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Items: 1 to 50 of 52

1.

Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling.

Stappenbeck F, Wang F, Tang LY, Zhang YE, Parhami F.

Cells. 2019 Oct 22;8(10). pii: E1297. doi: 10.3390/cells8101297.

2.
3.

Effect of Oxy133, an osteogenic oxysterol, on new bone formation in rat two-level posterolateral fusion model.

Buser Z, Drapeau S, Stappenbeck F, Pereira RC, Parhami F, Wang JC.

Eur Spine J. 2017 Nov;26(11):2763-2772. doi: 10.1007/s00586-017-5149-9. Epub 2017 May 25.

PMID:
28547574
4.

Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol.

Wang F, Stappenbeck F, Matsui W, Parhami F.

J Cell Biochem. 2017 Mar;118(3):499-509. doi: 10.1002/jcb.25668. Epub 2016 Sep 21.

5.

Oxy133, a novel osteogenic agent, promotes bone regeneration in an intramembranous bone-healing model.

Li A, Hokugo A, Segovia LA, Yalom A, Rezzadeh K, Zhou S, Zhang Z, Parhami F, Stappenbeck F, Jarrahy R.

J Tissue Eng Regen Med. 2017 May;11(5):1490-1499. doi: 10.1002/term.2047. Epub 2015 Jun 15.

PMID:
26073881
6.

Comparison of a novel oxysterol molecule and rhBMP2 fusion rates in a rabbit posterolateral lumbar spine model.

Scott TP, Phan KH, Tian H, Suzuki A, Montgomery SR, Johnson JS, Atti E, Tetratis S, Pereira RC, Wang JC, Daubs MD, Stappenbeck F, Parhami F.

Spine J. 2015 Apr 1;15(4):733-42. doi: 10.1016/j.spinee.2014.11.014. Epub 2014 Nov 28.

7.

Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma.

Agarwal JR, Wang Q, Tanno T, Rasheed Z, Merchant A, Ghosh N, Borrello I, Huff CA, Parhami F, Matsui W.

Mol Cancer Ther. 2014 Jul;13(7):1873-81. doi: 10.1158/1535-7163.MCT-13-0997. Epub 2014 May 7.

8.

A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding.

Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F.

J Bone Miner Res. 2014 Aug;29(8):1872-85. doi: 10.1002/jbmr.2213.

9.

A novel oxysterol promotes bone regeneration in rabbit cranial bone defects.

Hokugo A, Sorice S, Parhami F, Yalom A, Li A, Zuk P, Jarrahy R.

J Tissue Eng Regen Med. 2016 Jul;10(7):591-9. doi: 10.1002/term.1799. Epub 2013 Aug 29.

PMID:
23997014
10.

Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo.

Johnson JS, Meliton V, Kim WK, Lee KB, Wang JC, Nguyen K, Yoo D, Jung ME, Atti E, Tetradis S, Pereira RC, Magyar C, Nargizyan T, Hahn TJ, Farouz F, Thies S, Parhami F.

J Cell Biochem. 2011 Jun;112(6):1673-84. doi: 10.1002/jcb.23082.

11.

Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress.

Kim WK, Meliton V, Bourquard N, Hahn TJ, Parhami F.

J Cell Biochem. 2010 Dec 1;111(5):1199-209. doi: 10.1002/jcb.22846.

PMID:
20717924
12.

Bone density and hyperlipidemia: the T-lymphocyte connection.

Graham LS, Tintut Y, Parhami F, Kitchen CM, Ivanov Y, Tetradis S, Effros RB.

J Bone Miner Res. 2010 Nov;25(11):2460-9. doi: 10.1002/jbmr.148.

13.

Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

Kim WK, Meliton V, Tetradis S, Weinmaster G, Hahn TJ, Carlson M, Nelson SF, Parhami F.

J Bone Miner Res. 2010 Apr;25(4):782-95. doi: 10.1359/jbmr.091024.

14.

Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.

