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Emerging roles for the nucleus during neutrophil signal relay and NETosis.

Saunders CA, Parent CA.

Curr Opin Cell Biol. 2019 Dec 10;62:135-143. doi: 10.1016/ [Epub ahead of print] Review.


Non-canonical processes that shape the cell migration landscape.

Majumdar R, Steen K, Coulombe PA, Parent CA.

Curr Opin Cell Biol. 2019 Apr;57:123-134. doi: 10.1016/ Epub 2019 Mar 7. Review.


Actin Cytoskeleton and Focal Adhesions Regulate the Biased Migration of Breast Cancer Cells on Nanoscale Asymmetric Sawteeth.

Chen S, Hourwitz MJ, Campanello L, Fourkas JT, Losert W, Parent CA.

ACS Nano. 2019 Feb 26;13(2):1454-1468. doi: 10.1021/acsnano.8b07140. Epub 2019 Feb 6.


Genetic manipulation of PLB-985 cells and quantification of chemotaxis using the underagarose assay.

Saunders CA, Majumdar R, Molina Y, Subramanian BC, Parent CA.

Methods Cell Biol. 2019;149:31-56. doi: 10.1016/bs.mcb.2018.09.002. Epub 2018 Oct 29.


Getting TANned: How the tumor microenvironment drives neutrophil recruitment.

SenGupta S, Subramanian BC, Parent CA.

J Leukoc Biol. 2019 Mar;105(3):449-462. doi: 10.1002/JLB.3RI0718-282R. Epub 2018 Dec 14. Review.


Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

Wang F, Chen S, Liu HB, Parent CA, Coulombe PA.

J Cell Biol. 2018 Dec 3;217(12):4314-4330. doi: 10.1083/jcb.201712130. Epub 2018 Nov 2.


The LTB4-BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis.

Subramanian BC, Moissoglu K, Parent CA.

J Cell Sci. 2018 Sep 21;131(18). pii: jcs217422. doi: 10.1242/jcs.217422.


Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals.

Kriebel PW, Majumdar R, Jenkins LM, Senoo H, Wang W, Ammu S, Chen S, Narayan K, Iijima M, Parent CA.

J Cell Biol. 2018 Aug 6;217(8):2891-2910. doi: 10.1083/jcb.201710170. Epub 2018 Jun 8.


Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium.

Wang W, Chen S, Das S, Losert W, Parent CA.

J Cell Sci. 2018 May 4;131(9). pii: jcs216176. doi: 10.1242/jcs.216176.


Cell motility in cancer invasion and metastasis: insights from simple model organisms.

Stuelten CH, Parent CA, Montell DJ.

Nat Rev Cancer. 2018 May;18(5):296-312. doi: 10.1038/nrc.2018.15. Epub 2018 Mar 16. Review.


Lysophosphatidic acid regulates the motility of MCF10CA1a breast cancer cell sheets via two opposing signaling pathways.

Stuelten CH, Lee RM, Losert W, Parent CA.

Cell Signal. 2018 May;45:1-11. doi: 10.1016/j.cellsig.2018.01.005. Epub 2018 Jan 11.


The role of the LTB4-BLT1 axis in chemotactic gradient sensing and directed leukocyte migration.

Subramanian BC, Majumdar R, Parent CA.

Semin Immunol. 2017 Oct;33:16-29. doi: 10.1016/j.smim.2017.07.002. Review.


Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay.

Szatmary AC, Nossal R, Parent CA, Majumdar R.

Mol Biol Cell. 2017 Nov 7;28(23):3457-3470. doi: 10.1091/mbc.E17-05-0298. Epub 2017 Sep 27.


Adenylyl cyclase mRNA localizes to the posterior of polarized DICTYOSTELIUM cells during chemotaxis.

Das S, Parker JM, Guven C, Wang W, Kriebel PW, Losert W, Larson DR, Parent CA.

BMC Cell Biol. 2017 May 25;18(1):23. doi: 10.1186/s12860-017-0139-7.


Bacterial Siderophores Hijack Neutrophil Functions.

Saha P, Yeoh BS, Olvera RA, Xiao X, Singh V, Awasthi D, Subramanian BC, Chen Q, Dikshit M, Wang Y, Parent CA, Vijay-Kumar M.

J Immunol. 2017 Jun 1;198(11):4293-4303. doi: 10.4049/jimmunol.1700261. Epub 2017 Apr 21.


