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Items: 7

1.

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE.

Cancer Discov. 2018 Dec;8(12):1582-1597. doi: 10.1158/2159-8290.CD-18-0387. Epub 2018 Sep 25. Erratum in: Cancer Discov. 2019 Jul;9(7):980.

PMID:
30254093
2.

Photoredox Cyanomethylation of Indoles: Catalyst Modification and Mechanism.

O'Brien CJ, Droege DG, Jiu AY, Gandhi SS, Paras NA, Olson SH, Conrad J.

J Org Chem. 2018 Aug 17;83(16):8926-8935. doi: 10.1021/acs.joc.8b01146. Epub 2018 Jul 6.

3.

Convenient route to secondary sulfinates: application to the stereospecific synthesis of α-C-chiral sulfonamides.

Johnson MG, Gribble MW Jr, Houze JB, Paras NA.

Org Lett. 2014 Dec 5;16(23):6248-51. doi: 10.1021/ol503208z. Epub 2014 Nov 21.

PMID:
25415837
4.

Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.

Smith AL, DeMorin FF, Paras NA, Huang Q, Petkus JK, Doherty EM, Nixey T, Kim JL, Whittington DA, Epstein LF, Lee MR, Rose MJ, Babij C, Fernando M, Hess K, Le Q, Beltran P, Carnahan J.

J Med Chem. 2009 Oct 22;52(20):6189-92. doi: 10.1021/jm901081g.

PMID:
19764794
5.

Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids.

Bunin BA, Dener JM, Kelly DE, Paras NA, Tario JD, Tushup SP.

J Comb Chem. 2004 Jul-Aug;6(4):487-96.

PMID:
15244409
6.
7.

New strategies in organic catalysis: the first enantioselective organocatalytic Friedel-Crafts alkylation.

Paras NA, MacMillan DW.

J Am Chem Soc. 2001 May 9;123(18):4370-1. No abstract available.

PMID:
11457218

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