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Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment.

Sulea T, Rohani N, Baardsnes J, Corbeil CR, Deprez C, Cepero-Donates Y, Robert A, Schrag JD, Parat M, Duchesne M, Jaramillo ML, Purisima EO, Zwaagstra JC.

MAbs. 2020 Jan-Dec;12(1):1682866. doi: 10.1080/19420862.2019.1682866.


Corrigendum: Morphine Binds Creatine Kinase B and Inhibits Its Activity.

Weinsanto I, Mouheiche J, Laux-Biehlmann A, Delalande F, Marquette A, Chavant V, Gabel F, Cianferani S, Charlet A, Parat MO, Goumon Y.

Front Cell Neurosci. 2019 Jul 2;13:292. doi: 10.3389/fncel.2019.00292. eCollection 2019.


Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1.

Pu W, Nassar ZD, Khabbazi S, Xie N, McMahon KA, Parton RG, Riggins GJ, Harris JM, Parat MO.

J Neurooncol. 2019 Jun;143(2):207-220. doi: 10.1007/s11060-019-03161-8. Epub 2019 Apr 4.


Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice.

Khaw KY, Parat MO, Shaw PN, Nguyen TTT, Pandey S, Thurecht KJ, Falconer JR.

Sci Rep. 2019 Feb 8;9(1):1716. doi: 10.1038/s41598-018-37171-9.


Morphine Binds Creatine Kinase B and Inhibits Its Activity.

Weinsanto I, Mouheiche J, Laux-Biehlmann A, Delalande F, Marquette A, Chavant V, Gabel F, Cianferani S, Charlet A, Parat MO, Goumon Y.

Front Cell Neurosci. 2018 Dec 3;12:464. doi: 10.3389/fncel.2018.00464. eCollection 2018. Erratum in: Front Cell Neurosci. 2019 Jul 02;13:292.


Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice.

Weinsanto I, Laux-Biehlmann A, Mouheiche J, Maduna T, Delalande F, Chavant V, Gabel F, Darbon P, Charlet A, Poisbeau P, Lamshöft M, Van Dorsselaer A, Cianferani S, Parat MO, Goumon Y.

Br J Pharmacol. 2018 Oct;175(19):3844-3856. doi: 10.1111/bph.14454. Epub 2018 Aug 31.


Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile.

Xie N, Matigian N, Vithanage T, Gregory K, Nassar ZD, Cabot PJ, Shaw PN, Kirkpatrick CMJ, Cao KL, Sturgess D, Parat MO.

Clin Cancer Res. 2018 May 15;24(10):2319-2327. doi: 10.1158/1078-0432.CCR-18-0172. Epub 2018 Mar 6.


Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism.

Weinsanto I, Mouheiche J, Laux-Biehlmann A, Aouad M, Maduna T, Petit-Demoulière N, Chavant V, Poisbeau P, Darbon P, Charlet A, Giersch A, Parat MO, Goumon Y.

Mol Pain. 2018 Jan-Dec;14:1744806917754142. doi: 10.1177/1744806917754142. Epub 2018 Jan 21.


Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies.

Deora GS, Kantham S, Chan S, Dighe SN, Veliyath SK, McColl G, Parat MO, McGeary RP, Ross BP.

ACS Chem Neurosci. 2017 Dec 20;8(12):2667-2675. doi: 10.1021/acschemneuro.7b00229. Epub 2017 Sep 8.


Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion.

Xie N, Khabbazi S, Nassar ZD, Gregory K, Vithanage T, Anand-Apte B, Cabot PJ, Sturgess D, Shaw PN, Parat MO.

FASEB J. 2017 Dec;31(12):5208-5216. doi: 10.1096/fj.201700546R. Epub 2017 Aug 7.


Solvent Supercritical Fluid Technologies to Extract Bioactive Compounds from Natural Sources: A Review.

Khaw KY, Parat MO, Shaw PN, Falconer JR.

Molecules. 2017 Jul 14;22(7). pii: E1186. doi: 10.3390/molecules22071186. Review.


Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation.

Kantham S, Chan S, McColl G, Miles JA, Veliyath SK, Deora GS, Dighe SN, Khabbazi S, Parat MO, Ross BP.

ACS Chem Neurosci. 2017 Sep 20;8(9):1901-1912. doi: 10.1021/acschemneuro.7b00071. Epub 2017 Jul 19.


Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina.

Thakur SS, Ward MS, Popat A, Flemming NB, Parat MO, Barnett NL, Parekh HS.

PLoS One. 2017 May 25;12(5):e0178305. doi: 10.1371/journal.pone.0178305. eCollection 2017.


Bifunctional Succinylated ε-Polylysine-Coated Mesoporous Silica Nanoparticles for pH-Responsive and Intracellular Drug Delivery Targeting the Colon.

Nguyen CT, Webb RI, Lambert LK, Strounina E, Lee EC, Parat MO, McGuckin MA, Popat A, Cabot PJ, Ross BP.

ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9470-9483. doi: 10.1021/acsami.7b00411. Epub 2017 Mar 13.


Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice.

