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Items: 1 to 50 of 116

1.

Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold.

Van de Bittner KC, Cameron RC, Bustamante LY, Bundela R, Kessans SA, Vorster J, Nicholson MJ, Parker EJ.

Medchemcomm. 2019 May 27;10(7):1160-1164. doi: 10.1039/c9md00143c. eCollection 2019 Jul 1.

PMID:
31391888
2.

Hinge Twists and Population Shifts Deliver Regulated Catalysis for ATP-PRT in Histidine Biosynthesis.

Jiao W, Mittelstädt G, Moggré GJ, Parker EJ.

Biophys J. 2019 May 21;116(10):1887-1897. doi: 10.1016/j.bpj.2019.03.040. Epub 2019 Apr 9.

PMID:
31053263
3.

Domain cross-talk within a bifunctional enzyme provides catalytic and allosteric functionality in the biosynthesis of aromatic amino acids.

Bai Y, Lang EJM, Nazmi AR, Parker EJ.

J Biol Chem. 2019 Mar 29;294(13):4828-4842. doi: 10.1074/jbc.RA118.005220. Epub 2019 Jan 22.

PMID:
30670586
4.

Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass.

Sterritt OW, Lang EJM, Kessans SA, Ryan TM, Demeler B, Jameson GB, Parker EJ.

Biosci Rep. 2018 Oct 17;38(5). pii: BSR20181605. doi: 10.1042/BSR20181605. Print 2018 Oct 31.

5.

Foreign Animal Disease Outbreaks.

Bickett-Weddle DA, Sanderson MW, Parker EJ.

Vet Clin North Am Food Anim Pract. 2018 Jul;34(2):341-354. doi: 10.1016/j.cvfa.2018.02.005. Review.

PMID:
29935721
6.

'Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase.

Heikal A, Nakatani Y, Jiao W, Wilson C, Rennison D, Weimar MR, Parker EJ, Brimble MA, Cook GM.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2239-2243. doi: 10.1016/j.bmcl.2018.05.048. Epub 2018 May 26.

PMID:
29859905
7.

Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.

Petri J, Shimaki Y, Jiao W, Bridges HR, Russell ER, Parker EJ, Aragão D, Cook GM, Nakatani Y.

Biochim Biophys Acta Bioenerg. 2018 Jul;1859(7):482-490. doi: 10.1016/j.bbabio.2018.03.014. Epub 2018 Apr 3.

8.

MIDAS: A Modular DNA Assembly System for Synthetic Biology.

van Dolleweerd CJ, Kessans SA, Van de Bittner KC, Bustamante LY, Bundela R, Scott B, Nicholson MJ, Parker EJ.

ACS Synth Biol. 2018 Apr 20;7(4):1018-1029. doi: 10.1021/acssynbio.7b00363. Epub 2018 Apr 12.

PMID:
29620866
9.

A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux.

Sterritt OW, Kessans SA, Jameson GB, Parker EJ.

Biochemistry. 2018 May 8;57(18):2667-2678. doi: 10.1021/acs.biochem.8b00082. Epub 2018 Apr 16.

PMID:
29608284
10.

Exploring modular allostery via interchangeable regulatory domains.

Fan Y, Cross PJ, Jameson GB, Parker EJ.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3006-3011. doi: 10.1073/pnas.1717621115. Epub 2018 Mar 5.

11.

Draft Genome Sequence of the Filamentous Fungus Hypoxylon pulicicidum ATCC 74245.

Nicholson MJ, Van de Bittner KC, Ram A, Bustamante LY, Scott B, Parker EJ.

Genome Announc. 2018 Jan 11;6(2). pii: e01380-17. doi: 10.1128/genomeA.01380-17.

12.

Heterologous Biosynthesis of Nodulisporic Acid F.

Van de Bittner KC, Nicholson MJ, Bustamante LY, Kessans SA, Ram A, van Dolleweerd CJ, Scott B, Parker EJ.

