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Items: 30

1.

Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.

O'Flaherty L, Shnyder SD, Cooper PA, Cross SJ, Wakefield JG, Pardo OE, Seckl MJ, Tavaré JM.

PLoS One. 2019 Apr 10;14(4):e0214610. doi: 10.1371/journal.pone.0214610. eCollection 2019.

2.

Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors.

Rupniewska E, Roy R, Mauri FA, Liu X, Kaliszczak M, Bellezza G, Cagini L, Barbareschi M, Ferrero S, Tommasi AM, Aboagye E, Seckl MJ, Pardo OE.

Oncotarget. 2018 Jun 8;9(44):27346-27362. doi: 10.18632/oncotarget.25213. eCollection 2018 Jun 8.

3.

Emerging roles of hnRNPA1 in modulating malignant transformation.

Roy R, Huang Y, Seckl MJ, Pardo OE.

Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1431. Epub 2017 Aug 8. Review.

4.

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine.

Poursaitidis I, Wang X, Crighton T, Labuschagne C, Mason D, Cramer SL, Triplett K, Roy R, Pardo OE, Seckl MJ, Rowlinson SW, Stone E, Lamb RF.

Cell Rep. 2017 Mar 14;18(11):2547-2556. doi: 10.1016/j.celrep.2017.02.054.

5.

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer.

Li H, Stokes W, Chater E, Roy R, de Bruin E, Hu Y, Liu Z, Smit EF, Heynen GJ, Downward J, Seckl MJ, Wang Y, Tang H, Pardo OE.

Cell Discov. 2016 Sep 27;2:16031. eCollection 2016.

6.

miR-515-5p controls cancer cell migration through MARK4 regulation.

Pardo OE, Castellano L, Munro CE, Hu Y, Mauri F, Krell J, Lara R, Pinho FG, Choudhury T, Frampton AE, Pellegrino L, Pshezhetskiy D, Wang Y, Waxman J, Seckl MJ, Stebbing J.

EMBO Rep. 2016 Apr;17(4):570-84. doi: 10.15252/embr.201540970. Epub 2016 Feb 10.

7.

Meningioma dissemination and growth: a role for microRNAs.

Pardo OE.

Oncogene. 2015 Apr 2;34(14):1743-4. doi: 10.1038/onc.2014.263. No abstract available.

PMID:
25838054
8.

DAPK2 regulates oxidative stress in cancer cells by preserving mitochondrial function.

Schlegel CR, Georgiou ML, Misterek MB, Stöcker S, Chater ER, Munro CE, Pardo OE, Seckl MJ, Costa-Pereira AP.

Cell Death Dis. 2015 Mar 5;6:e1671. doi: 10.1038/cddis.2015.31.

9.

Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.

Vincent EE, Elder DJ, O'Flaherty L, Pardo OE, Dzien P, Phillips L, Morgan C, Pawade J, May MT, Sohail M, Hetzel MR, Seckl MJ, Tavaré JM.

PLoS One. 2014 Dec 8;9(12):e114725. doi: 10.1371/journal.pone.0114725. eCollection 2014.

10.

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

Roy R, Durie D, Li H, Liu BQ, Skehel JM, Mauri F, Cuorvo LV, Barbareschi M, Guo L, Holcik M, Seckl MJ, Pardo OE.

Nucleic Acids Res. 2014 Nov 10;42(20):12483-97. doi: 10.1093/nar/gku953. Epub 2014 Oct 16.

11.

Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.

Höland K, Boller D, Hagel C, Dolski S, Treszl A, Pardo OE, Cwiek P, Salm F, Leni Z, Shepherd PR, Styp-Rekowska B, Djonov V, von Bueren AO, Frei K, Arcaro A.

PLoS One. 2014 Apr 9;9(4):e94132. doi: 10.1371/journal.pone.0094132. eCollection 2014.

12.

The p90 RSK family members: common functions and isoform specificity.

Lara R, Seckl MJ, Pardo OE.

Cancer Res. 2013 Sep 1;73(17):5301-8. doi: 10.1158/0008-5472.CAN-12-4448. Epub 2013 Aug 22. Review.

13.

S6K2: The Neglected S6 Kinase Family Member.

Pardo OE, Seckl MJ.

Front Oncol. 2013 Jul 24;3:191. doi: 10.3389/fonc.2013.00191. eCollection 2013.

