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Items: 45

1.

Mechanisms involved in normal and pathological osteoclastogenesis.

Park-Min KH.

Cell Mol Life Sci. 2018 Jul;75(14):2519-2528. doi: 10.1007/s00018-018-2817-9. Epub 2018 Apr 18. Review.

PMID:
29670999
2.

Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS.

JCI Insight. 2017 Nov 16;2(22). pii: 95512. doi: 10.1172/jci.insight.95512. [Epub ahead of print]

3.

Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation.

Park SH, Kang K, Giannopoulou E, Qiao Y, Kang K, Kim G, Park-Min KH, Ivashkiv LB.

Nat Immunol. 2017 Oct;18(10):1104-1116. doi: 10.1038/ni.3818. Epub 2017 Aug 21.

4.

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.

Kang K, Park SH, Chen J, Qiao Y, Giannopoulou E, Berg K, Hanidu A, Li J, Nabozny G, Kang K, Park-Min KH, Ivashkiv LB.

Immunity. 2017 Aug 15;47(2):235-250.e4. doi: 10.1016/j.immuni.2017.07.017.

5.

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.

Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB.

Immunity. 2017 Jul 18;47(1):66-79.e5. doi: 10.1016/j.immuni.2017.06.018.

6.

MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.

Bae S, Lee MJ, Mun SH, Giannopoulou EG, Yong-Gonzalez V, Cross JR, Murata K, Giguère V, van der Meulen M, Park-Min KH.

J Clin Invest. 2017 Jun 30;127(7):2555-2568. doi: 10.1172/JCI89935. Epub 2017 May 22.

7.

Imidazopyridyl compounds as aldosterone synthase inhibitors.

Whitehead BR, Lo MM, Ali A, Park MK, Hoyt SB, Xiong Y, Cai J, Carswell E, Cooke A, MacLean J, Ratcliffe P, Robinson J, Bennett DJ, Clemas JA, Wisniewski T, Struthers M, Cully D, MacNeil DJ.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):143-146. doi: 10.1016/j.bmcl.2016.12.003. Epub 2016 Dec 2.

PMID:
27979595
8.

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.

Huynh L, Kusnadi A, Park SH, Murata K, Park-Min KH, Ivashkiv LB.

Sci Rep. 2016 Aug 25;6:31959. doi: 10.1038/srep31959.

9.

Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8.

Fang C, Qiao Y, Mun SH, Lee MJ, Murata K, Bae S, Zhao B, Park-Min KH, Ivashkiv LB.

J Immunol. 2016 Jun 1;196(11):4452-4456. doi: 10.4049/jimmunol.1501466. Epub 2016 Apr 29.

10.

Epigenetic regulation of bone cells.

Park-Min KH.

Connect Tissue Res. 2017 Jan;58(1):76-89. doi: 10.1080/03008207.2016.1177037. Epub 2016 Apr 14. Review.

11.

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Decker CE, Yang Z, Rimer R, Park-Min KH, Macaubas C, Mellins ED, Novack DV, Faccio R.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9. doi: 10.1073/pnas.1511285112. Epub 2015 Dec 7.

12.

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, Kleinman A, Styrkarsdottir U, Liu CT, Uggla C, Evans DS, Nielson CM, Walter K, Pettersson-Kymmer U, McCarthy S, Eriksson J, Kwan T, Jhamai M, Trajanoska K, Memari Y, Min J, Huang J, Danecek P, Wilmot B, Li R, Chou WC, Mokry LE, Moayyeri A, Claussnitzer M, Cheng CH, Cheung W, Medina-Gómez C, Ge B, Chen SH, Choi K, Oei L, Fraser J, Kraaij R, Hibbs MA, Gregson CL, Paquette D, Hofman A, Wibom C, Tranah GJ, Marshall M, Gardiner BB, Cremin K, Auer P, Hsu L, Ring S, Tung JY, Thorleifsson G, Enneman AW, van Schoor NM, de Groot LC, van der Velde N, Melin B, Kemp JP, Christiansen C, Sayers A, Zhou Y, Calderari S, van Rooij J, Carlson C, Peters U, Berlivet S, Dostie J, Uitterlinden AG, Williams SR, Farber C, Grinberg D, LaCroix AZ, Haessler J, Chasman DI, Giulianini F, Rose LM, Ridker PM, Eisman JA, Nguyen TV, Center JR, Nogues X, Garcia-Giralt N, Launer LL, Gudnason V, Mellström D, Vandenput L, Amin N, van Duijn CM, Karlsson MK, Ljunggren Ö, Svensson O, Hallmans G, Rousseau F, Giroux S, Bussière J, Arp PP, Koromani F, Prince RL, Lewis JR, Langdahl BL, Hermann AP, Jensen JE, Kaptoge S, Khaw KT, Reeve J, Formosa MM, Xuereb-Anastasi A, Åkesson K, McGuigan FE, Garg G, Olmos JM, Zarrabeitia MT, Riancho JA, Ralston SH, Alonso N, Jiang X, Goltzman D, Pastinen T, Grundberg E, Gauguier D, Orwoll ES, Karasik D, Davey-Smith G; AOGC Consortium, Smith AV, Siggeirsdottir K, Harris TB, Zillikens MC, van Meurs JB, Thorsteinsdottir U, Maurano MT, Timpson NJ, Soranzo N, Durbin R, Wilson SG, Ntzani EE, Brown MA, Stefansson K, Hinds DA, Spector T, Cupples LA, Ohlsson C, Greenwood CM; UK10K Consortium, Jackson RD, Rowe DW, Loomis CA, Evans DM, Ackert-Bicknell CL, Joyner AL, Duncan EL, Kiel DP, Rivadeneira F, Richards JB.