J Am Chem Soc. 2018 Jan 17;140(2):582-585. doi: 10.1021/jacs.7b10909. Epub 2018 Jan 8.

PMID:
29283570
13.

A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.

Mittelstädt G, Jiao W, Livingstone EK, Moggré GJ, Nazmi AR, Parker EJ.

Biochem J. 2018 Jan 5;475(1):247-260. doi: 10.1042/BCJ20170762.

PMID:
29208762
14.

Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups.

Evans GL, Furkert DP, Abermil N, Kundu P, de Lange KM, Parker EJ, Brimble MA, Baker EN, Lott JS.

Data Brief. 2017 Oct 31;15:1019-1029. doi: 10.1016/j.dib.2017.10.051. eCollection 2017 Dec.

15.

Crystal structure of type II NADH:quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 Å.

Nakatani Y, Jiao W, Aragão D, Shimaki Y, Petri J, Parker EJ, Cook GM.

Acta Crystallogr F Struct Biol Commun. 2017 Oct 1;73(Pt 10):541-549. doi: 10.1107/S2053230X17013073. Epub 2017 Sep 23.

16.

Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.

Moggré GJ, Poulin MB, Tyler PC, Schramm VL, Parker EJ.

ACS Chem Biol. 2017 Oct 20;12(10):2662-2670. doi: 10.1021/acschembio.7b00484. Epub 2017 Sep 19.

17.

Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.

Evans GL, Furkert DP, Abermil N, Kundu P, de Lange KM, Parker EJ, Brimble MA, Baker EN, Lott JS.

Biochim Biophys Acta Proteins Proteom. 2018 Feb;1866(2):264-274. doi: 10.1016/j.bbapap.2017.08.018. Epub 2017 Aug 26.

PMID:
28844746
18.

Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis.

Jiao W, Blackmore NJ, Nazmi AR, Parker EJ.

PLoS One. 2017 Jun 30;12(6):e0180052. doi: 10.1371/journal.pone.0180052. eCollection 2017.

19.

Change in Heat Capacity for Enzyme Catalysis Determines Temperature Dependence of Enzyme Catalyzed Rates.

Hobbs JK, Jiao W, Easter AD, Parker EJ, Schipper LA, Arcus VL.

ACS Chem Biol. 2017 Mar 17;12(3):868. doi: 10.1021/acschembio.7b00065. Epub 2017 Feb 21. No abstract available.

PMID:
28221017
20.

Oral Health Impact among Rural-dwelling Indigenous Adults in South Australia.

Parker EJ, Mills H, Spencer AJ, Mejia GC, Roberts-Thomson KF, Jamieson LM.

J Health Care Poor Underserved. 2016;27(1A):207-219.

PMID:
27763441
21.

Interdomain Conformational Changes Provide Allosteric Regulation en Route to Chorismate.

Nazmi AR, Lang EJM, Bai Y, Allison TM, Othman MH, Panjikar S, Arcus VL, Parker EJ.

J Biol Chem. 2016 Oct 14;291(42):21836-21847. doi: 10.1074/jbc.M116.741637. Epub 2016 Aug 8.

22.

Independent catalysis of the short form HisG from Lactococcus lactis.

Livingstone EK, Mittelstädt G, Given FM, Parker EJ.

FEBS Lett. 2016 Aug;590(16):2603-10. doi: 10.1002/1873-3468.12277. Epub 2016 Jul 30.

23.

Does self-efficacy mediate the effect of oral health literacy on self-rated oral health in an Indigenous population?

Jones K, Brennan DS, Parker EJ, Mills H, Jamieson L.

J Public Health Dent. 2016 Sep;76(4):350-355. doi: 10.1111/jphd.12162. Epub 2016 May 25.

PMID:
27222211
24.

Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.

Mittelstädt G, Moggré GJ, Panjikar S, Nazmi AR, Parker EJ.

Protein Sci. 2016 Aug;25(8):1492-506. doi: 10.1002/pro.2948. Epub 2016 Jun 6.

25.

Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using ᴅ-Amino Acids.

