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Items: 1 to 50 of 214

1.

First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and advances of new therapeutics.

Rauen KA, Alsaegh A, Ben-Shachar S, Berman Y, Blakeley J, Cordeiro I, Elgersma Y, Evans DG, Fisher MJ, Frayling IM, George J, Huson SM, Kerr B, Khire U, Korf B, Legius E, Messiaen L, van Minkelen R, Nampoothiri S, Ngeow J, Parada LF, Phadke S, Pillai A, Plotkin SR, Puri R, Raji A, Ramesh V, Ratner N, Shankar SP, Sharda S, Tambe A, Vikkula M, Widemann BC, Wolkenstein P, Upadhyaya M.

Am J Med Genet A. 2019 Jun;179(6):1091-1097. doi: 10.1002/ajmg.a.61125. Epub 2019 Mar 25.

PMID:
30908877
2.

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.

Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF.

Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6.

3.

Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction.

Alcantara Llaguno S, Sun D, Pedraza AM, Vera E, Wang Z, Burns DK, Parada LF.

Nat Neurosci. 2019 Apr;22(4):545-555. doi: 10.1038/s41593-018-0333-8. Epub 2019 Feb 18.

4.

TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response.

Ma Z, Zang T, Birnbaum SG, Wang Z, Johnson JE, Zhang CL, Parada LF.

Nat Commun. 2017 Nov 21;8(1):1668. doi: 10.1038/s41467-017-01709-8.

5.

Brain Tumor Stem Cells Remain in Play.

Parada LF, Dirks PB, Wechsler-Reya RJ.

J Clin Oncol. 2017 Jul 20;35(21):2428-2431. doi: 10.1200/JCO.2017.73.9540. Epub 2017 Jun 22. Review. No abstract available.

6.

Cell of origin of glioma: biological and clinical implications.

Alcantara Llaguno SR, Parada LF.

Br J Cancer. 2016 Dec 6;115(12):1445-1450. doi: 10.1038/bjc.2016.354. Epub 2016 Nov 10.

7.

Cell of Origin and Cancer Stem Cells in Tumor Suppressor Mouse Models of Glioblastoma.

Alcantara Llaguno SR, Xie X, Parada LF.

Cold Spring Harb Symp Quant Biol. 2016;81:31-36. doi: 10.1101/sqb.2016.81.030973. Epub 2016 Nov 4. Review.

8.

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes.

Alcantara Llaguno SR, Wang Z, Sun D, Chen J, Xu J, Kim E, Hatanpaa KJ, Raisanen JM, Burns DK, Johnson JE, Parada LF.

Cancer Cell. 2015 Oct 12;28(4):429-440. doi: 10.1016/j.ccell.2015.09.007.

9.

Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.

Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD.

J Immunol. 2015 Jul 1;195(1):31-5. doi: 10.4049/jimmunol.1402639. Epub 2015 May 22.

10.

Cell of origin for malignant gliomas and its implication in therapeutic development.

Zong H, Parada LF, Baker SJ.

Cold Spring Harb Perspect Biol. 2015 Jan 29;7(5). pii: a020610. doi: 10.1101/cshperspect.a020610. Review.

11.

The paraventricular thalamus controls a central amygdala fear circuit.

Penzo MA, Robert V, Tucciarone J, De Bundel D, Wang M, Van Aelst L, Darvas M, Parada LF, Palmiter RD, He M, Huang ZJ, Li B.

Nature. 2015 Mar 26;519(7544):455-9. doi: 10.1038/nature13978. Epub 2015 Jan 19.

12.

Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues.

Rauen KA, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, van der Vaart T, Vikkula M, Viskochil DH, Zenker M, Upadhyaya M.

Am J Med Genet A. 2015 Jan;167A(1):1-10. doi: 10.1002/ajmg.a.36793. Epub 2014 Nov 12.

13.

NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.

Sanchez-Ortiz E, Cho W, Nazarenko I, Mo W, Chen J, Parada LF.

Genes Dev. 2014 Nov 1;28(21):2407-20. doi: 10.1101/gad.246603.114.

14.

The soft underbelly of tumor cells.

Shi Y, Lim SK, Parada LF.

Cell Res. 2014 Aug;24(8):910-1. doi: 10.1038/cr.2014.72. Epub 2014 May 30.

15.

Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus.

Amiri A, Sanchez-Ortiz E, Cho W, Birnbaum SG, Xu J, McKay RM, Parada LF.

Autism Res. 2014 Feb;7(1):60-71. doi: 10.1002/aur.1342. Epub 2014 Jan 9.

PMID:
24408886
16.

Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors.

Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ.

Cancer Res. 2014 Jan 15;74(2):586-97. doi: 10.1158/0008-5472.CAN-13-1934. Epub 2013 Nov 27.

17.

PTEN knockdown alters dendritic spine/protrusion morphology, not density.

Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM.

J Comp Neurol. 2014 Apr 1;522(5):1171-90. doi: 10.1002/cne.23488.

