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Items: 1 to 50 of 122

1.

Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.

Lázaro S, Pérez-Crespo M, Lorz C, Bernardini A, Oteo M, Enguita AB, Romero E, Hernández P, Tomás L, Morcillo MÁ, Paramio JM, Santos M.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22300-22306. doi: 10.1073/pnas.1821745116. Epub 2019 Oct 14.

2.

Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status.

Dueñas M, Pérez-Figueroa A, Oliveira C, Suárez-Cabrera C, Sousa A, Oliveira P, Villacampa F, Paramio JM, Martínez-Fernández M.

Sci Rep. 2019 Jul 17;9(1):10362. doi: 10.1038/s41598-019-46652-4.

3.

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.

Segovia C, San José-Enériz E, Munera-Maravilla E, Martínez-Fernández M, Garate L, Miranda E, Vilas-Zornoza A, Lodewijk I, Rubio C, Segrelles C, Valcárcel LV, Rabal O, Casares N, Bernardini A, Suarez-Cabrera C, López-Calderón FF, Fortes P, Casado JA, Dueñas M, Villacampa F, Lasarte JJ, Guerrero-Ramos F, de Velasco G, Oyarzabal J, Castellano D, Agirre X, Prósper F, Paramio JM.

Nat Med. 2019 Jul;25(7):1073-1081. doi: 10.1038/s41591-019-0499-y. Epub 2019 Jul 3.

PMID:
31270502
4.

Integrative Metabolomic and Transcriptomic Analysis for the Study of Bladder Cancer.

Loras A, Suárez-Cabrera C, Martínez-Bisbal MC, Quintás G, Paramio JM, Martínez-Máñez R, Gil S, Ruiz-Cerdá JL.

Cancers (Basel). 2019 May 16;11(5). pii: E686. doi: 10.3390/cancers11050686.

5.

Competitive Repopulation Assay of Long-Term Epidermal Stem Cell Regeneration Potential.

Segrelles C, Santos-de-Frutos K, Paramio JM, Lorz C.

Methods Mol Biol. 2019 May 14. doi: 10.1007/7651_2019_234. [Epub ahead of print]

PMID:
31087286
6.

IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization.

Page A, Ortega A, Alameda JP, Navarro M, Paramio JM, Saiz-Pardo M, Almeida EI, Hernández P, Fernández-Aceñero MJ, García-Fernández RA, Casanova ML.

Comput Struct Biotechnol J. 2019 Feb 7;17:251-262. doi: 10.1016/j.csbj.2019.02.003. eCollection 2019.

7.

Premature aging and cancer development in transgenic mice lacking functional CYLD.

Alameda JP, Ramírez Á, García-Fernández RA, Navarro M, Page A, Segovia JC, Sanchez R, Suárez-Cabrera C, Paramio JM, Bravo A, Fernández-Aceñero MJ, Casanova ML.

Aging (Albany NY). 2019 Jan 10;11(1):127-159. doi: 10.18632/aging.101732.

8.

The transcriptional co-activator YAP: A new player in head and neck cancer.

Segrelles C, Paramio JM, Lorz C.

Oral Oncol. 2018 Nov;86:25-32. doi: 10.1016/j.oraloncology.2018.08.020. Epub 2018 Sep 11. Review.

PMID:
30409308
9.

Macrophage polarization as a novel weapon in conditioning tumor microenvironment for bladder cancer: can we turn demons into gods?

Rubio C, Munera-Maravilla E, Lodewijk I, Suarez-Cabrera C, Karaivanova V, Ruiz-Palomares R, Paramio JM, Dueñas M.

Clin Transl Oncol. 2019 Apr;21(4):391-403. doi: 10.1007/s12094-018-1952-y. Epub 2018 Oct 5. Review.

PMID:
30291519
10.

CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status.