Reichau S, Blackmore NJ, Jiao W, Parker EJ.

PLoS One. 2016 Apr 29;11(4):e0152723. doi: 10.1371/journal.pone.0152723. eCollection 2016.

26.

First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.

Arturo EC, Gupta K, Héroux A, Stith L, Cross PJ, Parker EJ, Loll PJ, Jaffe EK.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2394-9. doi: 10.1073/pnas.1516967113. Epub 2016 Feb 16.

27.

On the Temperature Dependence of Enzyme-Catalyzed Rates.

Arcus VL, Prentice EJ, Hobbs JK, Mulholland AJ, Van der Kamp MW, Pudney CR, Parker EJ, Schipper LA.

Biochemistry. 2016 Mar 29;55(12):1681-8. doi: 10.1021/acs.biochem.5b01094. Epub 2016 Mar 8.

PMID:
26881922
28.

Oral Health Impact among Rural-dwelling Indigenous Adults in South Australia.

Parker EJ, Mills H, Spencer AJ, Mejia GC, Roberts-Thomson KF, Jamieson LM.

J Health Care Poor Underserved. 2016 Feb;27(1 Suppl):207-19. doi: 10.1353/hpu.2016.0033.

PMID:
26853211
29.

The Functional Unit of Neisseria meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric.

Cross PJ, Heyes LC, Zhang S, Nazmi AR, Parker EJ.

PLoS One. 2016 Feb 1;11(2):e0145187. doi: 10.1371/journal.pone.0145187. eCollection 2016.

30.

Calculated pKa Variations Expose Dynamic Allosteric Communication Networks.

Lang EJ, Heyes LC, Jameson GB, Parker EJ.

J Am Chem Soc. 2016 Feb 17;138(6):2036-45. doi: 10.1021/jacs.5b13134. Epub 2016 Feb 5.

PMID:
26794122
31.

Development and psychometric validation of social cognitive theory scales in an oral health context.

Jones K, Parker EJ, Steffens MA, Logan RM, Brennan D, Jamieson LM.

Aust N Z J Public Health. 2016 Apr;40(2):193-5. doi: 10.1111/1753-6405.12500. Epub 2015 Dec 29.

PMID:
26714281
32.

Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.

Cookson TV, Evans GL, Castell A, Baker EN, Lott JS, Parker EJ.

Biochemistry. 2015 Oct 6;54(39):6082-92. doi: 10.1021/acs.biochem.5b00612.

PMID:
26356348
33.

Are Stage of Change constructs relevant for subjective oral health in a vulnerable population?

Jamieson LM, Parker EJ, Broughton J, Lawrence HP, Armfield JM.

Community Dent Health. 2015 Jun;32(2):111-6.

PMID:
26263605
34.

Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.

Blackmore NJ, Nazmi AR, Hutton RD, Webby MN, Baker EN, Jameson GB, Parker EJ.

J Biol Chem. 2015 Jul 17;290(29):18187-98. doi: 10.1074/jbc.M115.638700. Epub 2015 Jun 1.

35.

The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3.

Parker EJ.

Structure. 2015 Apr 7;23(4):608-9. doi: 10.1016/j.str.2015.03.005.

36.

Allosteric ACTion: the varied ACT domains regulating enzymes of amino-acid metabolism.

Lang EJ, Cross PJ, Mittelstädt G, Jameson GB, Parker EJ.

Curr Opin Struct Biol. 2014 Dec;29:102-11. doi: 10.1016/j.sbi.2014.10.007. Epub 2014 Nov 21. Review.

PMID:
25543886
37.

Editorial overview: Catalysis and regulation: enzyme catalysis, biosynthetic pathways and regulation.

Naismith JH, Parker EJ.

Curr Opin Struct Biol. 2014 Dec;29:iv-v. doi: 10.1016/j.sbi.2014.11.004. Epub 2014 Dec 2. No abstract available.

PMID:
25480465
38.
39.

Experience of racism and tooth brushing among pregnant Aboriginal Australians: exploring psychosocial mediators.