18.

Injury signals cooperate with Nf1 loss to relieve the tumor-suppressive environment of adult peripheral nerve.

Ribeiro S, Napoli I, White IJ, Parrinello S, Flanagan AM, Suter U, Parada LF, Lloyd AC.

Cell Rep. 2013 Oct 17;5(1):126-36. doi: 10.1016/j.celrep.2013.08.033. Epub 2013 Sep 26.

19.

The tumor suppressor CDKN3 controls mitosis.

Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen JR, Lehmann AS, Park SJ, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang FC, Parada LF, Clapp W.

J Cell Biol. 2013 Jun 24;201(7):997-1012. doi: 10.1083/jcb.201205125. Epub 2013 Jun 17. Erratum in: J Cell Biol. 2013 Aug 19;202(4):717.

20.

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.

Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, Golding SE, Deb S, Temesi DG, Lau A, O'Connor MJ, Choe KS, Parada LF, Lim SK, Mukhopadhyay ND, Valerie K.

Clin Cancer Res. 2013 Jun 15;19(12):3189-200. doi: 10.1158/1078-0432.CCR-12-3408. Epub 2013 Apr 25.

21.

The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes.

Oliver JA, Lapinski PE, Lubeck BA, Turner JS, Parada LF, Zhu Y, King PD.

Mol Immunol. 2013 Oct;55(3-4):292-302. doi: 10.1016/j.molimm.2013.03.005. Epub 2013 Mar 20.

22.

Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight.

Mason BL, Lobo MK, Parada LF, Lutter M.

Obesity (Silver Spring). 2013 Nov;21(11):2372-6. doi: 10.1002/oby.20382. Epub 2013 May 31.

23.

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.

Takeuchi K, Gertner MJ, Zhou J, Parada LF, Bennett MV, Zukin RS.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4738-43. doi: 10.1073/pnas.1222803110. Epub 2013 Mar 4.

24.

Transcription factor Sox11 is essential for both embryonic and adult neurogenesis.

Wang Y, Lin L, Lai H, Parada LF, Lei L.

Dev Dyn. 2013 Jun;242(6):638-53. doi: 10.1002/dvdy.23962. Epub 2013 Apr 28.

25.

CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors.

Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LF.

Cell. 2013 Feb 28;152(5):1077-90. doi: 10.1016/j.cell.2013.01.053. Epub 2013 Feb 21.

26.

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial.

Robertson KA, Nalepa G, Yang FC, Bowers DC, Ho CY, Hutchins GD, Croop JM, Vik TA, Denne SC, Parada LF, Hingtgen CM, Walsh LE, Yu M, Pradhan KR, Edwards-Brown MK, Cohen MD, Fletcher JW, Travers JB, Staser KW, Lee MW, Sherman MR, Davis CJ, Miller LC, Ingram DA, Clapp DW.

Lancet Oncol. 2012 Dec;13(12):1218-24. doi: 10.1016/S1470-2045(12)70414-X. Epub 2012 Oct 23.

27.

Neurofibromatosis type 1: modeling CNS dysfunction.

Gutmann DH, Parada LF, Silva AJ, Ratner N.

J Neurosci. 2012 Oct 10;32(41):14087-93. doi: 10.1523/JNEUROSCI.3242-12.2012. Review.

28.

Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development.

Li Y, Yui D, Luikart BW, McKay RM, Li Y, Rubenstein JL, Parada LF.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15491-6. Epub 2012 Sep 4.

29.

Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.

Kim TH, Song J, Alcantara Llaguno SR, Murnan E, Liyanarachchi S, Palanichamy K, Yi JY, Viapiano MS, Nakano I, Yoon SO, Wu H, Parada LF, Kwon CH.

PLoS One. 2012;7(8):e42818. doi: 10.1371/journal.pone.0042818. Epub 2012 Aug 15.

30.

A restricted cell population propagates glioblastoma growth after chemotherapy.

Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF.

Nature. 2012 Aug 23;488(7412):522-6. doi: 10.1038/nature11287.

31.

The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.

Acosta MT, Bearden CE, Castellanos FX, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ.

Am J Med Genet A. 2012 Sep;158A(9):2225-32. doi: 10.1002/ajmg.a.35535. Epub 2012 Jul 20. Review. Erratum in: Am J Med Genet A. 2013 Jan;161A(1):236. Castellanos, Xavier F [corrected to Castellanos, F Xavier].

32.

PTEN signaling in autism spectrum disorders.

Zhou J, Parada LF.

Curr Opin Neurobiol. 2012 Oct;22(5):873-9. doi: 10.1016/j.conb.2012.05.004. Epub 2012 Jun 2. Review.

PMID:
22664040
33.

Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis.

Amiri A, Cho W, Zhou J, Birnbaum SG, Sinton CM, McKay RM, Parada LF.

J Neurosci. 2012 Apr 25;32(17):5880-90. doi: 10.1523/JNEUROSCI.5462-11.2012.