Rubio C, Martínez-Fernández M, Segovia C, Lodewijk I, Suarez-Cabrera C, Segrelles C, López-Calderón F, Munera-Maravilla E, Santos M, Bernardini A, García-Escudero R, Lorz C, Gómez-Rodriguez MJ, de Velasco G, Otero I, Villacampa F, Guerrero-Ramos F, Ruiz S, de la Rosa F, Domínguez-Rodríguez S, Real FX, Malats N, Castellano D, Dueñas M, Paramio JM.

Clin Cancer Res. 2019 Jan 1;25(1):390-402. doi: 10.1158/1078-0432.CCR-18-0685. Epub 2018 Sep 21.

PMID:
30242024
11.

The Ras-related gene ERAS is involved in human and murine breast cancer.

Suárez-Cabrera C, de la Peña B, González LL, Page A, Martínez-Fernández M, Casanova ML, Paramio JM, Rojo-Sebastián A, Moreno-Bueno G, Maroto A, Ramírez Á, Navarro M.

Sci Rep. 2018 Aug 29;8(1):13038. doi: 10.1038/s41598-018-31326-4.

12.

Liquid Biopsy Biomarkers in Bladder Cancer: A Current Need for Patient Diagnosis and Monitoring.

Lodewijk I, Dueñas M, Rubio C, Munera-Maravilla E, Segovia C, Bernardini A, Teijeira A, Paramio JM, Suárez-Cabrera C.

Int J Mol Sci. 2018 Aug 24;19(9). pii: E2514. doi: 10.3390/ijms19092514. Review.

13.

Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.

Lorenzo-Martín LF, Citterio C, Menacho-Márquez M, Conde J, Larive RM, Rodríguez-Fdez S, García-Escudero R, Robles-Valero J, Cuadrado M, Fernández-Pisonero I, Dosil M, Sevilla MA, Montero MJ, Fernández-Salguero PM, Paramio JM, Bustelo XR.

Oncogene. 2019 Jan;38(2):209-227. doi: 10.1038/s41388-018-0433-7. Epub 2018 Aug 7.

14.

Bosutinib Inhibits EGFR Activation in Head and Neck Cancer.

Segrelles C, Contreras D, Navarro EM, Gutiérrez-Muñoz C, García-Escudero R, Paramio JM, Lorz C.

Int J Mol Sci. 2018 Jun 21;19(7). pii: E1824. doi: 10.3390/ijms19071824.

15.

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.

Liceras-Boillos P, Jimeno D, García-Navas R, Lorenzo-Martín LF, Menacho-Marquez M, Segrelles C, Gómez C, Calzada N, Fuentes-Mateos R, Paramio JM, Bustelo XR, Baltanás FC, Santos E.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00049-18. doi: 10.1128/MCB.00049-18. Print 2018 Aug 15.

16.

Thyroid Hormone Receptors Regulate the Expression of microRNAs with Key Roles in Skin Homeostasis.

Ruiz-Llorente L, Contreras-Jurado C, Martínez-Fernández M, Paramio JM, Aranda A.

Thyroid. 2018 Jul;28(7):921-932. doi: 10.1089/thy.2017.0369. Epub 2018 Jun 11.

PMID:
29742977
17.

Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway.

García-Escudero R, Segrelles C, Dueñas M, Pombo M, Ballestín C, Alonso-Riaño M, Nenclares P, Álvarez-Rodríguez R, Sánchez-Aniceto G, Ruíz-Alonso A, López-Cedrún JL, Paramio JM, Lorz C.

Oral Oncol. 2018 Apr;79:55-63. doi: 10.1016/j.oraloncology.2018.02.014. Epub 2018 Mar 3.

PMID:
29598951
18.

Ezh2-dependent therapies in bladder cancer: synthetic lethality.

Segovia C, Paramio JM.

Ann Transl Med. 2017 Dec;5(24):494. doi: 10.21037/atm.2017.10.08. No abstract available.

19.

Urothelial cancer proteomics provides both prognostic and functional information.

de Velasco G, Trilla-Fuertes L, Gamez-Pozo A, Urbanowicz M, Ruiz-Ares G, Sepúlveda JM, Prado-Vazquez G, Arevalillo JM, Zapater-Moros A, Navarro H, Lopez-Vacas R, Manneh R, Otero I, Villacampa F, Paramio JM, Vara JAF, Castellano D.