Nature. 2015 Oct 1;526(7571):112-7. doi: 10.1038/nature14878. Epub 2015 Sep 14.

13.

Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression.

Lee MJ, Lim E, Mun S, Bae S, Murata K, Ivashkiv LB, Park-Min KH.

J Cell Physiol. 2016 Feb;231(2):449-458. doi: 10.1002/jcp.25091.

14.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Park MK, London C, Xiong Y, Tata J, Bennett DJ, Cooke A, Cai J, Carswell E, Robinson J, MacLean J, Brown L, Belshaw S, Clarkson TR, Liu K, Liang GB, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Kuethe J, Rivera N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Ali A.

ACS Med Chem Lett. 2015 Apr 7;6(5):573-8. doi: 10.1021/acsmedchemlett.5b00054. eCollection 2015 May 14.

15.

Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.

Park-Min KH, Lim E, Lee MJ, Park SH, Giannopoulou E, Yarilina A, van der Meulen M, Zhao B, Smithers N, Witherington J, Lee K, Tak PP, Prinjha RK, Ivashkiv LB.

Nat Commun. 2014 Nov 13;5:5418. doi: 10.1038/ncomms6418.

16.

The glial-neuronal GRK2 pathway participates in the development of trigeminal neuropathic pain in rats.

Won KA, Kim MJ, Yang KY, Park JS, Lee MK, Park MK, Bae YC, Ahn DK.

J Pain. 2014 Mar;15(3):250-61. doi: 10.1016/j.jpain.2013.10.013. Epub 2013 Nov 8.

PMID:
24216329
17.

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP.

J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25.

18.

Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts.

Lee A, Qiao Y, Grigoriev G, Chen J, Park-Min KH, Park SH, Ivashkiv LB, Kalliolias GD.

Arthritis Rheum. 2013 Apr;65(4):928-38. doi: 10.1002/art.37853.

19.

Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling.

Park-Min KH, Lee EY, Moskowitz NK, Lim E, Lee SK, Lorenzo JA, Huang C, Melnick AM, Purdue PE, Goldring SR, Ivashkiv LB.

J Bone Miner Res. 2013 Jan;28(1):135-49. doi: 10.1002/jbmr.1739.

20.

A novel trigeminal neuropathic pain model: compression of the trigeminal nerve root produces prolonged nociception in rats.

Jeon HJ, Han SR, Park MK, Yang KY, Bae YC, Ahn DK.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):149-58. doi: 10.1016/j.pnpbp.2012.03.002. Epub 2012 Mar 15.

PMID:
22449477
21.

ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes.

Huynh L, Wang L, Shi C, Park-Min KH, Ivashkiv LB.

J Immunol. 2012 Apr 1;188(7):3447-57. doi: 10.4049/jimmunol.1102211. Epub 2012 Feb 24.

22.

Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8.

Ivashkiv LB, Zhao B, Park-Min KH, Takami M.

Ann N Y Acad Sci. 2011 Nov;1237:88-94. doi: 10.1111/j.1749-6632.2011.06217.x. Review.

23.

Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-κB in rats with trigeminal neuropathic pain.

Lee MK, Han SR, Park MK, Kim MJ, Bae YC, Kim SK, Park JS, Ahn DK.

Mol Pain. 2011 Aug 5;7:57. doi: 10.1186/1744-8069-7-57.

24.

Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages.

Park SH, Park-Min KH, Chen J, Hu X, Ivashkiv LB.

Nat Immunol. 2011 May 22;12(7):607-15. doi: 10.1038/ni.2043.

25.

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.

Hong Q, Bakshi RK, Palucki BL, Park MK, Ye Z, He S, Pollard PG, Sebhat IK, Liu J, Guo L, Cashen DE, Martin WJ, Weinberg DH, MacNeil T, Tang R, Tamvakopoulos C, Peng Q, Miller RR, Stearns RA, Chen HY, Chen AS, Strack AM, Fong TM, MacIntyre DE, Wyvratt MJ, Nargund RP.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2330-4. doi: 10.1016/j.bmcl.2011.02.090. Epub 2011 Mar 1.

PMID:
21439820
26.

Peripheral administration of NR2 antagonists attenuates orofacial formalin-induced nociceptive behavior in rats.

Park MK, Lee JH, Yang GY, Won KA, Kim MJ, Park YY, Bae YC, Ahn DK.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):982-6. doi: 10.1016/j.pnpbp.2011.01.018. Epub 2011 Feb 2.

PMID:
21295101
27.

Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta.

Lee B, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Sohn J, Park-Min KH, Ivashkiv LB, Ji JD.

