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Is host heparanase required for the rapid spread of heparan sulfate binding viruses?

Khanna M, Ranasinghe C, Browne AM, Li JP, Vlodavsky I, Parish CR.

Virology. 2019 Mar;529:1-6. doi: 10.1016/j.virol.2019.01.001. Epub 2019 Jan 3.


Phase I trial of Lipovaxin-MM, a novel dendritic cell-targeted liposomal vaccine for malignant melanoma.

Gargett T, Abbas MN, Rolan P, Price JD, Gosling KM, Ferrante A, Ruszkiewicz A, Atmosukarto IIC, Altin J, Parish CR, Brown MP.

Cancer Immunol Immunother. 2018 Sep;67(9):1461-1472. doi: 10.1007/s00262-018-2207-z. Epub 2018 Jul 16.


Melanoma protective antitumor immunity activated by catalytic DNA.

Cai H, Cho EA, Li Y, Sockler J, Parish CR, Chong BH, Edwards J, Dodds TJ, Ferguson PM, Wilmott JS, Scolyer RA, Halliday GM, Khachigian LM.

Oncogene. 2018 Sep;37(37):5115-5126. doi: 10.1038/s41388-018-0306-0. Epub 2018 May 29.


Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review.

Sheahan AV, Biankin AV, Parish CR, Khachigian LM.

Oncotarget. 2018 Apr 20;9(30):21613-21627. doi: 10.18632/oncotarget.25085. eCollection 2018 Apr 20. Review.


Promotion of mammalian angiogenesis by neolignans derived from soybean extracellular fluids.

Kordbacheh F, Carruthers TJ, Bezos A, Oakes M, Du Fall L, Hocart CH, Parish CR, Djordjevic MA.

PLoS One. 2018 May 8;13(5):e0196843. doi: 10.1371/journal.pone.0196843. eCollection 2018.


Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans.

Simeonovic CJ, Popp SK, Starrs LM, Brown DJ, Ziolkowski AF, Ludwig B, Bornstein SR, Wilson JD, Pugliese A, Kay TWH, Thomas HE, Loudovaris T, Choong FJ, Freeman C, Parish CR.

PLoS One. 2018 Feb 7;13(2):e0191360. doi: 10.1371/journal.pone.0191360. eCollection 2018.


Whole-exome sequencing in evaluation of patients with venous thromboembolism.

Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI.

Blood Adv. 2017 Jun 29;1(16):1224-1237. doi: 10.1182/bloodadvances.2017005249. eCollection 2017 Jul 11.


Developing Neolignans as Proangiogenic Agents: Stereoselective Total Syntheses and Preliminary Biological Evaluations of the Four Guaiacylglycerol 8-O-4'-Coniferyl Ethers.

Buckler JN, Banwell MG, Kordbacheh F, Parish CR, Santiago FS, Khachigian LM.

ACS Omega. 2017 Oct 31;2(10):7375-7388. doi: 10.1021/acsomega.7b01459. Epub 2017 Oct 30.


Extracellular histones induce erythrocyte fragility and anemia.

Kordbacheh F, O'Meara CH, Coupland LA, Lelliott PM, Parish CR.

Blood. 2017 Dec 28;130(26):2884-2888. doi: 10.1182/blood-2017-06-790519. Epub 2017 Nov 13.


Heparan sulfate as a receptor for poxvirus infections and as a target for antiviral agents.

Khanna M, Ranasinghe C, Jackson R, Parish CR.

J Gen Virol. 2017 Sep 21. doi: 10.1099/jgv.0.000921. [Epub ahead of print]


The influence of platelet membranes on tumour cell behaviour.

Coupland LA, Hindmarsh EJ, Gardiner EE, Parish CR.

Cancer Metastasis Rev. 2017 Jun;36(2):215-224. doi: 10.1007/s10555-017-9671-3. Review.


Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer.

Mishra AK, Parish CR, Wong ML, Licinio J, Blackburn AC.

PLoS One. 2017 May 25;12(5):e0178454. doi: 10.1371/journal.pone.0178454. eCollection 2017.


Antiangiogenic platinum through glycan targeting.

Peterson EJ, Daniel AG, Katner SJ, Bohlmann L, Chang CW, Bezos A, Parish CR, von Itzstein M, Berners-Price SJ, Farrell NP.

Chem Sci. 2017 Jan 1;8(1):241-252. doi: 10.1039/c6sc02515c. Epub 2016 Aug 12.


Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors.

Kirk NS, Bezos A, Willis AC, Sudta P, Suksamrarn S, Parish CR, Ranson M, Kelso MJ.

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1813-6. doi: 10.1016/j.bmcl.2016.02.033. Epub 2016 Feb 15.


Editorial: Carbohydrates: The Yet to be Tasted Sweet Spot of Immunity.

Coombe DR, Parish CR.

Front Immunol. 2015 Jun 17;6:314. doi: 10.3389/fimmu.2015.00314. eCollection 2015. No abstract available.


Islet heparan sulfate but not heparan sulfate proteoglycan core protein is lost during islet isolation and undergoes recovery post-islet transplantation.

