Ainsworth EA, Oldroyd GED, Schroeder JI.

Nature. 2019 Nov;575(7781):109-118. doi: 10.1038/s41586-019-1679-0. Epub 2019 Nov 6. Review.


The National Institute for Occupational Safety and Health B Reader Certification Program-An Update Report (1987 to 2018) and Future Directions.

Halldin CN, Hale JM, Weissman DN, Attfield MD, Parker JE, Petsonk EL, Cohen RA, Markle T, Blackley DJ, Wolfe AL, Tallaksen RJ, Laney AS.

J Occup Environ Med. 2019 Dec;61(12):1045-1051. doi: 10.1097/JOM.0000000000001735.


Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.

Voss M, Toelzer C, Bhandari DD, Parker JE, Niefind K.

J Struct Biol. 2019 Dec 1;208(3):107390. doi: 10.1016/j.jsb.2019.09.007. Epub 2019 Sep 21.


Spatially Resolved Dissolution and Speciation Changes of ZnO Nanorods during Short-Term in Situ Incubation in a Simulated Wastewater Environment.

Gomez-Gonzalez MA, Koronfel MA, Goode AE, Al-Ejji M, Voulvoulis N, Parker JE, Quinn PD, Scott TB, Xie F, Yallop ML, Porter AE, Ryan MP.

ACS Nano. 2019 Oct 22;13(10):11049-11061. doi: 10.1021/acsnano.9b02866. Epub 2019 Sep 20.


A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors.

Lapin D, Kovacova V, Sun X, Dongus JA, Bhandari D, von Born P, Bautor J, Guarneri N, Rzemieniewski J, Stuttmann J, Beyer A, Parker JE.

Plant Cell. 2019 Oct;31(10):2430-2455. doi: 10.1105/tpc.19.00118. Epub 2019 Jul 16.


Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens.

Warrilow AGS, Parker JE, Price CL, Rolley NJ, Nes WD, Kelly DE, Kelly SL.

Int J Antimicrob Agents. 2019 Oct;54(4):449-455. doi: 10.1016/j.ijantimicag.2019.07.011. Epub 2019 Jul 13.


Improving our understanding of metal implant failures: Multiscale chemical imaging of exogenous metals in ex-vivo biological tissues.

Morrell AP, Floyd H, W Mosselmans JF, Grover LM, Castillo-Michel H, Davis ET, Parker JE, Martin RA, Addison O.

Acta Biomater. 2019 Oct 15;98:284-293. doi: 10.1016/j.actbio.2019.05.071. Epub 2019 Jun 5.


Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus.

Rybak JM, Ge W, Wiederhold NP, Parker JE, Kelly SL, Rogers PD, Fortwendel JR.

mBio. 2019 Apr 2;10(2). pii: e00437-19. doi: 10.1128/mBio.00437-19.


Antagonistic Actions of FPA and IBM2 Regulate Transcript Processing from Genes Containing Heterochromatin.

Deremetz A, Le Roux C, Idir Y, Brousse C, Agorio A, Gy I, Parker JE, Bouché N.

Plant Physiol. 2019 May;180(1):392-403. doi: 10.1104/pp.18.01106. Epub 2019 Feb 27.


The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions.

Warrilow AG, Nishimoto AT, Parker JE, Price CL, Flowers SA, Kelly DE, Rogers PD, Kelly SL.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02586-18. doi: 10.1128/AAC.02586-18. Print 2019 May.


An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis.

Bhandari DD, Lapin D, Kracher B, von Born P, Bautor J, Niefind K, Parker JE.

Nat Commun. 2019 Feb 15;10(1):772. doi: 10.1038/s41467-019-08783-0.


Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.

Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):191-211. doi: 10.1016/j.bbalip.2018.11.006. Epub 2018 Nov 22.


ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait.

Ahmad S, Joseph L, Parker JE, Asadzadeh M, Kelly SL, Meis JF, Khan Z.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01900-18. doi: 10.1128/AAC.01900-18. Print 2019 Feb.


Exposure‒response relationships for silicosis and its progression in industrial sand workers.

Vacek PM, Glenn RE, Rando RJ, Parker JE, Kanne JP, Henry DA, Meyer CA.

Scand J Work Environ Health. 2019 May 1;45(3):280-288. doi: 10.5271/sjweh.3786. Epub 2018 Nov 18.


Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.

Zhou W, Warrilow AGS, Thomas CD, Ramos E, Parker JE, Price CL, Vanderloop BH, Fisher PM, Loftis MD, Kelly DE, Kelly SL, Nes WD.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1164-1178. doi: 10.1016/j.bbalip.2018.07.004. Epub 2018 Jul 22.


Retrospective Assessment of Respirable Quartz Exposure for a Silicosis Study of the Industrial Sand Industry.

