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Items: 46


Real-time transfer of lentiviral particles by producer cells using an engineered coculture system.

Timmins LM, Patel RS, Teryek MS, Parekkadan B.

Cytotechnology. 2019 Oct;71(5):1019-1031. doi: 10.1007/s10616-019-00343-0. Epub 2019 Sep 12.


Kinetics of MSC-based enzyme therapy for immunoregulation.

Burr A, Parekkadan B.

J Transl Med. 2019 Aug 13;17(1):263. doi: 10.1186/s12967-019-2000-6.


Quantitative assessment of LASSO probe assembly and long-read multiplexed cloning.

Shukor S, Tamayo A, Tosi L, Larman HB, Parekkadan B.

BMC Biotechnol. 2019 Jul 24;19(1):50. doi: 10.1186/s12896-019-0547-1.


Effects of intermittent T-cell cluster disaggregation on proliferative capacity and checkpoint marker expression.

Li M, Chin LY, Shukor S, Tamayo AG, Maus MV, Parekkadan B.

Autoimmunity. 2019 May;52(3):102-107. doi: 10.1080/08916934.2019.1630064. Epub 2019 Jun 25.


Computational Simulation of Adapter Length-Dependent LASSO Probe Capture Efficiency.

Liu J, Shukor S, Li S, Tamayo A, Tosi L, Larman B, Nanda V, Olson WK, Parekkadan B.

Biomolecules. 2019 May 22;9(5). pii: E199. doi: 10.3390/biom9050199.


Convergence of Cell Pharmacology and Drug Delivery.

Aijaz A, Vaninov N, Allen A, Barcia RN, Parekkadan B.

Stem Cells Transl Med. 2019 Sep;8(9):874-879. doi: 10.1002/sctm.19-0019. Epub 2019 May 15.


Biomanufacturing for clinically advanced cell therapies.

Aijaz A, Li M, Smith D, Khong D, LeBlon C, Fenton OS, Olabisi RM, Libutti S, Tischfield J, Maus MV, Deans R, Barcia RN, Anderson DG, Ritz J, Preti R, Parekkadan B.

Nat Biomed Eng. 2018 Jun;2(6):362-376. doi: 10.1038/s41551-018-0246-6. Epub 2018 Jun 11. Review.


Closed loop bioreactor system for the ex vivo expansion of human T cells.

Li M, Chin LY, Shukor S, Tamayo A, Maus MV, Parekkadan B.

Cytotherapy. 2019 Jan;21(1):76-82. doi: 10.1016/j.jcyt.2018.10.009. Epub 2018 Nov 27.


Image-Based Profiling of Patient-Derived Pancreatic Tumor-Stromal Cell Interactions Within a Micropatterned Tumor Model.

Mukundan S, Sharma K, Honselmann K, Singleton A, Liss A, Parekkadan B.

Technol Cancer Res Treat. 2018 Jan 1;17:1533033818803632. doi: 10.1177/1533033818803632.


Extracorporeal Stromal Cell Therapy for Subjects With Dialysis-Dependent Acute Kidney Injury.

Miller BLK, Garg P, Bronstein B, LaPointe E, Lin H, Charytan DM, Tilles AW, Parekkadan B.

Kidney Int Rep. 2018 Jun 2;3(5):1119-1127. doi: 10.1016/j.ekir.2018.05.009. eCollection 2018 Sep.


Artificial T Cell Mimetics to Combat Melanoma Tumor Growth.

Mukundan S, Guan D, Singleton A, Yang Y, Li M, Parekkadan B.

Am J Adv Drug Deliv. 2018;6(1):21-32.


The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation.

Knoblich K, Cruz Migoni S, Siew SM, Jinks E, Kaul B, Jeffery HC, Baker AT, Suliman M, Vrzalikova K, Mehenna H, Murray PG, Barone F, Oo YH, Newsome PN, Hirschfield G, Kelly D, Lee SP, Parekkadan B, Turley SJ, Fletcher AL.

PLoS Biol. 2018 Sep 4;16(9):e2005046. doi: 10.1371/journal.pbio.2005046. eCollection 2018 Sep.


Therapeutic Delivery Specifications Identified Through Compartmental Analysis of a Mesenchymal Stromal Cell-Immune Reaction.

Li M, Khong D, Chin LY, Singleton A, Parekkadan B.