Ben J, Jamieson LM, Priest N, Parker EJ, Roberts-Thomson KF, Lawrence HP, Broughton J, Paradies Y.

Community Dent Health. 2014 Sep;31(3):145-52.

PMID:
25300148
40.

Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - The importance of accommodating the active site water.

Heyes LC, Reichau S, Cross PJ, Jameson GB, Parker EJ.

Bioorg Chem. 2014 Dec;57:242-250. doi: 10.1016/j.bioorg.2014.08.003. Epub 2014 Aug 27.

PMID:
25245459
41.

Probing the determinants of phosphorylated sugar-substrate binding for human sialic acid synthase.

Cotton TR, Joseph DD, Jiao W, Parker EJ.

Biochim Biophys Acta. 2014 Dec;1844(12):2257-64. doi: 10.1016/j.bbapap.2014.09.014. Epub 2014 Sep 19.

PMID:
25242570
42.

Development and evaluation of the Stages of Change in Oral Health instrument.

Jamieson LM, Armfield JM, Parker EJ, Roberts-Thomson KF, Broughton J, Lawrence HP.

Int Dent J. 2014 Oct;64(5):269-77. doi: 10.1111/idj.12119. Epub 2014 Aug 14.

PMID:
25131429
43.

Self-reported racism and experience of toothache among pregnant Aboriginal Australians: the role of perceived stress, sense of control, and social support.

Ben J, Paradies Y, Priest N, Parker EJ, Roberts-Thomson KF, Lawrence HP, Broughton J, Jamieson LM.

J Public Health Dent. 2014 Fall;74(4):301-9. doi: 10.1111/jphd.12059. Epub 2014 Jul 2.

PMID:
24989691
44.

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.

Cookson TV, Castell A, Bulloch EM, Evans GL, Short FL, Baker EN, Lott JS, Parker EJ.

Biochem J. 2014 Jul 1;461(1):87-98. doi: 10.1042/BJ20140209.

PMID:
24712732
45.

Self-efficacy and self-rated oral health among pregnant aboriginal Australian women.

Jamieson LM, Parker EJ, Roberts-Thomson KF, Lawrence HP, Broughton J.

BMC Oral Health. 2014 Apr 2;14:29. doi: 10.1186/1472-6831-14-29.

46.

Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic acid synthase.

Joseph DD, Jiao W, Kessans SA, Parker EJ.

Proteins. 2014 Sep;82(9):2054-66. doi: 10.1002/prot.24558. Epub 2014 Apr 16.

PMID:
24633984
47.

Modifying the determinants of α-ketoacid substrate selectivity in mycobacterium tuberculosis α-isopropylmalate synthase.

Hunter MF, Parker EJ.

FEBS Lett. 2014 May 2;588(9):1603-7. doi: 10.1016/j.febslet.2014.02.053. Epub 2014 Mar 5.

48.

Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity.

Nazmi AR, Schofield LR, Dobson RC, Jameson GB, Parker EJ.

J Mol Biol. 2014 Feb 6;426(3):656-73. doi: 10.1016/j.jmb.2013.11.008. Epub 2013 Nov 14.

PMID:
24239948
49.

Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates.

Hobbs JK, Jiao W, Easter AD, Parker EJ, Schipper LA, Arcus VL.

ACS Chem Biol. 2013 Nov 15;8(11):2388-93. doi: 10.1021/cb4005029. Epub 2013 Sep 17. Erratum in: ACS Chem Biol. 2017 Mar 17;12 (3):868.

PMID:
24015933
50.

Deletion and gene expression analyses define the paxilline biosynthetic gene cluster in Penicillium paxilli.

Scott B, Young CA, Saikia S, McMillan LK, Monahan BJ, Koulman A, Astin J, Eaton CJ, Bryant A, Wrenn RE, Finch SC, Tapper BA, Parker EJ, Jameson GB.

Toxins (Basel). 2013 Aug 14;5(8):1422-46. doi: 10.3390/toxins5081422.

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