Sci Rep. 2017 Nov 17;7(1):15819. doi: 10.1038/s41598-017-15920-6.

20.

BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer.

Martínez VG, Rubio C, Martínez-Fernández M, Segovia C, López-Calderón F, Garín MI, Teijeira A, Munera-Maravilla E, Varas A, Sacedón R, Guerrero F, Villacampa F, de la Rosa F, Castellano D, López-Collazo E, Paramio JM, Vicente Á, Dueñas M.

Clin Cancer Res. 2017 Dec 1;23(23):7388-7399. doi: 10.1158/1078-0432.CCR-17-1004. Epub 2017 Sep 19.

21.

Correction: IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development

Alameda JP, Navarro M, Ramírez Á, Page A, Suárez-Cabrera C, Moreno-Maldonado R, Paramio JM, del Carmen Fariña M, Fernández-Aceñero MJ, Bravo A.

Oncotarget. 2017 Aug 7;8(32):53887. doi: 10.18632/oncotarget.20002. eCollection 2017 Aug 8.

22.

Correction: Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer.

Alameda JP, Gaspar M, Ramírez Á, Navarro M, Page A, Suárez-Cabrera C, Fernández MG, Mérida JR, Paramio JM, García-Fernández RA, Fernández-Aceñero MJ, Casanova ML.

Oncotarget. 2017 Aug 7;8(32):53886. doi: 10.18632/oncotarget.20001. eCollection 2017 Aug 8.

23.

Correction: Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.

Costa C, Santos M, Martínez-Fernández M, Lorz C, Lázaro S, Paramio JM.

Oncotarget. 2017 Jul 25;8(30):50324. doi: 10.18632/oncotarget.19511. No abstract available.

24.

Correction: Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

Lázaro S, Pérez-Crespo M, Enguita AB, Hernández P, Martínez-Palacio J, Oteo M, Sage J, Paramio JM, Santos M.

Oncotarget. 2017 Jul 25;8(30):50323. doi: 10.18632/oncotarget.19510. No abstract available.

25.

IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent.

Page A, Bravo A, Suarez-Cabrera C, Alameda JP, Casanova ML, Lorz C, Segrelles C, Segovia JC, Paramio JM, Navarro M, Ramirez A.

Mol Cancer Res. 2017 Sep;15(9):1255-1264. doi: 10.1158/1541-7786.MCR-17-0157. Epub 2017 Jun 5.

26.

Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma.

Puente J, Laínez N, Dueñas M, Méndez-Vidal MJ, Esteban E, Castellano D, Martinez-Fernández M, Basterretxea L, Juan-Fita MJ, Antón L, León L, Lambea J, Pérez-Valderrama B, Vázquez S, Suarez C, Del Muro XG, Gallardo E, Maroto JP, Samaniego ML, Suárez-Paniagua B, Sanz J, Paramio JM; SOGUG (Spanish Oncology Genitourinary Group).

Oncotarget. 2017 May 2;8(18):30410-30421. doi: 10.18632/oncotarget.16494.

27.

Correction: Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.

Page A, Navarro M, Suarez-Cabrera C, Alameda JP, Casanova ML, Paramio JM, Bravo A, Ramirez A.

Oncotarget. 2017 Mar 28;8(13):22304. doi: 10.18632/oncotarget.16592. No abstract available.

28.

Clusterization in head and neck squamous carcinomas based on lncRNA expression: molecular and clinical correlates.

de Lena PG, Paz-Gallardo A, Paramio JM, García-Escudero R.

Clin Epigenetics. 2017 Apr 8;9:36. doi: 10.1186/s13148-017-0334-6. eCollection 2017.

29.

UroMark-a urinary biomarker assay for the detection of bladder cancer.