Sci Rep. 2018 May 1;8(1):6816. doi: 10.1038/s41598-018-24971-2.


Stromalized microreactor supports murine hematopoietic progenitor enrichment.

Khong D, Li M, Singleton A, Chin LY, Parekkadan B.

Biomed Microdevices. 2018 Jan 20;20(1):13. doi: 10.1007/s10544-017-0255-3.


Long-adapter single-strand oligonucleotide probes for the massively multiplexed cloning of kilobase genome regions.

Tosi L, Sridhara V, Yang Y, Guan D, Shpilker P, Segata N, Larman HB, Parekkadan B.

Nat Biomed Eng. 2017;1. pii: 0092. doi: 10.1038/s41551-017-0092. Epub 2017 Jun 26.


Orthogonal potency analysis of mesenchymal stromal cell function during ex vivo expansion.

Khong D, Li M, Singleton A, Chin LY, Mukundan S, Parekkadan B.

Exp Cell Res. 2018 Jan 1;362(1):102-110. doi: 10.1016/j.yexcr.2017.11.007. Epub 2017 Nov 11.


An engineered biomarker system to monitor and modulate immune clearance of cell therapies.

Singleton A, Khong D, Chin LY, Mukundan S, Li M, Parekkadan B.

Cytotherapy. 2017 Dec;19(12):1537-1545. doi: 10.1016/j.jcyt.2017.08.003. Epub 2017 Sep 13.


Multiple genetically engineered humanized microenvironments in a single mouse.

Lee J, Heckl D, Parekkadan B.

Biomater Res. 2016 Jun 28;20:19. doi: 10.1186/s40824-016-0066-2. eCollection 2016.


Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis.

Shen K, Luk S, Elman J, Murray R, Mukundan S, Parekkadan B.

Sci Rep. 2016 Feb 19;6:21239. doi: 10.1038/srep21239.


Scaffold-integrated microchips for end-to-end in vitro tumor cell attachment and xenograft formation.

Lee J, Kohl N, Shanbhang S, Parekkadan B.

Technology (Singap World Sci). 2015 Dec;3(4):179-188. Epub 2015 Jun 23.


Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.

Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B.

Nat Commun. 2014 Dec 9;5:5662. doi: 10.1038/ncomms6662.


Bioengineered implantable scaffolds as a tool to study stromal-derived factors in metastatic cancer models.

Bersani F, Lee J, Yu M, Morris R, Desai R, Ramaswamy S, Toner M, Haber DA, Parekkadan B.

Cancer Res. 2014 Dec 15;74(24):7229-38. doi: 10.1158/0008-5472.CAN-14-1809. Epub 2014 Oct 22.


Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis.

Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B.

Sci Transl Med. 2014 Aug 13;6(249):249ra109. doi: 10.1126/scitranslmed.3009377.


Microcavity substrates casted from self-assembled microsphere monolayers for spheroid cell culture.

Shen K, Lee J, Yarmush ML, Parekkadan B.

Biomed Microdevices. 2014 Aug;16(4):609-15. doi: 10.1007/s10544-014-9863-3.


Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.

Elman JS, Murray RC, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B.

PLoS One. 2014 Feb 21;9(2):e89882. doi: 10.1371/journal.pone.0089882. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99813. Murray, Ryan M [corrected to Murray, Ryan C].


Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.

Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Yarmush J, Jiao Y, Fletcher A, Lee J, Cima MJ, Yarmush ML, Parekkadan B.

Mol Ther. 2014 May;22(5):999-1007. doi: 10.1038/mt.2014.17. Epub 2014 Feb 5.


A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation.

Elman JS, Li M, Wang F, Gimble JM, Parekkadan B.

J Inflamm (Lond). 2014 Jan 7;11(1):1. doi: 10.1186/1476-9255-11-1.


Capture and printing of fixed stromal cell membranes for bioactive display on PDMS surfaces.

Lee J, Wang JB, Bersani F, Parekkadan B.

Langmuir. 2013 Aug 27;29(34):10611-6. doi: 10.1021/la4012795. Epub 2013 Aug 12.


Secreted factors from bone marrow stromal cells upregulate IL-10 and reverse acute kidney injury.

Milwid JM, Ichimura T, Li M, Jiao Y, Lee J, Yarmush JS, Parekkadan B, Tilles AW, Bonventre JV, Yarmush ML.

Stem Cells Int. 2012;2012:392050. doi: 10.1155/2012/392050. Epub 2012 Dec 19.