34.

Overactivation of Ras signaling pathway in CD133+ MPNST cells.

Borrego-Diaz E, Terai K, Lialyte K, Wise AL, Esfandyari T, Behbod F, Mautner VF, Spyra M, Taylor S, Parada LF, Upadhyaya M, Farassati F.

J Neurooncol. 2012 Jul;108(3):423-34. doi: 10.1007/s11060-012-0852-1. Epub 2012 Apr 8.

PMID:
22484909
35.

Malignant glioma: lessons from genomics, mouse models, and stem cells.

Chen J, McKay RM, Parada LF.

Cell. 2012 Mar 30;149(1):36-47. doi: 10.1016/j.cell.2012.03.009. Review.

36.

TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.

Sanchez-Ortiz E, Yui D, Song D, Li Y, Rubenstein JL, Reichardt LF, Parada LF.

J Neurosci. 2012 Mar 21;32(12):4065-79. doi: 10.1523/JNEUROSCI.6314-11.2012.

37.

Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants.

Li Y, Li Y, McKay RM, Riethmacher D, Parada LF.

J Neurosci. 2012 Mar 7;32(10):3529-39. doi: 10.1523/JNEUROSCI.3469-11.2012.

38.

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration.

Colombo E, Cordiglieri C, Melli G, Newcombe J, Krumbholz M, Parada LF, Medico E, Hohlfeld R, Meinl E, Farina C.

J Exp Med. 2012 Mar 12;209(3):521-35. doi: 10.1084/jem.20110698. Epub 2012 Mar 5.

39.

Phenotypic characterization of transgenic mice harboring Nf1+/- or Nf1-/- osteoclasts in otherwise Nf1+/+ background.

Alanne MH, Siljamäki E, Peltonen S, Väänänen K, Windle JJ, Parada LF, Määttä JA, Peltonen J.

J Cell Biochem. 2012 Jun;113(6):2136-46. doi: 10.1002/jcb.24088.

PMID:
22307743
40.

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.

Fassl A, Tagscherer KE, Richter J, Berriel Diaz M, Alcantara Llaguno SR, Campos B, Kopitz J, Herold-Mende C, Herzig S, Schmidt MHH, Parada LF, Wiestler OD, Roth W.

Oncogene. 2012 Nov 1;31(44):4698-708. doi: 10.1038/onc.2011.615. Epub 2012 Jan 16.

PMID:
22249262
41.

Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle.

Zhou J, Shrikhande G, Xu J, McKay RM, Burns DK, Johnson JE, Parada LF.

Genes Dev. 2011 Aug 1;25(15):1595-600. doi: 10.1101/gad.16750211.

42.

miR-132 mediates the integration of newborn neurons into the adult dentate gyrus.

Luikart BW, Bensen AL, Washburn EK, Perederiy JV, Su KG, Li Y, Kernie SG, Parada LF, Westbrook GL.

PLoS One. 2011;6(5):e19077. doi: 10.1371/journal.pone.0019077. Epub 2011 May 17.

43.

Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development.

Le LQ, Liu C, Shipman T, Chen Z, Suter U, Parada LF.

Cancer Res. 2011 Jul 1;71(13):4686-95. doi: 10.1158/0008-5472.CAN-10-4577. Epub 2011 May 6.

44.

Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury.

Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, Powell CM, Kernie SG.

J Neurosci. 2011 Mar 30;31(13):4906-16. doi: 10.1523/JNEUROSCI.5265-10.2011.

45.

Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models.

Lim SK, Llaguno SR, McKay RM, Parada LF.

BMB Rep. 2011 Mar;44(3):158-64. doi: 10.5483/BMBRep.2011.44.3.158. Review.

46.

Genetic modeling of gliomas in mice: new tools to tackle old problems.

Hambardzumyan D, Parada LF, Holland EC, Charest A.

Glia. 2011 Aug;59(8):1155-68. doi: 10.1002/glia.21142. Epub 2011 Feb 8. Review.

47.

Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration.

Harada C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K, Parada LF, Harada T.

Nat Commun. 2011 Feb 8;2:189. doi: 10.1038/ncomms1190.

48.

Stem cells in brain tumor development.

Alcantara Llaguno SR, Chen Y, McKay RM, Parada LF.

Curr Top Dev Biol. 2011;94:15-44. doi: 10.1016/B978-0-12-380916-2.00002-4.

PMID:
21295683
49.

Back to the future: proceedings from the 2010 NF Conference.

Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y, Hunter-Schaedle K, Giancotti FG.

Am J Med Genet A. 2011 Feb;155A(2):307-21. doi: 10.1002/ajmg.a.33804. Epub 2010 Dec 22.

50.

Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.

Namekata K, Harada C, Taya C, Guo X, Kimura H, Parada LF, Harada T.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7586-91. doi: 10.1073/pnas.0914514107. Epub 2010 Apr 5.

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