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Items: 1 to 50 of 285

1.

First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and advances of new therapeutics.

Rauen KA, Alsaegh A, Ben-Shachar S, Berman Y, Blakeley J, Cordeiro I, Elgersma Y, Evans DG, Fisher MJ, Frayling IM, George J, Huson SM, Kerr B, Khire U, Korf B, Legius E, Messiaen L, van Minkelen R, Nampoothiri S, Ngeow J, Parada LF, Phadke S, Pillai A, Plotkin SR, Puri R, Raji A, Ramesh V, Ratner N, Shankar SP, Sharda S, Tambe A, Vikkula M, Widemann BC, Wolkenstein P, Upadhyaya M.

Am J Med Genet A. 2019 Jun;179(6):1091-1097. doi: 10.1002/ajmg.a.61125. Epub 2019 Mar 25.

PMID:
30908877
2.

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.

Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF.

Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6.

PMID:
30842654
3.

Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction.

Alcantara Llaguno S, Sun D, Pedraza AM, Vera E, Wang Z, Burns DK, Parada LF.

Nat Neurosci. 2019 Apr;22(4):545-555. doi: 10.1038/s41593-018-0333-8. Epub 2019 Feb 18.

PMID:
30778149
4.

Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family.

Llavero F, Luque Montoro M, Arrazola Sastre A, Fernández-Moreno D, Lacerda HM, Parada LA, Lucia A, Zugaza JL.

J Biol Chem. 2019 Mar 22;294(12):4345-4358. doi: 10.1074/jbc.RA118.005997. Epub 2019 Jan 15.

PMID:
30647127
5.

Augmented Reality Microsurgical Planning with a Smartphone (ARM-PS): A dissection route map in your pocket.

Pereira N, Kufeke M, Parada L, Troncoso E, Bahamondes J, Sanchez L, Roa R.

J Plast Reconstr Aesthet Surg. 2019 May;72(5):759-762. doi: 10.1016/j.bjps.2018.12.023. Epub 2018 Dec 14.

PMID:
30611677
6.

Size matters in the case of graphic health warnings: Evidence from physiological measures.

Gantiva C, Sotaquirá M, Marroquín M, Carné C, Parada L, Muñoz MA.

Addict Behav. 2019 May;92:64-68. doi: 10.1016/j.addbeh.2018.12.003. Epub 2018 Dec 7.

PMID:
30597332
7.

PLAGL1 gene function during hepatoma cells proliferation.

Vega-Benedetti AF, Saucedo CN, Zavattari P, Vanni R, Royo F, Llavero F, Zugaza JL, Parada LA.

Oncotarget. 2018 Aug 28;9(67):32775-32794. doi: 10.18632/oncotarget.25996. eCollection 2018 Aug 28.

8.

Preparation and Characterization of Poloxamer 407 Solid Dispersions as an Alternative Strategy to Improve Benznidazole Bioperformance.

Simonazzi A, Davies C, Cid AG, Gonzo E, Parada L, Bermúdez JM.

J Pharm Sci. 2018 Nov;107(11):2829-2836. doi: 10.1016/j.xphs.2018.06.027. Epub 2018 Jul 10.

PMID:
30005984
9.

TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response.

Ma Z, Zang T, Birnbaum SG, Wang Z, Johnson JE, Zhang CL, Parada LF.

Nat Commun. 2017 Nov 21;8(1):1668. doi: 10.1038/s41467-017-01709-8.

10.

Brain Tumor Stem Cells Remain in Play.

Parada LF, Dirks PB, Wechsler-Reya RJ.

J Clin Oncol. 2017 Jul 20;35(21):2428-2431. doi: 10.1200/JCO.2017.73.9540. Epub 2017 Jun 22. Review. No abstract available.

11.

Cell of origin of glioma: biological and clinical implications.

Alcantara Llaguno SR, Parada LF.

Br J Cancer. 2016 Dec 6;115(12):1445-1450. doi: 10.1038/bjc.2016.354. Epub 2016 Nov 10.

12.

Gallbladder cancer: South American experience.