Collective cell migration over long time scales reveals distinct phenotypes.

Lee RM, Stuelten CH, Parent CA, Losert W.

Converg Sci Phys Oncol. 2016 Jun;2(2). pii: 025001. doi: 10.1088/2057-1739/2/2/025001. Epub 2016 May 19.


A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration.

Liao XH, Meena NP, Southall N, Liu L, Swaroop M, Zhang AL, Xiang JJ, Parent CA, Zheng W, Kimmel AR.

Sci Rep. 2016 Mar 9;6:22273. doi: 10.1038/srep22273.


Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis.

Majumdar R, Tavakoli Tameh A, Parent CA.

PLoS Biol. 2016 Jan 7;14(1):e1002336. doi: 10.1371/journal.pbio.1002336. eCollection 2016 Jan.


Asymmetric nanotopography biases cytoskeletal dynamics and promotes unidirectional cell guidance.

Sun X, Driscoll MK, Guven C, Das S, Parent CA, Fourkas JT, Losert W.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12557-62. doi: 10.1073/pnas.1502970112. Epub 2015 Sep 28.


Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1.

Lammers KM, Chieppa M, Liu L, Liu S, Omatsu T, Janka-Junttila M, Casolaro V, Reinecker HC, Parent CA, Fasano A.

PLoS One. 2015 Sep 17;10(9):e0138338. doi: 10.1371/journal.pone.0138338. eCollection 2015.


The interplay of cell-cell and cell-substrate adhesion in collective cell migration.

Wang C, Chowdhury S, Driscoll M, Parent CA, Gupta SK, Losert W.

J R Soc Interface. 2014 Nov 6;11(100):20140684. doi: 10.1098/rsif.2014.0684.


New paradigms in the establishment and maintenance of gradients during directed cell migration.

Majumdar R, Sixt M, Parent CA.

Curr Opin Cell Biol. 2014 Oct;30:33-40. doi: 10.1016/ Epub 2014 Jun 22. Review.


PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils.

Liu L, Gritz D, Parent CA.

Mol Biol Cell. 2014 May;25(9):1446-57. doi: 10.1091/mbc.E14-01-0037. Epub 2014 Mar 5.


Dictyostelium cells migrate similarly on surfaces of varying chemical composition.

McCann CP, Rericha EC, Wang C, Losert W, Parent CA.

PLoS One. 2014 Feb 6;9(2):e87981. doi: 10.1371/journal.pone.0087981. eCollection 2014.


Cell migration: sinking in a gradient.

Moissoglu K, Majumdar R, Parent CA.

Curr Biol. 2014 Jan 6;24(1):R23-R25. doi: 10.1016/j.cub.2013.10.075.


[Leukotriene B(4): a lipid at the heart of inflammation].

Afonso PV, Parent CA.

Med Sci (Paris). 2013 Dec;29(12):1083-5. doi: 10.1051/medsci/20132912007. Epub 2013 Dec 20. French. No abstract available.


The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration.

Parent CA, Weiner OD.

Curr Opin Cell Biol. 2013 Oct;25(5):523-5. doi: 10.1016/ Epub 2013 Aug 5. No abstract available.


Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay.

Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, Kimmel AR.

J Cell Sci. 2013 Oct 15;126(Pt 20):4614-26. doi: 10.1242/jcs.122952. Epub 2013 Jul 31.


Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.

Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller W, Parent CA, Germain RN.

Nature. 2013 Jun 20;498(7454):371-5. doi: 10.1038/nature12175. Epub 2013 May 26.


Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.

Weiger MC, Vedham V, Stuelten CH, Shou K, Herrera M, Sato M, Losert W, Parent CA.

PLoS One. 2013;8(3):e58859. doi: 10.1371/journal.pone.0058859. Epub 2013 Mar 19.


Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices.

Afonso PV, McCann CP, Kapnick SM, Parent CA.

Blood. 2013 Feb 28;121(9):1644-50. doi: 10.1182/blood-2012-08-451575. Epub 2012 Dec 11.


Radil controls neutrophil adhesion and motility through β2-integrin activation.

Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA.

Mol Biol Cell. 2012 Dec;23(24):4751-65. doi: 10.1091/mbc.E12-05-0408. Epub 2012 Oct 24.


LTB4 is a signal-relay molecule during neutrophil chemotaxis.