Xie N, Gomes FP, Deora V, Gregory K, Vithanage T, Nassar ZD, Cabot PJ, Sturgess D, Shaw PN, Parat MO.

Brain Behav Immun. 2017 Mar;61:244-258. doi: 10.1016/j.bbi.2016.12.002. Epub 2016 Dec 7.


The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation In Vitro.

Khabbazi S, Xie N, Pu W, Goumon Y, Parat MO.

Front Pharmacol. 2016 Nov 17;7:441. eCollection 2016.


Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro.

Khabbazi S, Nassar ZD, Goumon Y, Parat MO.

Sci Rep. 2016 Aug 12;6:31572. doi: 10.1038/srep31572.


Application of the Protein Maker as a platform purification system for therapeutic antibody research and development.

Hélie G, Parat M, Massé F, Gerdts CJ, Loisel TP, Matte A.

Comput Struct Biotechnol J. 2016 Jun 16;14:238-44. doi: 10.1016/j.csbj.2016.06.001. eCollection 2016.


Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.

Dighe SN, Deora GS, De la Mora E, Nachon F, Chan S, Parat MO, Brazzolotto X, Ross BP.

J Med Chem. 2016 Aug 25;59(16):7683-9. doi: 10.1021/acs.jmedchem.6b00356. Epub 2016 Jul 26.


Traditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma.

Nguyen TT, Parat MO, Shaw PN, Hewavitharana AK, Hodson MP.

PLoS One. 2016 Feb 1;11(2):e0147956. doi: 10.1371/journal.pone.0147956. eCollection 2016.


Molecular Determinants of the Cellular Entry of Asymmetric Peptide Dendrimers and Role of Caveolae.

Rewatkar PV, Parekh HS, Parat MO.

PLoS One. 2016 Jan 20;11(1):e0147491. doi: 10.1371/journal.pone.0147491. eCollection 2016.


Chemical Characterization and in Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica papaya Leaf Extracts.

Nguyen TT, Parat MO, Hodson MP, Pan J, Shaw PN, Hewavitharana AK.

Toxins (Basel). 2015 Dec 24;8(1). pii: E7. doi: 10.3390/toxins8010007.


Cavin Family: New Players in the Biology of Caveolae.

Nassar ZD, Parat MO.

Int Rev Cell Mol Biol. 2015;320:235-305. doi: 10.1016/bs.ircmb.2015.07.009. Epub 2015 Aug 31. Review.


Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis.

Nassar ZD, Hill MM, Parton RG, Francois M, Parat MO.

Oncoscience. 2015 Aug 3;2(7):635-45. eCollection 2015.


Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.

Khabbazi S, Goumon Y, Parat MO.

Sci Rep. 2015 Jun 16;5:11389. doi: 10.1038/srep11389.


Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1.

Moon H, Ruelcke JE, Choi E, Sharpe LJ, Nassar ZD, Bielefeldt-Ohmann H, Parat MO, Shah A, Francois M, Inder KL, Brown AJ, Russell PJ, Parton RG, Hill MM.

Oncotarget. 2015 Apr 10;6(10):7438-53.


Are caveolae a cellular entry route for non-viral therapeutic delivery systems?

Rewatkar PV, Parton RG, Parekh HS, Parat MO.

Adv Drug Deliv Rev. 2015 Aug 30;91:92-108. doi: 10.1016/j.addr.2015.01.003. Epub 2015 Jan 8. Review.


Consensus statement from the BJA Workshop on Cancer and Anaesthesia.

Buggy DJ, Borgeat A, Cata J, Doherty DG, Doornebal CW, Forget P, Gottumukkala V, Gottschalk A, Gupta A, Gupta K, Hales TG, Hemmings HC, Hollmann MW, Kurz A, Ma D, Parat MO, Sessler DI, Shorten G, Singleton P.

Br J Anaesth. 2015 Jan;114(1):2-3. doi: 10.1093/bja/aeu262. Epub 2014 Aug 7. No abstract available.


Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis.

Afsharimani B, Doornebal CW, Cabot PJ, Hollmann MW, Parat MO.

Br J Pharmacol. 2015 Jan;172(2):251-9. doi: 10.1111/bph.12589. Epub 2014 Jul 1. Review.


Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells.

Afsharimani B, Cabot PJ, Parat MO.

Br J Anaesth. 2014 Jul;113 Suppl 1:i22-31. doi: 10.1093/bja/aet468. Epub 2014 Jan 12.


PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis.

Nassar ZD, Moon H, Duong T, Neo L, Hill MM, Francois M, Parton RG, Parat MO.

Oncotarget. 2013 Oct;4(10):1844-55.


Morphine and breast tumor metastasis: the role of matrix-degrading enzymes.

Afsharimani B, Baran J, Watanabe S, Lindner D, Cabot PJ, Parat MO.

Clin Exp Metastasis. 2014 Feb;31(2):149-58. doi: 10.1007/s10585-013-9616-3. Epub 2013 Sep 26.


Caveola-forming proteins caveolin-1 and PTRF in prostate cancer.