14.

Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.

Liwak U, Thakor N, Jordan LE, Roy R, Lewis SM, Pardo OE, Seckl M, Holcik M.

Mol Cell Biol. 2012 May;32(10):1818-29. doi: 10.1128/MCB.06317-11. Epub 2012 Mar 19.

15.

An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis.

Lara R, Mauri FA, Taylor H, Derua R, Shia A, Gray C, Nicols A, Shiner RJ, Schofield E, Bates PA, Waelkens E, Dallman M, Lamb J, Zicha D, Downward J, Seckl MJ, Pardo OE.

Oncogene. 2011 Aug 11;30(32):3513-21. doi: 10.1038/onc.2011.61. Epub 2011 Mar 21.

PMID:
21423205
16.

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

De Laurentiis A, Pardo OE, Palamidessi A, Jackson SP, Schoenwaelder SM, Reichmann E, Scita G, Arcaro A.

Cell Signal. 2011 Mar;23(3):529-41. doi: 10.1016/j.cellsig.2010.10.021. Epub 2010 Nov 5.

PMID:
21056654
17.

Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.

Goh ET, Pardo OE, Michael N, Niewiarowski A, Totty N, Volkova D, Tsaneva IR, Seckl MJ, Gout I.

J Biol Chem. 2010 May 28;285(22):17065-76. doi: 10.1074/jbc.M109.078782. Epub 2010 Mar 22.

18.

The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo.

Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW, Aboagye EO, Seckl MJ.

Cancer Res. 2009 Nov 15;69(22):8645-51. doi: 10.1158/0008-5472.CAN-09-1576. Epub 2009 Nov 10.

19.

AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001.

Marinov M, Ziogas A, Pardo OE, Tan LT, Dhillon T, Mauri FA, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl MJ, Arcaro A.

Clin Cancer Res. 2009 Feb 15;15(4):1277-87. doi: 10.1158/1078-0432.CCR-08-2166.

20.

FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.

Pardo OE, Wellbrock C, Khanzada UK, Aubert M, Arozarena I, Davidson S, Bowen F, Parker PJ, Filonenko VV, Gout IT, Sebire N, Marais R, Downward J, Seckl MJ.

EMBO J. 2006 Jul 12;25(13):3078-88. Epub 2006 Jun 29.

21.

Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.

Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A.

Mol Biol Cell. 2006 Sep;17(9):3729-44. Epub 2006 Jun 14.

22.

Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling.

Khanzada UK, Pardo OE, Meier C, Downward J, Seckl MJ, Arcaro A.

Oncogene. 2006 Feb 9;25(6):877-87.

PMID:
16170339
23.

CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.

Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R, D'Arrigo C, Ryder K, Menke A, Gress T, Downward J.

Cancer Cell. 2005 Jun;7(6):521-32.

24.

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells.

Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD, Lemoine NR, Mehmet H, Seckl MJ, Downward J.

Mol Cell Biol. 2003 Nov;23(21):7600-10. Erratum in: Mol Cell Biol. 2004 Aug;24(15):6887.

25.

Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues.

McDonald RW, Bunjobpon W, Liu T, Fessler S, Pardo OE, Freer IK, Glaser M, Seckl MJ, Robins DJ.

Anticancer Drug Des. 2001 Dec;16(6):261-70.

PMID:
12375879
26.
27.

Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells.

Pardo OE, Arcaro A, Salerno G, Tetley TD, Valovka T, Gout I, Seckl MJ.

Oncogene. 2001 Nov 15;20(52):7658-67.

28.

Heat shock proteins in cancer therapy.

Lukacs KV, Pardo OE, Colston MJ, Geddes DM, Alton EW.

Adv Exp Med Biol. 2000;465:363-8. Review. No abstract available.

PMID:
10810640
29.

In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice.

Lukacs KV, Porter CD, Pardo OE, Oakley RE, Steel RM, Judd DV, Browning JE, Geddes DM, Alton EW.

Hum Gene Ther. 1999 Sep 20;10(14):2373-9.

PMID:
10515457
30.

Cancer gene therapy with a heat shock protein gene.

Pardo OE, Colston JM, Lukacs KV.

Adv Exp Med Biol. 1998;451:217-23. No abstract available.

PMID:
10026875

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