Arroyo GF, Gentile A, Parada LA.

Chin Clin Oncol. 2016 Oct;5(5):67. doi: 10.21037/cco.2016.10.01. Review.

13.

Cell of Origin and Cancer Stem Cells in Tumor Suppressor Mouse Models of Glioblastoma.

Alcantara Llaguno SR, Xie X, Parada LF.

Cold Spring Harb Symp Quant Biol. 2016;81:31-36. doi: 10.1101/sqb.2016.81.030973. Epub 2016 Nov 4. Review.

14.

Exposure to Inorganic Arsenic Is Associated with Increased Mitochondrial DNA Copy Number and Longer Telomere Length in Peripheral Blood.

Ameer SS, Xu Y, Engström K, Li H, Tallving P, Nermell B, Boemo A, Parada LA, Peñaloza LG, Concha G, Harari F, Vahter M, Broberg K.

Front Cell Dev Biol. 2016 Aug 22;4:87. doi: 10.3389/fcell.2016.00087. eCollection 2016.

15.

Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway.

Llavero F, Artaso A, Lacerda HM, Parada LA, Zugaza JL.

Cell Signal. 2016 Nov;28(11):1713-24. doi: 10.1016/j.cellsig.2016.07.014. Epub 2016 Aug 9.

16.

PLAGL1: an important player in diverse pathological processes.

Vega-Benedetti AF, Saucedo C, Zavattari P, Vanni R, Zugaza JL, Parada LA.

J Appl Genet. 2017 Feb;58(1):71-78. doi: 10.1007/s13353-016-0355-4. Epub 2016 Jun 16. Review.

PMID:
27311313
17.

Tolerability of the COX-1/COX-2 inhibitor lornoxicam in the treatment of acute and rheumatic pain.

Parada L, Marstein JP, Danilov A.

Pain Manag. 2016 Oct;6(5):445-54. doi: 10.2217/pmt.16.7. Epub 2016 Apr 18.

PMID:
27086708
18.

Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes.

Zaldua N, Llavero F, Artaso A, Gálvez P, Lacerda HM, Parada LA, Zugaza JL.

FEBS J. 2016 Feb;283(4):647-61. doi: 10.1111/febs.13617. Epub 2016 Jan 4.

19.

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes.

Alcantara Llaguno SR, Wang Z, Sun D, Chen J, Xu J, Kim E, Hatanpaa KJ, Raisanen JM, Burns DK, Johnson JE, Parada LF.

Cancer Cell. 2015 Oct 12;28(4):429-440. doi: 10.1016/j.ccell.2015.09.007.

20.

Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.

Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD.

J Immunol. 2015 Jul 1;195(1):31-5. doi: 10.4049/jimmunol.1402639. Epub 2015 May 22.

21.

Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells.

Llavero F, Urzelai B, Osinalde N, Gálvez P, Lacerda HM, Parada LA, Zugaza JL.

J Biol Chem. 2015 Apr 3;290(14):9171-82. doi: 10.1074/jbc.M114.608414. Epub 2015 Feb 18.

22.

Expression of the DYRK1A gene correlates with its 3D positioning in the interphase nucleus of Down syndrome cells.

Paz N, Felipe-Blanco I, Royo F, Zabala A, Guerra-Merino I, García-Orad Á, Zugaza JL, Parada LA.

Chromosome Res. 2015 Jun;23(2):285-98. doi: 10.1007/s10577-015-9467-7. Epub 2015 Feb 3.

PMID:
25645734
23.

Cell of origin for malignant gliomas and its implication in therapeutic development.

Zong H, Parada LF, Baker SJ.

Cold Spring Harb Perspect Biol. 2015 Jan 29;7(5). pii: a020610. doi: 10.1101/cshperspect.a020610. Review.

24.

The paraventricular thalamus controls a central amygdala fear circuit.

Penzo MA, Robert V, Tucciarone J, De Bundel D, Wang M, Van Aelst L, Darvas M, Parada LF, Palmiter RD, He M, Huang ZJ, Li B.