Graham LS, Parhami F, Tintut Y, Kitchen CM, Demer LL, Effros RB.

Clin Immunol. 2009 Nov;133(2):265-75. doi: 10.1016/j.clim.2009.07.011. Epub 2009 Aug 22.

15.

Negative regulation of Hedgehog signaling by liver X receptors.

Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F.

Mol Endocrinol. 2009 Oct;23(10):1532-43. doi: 10.1210/me.2008-0453. Epub 2009 Jul 16.

16.

The small molecule phenamil induces osteoblast differentiation and mineralization.

Park KW, Waki H, Kim WK, Davies BS, Young SG, Parhami F, Tontonoz P.

Mol Cell Biol. 2009 Jul;29(14):3905-14. doi: 10.1128/MCB.00002-09. Epub 2009 May 11.

17.

Nuclear receptor profile in calvarial bone cells undergoing osteogenic versus adipogenic differentiation.

Pirih FQ, Abayahoudian R, Elashoff D, Parhami F, Nervina JM, Tetradis S.

J Cell Biochem. 2008 Dec 1;105(5):1316-26. doi: 10.1002/jcb.21931.

18.

Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling.

Amantea CM, Kim WK, Meliton V, Tetradis S, Parhami F.

J Cell Biochem. 2008 Oct 1;105(2):424-36. doi: 10.1002/jcb.21840.

19.
20.

Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo.

Aghaloo TL, Amantea CM, Cowan CM, Richardson JA, Wu BM, Parhami F, Tetradis S.

J Orthop Res. 2007 Nov;25(11):1488-97.

21.

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells.

Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F.

J Biol Chem. 2007 Mar 23;282(12):8959-68. Epub 2007 Jan 2.

22.

Oxysterol-induced osteoblastic differentiation of pluripotent mesenchymal cells is mediated through a PKC- and PKA-dependent pathway.

Richardson JA, Amantea CM, Kianmahd B, Tetradis S, Lieberman JR, Hahn TJ, Parhami F.

J Cell Biochem. 2007 Apr 1;100(5):1131-45.

PMID:
17031848
23.

Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells.

Shouhed D, Kha HT, Richardson JA, Amantea CM, Hahn TJ, Parhami F.

J Cell Biochem. 2005 Aug 15;95(6):1276-83.

PMID:
15880703
24.

Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat.

Kha HT, Basseri B, Shouhed D, Richardson J, Tetradis S, Hahn TJ, Parhami F.

J Bone Miner Res. 2004 May;19(5):830-40. Epub 2004 Jan 12.

25.

Possible role of oxidized lipids in osteoporosis: could hyperlipidemia be a risk factor?

Parhami F.

Prostaglandins Leukot Essent Fatty Acids. 2003 Jun;68(6):373-8. Review.

PMID:
12798657
26.

Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells.

Parhami F, Mody N, Gharavi N, Ballard AJ, Tintut Y, Demer LL.

J Bone Miner Res. 2002 Nov;17(11):1997-2003.

27.

High-density lipoprotein regulates calcification of vascular cells.

Parhami F, Basseri B, Hwang J, Tintut Y, Demer LL.

Circ Res. 2002 Oct 4;91(7):570-6.

PMID:
12364384
28.

Novel mechanisms in accelerated vascular calcification in renal disease patients.

Demer LL, Tintut Y, Parhami F.

Curr Opin Nephrol Hypertens. 2002 Jul;11(4):437-43. Review. Erratum in: Curr Opin Nephrol Hypertens. 2003 Mar;12(2):221..

PMID:
12105395
29.

8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway.

Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL.

J Biol Chem. 2002 Apr 19;277(16):14221-6. Epub 2002 Feb 4.

30.

Monocyte/macrophage regulation of vascular calcification in vitro.

Tintut Y, Patel J, Territo M, Saini T, Parhami F, Demer LL.

Circulation. 2002 Feb 5;105(5):650-5.

PMID:
11827934
31.

Oxidative stress modulates osteoblastic differentiation of vascular and bone cells.