Rando RJ, Vacek PM, Glenn RE, Kwon CW, Parker JE.

Ann Work Expo Health. 2018 Oct 15;62(8):1021-1032. doi: 10.1093/annweh/wxy064.


Chemical Activation of EDS1/PAD4 Signaling Leading to Pathogen Resistance in Arabidopsis.

Joglekar S, Suliman M, Bartsch M, Halder V, Maintz J, Bautor J, Zeier J, Parker JE, Kombrink E.

Plant Cell Physiol. 2018 Aug 1;59(8):1592-1607. doi: 10.1093/pcp/pcy106.


Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity.

Cui H, Qiu J, Zhou Y, Bhandari DD, Zhao C, Bautor J, Parker JE.

Mol Plant. 2018 Aug 6;11(8):1053-1066. doi: 10.1016/j.molp.2018.05.007. Epub 2018 May 26.


Assessment of physicians' proficiency in reading chest radiographs for pneumoconiosis, based on a 60-film examination set with two factors constituting eight indices.

Tamura T, Kusaka Y, Suganuma N, Suzuki K, Subhannachart P, Siriruttanapruk S, Dumavibhat N, Zhang X, Sishodiya PK, Thanh TA, Hering KG, Parker JE, Algranti E, O'Connor FS, Shida H, Akira M.

Ind Health. 2018 Oct 3;56(5):382-393. doi: 10.2486/indhealth.2017-0115. Epub 2018 May 26.


NLR Mutations Suppressing Immune Hybrid Incompatibility and Their Effects on Disease Resistance.

Atanasov KE, Liu C, Erban A, Kopka J, Parker JE, Alcázar R.

Plant Physiol. 2018 Jul;177(3):1152-1169. doi: 10.1104/pp.18.00462. Epub 2018 May 23.


Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity.

Luna-Tapia A, Willems HME, Parker JE, Tournu H, Barker KS, Nishimoto AT, Rogers PD, Kelly SL, Peters BM, Palmer GE.

mBio. 2018 May 22;9(3). pii: e00225-18. doi: 10.1128/mBio.00225-18.


In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.


A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana.

Jacob F, Kracher B, Mine A, Seyfferth C, Blanvillain-Baufumé S, Parker JE, Tsuda K, Schulze-Lefert P, Maekawa T.

New Phytol. 2018 Mar;217(4):1667-1680. doi: 10.1111/nph.14943. Epub 2017 Dec 11.


Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes.

Butts A, DeJarnette C, Peters TL, Parker JE, Kerns ME, Eberle KE, Kelly SL, Palmer GE.

mSphere. 2017 Oct 4;2(5). pii: e00379-17. doi: 10.1128/mSphere.00379-17. eCollection 2017 Sep-Oct.


Host-seeking activity of a Tanzanian population of Anopheles arabiensis at an insecticide treated bed net.

Parker JEA, Angarita Jaimes NC, Gleave K, Mashauri F, Abe M, Martine J, Towers CE, Towers D, McCall PJ.

Malar J. 2017 Jul 4;16(1):270. doi: 10.1186/s12936-017-1909-6.


Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.

Rybak JM, Dickens CM, Parker JE, Caudle KE, Manigaba K, Whaley SG, Nishimoto AT, Luna-Tapia A, Roy S, Zhang Q, Barker KS, Palmer GE, Sutter TR, Homayouni R, Wiederhold NP, Kelly SL, Rogers PD.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00651-17. doi: 10.1128/AAC.00651-17. Print 2017 Sep.


Derivation and Validation of a Prognostic Model to Predict 6-Month Mortality in an Intensive Care Unit Population.

Hadique S, Culp S, Sangani RG, Chapman KD, Khan S, Parker JE, Moss AH.

Ann Am Thorac Soc. 2017 Oct;14(10):1556-1561. doi: 10.1513/AnnalsATS.201702-159OC.


NLR locus-mediated trade-off between abiotic and biotic stress adaptation in Arabidopsis.

Ariga H, Katori T, Tsuchimatsu T, Hirase T, Tajima Y, Parker JE, Alcázar R, Koornneef M, Hoekenga O, Lipka AE, Gore MA, Sakakibara H, Kojima M, Kobayashi Y, Iuchi S, Kobayashi M, Shinozaki K, Sakata Y, Hayashi T, Saijo Y, Taji T.

Nat Plants. 2017 May 26;3:17072. doi: 10.1038/nplants.2017.72.


Monoterpenes Support Systemic Acquired Resistance within and between Plants.

Riedlmeier M, Ghirardo A, Wenig M, Knappe C, Koch K, Georgii E, Dey S, Parker JE, Schnitzler JP, Vlot AC.