Feber A, Dhami P, Dong L, de Winter P, Tan WS, Martínez-Fernández M, Paul DS, Hynes-Allen A, Rezaee S, Gurung P, Rodney S, Mehmood A, Villacampa F, de la Rosa F, Jameson C, Cheng KK, Zeegers MP, Bryan RT, James ND, Paramio JM, Freeman A, Beck S, Kelly JD.

Clin Epigenetics. 2017 Jan 31;9:8. doi: 10.1186/s13148-016-0303-5. eCollection 2017.

30.

A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer.

Suárez-Cabrera C, Quintana RM, Bravo A, Casanova ML, Page A, Alameda JP, Paramio JM, Maroto A, Salamanca J, Dupuy AJ, Ramírez A, Navarro M.

Cancer Res. 2017 Mar 15;77(6):1357-1368. doi: 10.1158/0008-5472.CAN-16-1586. Epub 2017 Jan 20.

31.

Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer.

Segovia C, Martínez-Fernández M, Dueñas M, Rubio C, López-Calderón FF, Costa C, Saiz-Ladera C, Fernández-Grajera M, Duarte J, Muñoz HG, de la Rosa F, Villacampa F, Castellano D, Paramio JM.

Oncotarget. 2017 Feb 7;8(6):10531-10542. doi: 10.18632/oncotarget.14453.

32.

Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

Lázaro S, Pérez-Crespo M, Enguita AB, Hernández P, Martínez-Palacio J, Oteo M, Sage J, Paramio JM, Santos M.

Oncotarget. 2017 Jan 17;8(3):4373-4386. doi: 10.18632/oncotarget.13875. Erratum in: Oncotarget. 2017 Jul 25;8(30):50323.

33.

IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development.

Alameda JP, Navarro M, Ramírez Á, Page A, Suárez-Cabrera C, Moreno-Maldonado R, Paramio JM, del Carmen Fariña MR, Del Río M, Fernández-Aceñero MJ, Bravo A, de Los Llanos Casanova MR.

Oncotarget. 2016 Nov 22;7(47):76779-76792. doi: 10.18632/oncotarget.12527. Erratum in: Oncotarget. 2017 Aug 7;8(32):53887.

34.

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.

Costa C, Santos M, Martínez-Fernández M, Lorz C, Lázaro S, Paramio JM.

Oncotarget. 2016 Nov 15;7(46):75712-75728. doi: 10.18632/oncotarget.12362. Erratum in: Oncotarget. 2017 Jul 25;8(30):50324.

35.

Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer.

Alameda JP, Gaspar M, Ramírez Á, Navarro M, Page A, Suárez-Cabrera C, Fernández MG, Mérida JR, Paramio JM, García-Fernández RA, Fernández-Aceñero MJ, Casanova ML.

Oncotarget. 2016 May 17;7(20):29531-47. doi: 10.18632/oncotarget.8792. Erratum in: Oncotarget. 2017 Aug 7;8(32):53886.

36.

Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.

Page A, Navarro M, Suarez-Cabrera C, Alameda JP, Casanova ML, Paramio JM, Bravo A, Ramirez A.

Oncotarget. 2016 Apr 12;7(15):20902-18. doi: 10.18632/oncotarget.7897. Erratum in: Oncotarget. 2017 Mar 28;8(13):22304.

37.

RNA Detection in Urine: From RNA Extraction to Good Normalizer Molecules.

Martínez-Fernández M, Paramio JM, Dueñas M.

J Mol Diagn. 2016 Jan;18(1):15-22. doi: 10.1016/j.jmoldx.2015.07.008. Epub 2015 Nov 14.

PMID:
26586227
38.

EZH2 in Bladder Cancer, a Promising Therapeutic Target.

Martínez-Fernández M, Rubio C, Segovia C, López-Calderón FF, Dueñas M, Paramio JM.

Int J Mol Sci. 2015 Nov 13;16(11):27107-32. doi: 10.3390/ijms161126000. Review.

39.

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer.