Choong FJ, Freeman C, Parish CR, Simeonovic CJ.

Am J Transplant. 2015 Nov;15(11):2851-64. doi: 10.1111/ajt.13366. Epub 2015 Jun 23.


Activation of tumour cell ECM degradation by thrombin-activated platelet membranes: potentially a P-selectin and GPIIb/IIIa-dependent process.

Pang JH, Coupland LA, Freeman C, Chong BH, Parish CR.

Clin Exp Metastasis. 2015 Jun;32(5):495-505. doi: 10.1007/s10585-015-9722-5. Epub 2015 May 16.


Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice.

Fraser ST, Midwinter RG, Coupland LA, Kong S, Berger BS, Yeo JH, Andrade OC, Cromer D, Suarna C, Lam M, Maghzal GJ, Chong BH, Parish CR, Stocker R.

Haematologica. 2015 May;100(5):601-10. doi: 10.3324/haematol.2014.116368. Epub 2015 Feb 14.


Lipo-chitin oligosaccharides, plant symbiosis signalling molecules that modulate mammalian angiogenesis in vitro.

Djordjevic MA, Bezos A, Susanti, Marmuse L, Driguez H, Samain E, Vauzeilles B, Beau JM, Kordbacheh F, Rolfe BG, Schwörer R, Daines AM, Gresshoff PM, Parish CR.

PLoS One. 2014 Dec 23;9(12):e112635. doi: 10.1371/journal.pone.0112635. eCollection 2014.


The uptake of soluble and nanoparticulate imaging isotope in model liver tumours after intra-venous and intra-arterial administration.

Stephens RW, Knox KJ, Philip LA, Debono KM, Bell JL, King DW, Parish CR, Senden TJ, Tanudji MR, Winter JG, Bickley SA, Tapner MJ, Pang JH, Jones SK.

Biomaterials. 2015 Jan;39:218-24. doi: 10.1016/j.biomaterials.2014.11.001. Epub 2014 Nov 20.


Extracellular matrix components in the pathogenesis of type 1 diabetes.

Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN.

Curr Diab Rep. 2014 Dec;14(12):552. doi: 10.1007/s11892-014-0552-7. Review.


Use of an in vivo FTA assay to assess the magnitude, functional avidity and epitope variant cross-reactivity of T cell responses following HIV-1 recombinant poxvirus vaccination.

Wijesundara DK, Ranasinghe C, Jackson RJ, Lidbury BA, Parish CR, Quah BJ.

PLoS One. 2014 Aug 29;9(8):e105366. doi: 10.1371/journal.pone.0105366. eCollection 2014.


Platelets, selectins, and the control of tumor metastasis.

Coupland LA, Parish CR.

Semin Oncol. 2014 Jun;41(3):422-34. doi: 10.1053/j.seminoncol.2014.04.003. Epub 2014 Apr 24. Review.


The use of fluorescent target arrays for assessment of T cell responses in vivo.

Quah BJ, Wijesundara DK, Ranasinghe C, Parish CR.

J Vis Exp. 2014 Jun 19;(88):e51627. doi: 10.3791/51627.


Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span.

Yabas M, Coupland LA, Cromer D, Winterberg M, Teoh NC, D'Rozario J, Kirk K, Bröer S, Parish CR, Enders A.

J Biol Chem. 2014 Jul 11;289(28):19531-7. doi: 10.1074/jbc.C114.570267. Epub 2014 Jun 4.


Heparanase and autoimmune diabetes.

Simeonovic CJ, Ziolkowski AF, Wu Z, Choong FJ, Freeman C, Parish CR.

Front Immunol. 2013 Dec 26;4:471. doi: 10.3389/fimmu.2013.00471. Review.


Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity.

Simon Davis DA, Parish CR.

Front Immunol. 2013 Dec 18;4:470. doi: 10.3389/fimmu.2013.00470.


New insights into intracellular locations and functions of heme oxygenase-1.

Dunn LL, Midwinter RG, Ni J, Hamid HA, Parish CR, Stocker R.

Antioxid Redox Signal. 2014 Apr 10;20(11):1723-42. doi: 10.1089/ars.2013.5675. Epub 2014 Feb 28. Review.


The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil.

Watson CA, Vine KL, Locke JM, Bezos A, Parish CR, Ranson M.

Anticancer Drugs. 2013 Aug;24(7):704-14. doi: 10.1097/CAD.0b013e3283626fdd.


The accumulation of circulating histones on heparan sulphate in the capillary glycocalyx of the lungs.

Freeman CG, Parish CR, Knox KJ, Blackmore JL, Lobov SA, King DW, Senden TJ, Stephens RW.

Biomaterials. 2013 Jul;34(22):5670-6. doi: 10.1016/j.biomaterials.2013.03.091. Epub 2013 Apr 25.


Beware of NK cells in pre-clinical metastasis models.

Coupland LA, Chong BH, Parish CR.

Clin Exp Metastasis. 2013 Oct;30(7):945-7. doi: 10.1007/s10585-013-9582-9. Epub 2013 Apr 19. No abstract available.


Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation.

Parish CR, Freeman C, Ziolkowski AF, He YQ, Sutcliffe EL, Zafar A, Rao S, Simeonovic CJ.

Matrix Biol. 2013 Jun 24;32(5):228-33. doi: 10.1016/j.matbio.2013.02.007. Epub 2013 Mar 13. Review.


Pancreatic islet basement membrane loss and remodeling after mouse islet isolation and transplantation: impact for allograft rejection.

Irving-Rodgers HF, Choong FJ, Hummitzsch K, Parish CR, Rodgers RJ, Simeonovic CJ.

Cell Transplant. 2014 Jan;23(1):59-72. doi: 10.3727/096368912X659880. Epub 2012 Dec 4.


Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo.

Quah BJ, Wijesundara DK, Ranasinghe C, Parish CR.

J Immunol Methods. 2013 Jan 31;387(1-2):181-90. doi: 10.1016/j.jim.2012.10.013. Epub 2012 Oct 30.


Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.

Hu J, Song X, He YQ, Freeman C, Parish CR, Yuan L, Yu H, Tang S.

Invest Ophthalmol Vis Sci. 2012 Oct 3;53(11):6810-7. doi: 10.1167/iovs.11-9144.


Platelets and P-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells.

Coupland LA, Chong BH, Parish CR.

Cancer Res. 2012 Sep 15;72(18):4662-71. doi: 10.1158/0008-5472.CAN-11-4010. Epub 2012 Jul 26.


Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme.

Chan CW, Kaplan W, Parish CR, Khachigian LM.

PLoS One. 2012;7(7):e39160. doi: 10.1371/journal.pone.0039160. Epub 2012 Jul 17.


Destroying c-jun Messenger: new insights into biological mechanisms of DNAzyme function.

Khachigian LM, Cai H, Moloney FJ, Parish CR, Chong BH, Stocker R, Barnetson RS, Halliday GM.

Oncotarget. 2012 Jun;3(6):594-5.


The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes.

He YQ, Sutcliffe EL, Bunting KL, Li J, Goodall KJ, Poon IK, Hulett MD, Freeman C, Zafar A, McInnes RL, Taya T, Parish CR, Rao S.

Transcription. 2012 May-Jun;3(3):130-45. doi: 10.4161/trns.19998.


Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo.

Quah BJ, Wijesundara DK, Ranasinghe C, Parish CR.

Cytometry A. 2012 Aug;81(8):679-90. doi: 10.1002/cyto.a.22084. Epub 2012 Jun 27.


DNAzyme targeting c-jun suppresses skin cancer growth.

Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GJ, Stocker R, Parish CR, Chong BH, Lieschke GJ, Wong TW, Chesterman CN, Francis DJ, Moloney FJ, Barnetson RS, Halliday GM, Khachigian LM.

Sci Transl Med. 2012 Jun 20;4(139):139ra82. doi: 10.1126/scitranslmed.3003960.


New and improved methods for measuring lymphocyte proliferation in vitro and in vivo using CFSE-like fluorescent dyes.

Quah BJ, Parish CR.

J Immunol Methods. 2012 May 31;379(1-2):1-14. doi: 10.1016/j.jim.2012.02.012. Epub 2012 Feb 21.


Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.

Ishii H, Hulett MD, Li JM, Santiago FS, Parish CR, Khachigian LM.

Int J Oncol. 2012 May;40(5):1575-80. doi: 10.3892/ijo.2012.1362. Epub 2012 Feb 9.


Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.

Ziolkowski AF, Popp SK, Freeman C, Parish CR, Simeonovic CJ.

J Clin Invest. 2012 Jan;122(1):132-41. doi: 10.1172/JCI46177. Epub 2011 Dec 19.


Cat's whiskers tea (Orthosiphon stamineus) extract inhibits growth of colon tumor in nude mice and angiogenesis in endothelial cells via suppressing VEGFR phosphorylation.

Ahamed MB, Aisha AF, Nassar ZD, Siddiqui JM, Ismail Z, Omari SM, Parish CR, Majid AM.

Nutr Cancer. 2012;64(1):89-99. doi: 10.1080/01635581.2012.630160. Epub 2011 Dec 2.


Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase).

Gandhi NS, Freeman C, Parish CR, Mancera RL.

Glycobiology. 2012 Jan;22(1):35-55. doi: 10.1093/glycob/cwr095. Epub 2011 Jul 11.


Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.

Chen J, Liu MY, Parish CR, Chong BH, Khachigian L.

Int J Biochem Cell Biol. 2011 Jun;43(6):905-12. doi: 10.1016/j.biocel.2011.03.004. Epub 2011 Mar 17.


Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.

Sutcliffe EL, Bunting KL, He YQ, Li J, Phetsouphanh C, Seddiki N, Zafar A, Hindmarsh EJ, Parish CR, Kelleher AD, McInnes RL, Taya T, Milburn PJ, Rao S.

Mol Cell. 2011 Mar 18;41(6):704-19. doi: 10.1016/j.molcel.2011.02.030.

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