Plant Cell. 2017 Jun;29(6):1440-1459. doi: 10.1105/tpc.16.00898. Epub 2017 May 23.


The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.

Warrilow AGS, Parker JE, Price CL, Garvey EP, Hoekstra WJ, Schotzinger RJ, Wiederhold NP, Nes WD, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00333-17. doi: 10.1128/AAC.00333-17. Print 2017 Jul.


Qualitative Behavior of the Low-Frequency Vibrational Dynamics of Microtubules and the Surrounding Water.

Moix JM, Parker JE, Echchgadda I.

J Phys Chem B. 2017 Apr 13;121(14):3024-3031. doi: 10.1021/acs.jpcb.7b01508. Epub 2017 Mar 30.


In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.

Colley T, Alanio A, Kelly SL, Sehra G, Kizawa Y, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Anderson-Dring L, Nakaoki T, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, Cooke M, Bretagne S, King-Underwood J, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. doi: 10.1128/AAC.02280-16. Print 2017 May.


A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in Arabidopsis immunity.

Cui H, Gobbato E, Kracher B, Qiu J, Bautor J, Parker JE.

New Phytol. 2017 Mar;213(4):1802-1817. doi: 10.1111/nph.14302. Epub 2016 Nov 15.


Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat.

Regal JF, Strehlke ME, Peterson JM, Wing CR, Parker JE, Nieto NF, Bemis LT, Gilbert JS, Fleming SD.

Mol Immunol. 2016 Oct;78:38-47. doi: 10.1016/j.molimm.2016.08.016. Epub 2016 Aug 30.


Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence.

McCourt P, Liu HY, Parker JE, Gallo-Ebert C, Donigan M, Bata A, Giordano C, Kelly SL, Nickels JT Jr.

G3 (Bethesda). 2016 Nov 8;6(11):3455-3465. doi: 10.1534/g3.116.033969.


Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.

Warrilow AG, Price CL, Parker JE, Rolley NJ, Smyrniotis CJ, Hughes DD, Thoss V, Nes WD, Kelly DE, Holman TR, Kelly SL.

Sci Rep. 2016 Jun 13;6:27690. doi: 10.1038/srep27690.


Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein Mutants.

Kunz HH, Park J, Mevers E, García AV, Highhouse S, Gerwick WH, Parker JE, Schroeder JI.

PLoS One. 2016 May 24;11(5):e0155937. doi: 10.1371/journal.pone.0155937. eCollection 2016.


The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.

Warrilow AG, Parker JE, Price CL, Nes WD, Garvey EP, Hoekstra WJ, Schotzinger RJ, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8. doi: 10.1128/AAC.00349-16. Print 2016 Aug.


Arabidopsis thaliana DM2h (R8) within the Landsberg RPP1-like Resistance Locus Underlies Three Different Cases of EDS1-Conditioned Autoimmunity.

Stuttmann J, Peine N, Garcia AV, Wagner C, Choudhury SR, Wang Y, James GV, Griebel T, Alcázar R, Tsuda K, Schneeberger K, Parker JE.

PLoS Genet. 2016 Apr 15;12(4):e1005990. doi: 10.1371/journal.pgen.1005990. eCollection 2016 Apr.


A novel video-tracking system to quantify the behaviour of nocturnal mosquitoes attacking human hosts in the field.

Angarita-Jaimes NC, Parker JE, Abe M, Mashauri F, Martine J, Towers CE, McCall PJ, Towers DP.

J R Soc Interface. 2016 Apr;13(117). pii: 20150974. doi: 10.1098/rsif.2015.0974. Epub 2016 Apr 13.


A glimpse into the future of genome-enabled plant biology from the shores of Cold Spring Harbor.

Rhee SY, Parker JE, Mockler TC.

Genome Biol. 2016 Jan 11;17:3. doi: 10.1186/s13059-016-0870-y.


Compositional dependence of anomalous thermal expansion in perovskite-like ABX3 formates.

Collings IE, Hill JA, Cairns AB, Cooper RI, Thompson AL, Parker JE, Tang CC, Goodwin AL.

Dalton Trans. 2016 Mar 14;45(10):4169-78. doi: 10.1039/c5dt03263f.


Characterizing Damage of Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) in Blueberries.

Wiman NG, Parker JE, Rodriguez-Saona C, Walton VM.

J Econ Entomol. 2015 Jun;108(3):1156-63. doi: 10.1093/jee/tov036. Epub 2015 Mar 22.


In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus.

Warrilow AG, Parker JE, Price CL, Nes WD, Kelly SL, Kelly DE.

Antimicrob Agents Chemother. 2015 Dec;59(12):7771-8. doi: 10.1128/AAC.01806-15. Epub 2015 Oct 12.

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