Nature. 2015 Mar 26;519(7544):455-9. doi: 10.1038/nature13978. Epub 2015 Jan 19.

25.

Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging.

Martín-Guerrero I, de Prado E, Lopez-Lopez E, Ardanaz M, Vitoria JC, Parada LA, García-Orad C, García-Orad A.

Age (Dordr). 2014;36(6):9730. doi: 10.1007/s11357-014-9730-4. Epub 2014 Nov 16.

26.

Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues.

Rauen KA, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, van der Vaart T, Vikkula M, Viskochil DH, Zenker M, Upadhyaya M.

Am J Med Genet A. 2015 Jan;167A(1):1-10. doi: 10.1002/ajmg.a.36793. Epub 2014 Nov 12.

27.

NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.

Sanchez-Ortiz E, Cho W, Nazarenko I, Mo W, Chen J, Parada LF.

Genes Dev. 2014 Nov 1;28(21):2407-20. doi: 10.1101/gad.246603.114.

28.

Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole.

Davies C, Dey N, Negrette OS, Parada LA, Basombrio MA, Garg NJ.

PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3231. doi: 10.1371/journal.pntd.0003231. eCollection 2014 Oct.

29.

In vivo antileishmanial efficacy of miltefosine against Leishmania (Leishmania) amazonensis.

García Bustos MF, Barrio A, Prieto GG, de Raspi EM, Cimino RO, Cardozo RM, Parada LA, Yeo M, Soto J, Uncos DA, Parodi C, Basombrío MA.

J Parasitol. 2014 Dec;100(6):840-7. doi: 10.1645/13-376.1.

PMID:
25014108
30.

[The cost-effectiveness of interferon beta treatment in patients with a clinically isolated syndrome in Colombia].

Zarco LA, Millán SP, Londoño D, Parada L, Taborda A, Borda MG.

Biomedica. 2014 Jan-Mar;34(1):110-7. doi: 10.1590/S0120-41572014000100014. Spanish.

31.

The soft underbelly of tumor cells.

Shi Y, Lim SK, Parada LF.

Cell Res. 2014 Aug;24(8):910-1. doi: 10.1038/cr.2014.72. Epub 2014 May 30.

32.

Trkb signaling in pericytes is required for cardiac microvessel stabilization.

Anastasia A, Deinhardt K, Wang S, Martin L, Nichol D, Irmady K, Trinh J, Parada L, Rafii S, Hempstead BL, Kermani P.

PLoS One. 2014 Jan 31;9(1):e87406. doi: 10.1371/journal.pone.0087406. eCollection 2014.

33.

Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus.

Amiri A, Sanchez-Ortiz E, Cho W, Birnbaum SG, Xu J, McKay RM, Parada LF.

Autism Res. 2014 Feb;7(1):60-71. doi: 10.1002/aur.1342. Epub 2014 Jan 9.

PMID:
24408886
34.

Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors.

Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ.

Cancer Res. 2014 Jan 15;74(2):586-97. doi: 10.1158/0008-5472.CAN-13-1934. Epub 2013 Nov 27.

35.

PTEN knockdown alters dendritic spine/protrusion morphology, not density.

Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM.

J Comp Neurol. 2014 Apr 1;522(5):1171-90. doi: 10.1002/cne.23488.

36.

Injury signals cooperate with Nf1 loss to relieve the tumor-suppressive environment of adult peripheral nerve.

Ribeiro S, Napoli I, White IJ, Parrinello S, Flanagan AM, Suter U, Parada LF, Lloyd AC.

Cell Rep. 2013 Oct 17;5(1):126-36. doi: 10.1016/j.celrep.2013.08.033. Epub 2013 Sep 26.

37.

ATP antagonizes thrombin-induced signal transduction through 12(S)-HETE and cAMP.

Burzaco J, Conde M, Parada LA, Zugaza JL, Dehaye JP, Marino A.

PLoS One. 2013 Jun 24;8(6):e67117. doi: 10.1371/journal.pone.0067117. Print 2013.

38.

The tumor suppressor CDKN3 controls mitosis.

Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen JR, Lehmann AS, Park SJ, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang FC, Parada LF, Clapp W.

J Cell Biol. 2013 Jun 24;201(7):997-1012. doi: 10.1083/jcb.201205125. Epub 2013 Jun 17. Erratum in: J Cell Biol. 2013 Aug 19;202(4):717.

39.

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.

Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, Golding SE, Deb S, Temesi DG, Lau A, O'Connor MJ, Choe KS, Parada LF, Lim SK, Mukhopadhyay ND, Valerie K.

Clin Cancer Res. 2013 Jun 15;19(12):3189-200. doi: 10.1158/1078-0432.CCR-12-3408. Epub 2013 Apr 25.

40.

Combined fluorescent-chromogenic in situ hybridization for identification and laser microdissection of interphase chromosomes.

Paz N, Zabala A, Royo F, García-Orad Á, Zugaza JL, Parada LA.

PLoS One. 2013;8(4):e60238. doi: 10.1371/journal.pone.0060238. Epub 2013 Apr 2.

41.

The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes.

Oliver JA, Lapinski PE, Lubeck BA, Turner JS, Parada LF, Zhu Y, King PD.

Mol Immunol. 2013 Oct;55(3-4):292-302. doi: 10.1016/j.molimm.2013.03.005. Epub 2013 Mar 20.

42.

Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight.

Mason BL, Lobo MK, Parada LF, Lutter M.

Obesity (Silver Spring). 2013 Nov;21(11):2372-6. doi: 10.1002/oby.20382. Epub 2013 May 31.

43.

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.

Takeuchi K, Gertner MJ, Zhou J, Parada LF, Bennett MV, Zukin RS.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4738-43. doi: 10.1073/pnas.1222803110. Epub 2013 Mar 4.

44.

Transcription factor Sox11 is essential for both embryonic and adult neurogenesis.

Wang Y, Lin L, Lai H, Parada LF, Lei L.

Dev Dyn. 2013 Jun;242(6):638-53. doi: 10.1002/dvdy.23962. Epub 2013 Apr 28.

45.

CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors.

Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LF.

Cell. 2013 Feb 28;152(5):1077-90. doi: 10.1016/j.cell.2013.01.053. Epub 2013 Feb 21.

46.

1-42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death.

Manterola L, Hernando-Rodríguez M, Ruiz A, Apraiz A, Arrizabalaga O, Vellón L, Alberdi E, Cavaliere F, Lacerda HM, Jimenez S, Parada LA, Matute C, Zugaza JL.

Transl Psychiatry. 2013 Jan 22;3:e219. doi: 10.1038/tp.2012.147.

47.

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial.

Robertson KA, Nalepa G, Yang FC, Bowers DC, Ho CY, Hutchins GD, Croop JM, Vik TA, Denne SC, Parada LF, Hingtgen CM, Walsh LE, Yu M, Pradhan KR, Edwards-Brown MK, Cohen MD, Fletcher JW, Travers JB, Staser KW, Lee MW, Sherman MR, Davis CJ, Miller LC, Ingram DA, Clapp DW.

Lancet Oncol. 2012 Dec;13(12):1218-24. doi: 10.1016/S1470-2045(12)70414-X. Epub 2012 Oct 23.

48.

Neurofibromatosis type 1: modeling CNS dysfunction.

Gutmann DH, Parada LF, Silva AJ, Ratner N.

J Neurosci. 2012 Oct 10;32(41):14087-93. doi: 10.1523/JNEUROSCI.3242-12.2012. Review.

49.

Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development.

Li Y, Yui D, Luikart BW, McKay RM, Li Y, Rubenstein JL, Parada LF.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15491-6. Epub 2012 Sep 4.

50.

Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.

Kim TH, Song J, Alcantara Llaguno SR, Murnan E, Liyanarachchi S, Palanichamy K, Yi JY, Viapiano MS, Nakano I, Yoon SO, Wu H, Parada LF, Kwon CH.

PLoS One. 2012;7(8):e42818. doi: 10.1371/journal.pone.0042818. Epub 2012 Aug 15.

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