J Immunol. 2010 Nov 15;185(10):5926-34. doi: 10.4049/jimmunol.1001591. Epub 2010 Oct 8.

28.

Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.

Wang L, Gordon RA, Huynh L, Su X, Park Min KH, Han J, Arthur JS, Kalliolias GD, Ivashkiv LB.

Immunity. 2010 Apr 23;32(4):518-30. doi: 10.1016/j.immuni.2010.03.014. Epub 2010 Apr 1.

29.

Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling.

Kalliolias GD, Zhao B, Triantafyllopoulou A, Park-Min KH, Ivashkiv LB.

Arthritis Rheum. 2010 Feb;62(2):402-13. doi: 10.1002/art.27200.

30.

Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.

Ji JD, Park-Min KH, Shen Z, Fajardo RJ, Goldring SR, McHugh KP, Ivashkiv LB.

J Immunol. 2009 Dec 1;183(11):7223-33. doi: 10.4049/jimmunol.0900072. Epub 2009 Nov 4.

31.

IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.

Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB, Nakamura M, Ivashkiv LB.

J Immunol. 2009 Aug 15;183(4):2444-55. doi: 10.4049/jimmunol.0804165. Epub 2009 Jul 22.

32.

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

Ji JD, Park-Min KH, Ivashkiv LB.

Hum Immunol. 2009 Apr;70(4):211-7. doi: 10.1016/j.humimm.2009.01.026. Epub 2009 Feb 7.

33.

Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2.

Hu Y, Park-Min KH, Yarilina A, Ivashkiv LB.

J Leukoc Biol. 2008 Nov;84(5):1353-60. doi: 10.1189/jlb.0107040. Epub 2008 Aug 4.

34.

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes.

Yarilina A, Park-Min KH, Antoniv T, Hu X, Ivashkiv LB.

Nat Immunol. 2008 Apr;9(4):378-87. doi: 10.1038/ni1576. Epub 2008 Mar 16.

PMID:
18345002
35.

'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.

Wang L, Tassiulas I, Park-Min KH, Reid AC, Gil-Henn H, Schlessinger J, Baron R, Zhang JJ, Ivashkiv LB.

Nat Immunol. 2008 Feb;9(2):186-93. Epub 2007 Dec 16.

PMID:
18084294
36.

Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.

Tassiulas I, Park-Min KH, Hu Y, Kellerman L, Mevorach D, Ivashkiv LB.

Hum Immunol. 2007 Mar;68(3):156-64. Epub 2007 Jan 8.

37.

FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.

Park-Min KH, Serbina NV, Yang W, Ma X, Krystal G, Neel BG, Nutt SL, Hu X, Ivashkiv LB.

Immunity. 2007 Jan;26(1):67-78.

38.

Kinetics of IL-10-induced gene expression in human macrophages.

Antoniv TT, Park-Min KH, Ivashkiv LB.

Immunobiology. 2005;210(2-4):87-95.

PMID:
16164015
39.

Regulation of macrophage phenotype by long-term exposure to IL-10.

Park-Min KH, Antoniv TT, Ivashkiv LB.

Immunobiology. 2005;210(2-4):77-86.

PMID:
16164014
40.
41.

2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists.

Palucki BL, Park MK, Nargund RP, Tang R, MacNeil T, Weinberg DH, Vongs A, Rosenblum CI, Doss GA, Miller RR, Stearns RA, Peng Q, Tamvakopoulos C, Van der Ploeg LH, Patchett AA.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):1993-6.

PMID:
15808454
42.

Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.

Doss GA, Miller RR, Zhang Z, Teffera Y, Nargund RP, Palucki B, Park MK, Tang YS, Evans DC, Baillie TA, Stearns RA.

Chem Res Toxicol. 2005 Feb;18(2):271-6.

PMID:
15720132
43.

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist.

Palucki BL, Park MK, Nargund RP, Ye Z, Sebhat IK, Pollard PG, Kalyani RN, Tang R, Macneil T, Weinberg DH, Vongs A, Rosenblum CI, Doss GA, Miller RR, Stearns RA, Peng Q, Tamvakopoulos C, McGowan E, Martin WJ, Metzger JM, Shepherd CA, Strack AM, Macintyre DE, Van der Ploeg LH, Patchett AA.

Bioorg Med Chem Lett. 2005 Jan 3;15(1):171-5.

PMID:
15582434
44.

Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis.

Ji JD, Tassiulas I, Park-Min KH, Aydin A, Mecklenbrauker I, Tarakhovsky A, Pricop L, Salmon JE, Ivashkiv LB.

J Exp Med. 2003 Jun 2;197(11):1573-83.

45.

Suppression of tumor necrosis factor-alpha and inducible nitric oxide synthase gene expression by THI 52, a new synthetic naphthyl-benzylisoquinoline alkaloid.

Kang YJ, Lee BK, Lee YS, Seo HG, Park MK, Kim HJ, Pyo HS, Chong WS, Jung HJ, Yun-Choi HS, Lee DH, Chang KC.

Biochem Pharmacol. 2003 Feb 1;65(3):457-64.

PMID:
12527339

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