Martínez-Fernández M, Dueñas M, Feber A, Segovia C, García-Escudero R, Rubio C, López-Calderón FF, Díaz-García C, Villacampa F, Duarte J, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM.

Oncotarget. 2015 Dec 8;6(39):42258-75. doi: 10.18632/oncotarget.5546.

40.

Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer.

Martínez-Fernández M, Feber A, Dueñas M, Segovia C, Rubio C, Fernandez M, Villacampa F, Duarte J, López-Calderón FF, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM.

Clin Epigenetics. 2015 Oct 8;7:109. doi: 10.1186/s13148-015-0141-x. eCollection 2015.

41.

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.

Bornachea O, López-Calderón FF, Dueñas M, Segrelles C, Lorz C, Suárez-Cabrera C, Marañón M, Paradela-Dobarro B, Santos M, Paramio JM.

Oncotarget. 2015 Sep 15;6(27):24230-45.

42.

Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.

Zur R, Garcia-Ibanez L, Nunez-Buiza A, Aparicio N, Liappas G, Escós A, Risco A, Page A, Saiz-Ladera C, Alsina-Beauchamp D, Montans J, Paramio JM, Cuenda A.

Oncotarget. 2015 May 30;6(15):12920-35.

43.

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.

Palla AR, Piazzolla D, Alcazar N, Cañamero M, Graña O, Gómez-López G, Dominguez O, Dueñas M, Paramio JM, Serrano M.

Sci Rep. 2015 May 19;5:10205. doi: 10.1038/srep10205.

44.

Thyroid hormone signaling controls hair follicle stem cell function.

Contreras-Jurado C, Lorz C, García-Serrano L, Paramio JM, Aranda A.

Mol Biol Cell. 2015 Apr 1;26(7):1263-72. doi: 10.1091/mbc.E14-07-1251. Epub 2015 Feb 5.

45.

NOTCH pathway inactivation promotes bladder cancer progression.

Maraver A, Fernandez-Marcos PJ, Cash TP, Mendez-Pertuz M, Dueñas M, Maietta P, Martinelli P, Muñoz-Martin M, Martínez-Fernández M, Cañamero M, Roncador G, Martinez-Torrecuadrada JL, Grivas D, de la Pompa JL, Valencia A, Paramio JM, Real FX, Serrano M.

J Clin Invest. 2015 Feb;125(2):824-30. doi: 10.1172/JCI78185. Epub 2015 Jan 9.

46.

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.

Carnero A, Paramio JM.

Front Oncol. 2014 Sep 23;4:252. doi: 10.3389/fonc.2014.00252. eCollection 2014. Review.

47.

Impaired hair growth and wound healing in mice lacking thyroid hormone receptors.

Contreras-Jurado C, García-Serrano L, Martínez-Fernández M, Ruiz-Llorente L, Paramio JM, Aranda A.

PLoS One. 2014 Sep 25;9(9):e108137. doi: 10.1371/journal.pone.0108137. eCollection 2014.

48.

In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.

Santos M, Martínez-Fernández M, Dueñas M, García-Escudero R, Alfaya B, Villacampa F, Saiz-Ladera C, Costa C, Oteo M, Duarte J, Martínez V, Gómez-Rodriguez MJ, Martín ML, Fernández M, Viatour P, Morcillo MA, Sage J, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Paramio JM.

Cancer Res. 2014 Nov 15;74(22):6565-6577. doi: 10.1158/0008-5472.CAN-14-1218. Epub 2014 Sep 24.

49.

Akt signaling leads to stem cell activation and promotes tumor development in epidermis.

Segrelles C, García-Escudero R, Garín MI, Aranda JF, Hernández P, Ariza JM, Santos M, Paramio JM, Lorz C.

Stem Cells. 2014 Jul;32(7):1917-28. doi: 10.1002/stem.1669.

50.

Skin Tumors Rb(eing) Uncovered.

Costa C, Paramio JM, Santos M.

Front Oncol. 2013 Dec 17;3:307. doi: 10.3389/fonc.2013.00307. Review.

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