Afonso PV, Janka-Junttila M, Lee YJ, McCann CP, Oliver CM, Aamer KA, Losert W, Cicerone MT, Parent CA.

Dev Cell. 2012 May 15;22(5):1079-91. doi: 10.1016/j.devcel.2012.02.003. Epub 2012 Apr 26.


Phosphoinositides in chemotaxis.

Weiger MC, Parent CA.

Subcell Biochem. 2012;59:217-54. doi: 10.1007/978-94-007-3015-1_7. Review.


Neutrophils under tension.

Afonso PV, Parent CA.

Dev Cell. 2012 Feb 14;22(2):236-8. doi: 10.1016/j.devcel.2012.01.017.


A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.

Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, Veenstra TD, Parent CA, Jin T.

Dev Cell. 2012 Jan 17;22(1):92-103. doi: 10.1016/j.devcel.2011.11.007.


Review series: TOR kinase complexes and cell migration.

Liu L, Parent CA.

J Cell Biol. 2011 Sep 19;194(6):815-24. doi: 10.1083/jcb.201102090. Review.


Direct biochemical measurements of signal relay during Dictyostelium development.

Das S, Rericha EC, Bagorda A, Parent CA.

J Biol Chem. 2011 Nov 4;286(44):38649-58. doi: 10.1074/jbc.M111.284182. Epub 2011 Sep 12.


Glia maturation factor-γ mediates neutrophil chemotaxis.

Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.

J Leukoc Biol. 2011 Sep;90(3):529-38. doi: 10.1189/jlb.0710424. Epub 2011 Jun 7.


PI3K and chemotaxis: a priming issue?

Afonso PV, Parent CA.

Sci Signal. 2011 Apr 26;4(170):pe22. doi: 10.1126/scisignal.2002019. Review.


Cells on the move in Philadelphia.

Sixt M, Parent CA.

Mol Biol Cell. 2011 Mar 15;22(6):724. doi: 10.1091/mbc.E10-12-0958. No abstract available.


mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion.

Liu L, Das S, Losert W, Parent CA.

Dev Cell. 2010 Dec 14;19(6):845-57. doi: 10.1016/j.devcel.2010.11.004.


Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.

Zhang S, Readinger JA, DuBois W, Janka-Junttila M, Robinson R, Pruitt M, Bliskovsky V, Wu JZ, Sakakibara K, Patel J, Parent CA, Tessarollo L, Schwartzberg PL, Mock BA.

Blood. 2011 Jan 27;117(4):1228-38. doi: 10.1182/blood-2010-05-287821. Epub 2010 Nov 15.


Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis.

Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN.

J Cell Biol. 2010 Jul 26;190(2):233-45. doi: 10.1083/jcb.201001129.


Expression of Y53A-actin in Dictyostelium disrupts the cytoskeleton and inhibits intracellular and intercellular chemotactic signaling.

Shu S, Liu X, Kriebel PW, Hong MS, Daniels MP, Parent CA, Korn ED.

J Biol Chem. 2010 Sep 3;285(36):27713-25. doi: 10.1074/jbc.M110.116277. Epub 2010 Jul 7.


Cell speed, persistence and information transmission during signal relay and collective migration.

McCann CP, Kriebel PW, Parent CA, Losert W.

J Cell Sci. 2010 May 15;123(Pt 10):1724-31. doi: 10.1242/jcs.060137. Epub 2010 Apr 27.


ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis.

Chen PW, Randazzo PA, Parent CA.

PLoS One. 2010 Jan 7;5(1):e8624. doi: 10.1371/journal.pone.0008624.


Real-time measurements of cAMP production in live Dictyostelium cells.

Bagorda A, Das S, Rericha EC, Chen D, Davidson J, Parent CA.

J Cell Sci. 2009 Nov 1;122(Pt 21):3907-14. doi: 10.1242/jcs.051987. Epub 2009 Oct 6.


Group migration and signal relay in Dictyostelium.

Kriebel PW, Parent CA.

Methods Mol Biol. 2009;571:111-24. doi: 10.1007/978-1-60761-198-1_7.


The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation.

Garcia GL, Rericha EC, Heger CD, Goldsmith PK, Parent CA.

Mol Biol Cell. 2009 Jul;20(14):3295-304. doi: 10.1091/mbc.E09-03-0223. Epub 2009 May 28.

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