Implantable microenvironments to attract hematopoietic stem/cancer cells.

Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19638-43. doi: 10.1073/pnas.1208384109. Epub 2012 Nov 12.


Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure.

Patel SJ, Milwid JM, King KR, Bohr S, Iracheta-Vellve A, Li M, Vitalo A, Parekkadan B, Jindal R, Yarmush ML.

Nat Biotechnol. 2012 Jan 15;30(2):179-83. doi: 10.1038/nbt.2089. Erratum in: Nat Biotechnol. 2014 Mar;32(3):291. Iracheta-Velle, Arvin [corrected to Iracheta-Vellve, Arvin].


Aire controls mesenchymal stem cell-mediated suppression in chronic colitis.

Parekkadan B, Fletcher AL, Li M, Tjota MY, Bellemare-Pelletier A, Milwid JM, Lee JW, Yarmush ML, Turley SJ.

Mol Ther. 2012 Jan;20(1):178-86. doi: 10.1038/mt.2011.192. Epub 2011 Sep 27.


Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors.

Li M, Tilles AW, Milwid JM, Hammad M, Lee J, Yarmush ML, Parekkadan B.

J Tissue Eng Regen Med. 2012 May;6(5):369-77. doi: 10.1002/term.439. Epub 2011 Jun 28.


Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes.

Parekkadan B, Upadhyay R, Dunham J, Iwamoto Y, Mizoguchi E, Mizoguchi A, Weissleder R, Yarmush ML.

Gastroenterology. 2011 Mar;140(3):966-75. doi: 10.1053/j.gastro.2010.10.013. Epub 2010 Oct 16.


A mesenchymal stem cell potency assay.

Jiao J, Milwid JM, Yarmush ML, Parekkadan B.

Methods Mol Biol. 2011;677:221-31. doi: 10.1007/978-1-60761-869-0_16.


Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.

Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML.

Mol Ther. 2010 Oct;18(10):1857-64. doi: 10.1038/mt.2010.155. Epub 2010 Jul 27.


Mesenchymal stem cells: Mechanisms of immunomodulation and homing.

Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML.

Cell Transplant. 2010;19(6):667-79. doi: 10.3727/096368910X508762. Epub 2010 Jun 3. Review.


Mesenchymal stem cells as therapeutics.

Parekkadan B, Milwid JM.

Annu Rev Biomed Eng. 2010 Aug 15;12:87-117. doi: 10.1146/annurev-bioeng-070909-105309. Review.


Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure.

Yagi H, Parekkadan B, Suganuma K, Soto-Gutierrez A, Tompkins RG, Tilles AW, Yarmush ML.

Tissue Eng Part A. 2009 Nov;15(11):3377-88. doi: 10.1089/ten.TEA.2008.0681.


Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells.

Parekkadan B, Berdichevsky Y, Irimia D, Leeder A, Yarmush G, Toner M, Levine JB, Yarmush ML.

Neurosci Lett. 2008 Jun 20;438(2):190-5. doi: 10.1016/j.neulet.2008.03.094. Epub 2008 Apr 11.


Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells.

Parekkadan B, Tilles AW, Yarmush ML.

Stem Cells. 2008 Jul;26(7):1913-9. doi: 10.1634/stemcells.2007-0790. Epub 2008 Apr 17.


Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo.

van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, Yarmush ML.

Hepatology. 2008 May;47(5):1634-43. doi: 10.1002/hep.22236.


Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats.

Levine JB, Leeder AD, Parekkadan B, Berdichevsky Y, Rauch SL, Smoller JW, Konradi C, Berthiaume F, Yarmush ML.

Neuroscience. 2008 Jan 24;151(2):589-603. Epub 2007 Oct 24.


Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure.

Parekkadan B, van Poll D, Suganuma K, Carter EA, Berthiaume F, Tilles AW, Yarmush ML.

PLoS One. 2007 Sep 26;2(9):e941.


Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells.

Parekkadan B, van Poll D, Megeed Z, Kobayashi N, Tilles AW, Berthiaume F, Yarmush ML.

Biochem Biophys Res Commun. 2007 Nov 16;363(2):247-52. Epub 2007 May 30.


Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood.

Parekkadan B, Sethu P, van Poll D, Yarmush ML, Toner M.

Tissue Eng. 2007 Oct;13(10):2465-73.


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