Nassar ZD, Hill MM, Parton RG, Parat MO.

Nat Rev Urol. 2013 Sep;10(9):529-36. doi: 10.1038/nrurol.2013.168. Epub 2013 Aug 13. Review.


Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line.

Davis FM, Parsonage MT, Cabot PJ, Parat MO, Thompson EW, Roberts-Thomson SJ, Monteith GR.

Cancer Cell Int. 2013 Jul 29;13(1):76. doi: 10.1186/1475-2867-13-76.


Anticancer activity of Carica papaya: a review.

Nguyen TT, Shaw PN, Parat MO, Hewavitharana AK.

Mol Nutr Food Res. 2013 Jan;57(1):153-64. doi: 10.1002/mnfr.201200388. Epub 2012 Dec 5. Review.


Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1.

Hill MM, Daud NH, Aung CS, Loo D, Martin S, Murphy S, Black DM, Barry R, Simpson F, Liu L, Pilch PF, Hancock JF, Parat MO, Parton RG.

PLoS One. 2012;7(8):e43041. doi: 10.1371/journal.pone.0043041. Epub 2012 Aug 13.


Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer.

Peters AA, Simpson PT, Bassett JJ, Lee JM, Da Silva L, Reid LE, Song S, Parat MO, Lakhani SR, Kenny PA, Roberts-Thomson SJ, Monteith GR.

Mol Cancer Ther. 2012 Oct;11(10):2158-68. doi: 10.1158/1535-7163.MCT-11-0965. Epub 2012 Jul 17.


Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages.

Fu Y, Moore XL, Lee MK, Fernández-Rojo MA, Parat MO, Parton RG, Meikle PJ, Sviridov D, Chin-Dusting JP.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):e117-25. doi: 10.1161/ATVBAHA.112.254151. Epub 2012 Jul 5.


Non-stimulated, agonist-stimulated and store-operated Ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry.

Davis FM, Peters AA, Grice DM, Cabot PJ, Parat MO, Roberts-Thomson SJ, Monteith GR.

PLoS One. 2012;7(5):e36923. doi: 10.1371/journal.pone.0036923. Epub 2012 May 30.


Caveolin-1, caveolae, and glioblastoma.

Parat MO, Riggins GJ.

Neuro Oncol. 2012 Jun;14(6):679-88. doi: 10.1093/neuonc/nos079. Epub 2012 Apr 16. Review.


Altered angiogenesis in caveolin-1 gene-deficient mice is restored by ablation of endothelial nitric oxide synthase.

Morais C, Ebrahem Q, Anand-Apte B, Parat MO.

Am J Pathol. 2012 Apr;180(4):1702-14. doi: 10.1016/j.ajpath.2011.12.018. Epub 2012 Feb 7.


Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.

Weber GL, Parat MO, Binder ZA, Gallia GL, Riggins GJ.

Oncotarget. 2011 Nov;2(11):833-49.


Morphine use in cancer surgery.

Afsharimani B, Cabot PJ, Parat MO.

Front Pharmacol. 2011 Aug 8;2:46. doi: 10.3389/fphar.2011.00046. eCollection 2011.


Remodeling of purinergic receptor-mediated Ca2+ signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells.

Davis FM, Kenny PA, Soo ET, van Denderen BJ, Thompson EW, Cabot PJ, Parat MO, Roberts-Thomson SJ, Monteith GR.

PLoS One. 2011;6(8):e23464. doi: 10.1371/journal.pone.0023464. Epub 2011 Aug 5.


Morphine and tumor growth and metastasis.

Afsharimani B, Cabot P, Parat MO.

Cancer Metastasis Rev. 2011 Jun;30(2):225-38. doi: 10.1007/s10555-011-9285-0. Review.


PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: role of matrix metalloprotease 9.

Aung CS, Hill MM, Bastiani M, Parton RG, Parat MO.

Eur J Cell Biol. 2011 Feb-Mar;90(2-3):136-42. doi: 10.1016/j.ejcb.2010.06.004. Epub 2010 Aug 21.


Mango extracts and the mango component mangiferin promote endothelial cell migration.

Daud NH, Aung CS, Hewavitharana AK, Wilkinson AS, Pierson JT, Roberts-Thomson SJ, Shaw PN, Monteith GR, Gidley MJ, Parat MO.

J Agric Food Chem. 2010 Apr 28;58(8):5181-6. doi: 10.1021/jf100249s.


Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor A activation.

Parat M, Blanchet J, De Léan A.

Biochemistry. 2010 Jun 8;49(22):4601-10. doi: 10.1021/bi901711w.


The biology of caveolae: achievements and perspectives.

Parat MO.

Int Rev Cell Mol Biol. 2009;273:117-62. doi: 10.1016/S1937-6448(08)01804-2. Review.


Altered localization of H-Ras in caveolin-1-null cells is palmitoylation-independent.

Baran J, Mundy DI, Vasanji A, Parat MO.

J Cell Commun Signal. 2007 Dec;1(3-4):195-204. doi: 10.1007/s12079-008-0017-3. Epub 2008 Feb 17.

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