Mody N, Parhami F, Sarafian TA, Demer LL.

Free Radic Biol Med. 2001 Aug 15;31(4):509-19.

PMID:
11498284
32.

Regulation of vascular calcification in atherosclerosis.

Parhami F, Tintut Y, Patel JK, Mody N, Hemmat A, Demer LL.

Z Kardiol. 2001;90 Suppl 3:27-30.

PMID:
11374029
33.

Leptin enhances the calcification of vascular cells: artery wall as a target of leptin.

Parhami F, Tintut Y, Ballard A, Fogelman AM, Demer LL.

Circ Res. 2001 May 11;88(9):954-60.

PMID:
11349006
34.

Atherogenic high-fat diet reduces bone mineralization in mice.

Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL.

J Bone Miner Res. 2001 Jan;16(1):182-8.

35.

Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway.

Tintut Y, Patel J, Parhami F, Demer LL.

Circulation. 2000 Nov 21;102(21):2636-42.

PMID:
11085968
36.

Role of lipids in osteoporosis.

Parhami F, Garfinkel A, Demer LL.

Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2346-8. Review.

PMID:
11073836
37.

Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells.

Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M, Demer LL.

J Bone Miner Res. 1999 Dec;14(12):2067-78.

38.
39.

Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.

Jackson SM, Parhami F, Xi XP, Berliner JA, Hsueh WA, Law RE, Demer LL.

Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2094-104.

PMID:
10479650
40.

Fibronectin and collagen I matrixes promote calcification of vascular cells in vitro, whereas collagen IV matrix is inhibitory.

Watson KE, Parhami F, Shin V, Demer LL.

Arterioscler Thromb Vasc Biol. 1998 Dec;18(12):1964-71.

PMID:
9848891
41.

cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification.

Tintut Y, Parhami F, Boström K, Jackson SM, Demer LL.

J Biol Chem. 1998 Mar 27;273(13):7547-53.

42.

Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids?

Parhami F, Demer LL.

Curr Opin Lipidol. 1997 Oct;8(5):312-4. Review.

PMID:
9335955
43.

Induction of P-selectin by oxidized lipoproteins. Separate effects on synthesis and surface expression.

Vora DK, Fang ZT, Liva SM, Tyner TR, Parhami F, Watson AD, Drake TA, Territo MC, Berliner JA.

Circ Res. 1997 Jun;80(6):810-8.

PMID:
9168783
44.

Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients.

Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA, Demer LL.

Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):680-7.

PMID:
9108780
45.

Role of molecular regulation in vascular calcification.

Parhami F, Boström K, Watson K, Demer LL.

J Atheroscler Thromb. 1996;3(2):90-4. Review.

PMID:
9226460
46.

Stimulation of Gs and inhibition of Gi protein functions by minimally oxidized LDL.

Parhami F, Fang ZT, Yang B, Fogelman AM, Berliner JA.

Arterioscler Thromb Vasc Biol. 1995 Nov;15(11):2019-24.

PMID:
7583584
47.

Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL.

Kim JA, Territo MC, Wayner E, Carlos TM, Parhami F, Smith CW, Haberland ME, Fogelman AM, Berliner JA.

Arterioscler Thromb. 1994 Mar;14(3):427-33.

PMID:
8123647
48.

Regulation of endothelial cell tissue factor expression by minimally oxidized LDL and lipopolysaccharide.

Fei H, Berliner JA, Parhami F, Drake TA.

Arterioscler Thromb. 1993 Nov;13(11):1711-7.

PMID:
8218112
49.

Regulation of monocyte and neutrophil entry into the vessel wall.

Berliner JA, Parhami F, Fang ZT, Fogelman AM, Territo C.

Behring Inst Mitt. 1993 Aug;(92):87-91. Review. No abstract available.

PMID:
8250819
50.

Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.

Parhami F, Fang ZT, Fogelman AM, Andalibi A, Territo MC, Berliner JA.

J Clin Invest. 1993 Jul;92(1):471-8.

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